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  • Jiake Xu
2020

Arctiin abrogates osteoclastogenesis and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation

Chen, D., Ye, Z., Wang, C., Wang, Q., Wang, H., Kuek, V., Wang, Z., Qiu, H., Yuan, J., Kenny, J., Yang, F., He, J., Liu, Y., Wang, G., Zhang, M., Zhang, G., Wang, J., Chen, P. & Xu, J., Sep 2020, In : Pharmacological Research. 159, 104944.

Research output: Contribution to journalArticle

Asiatic Acid Inhibits OVX-Induced Osteoporosis and Osteoclastogenesis Via Regulating RANKL-Mediated NF-κb and Nfatc1 Signaling Pathways

Hong, G., Zhou, L., Han, X., Sun, P., Chen, Z., He, W., Tickner, J., Chen, L., Shi, X. & Xu, J., 27 Mar 2020, In : Frontiers in Pharmacology. 11, 331.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Betulinic Acid Protects From Bone Loss in Ovariectomized Mice and Suppresses RANKL-Associated Osteoclastogenesis by Inhibiting the MAPK and NFATc1 Pathways

Wei, J., Li, Y., Liu, Q., Lan, Y., Wei, C., Tian, K., Wu, L., Lin, C., Xu, J., Zhao, J. & Yang, Y., 7 Jul 2020, In : Frontiers in Pharmacology. 11, 1025.

Research output: Contribution to journalArticle

Open Access

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts

Mullin, B., Tickner, J., Zhu, K., Kenny, J., Mullin, S., Brown, S. J., Dudbridge, F., Pavlos, N., Mocarski, E. S., Walsh, J. P., Xu, J. & Wilson, S., 26 Mar 2020, In : Genome Biology. 21, 1, 80.

Research output: Contribution to journalArticle

Open Access

Conditional Knockout of PKC-δ in Osteoclasts Favors Bone Mass Accrual in Males Due to Decreased Osteoclast Function

Li, S., He, T., Wu, D., Zhang, L., Chen, R., Liu, B., Yuan, J., Tickner, J., Qin, A., Xu, J. & Rong, L., 9 Jun 2020, In : Frontiers in Cell and Developmental Biology. 8, 450.

Research output: Contribution to journalArticle

Open Access

Dracorhodin perchlorate inhibits osteoclastogenesis through repressing RANKL-stimulated NFATc1 activity

Liu, Y., Wang, Z., Ma, C., Wei, Z., Chen, K., Wang, C., Zhou, C., Chen, L., Zhang, Q., Chen, Z., He, W. & Xu, J., 1 Mar 2020, In : Journal of Cellular and Molecular Medicine. 24, 6, p. 3303-3313 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Ellagic acid protects ovariectomy-induced bone loss in mice by inhibiting osteoclast differentiation and bone resorption

Lin, X., Yuan, G., Li, Z., Zhou, M., Hu, X., Song, F., Shao, S., Fu, F., Zhao, J., Xu, J., Liu, Q. & Feng, H., 1 Sep 2020, In : Journal of Cellular Physiology. 235, 9, p. 5951-5961 11 p.

Research output: Contribution to journalArticle

Endothelial cells produce angiocrine factors to regulate bone and cartilage via versatile mechanisms

Zhu, S., Bennett, S., Kuek, V., Xiang, C., Xu, H., Rosen, V. & Xu, J., 1 May 2020, In : Theranostics. 10, 13, p. 5957-5965 9 p.

Research output: Contribution to journalReview article

Open Access

Fibrochondrogenic differentiation potential of tendon-derived stem/progenitor cells from human patellar tendon

Qin, S., Wang, W., Liu, Z., Hua, X., Fu, S. C., Dong, F., Li, A., Liu, Z., Wang, P., Dai, L., Liang, P., Zhang, J., Cao, W., Xiong, X., Chen, H. & Xu, J., May 2020, In : Journal of Orthopaedic Translation. 22, p. 101-108 8 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways

Yuan, Y., Chen, K., Chen, X., Wang, C., Qiu, H., Cao, Z., Song, D., Sun, Y., Guo, J., Tickner, J., Xu, J. & Zou, J., 10 Mar 2020, In : Frontiers in Pharmacology. 11, 238.

