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  • 2020
  • 2019
  • 2016

Author

  • Jiake Xu
Abstract
Abstract/Meeting Abstract

PIP5k1 beta controls bone homeostasis through modulating both osteoclast and osteoblast differentiation

Zhao, X., Cui, P., Wang, C., Zhao, J., Zhang, X. & Xu, J., Dec 2019, In : Journal of Bone and Mineral Research. 34, p. 328-328 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Article

A005, a novel inhibitor of phosphatidylinositol 3-kinase/mammalian target of rapamycin, prevents osteosarcoma-induced osteolysis

Lian, Z., Han, J., Huang, L., Wei, C., Fan, Y., Xu, J., Zhou, M., Feng, H., Liu, Q., Chen, L., Li, Z., Cheng, H., Yuan, G., Lin, X., Song, F., Su, Y., Wang, C., Huang, G., Qin, A., Song, Y. & 1 others, Yao, G., 1 Jan 2019, In : Carcinogenesis. 40, 2, p. E1-E13

Research output: Contribution to journalArticle

2 Citations (Scopus)

Amyloid β peptide enhances RANKL-induced osteoclast activation through NF-κB, ERK, and calcium oscillation signaling

Li, S., Yang, B., Teguh, D., Zhou, L., Xu, J. & Rong, L., 1 Oct 2016, In : International Journal of Molecular Sciences. 17, 10, 1683.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Analysis of circulating microRNAs aberrantly expressed in alcohol-induced osteonecrosis of femoral head

Hong, G., Han, X., He, W., Xu, J., Sun, P., Shen, Y., Wei, Q. & Chen, Z., 1 Dec 2019, In : Scientific Reports. 9, 1, 18926.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Arctiin abrogates osteoclastogenesis and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation

Chen, D., Ye, Z., Wang, C., Wang, Q., Wang, H., Kuek, V., Wang, Z., Qiu, H., Yuan, J., Kenny, J., Yang, F., He, J., Liu, Y., Wang, G., Zhang, M., Zhang, G., Wang, J., Chen, P. & Xu, J., Sep 2020, In : Pharmacological Research. 159, 104944.

Research output: Contribution to journalArticle

Asiatic Acid Inhibits OVX-Induced Osteoporosis and Osteoclastogenesis Via Regulating RANKL-Mediated NF-κb and Nfatc1 Signaling Pathways

Hong, G., Zhou, L., Han, X., Sun, P., Chen, Z., He, W., Tickner, J., Chen, L., Shi, X. & Xu, J., 27 Mar 2020, In : Frontiers in Pharmacology. 11, 331.

Research output: Contribution to journalArticle

Open Access

Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-kappa B signaling pathways

He, L., Hong, G., Zhou, L., Zhang, J., Fang, J., He, W., Tickner, J., Han, X., Zhao, L. & Xu, J., Apr 2019, In : Journal of Cellular Physiology. 234, 4, p. 4267-4276 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Asperpyrone A attenuates RANKL-induced osteoclast formation through inhibiting NFATc1, Ca2+ signalling and oxidative stress

Chen, X., Wang, C., Qiu, H., Yuan, Y., Chen, K., Cao, Z., Xiang Tan, R., Tickner, J., Xu, J. & Zou, J., 1 Dec 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8269-8279 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Astilbin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis

Jin, H., Wang, Q., Chen, K., Xu, K., Pan, H., Chu, F., Ye, Z., Wang, Z., Tickner, J., Qiu, H., Wang, C., Kenny, J., Xu, H., Wang, T. & Xu, J., 1 Dec 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8355-8368 14 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
5 Citations (Scopus)

Cajaninstilbene acid inhibits osteoporosis through suppressing osteoclast formation and RANKL-induced signaling pathways

Sun, Y., Liu, Y., He, W., Wang, C., Tickner, J., Kuek, V., Zhou, C., Wang, H., Zou, X., Hong, Z., Yang, F., Shao, M., Chen, L. & Xu, J., 1 Jul 2019, In : Journal of Cellular Physiology. 234, 7, p. 11792-11804 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Calmodulin interacts with Rab3D and modulates osteoclastic bone resorption