Research output: Contribution to journalArticle

Open Access

Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version)

Zhao, D., Zhang, F., Wang, B., Liu, B., Li, L., Kim, S. Y., Goodman, S. B., Hernigou, P., Cui, Q., Lineaweaver, W. C., Xu, J., Drescher, W. R. & Qin, L., Mar 2020, In : Journal of Orthopaedic Translation. 21, p. 100-110 11 p.

Research output: Contribution to journalShort survey

Open Access
4 Citations (Scopus)

Hederagenin protects mice against ovariectomy-induced bone loss by inhibiting RANKL-induced osteoclastogenesis and bone resorption

Tian, K., Su, Y., Ding, J., Wang, D., Zhan, Y., Li, Y., Liang, J., Lin, X., Song, F., Wang, Z., Xu, J., Liu, Q. & Zhao, J., 1 Mar 2020, In : Life Sciences. 244, 117336.

Research output: Contribution to journalArticle

Hymenialdisine: A Marine Natural Product That Acts on Both Osteoblasts and Osteoclasts and Prevents Estrogen-Dependent Bone Loss in Mice

Wang, Q., Chen, D., Jin, H., Ye, Z., Wang, C., Chen, K., Kuek, V., Xu, K., Qiu, H., Chen, P., Song, D., Zhao, J., Liu, Q., Davis, R. A., Song, F. & Xu, J., 1 Aug 2020, In : Journal of Bone and Mineral Research. 35, 8, p. 1582-1596 15 p.

Research output: Contribution to journalArticle

Jatrophane Diterpenoids from Euphorbia esula as Inhibitors of RANKL-Induced Osteoclastogenesis

Yuan, S., Hua, P., Zhao, C., Zhou, H., Xu, J., Xu, J. & Gu, Q., 1 Apr 2020, In : Journal of Natural Products. 83, 4, p. 1005–1017

Research output: Contribution to journalArticle

1 Citation (Scopus)

Molecular structure, expression, and functional role of Clec11a in skeletal biology and cancers

Wang, M., Guo, J., Zhang, L., Kuek, V., Xu, J. & Zou, J., 1 Oct 2020, In : Journal of Cellular Physiology. 235, 10, p. 6357-6365 9 p.

Research output: Contribution to journalReview article

Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts

Chen, K., Liu, Y., He, J., Pavlos, N., Wang, C., Kenny, J., Yuan, J., Zhang, Q., Xu, J. & He, W., 2020, In : International Journal of Biological Sciences. 16, 11, p. 1888-1900 13 p.

Research output: Contribution to journalArticle

Open Access

The repair and autophagy mechanisms of hypoxia-regulated bFGF-modified primary embryonic neural stem cells in spinal cord injury

Zhu, S., Chen, M., Deng, L., Zhang, J., Ni, W., Wang, X., Yao, F., Li, X., Xu, H., Xu, J. & Xiao, J., 6 Feb 2020, In : Stem Cells Translational Medicine. 17 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

The role of glial cell line-derived neurotrophic factor family member artemin in neurological disorders and cancers

Zhu, S., Li, Y., Bennett, S., Chen, J., Weng, I. Z., Huang, L., Xu, H. & Xu, J., 1 Jul 2020, In : Cell Proliferation. 53, 7, e12860.

Research output: Contribution to journalReview article

Open Access

Vindoline inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in mice

Zhan, Y., Liang, J., Tian, K., Che, Z., Wang, Z., Yang, X., Su, Y., Lin, X., Song, F., Zhao, J., Xu, J., Liu, Q. & Zhou, B., 1 Jan 2020, In : Frontiers in Pharmacology. 10, 01587.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2019

A005, a novel inhibitor of phosphatidylinositol 3-kinase/mammalian target of rapamycin, prevents osteosarcoma-induced osteolysis

Lian, Z., Han, J., Huang, L., Wei, C., Fan, Y., Xu, J., Zhou, M., Feng, H., Liu, Q., Chen, L., Li, Z., Cheng, H., Yuan, G., Lin, X., Song, F., Su, Y., Wang, C., Huang, G., Qin, A., Song, Y. & 1 others, Yao, G., 1 Jan 2019, In : Carcinogenesis. 40, 2, p. E1-E13

Research output: Contribution to journalArticle

3 Citations (Scopus)

Advanced Genetic Approaches in Discovery and Characterization of Genes Involved With Osteoporosis in Mouse and Human

Yuan, J., Tickner, J., Mullin, B. H., Zhao, J., Zeng, Z., Morahan, G. & Xu, J., 2 Apr 2019, In : Frontiers in Genetics. 10, 13 p., 288.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

Analysis of circulating microRNAs aberrantly expressed in alcohol-induced osteonecrosis of femoral head

Hong, G., Han, X., He, W., Xu, J., Sun, P., Shen, Y., Wei, Q. & Chen, Z., 1 Dec 2019, In : Scientific Reports. 9, 1, 18926.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-kappa B signaling pathways

He, L., Hong, G., Zhou, L., Zhang, J., Fang, J., He, W., Tickner, J., Han, X., Zhao, L. & Xu, J., Apr 2019, In : Journal of Cellular Physiology. 234, 4, p. 4267-4276 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Asperpyrone A attenuates RANKL-induced osteoclast formation through inhibiting NFATc1, Ca2+ signalling and oxidative stress

Chen, X., Wang, C., Qiu, H., Yuan, Y., Chen, K., Cao, Z., Xiang Tan, R., Tickner, J., Xu, J. & Zou, J., 1 Dec 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8269-8279 11 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Astilbin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis

Jin, H., Wang, Q., Chen, K., Xu, K., Pan, H., Chu, F., Ye, Z., Wang, Z., Tickner, J., Qiu, H., Wang, C., Kenny, J., Xu, H., Wang, T. & Xu, J., 1 Dec 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8355-8368 14 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Cajaninstilbene acid inhibits osteoporosis through suppressing osteoclast formation and RANKL-induced signaling pathways

Sun, Y., Liu, Y., He, W., Wang, C., Tickner, J., Kuek, V., Zhou, C., Wang, H., Zou, X., Hong, Z., Yang, F., Shao, M., Chen, L. & Xu, J., 1 Jul 2019, In : Journal of Cellular Physiology. 234, 7, p. 11792-11804 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Cepharanthine suppresses osteoclast formation by modulating the nuclear factor-κB and nuclear factor of activated T-cell signaling pathways

Lin, X., Song, F., Zhou, L., Wang, Z., Wei, C., Xu, J., Zhao, J. & Liu, Q., 1 Feb 2019, In : Journal of Cellular Biochemistry. 120, 2, p. 1990-1996 7 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
64 Downloads (Pure)

Chondromodulin-1 in health, osteoarthritis, cancer, and heart disease

Zhu, S., Qiu, H., Bennett, S., Kuek, V., Rosen, V., Xu, H. & Xu, J., Nov 2019, In : Cellular and Molecular Life Sciences. 76, 22, p. 4493-4502

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

Connecting Versatile lncRNAs with Heterogeneous Nuclear Ribonucleoprotein K and Pathogenic Disorders

Zhu, S., Wang, Z. & Xu, J., 1 Sep 2019, In : Trends in Biochemical Sciences. 44, 9, p. 733-736 4 p.