Zhu, S., Chim, S. M., Cheng, T., Ang, E., Ng, B., Lim, B., Chen, K., Qiu, H., Tickner, J., Xu, H., Pavlos, N. & Xu, J., 29 Nov 2016, In : Scientific Reports. 6, p. 1-9

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Cepharanthine suppresses osteoclast formation by modulating the nuclear factor-κB and nuclear factor of activated T-cell signaling pathways

Lin, X., Song, F., Zhou, L., Wang, Z., Wei, C., Xu, J., Zhao, J. & Liu, Q., 1 Feb 2019, In : Journal of Cellular Biochemistry. 120, 2, p. 1990-1996 7 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
57 Downloads (Pure)

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts

Mullin, B., Tickner, J., Zhu, K., Kenny, J., Mullin, S., Brown, S. J., Dudbridge, F., Pavlos, N., Mocarski, E. S., Walsh, J. P., Xu, J. & Wilson, S., 26 Mar 2020, In : Genome Biology. 21, 1, 80.

Research output: Contribution to journalArticle

Open Access

Conditional Knockout of PKC-δ in Osteoclasts Favors Bone Mass Accrual in Males Due to Decreased Osteoclast Function

Li, S., He, T., Wu, D., Zhang, L., Chen, R., Liu, B., Yuan, J., Tickner, J., Qin, A., Xu, J. & Rong, L., 9 Jun 2020, In : Frontiers in Cell and Developmental Biology. 8, 450.

Research output: Contribution to journalArticle

Open Access

Cumambrin A prevents OVX-induced osteoporosis via the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways

Zhou, L., Liu, Q., Hong, G., Song, F., Zhao, J., Yuan, J., Xu, J., Tan, R. X., Tickner, J., Gu, Q. & Xu, J., 1 Jun 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 6, p. 6726-6735 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Cytochalasin Z11 inhibits RANKL-induced osteoclastogenesis: Via suppressing NFATc1 activation

Wang, L., Chen, K., He, J., Kenny, J., Yuan, Y., Chen, J., Liu, Q., Tan, R., Zhao, J. & Xu, J., 25 Nov 2019, In : RSC Advances. 9, 66, p. 38438-38446 9 p.

Research output: Contribution to journalArticle

Open Access

Daphnetin attenuates LPS-induced osteolysis and RANKL mediated osteoclastogenesis through suppression of ERK and NFATc1 pathways

Wu, Z., Wu, H., Li, C., Fu, F., Ding, J., Shao, S., Li, K., Yu, X., Su, Y., Liang, J., Lin, X., Yuan, G., Zhou, J., Song, F., Zhao, J., Xu, J., Liu, Q. & Xu, F., 1 Oct 2019, In : Journal of Cellular Physiology. 234, 10, p. 17812-17823 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation

Zhou, C., You, Y., Shen, W., Zhu, Y. Z., Peng, J., Feng, H. T., Wang, Y., Li, D., Shao, W. W., Li, C. X., Li, W. Z., Xu, J. & Shen, X., 2016, In : Annals of the Rheumatic Diseases. n/a, p. 1-8

Research output: Contribution to journalArticle

14 Citations (Scopus)

Dehydrocostus lactone (DHC) suppresses estrogen deficiency-induced osteoporosis

Li, Z., Yuan, G., Lin, X., Liu, Q., Xu, J., Lian, Z., Song, F., Zheng, J., Xie, D., Chen, L., Wang, X., Feng, H., Zhou, M. & Yao, G., 1 May 2019, In : Biochemical Pharmacology. 163, p. 279-289 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Dihydroartemisinin, an Anti-Malaria Drug, Suppresses Estrogen Deficiency-Induced Osteoporosis, Osteoclast Formation, and RANKL-Induced Signaling Pathways

Zhou, L., Liu, Q., Yang, M., Wang, T., Yao, J., Cheng, J. W., Yuan, J., Lin, X., Zhao, J., Tickner, J. & Xu, J., May 2016, In : Journal of Bone and Mineral Research. 31, 5, p. 964-974

Research output: Contribution to journalArticle

Open Access
File
49 Citations (Scopus)
301 Downloads (Pure)

Diosmetin inhibits osteoclast formation and differentiation and prevents LPS-induced osteolysis in mice

Shao, S., Fu, F., Wang, Z., Song, F., Li, C., Wu, Z. X., Ding, J., Li, K., Xiao, Y., Su, Y., Lin, X., Yuan, G., Zhao, J., Liu, Q. & Xu, J., 1 Aug 2019, In : Journal of Cellular Physiology. 234, 8, p. 12701-12713 13 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
5 Downloads (Pure)

Discovery of new inhibitors against both NF-κB and osteoclastogenesis from in-house library with α, β-unsaturated-enone fragment

Zhao, C., Huang, D., Li, R., Xu, J., Gu, Q. & Xu, J., 1 Jun 2019, In : Bioorganic Chemistry. 87, p. 638-646 9 p.

Research output: Contribution to journalArticle

Double network shape memory hydrogels activated by near-infrared with high mechanical toughness, nontoxicity, and 3D printability

Dai, W., Guo, H., Gao, B., Ruan, M., Xu, L., Wu, J., Kirk, T. B., Xu, J., Ma, D. & Xue, W., 15 Jan 2019, In : Chemical Engineering Journal. 356, p. 934-949 16 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Dracorhodin perchlorate inhibits osteoclastogenesis through repressing RANKL-stimulated NFATc1 activity

Liu, Y., Wang, Z., Ma, C., Wei, Z., Chen, K., Wang, C., Zhou, C., Chen, L., Zhang, Q., Chen, Z., He, W. & Xu, J., 1 Mar 2020, In : Journal of Cellular and Molecular Medicine. 24, 6, p. 3303-3313 11 p.

Research output: Contribution to journalArticle

Open Access

Ellagic acid protects ovariectomy-induced bone loss in mice by inhibiting osteoclast differentiation and bone resorption

Lin, X., Yuan, G., Li, Z., Zhou, M., Hu, X., Song, F., Shao, S., Fu, F., Zhao, J., Xu, J., Liu, Q. & Feng, H., 1 Sep 2020, In : Journal of Cellular Physiology. 235, 9, p. 5951-5961 11 p.

Research output: Contribution to journalArticle

Eriodictyol Inhibits RANKL-Induced Osteoclast Formation and Function Via Inhibition of NFATc1 Activity

Song, F., Zhou, L., Zhao, J., Liu, Q., Yang, M., Tan, R., Xu, J., Zhang, G., Quinn, J. M. W., Tickner, J., Huang, Y. & Xu, J., Sep 2016, In : Journal of Cellular Physiology. 231, 9, p. 1983-1993

Research output: Contribution to journalArticle

21 Citations (Scopus)

Evodiamine inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in mice

Jin, H., Yao, L., Chen, K., Liu, Y., Wang, Q., Wang, Z., Liu, Q., Cao, Z., Kenny, J., Tickner, J., Wang, X. & Xu, J., Jan 2019, In : Journal of Cellular and Molecular Medicine. 23, 1, p. 522-534 13 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Folate-targeting redox hyperbranched poly(amido amine)s delivering MMP-9 siRNA for cancer therapy

Li, M., Zhou, X., Zeng, X., Wang, C., Xu, J., Ma, D. & Xue, W., 2016, In : Journal of Materials Chemistry B. 4, 3, p. 547-556

Research output: Contribution to journalArticle

32 Citations (Scopus)

Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways

Yuan, Y., Chen, K., Chen, X., Wang, C., Qiu, H., Cao, Z., Song, D., Sun, Y., Guo, J., Tickner, J., Xu, J. & Zou, J., 10 Mar 2020, In : Frontiers in Pharmacology. 11, 238.

Research output: Contribution to journalArticle

Open Access
Open Access
4 Citations (Scopus)

Hederagenin protects mice against ovariectomy-induced bone loss by inhibiting RANKL-induced osteoclastogenesis and bone resorption

Tian, K., Su, Y., Ding, J., Wang, D., Zhan, Y., Li, Y., Liang, J., Lin, X., Song, F., Wang, Z., Xu, J., Liu, Q. & Zhao, J., 1 Mar 2020, In : Life Sciences. 244, 117336.

Research output: Contribution to journalArticle

Helvolic acid attenuates osteoclast formation and function via suppressing RANKL-induced NFATc1 activation

Chen, K., Yuan, Y., Wang, Z., Song, D., Zhao, J., Cao, Z., Chen, J., Guo, Q., Chen, L., Tickner, J. & Xu, J., May 2019, In : Journal of Cellular Physiology. 234, 5, p. 6477-6488 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
34 Downloads (Pure)

Hemocompatibility evaluation in vitro of methoxy polyethyleneglycol-polycaprolactone copolymer solutions

Hu, Q., Zhang, Y., Wang, C., Xu, J., Wu, J., Liu, Z. & Xue, W., 2016, In : Journal of Biomedical Materials Research - Part A. 104, 3, p. 802-812

Research output: Contribution to journalArticle

7 Citations (Scopus)

Jatrophane Diterpenoids from Euphorbia esula as Inhibitors of RANKL-Induced Osteoclastogenesis

Yuan, S., Hua, P., Zhao, C., Zhou, H., Xu, J., Xu, J. & Gu, Q., 1 Apr 2020, In : Journal of Natural Products. 83, 4, p. 1005–1017

Research output: Contribution to journalArticle

Loureirin B suppresses RANKL-induced osteoclastogenesis and ovariectomized osteoporosis via attenuating NFATc1 and ROS activities

Liu, Y., Wang, C., Wang, G., Sun, Y., Deng, Z., Chen, L., Chen, K., Tickner, J., Kenny, J., Song, D., Zhang, Q., Wang, H., Chen, Z., Zhou, C., He, W. & Xu, J., 2019, In : Theranostics. 9, 16, p. 4648-4662 15 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Madecassoside inhibits estrogen deficiency-induced osteoporosis by suppressing RANKL-induced osteoclastogenesis

Wang, Q., Yao, L., Xu, K., Jin, H., Chen, K., Wang, Z., Liu, Q., Cao, Z., Kenny, J., Liu, Y., Tickner, J., Xu, H. & Xu, J., Jan 2019, In : Journal of Cellular and Molecular Medicine. 23, 1, p. 380-394 15 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

MiR-214 Attenuates the Osteogenic Effects of Mechanical Loading on Osteoblasts

Yuan, Y., Guo, J., Zhang, L., Tong, X., Zhang, S., Zhou, X., Zhang, M., Chen, X., Lei, L., Li, H., Liu, T. C. Y., Xu, J. & Zou, J., Dec 2019, In : International Journal of Sports Medicine. 40, 14, p. 931-940 10 p.

Research output: Contribution to journalArticle

Modulating calcium-mediated NFATc1 and mitogen-activated protein kinase deactivation underlies the inhibitory effects of kavain on osteoclastogenesis and bone resorption

Guo, Q., Cao, Z., Wu, B., Chen, F., Tickner, J., Wang, Z., Qiu, H., Wang, C., Chen, K., Tan, R., Gao, Q. & Xu, J., Jan 2019, In : Journal of Cellular Physiology. 234, 1, p. 789-801 13 p.

Research output: Contribution to journalArticle

File
5 Citations (Scopus)
240 Downloads (Pure)
Open Access
10 Citations (Scopus)

Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats

Su, Y., Chung, R., Ruan, C., Chim, S., Kuek, V., Dwivedi, P., Hassanshahi, M., Chen, K., Xie, Y., Chen, L., Foster, B., Rosen, V., Zhou, X., Xu, J. & Xian, C., Jun 2016, In : Journal of Bone & Mineral Research. 31, 6, p. 1258-1274

Research output: Contribution to journalArticle

25 Citations (Scopus)

Nitidine chloride prevents OVX-induced bone loss via suppressing NFATc1-mediated osteoclast differentiation

Liu, Q., Wang, T., Zhou, L., Song, F., Qin, A., Feng, H. T., Lin, X. X., Lin, Z., Yuan, J. B., Tickner, J., Liu, H. G., Zheng, M. H., Xu, J. & Zhao, J. M., 8 Nov 2016, In : Scientific Reports. 6, p. 1-10 36662 .

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

NPNT is expressed by osteoblasts and mediates angiogenesis via the activation of extracellular signal-regulated kinase

Kuek, V., Yang, Z., Chim, S., Zhu, S., Xu, H., Chow, S. T., Tickner, J., Rosen, V., Erber, W., Li, X., An, Q., Qian, Y. & Xu, J., 26 Oct 2016, In : Scientific Reports. 6, p. 1-13 13 p., 36210.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
361 Downloads (Pure)

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Li, D., Liu, J., Guo, B., Liang, C., Dang, L., Lu, C., He, X., Cheung, H. Y. S., Xu, L., He, B., Liu, B., Shaikh, A. B., Li, F., Wang, L., Yang, Z., Au, D. W. T., Peng, S., Zhang, Z., Zhang, B. T., Pan, X. & 13 others, Qian, A., Shang, P., Xiao, L., Jiang, B., Wong, C. K. C., Xu, J., Bian, Z., Liang, Z., Guo, D. A., Zhu, H., Tan, W., Lu, A. & Zhang, G., 2016, In : Nature Communications. 7

Research output: Contribution to journalArticle

152 Citations (Scopus)

Osthole inhibits osteoclasts formation and bone resorption by regulating NF-κB signaling and NFATc1 activations stimulated by RANKL

Ma, Y., Wang, L., Zheng, S., Xu, J., Pan, Y., Tu, P., Sun, J. & Guo, Y., 1 Sep 2019, In : Journal of Cellular Biochemistry. 120, 9, p. 16052-16061 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Pectolinarigenin prevents bone loss in ovariectomized mice and inhibits RANKL-induced osteoclastogenesis via blocking activation of MAPK and NFATc1 signaling

Xiao, Y., Li, K., Wang, Z., Fu, F., Shao, S., Song, F., Zhao, J., Chen, W., Liu, Q. & Xu, J., 1 Aug 2019, In : Journal of Cellular Physiology. 234, 8, p. 13959-13968 10 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
4 Downloads (Pure)

Pseurotin A inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppressing reactive oxygen species

Chen, K., Qiu, P., Yuan, Y., Zheng, L., He, J., Wang, C., Guo, Q., Kenny, J., Liu, Q., Zhao, J., Chen, J., Tickner, J., Fan, S., Lin, X. & Xu, J., 28 Feb 2019, In : Theranostics. 9, 6, p. 1634-1650

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
455 Downloads (Pure)

Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways

Liao, S., Song, F., Feng, W., Ding, X., Yao, J., Song, H., Liu, Y., Ma, S., Wang, Z., Lin, X., Xu, J., Zhao, J. & Liu, Q., 1 Oct 2019, In : Journal of Cellular Physiology. 234, 10, p. 17600-17611 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Salidroside promotes rat spinal cord injury recovery by inhibiting inflammatory cytokine expression and NF-κB and MAPK signaling pathways

Su, Y., Zong, S., Wei, C., Song, F., Feng, H., Qin, A., Lian, Z., Fu, F., Shao, S., Fang, F., Wu, T., Xu, J., Liu, Q. & Zhao, J., 1 Aug 2019, In : Journal of Cellular Physiology. 234, 8, p. 14259-14269 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)