Research output: Contribution to journalShort survey

1 Citation (Scopus)

Cumambrin A prevents OVX-induced osteoporosis via the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways

Zhou, L., Liu, Q., Hong, G., Song, F., Zhao, J., Yuan, J., Xu, J., Tan, R. X., Tickner, J., Gu, Q. & Xu, J., 1 Jun 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 6, p. 6726-6735 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Cytochalasin Z11 inhibits RANKL-induced osteoclastogenesis: Via suppressing NFATc1 activation

Wang, L., Chen, K., He, J., Kenny, J., Yuan, Y., Chen, J., Liu, Q., Tan, R., Zhao, J. & Xu, J., 25 Nov 2019, In : RSC Advances. 9, 66, p. 38438-38446 9 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Daphnetin attenuates LPS-induced osteolysis and RANKL mediated osteoclastogenesis through suppression of ERK and NFATc1 pathways

Wu, Z., Wu, H., Li, C., Fu, F., Ding, J., Shao, S., Li, K., Yu, X., Su, Y., Liang, J., Lin, X., Yuan, G., Zhou, J., Song, F., Zhao, J., Xu, J., Liu, Q. & Xu, F., 1 Oct 2019, In : Journal of Cellular Physiology. 234, 10, p. 17812-17823 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Dehydrocostus lactone (DHC) suppresses estrogen deficiency-induced osteoporosis

Li, Z., Yuan, G., Lin, X., Liu, Q., Xu, J., Lian, Z., Song, F., Zheng, J., Xie, D., Chen, L., Wang, X., Feng, H., Zhou, M. & Yao, G., 1 May 2019, In : Biochemical Pharmacology. 163, p. 279-289 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Diosmetin inhibits osteoclast formation and differentiation and prevents LPS-induced osteolysis in mice

Shao, S., Fu, F., Wang, Z., Song, F., Li, C., Wu, Z. X., Ding, J., Li, K., Xiao, Y., Su, Y., Lin, X., Yuan, G., Zhao, J., Liu, Q. & Xu, J., 1 Aug 2019, In : Journal of Cellular Physiology. 234, 8, p. 12701-12713 13 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
9 Downloads (Pure)

Discovery of new inhibitors against both NF-κB and osteoclastogenesis from in-house library with α, β-unsaturated-enone fragment

Zhao, C., Huang, D., Li, R., Xu, J., Gu, Q. & Xu, J., 1 Jun 2019, In : Bioorganic Chemistry. 87, p. 638-646 9 p.

Research output: Contribution to journalArticle

Double network shape memory hydrogels activated by near-infrared with high mechanical toughness, nontoxicity, and 3D printability

Dai, W., Guo, H., Gao, B., Ruan, M., Xu, L., Wu, J., Kirk, T. B., Xu, J., Ma, D. & Xue, W., 15 Jan 2019, In : Chemical Engineering Journal. 356, p. 934-949 16 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Emerging Trend in the Pharmacotherapy of Osteoarthritis

Zhang, W., Robertson, W. B., Zhao, J., Chen, W. & Xu, J., 2 Jul 2019, In : Frontiers in Endocrinology. 10, 9 p., 431.

Research output: Contribution to journalReview article

Open Access
12 Citations (Scopus)

Evodiamine inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in mice

Jin, H., Yao, L., Chen, K., Liu, Y., Wang, Q., Wang, Z., Liu, Q., Cao, Z., Kenny, J., Tickner, J., Wang, X. & Xu, J., Jan 2019, In : Journal of Cellular and Molecular Medicine. 23, 1, p. 522-534 13 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)
Open Access
4 Citations (Scopus)

Helvolic acid attenuates osteoclast formation and function via suppressing RANKL-induced NFATc1 activation

Chen, K., Yuan, Y., Wang, Z., Song, D., Zhao, J., Cao, Z., Chen, J., Guo, Q., Chen, L., Tickner, J. & Xu, J., May 2019, In : Journal of Cellular Physiology. 234, 5, p. 6477-6488 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
43 Downloads (Pure)

Loureirin B suppresses RANKL-induced osteoclastogenesis and ovariectomized osteoporosis via attenuating NFATc1 and ROS activities

Liu, Y., Wang, C., Wang, G., Sun, Y., Deng, Z., Chen, L., Chen, K., Tickner, J., Kenny, J., Song, D., Zhang, Q., Wang, H., Chen, Z., Zhou, C., He, W. & Xu, J., 2019, In : Theranostics. 9, 16, p. 4648-4662 15 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Madecassoside inhibits estrogen deficiency-induced osteoporosis by suppressing RANKL-induced osteoclastogenesis

Wang, Q., Yao, L., Xu, K., Jin, H., Chen, K., Wang, Z., Liu, Q., Cao, Z., Kenny, J., Liu, Y., Tickner, J., Xu, H. & Xu, J., Jan 2019, In : Journal of Cellular and Molecular Medicine. 23, 1, p. 380-394 15 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

MiR-214 Attenuates the Osteogenic Effects of Mechanical Loading on Osteoblasts

Yuan, Y., Guo, J., Zhang, L., Tong, X., Zhang, S., Zhou, X., Zhang, M., Chen, X., Lei, L., Li, H., Liu, T. C. Y., Xu, J. & Zou, J., Dec 2019, In : International Journal of Sports Medicine. 40, 14, p. 931-940 10 p.

Research output: Contribution to journalArticle

MiR-214 is an important regulator of the musculoskeletal metabolism and disease

Sun, Y., Kuek, V., Liu, Y., Tickner, J., Yuan, Y., Chen, L., Zeng, Z., Shao, M., He, W. & Xu, J., Jan 2019, In : Journal of Cellular Physiology. 234, 1, p. 231-245 15 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Modulating calcium-mediated NFATc1 and mitogen-activated protein kinase deactivation underlies the inhibitory effects of kavain on osteoclastogenesis and bone resorption

Guo, Q., Cao, Z., Wu, B., Chen, F., Tickner, J., Wang, Z., Qiu, H., Wang, C., Chen, K., Tan, R., Gao, Q. & Xu, J., Jan 2019, In : Journal of Cellular Physiology. 234, 1, p. 789-801 13 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
245 Downloads (Pure)

Molecular structure and the role of high-temperature requirement protein 1 in skeletal disorders and cancers

Li, Y., Yuan, J., Rothzerg, E., Wu, X., Xu, H., Zhu, S. & Xu, J., 22 Dec 2019, In : Cell Proliferation. e12746.

Research output: Contribution to journalReview article

Open Access

Osthole inhibits osteoclasts formation and bone resorption by regulating NF-κB signaling and NFATc1 activations stimulated by RANKL

Ma, Y., Wang, L., Zheng, S., Xu, J., Pan, Y., Tu, P., Sun, J. & Guo, Y., 1 Sep 2019, In : Journal of Cellular Biochemistry. 120, 9, p. 16052-16061 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Pathological mechanisms and therapeutic outlooks for arthrofibrosis

Usher, K. M., Zhu, S., Mavropalias, G., Carrino, J. A., Zhao, J. & Xu, J., 1 Dec 2019, In : Bone Research. 7, 1, 9.

Research output: Contribution to journalReview article

Open Access
9 Citations (Scopus)

Pectolinarigenin prevents bone loss in ovariectomized mice and inhibits RANKL-induced osteoclastogenesis via blocking activation of MAPK and NFATc1 signaling

Xiao, Y., Li, K., Wang, Z., Fu, F., Shao, S., Song, F., Zhao, J., Chen, W., Liu, Q. & Xu, J., 1 Aug 2019, In : Journal of Cellular Physiology. 234, 8, p. 13959-13968 10 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
10 Downloads (Pure)

PIP5k1 beta controls bone homeostasis through modulating both osteoclast and osteoblast differentiation

Zhao, X., Cui, P., Wang, C., Zhao, J., Zhang, X. & Xu, J., Dec 2019, In : Journal of Bone and Mineral Research. 34, p. 328-328 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract