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  • 2020
  • 2017
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Author

  • Jiake Xu
Abstract
Article

Amyloid β peptide enhances RANKL-induced osteoclast activation through NF-κB, ERK, and calcium oscillation signaling

Li, S., Yang, B., Teguh, D., Zhou, L., Xu, J. & Rong, L., 1 Oct 2016, In : International Journal of Molecular Sciences. 17, 10, 1683.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

A polyamidoamne dendrimer functionalized graphene oxide for DOX and MMP-9 shRNA plasmid co-delivery

Gu, Y., Guo, Y., Wang, C., Xu, J., Wu, J., Kirk, T. B., Ma, D. & Xue, W., 1 Jan 2017, In : Materials Science and Engineering C. 70, p. 572-585 14 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Arctiin abrogates osteoclastogenesis and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation

Chen, D., Ye, Z., Wang, C., Wang, Q., Wang, H., Kuek, V., Wang, Z., Qiu, H., Yuan, J., Kenny, J., Yang, F., He, J., Liu, Y., Wang, G., Zhang, M., Zhang, G., Wang, J., Chen, P. & Xu, J., Sep 2020, In : Pharmacological Research. 159, 104944.

Research output: Contribution to journalArticle

Artesunate suppresses RANKL-induced osteoclastogenesis through inhibition of PLCγ1-Ca2+–NFATc1 signaling pathway and prevents ovariectomy-induced bone loss

Zeng, X., Zhang, Y., Wang, S., Wang, K., Tao, L., Zou, M., Chen, N., Xu, J., Liu, S. & Li, X., 15 Jan 2017, In : Biochemical Pharmacology. 124, p. 57-68 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Asiatic Acid Inhibits OVX-Induced Osteoporosis and Osteoclastogenesis Via Regulating RANKL-Mediated NF-κb and Nfatc1 Signaling Pathways

Hong, G., Zhou, L., Han, X., Sun, P., Chen, Z., He, W., Tickner, J., Chen, L., Shi, X. & Xu, J., 27 Mar 2020, In : Frontiers in Pharmacology. 11, 331.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Bajijiasu abrogates osteoclast differentiation via the suppression of RANKL signaling pathways through NF-κB and NFAT

Hong, G., Zhou, L., Shi, X., He, W., Wang, H., Wei, Q., Chen, P., Qi, L., Tickner, J., Lin, L. & Xu, J., 19 Jan 2017, In : International Journal of Molecular Sciences. 18, 1, 12 p., 203.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Biocompatibility and cellular uptake mechanisms of poly(N -isopropylacrylamide) in different cells

Guo, Z., Li, S., Wang, C., Xu, J., Kirk, B., Wu, J., Liu, Z. & Xue, W., 1 Jan 2017, In : Journal of Bioactive and Compatible Polymers. 32, 1, p. 17-31 15 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Biocompatible hyperbranched polyglycerol modified β-cyclodextrin derivatives for docetaxel delivery

Xu, Z., Zhang, Y., Hu, Q., Tang, Q., Xu, J., Wu, J., Kirk, T. B., Ma, D. & Xue, W., 1 Feb 2017, In : Materials Science and Engineering C. 71, p. 965-972 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Calmodulin interacts with Rab3D and modulates osteoclastic bone resorption

Zhu, S., Chim, S. M., Cheng, T., Ang, E., Ng, B., Lim, B., Chen, K., Qiu, H., Tickner, J., Xu, H., Pavlos, N. & Xu, J., 29 Nov 2016, In : Scientific Reports. 6, p. 1-9

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts

Mullin, B., Tickner, J., Zhu, K., Kenny, J., Mullin, S., Brown, S. J., Dudbridge, F., Pavlos, N., Mocarski, E. S., Walsh, J. P., Xu, J. & Wilson, S., 26 Mar 2020, In : Genome Biology. 21, 1, 80.

Research output: Contribution to journalArticle

Open Access

CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma

Shang, Y., He, J., Wang, Y., Feng, Q., Zhang, Y., Guo, J., Li, J., Li, S., Wang, Y., Yan, G., Ren, F., Shi, Y., Xu, J., Zeps, N., Zhai, Y., He, D. & Chang, Z., 20 Jul 2017, In : Oncogene. 36, 29, p. 4191-4200 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Conditional Knockout of PKC-δ in Osteoclasts Favors Bone Mass Accrual in Males Due to Decreased Osteoclast Function

Li, S., He, T., Wu, D., Zhang, L., Chen, R., Liu, B., Yuan, J., Tickner, J., Qin, A., Xu, J. & Rong, L., 9 Jun 2020, In : Frontiers in Cell and Developmental Biology. 8, 450.

Research output: Contribution to journalArticle

Open Access

Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation

Zhou, C., You, Y., Shen, W., Zhu, Y. Z., Peng, J., Feng, H. T., Wang, Y., Li, D., Shao, W. W., Li, C. X., Li, W. Z., Xu, J. & Shen, X., 2016, In : Annals of the Rheumatic Diseases. n/a, p. 1-8

Research output: Contribution to journalArticle

14 Citations (Scopus)

Differential protein expression between normal and degenerated human nucleus pulposus cells by proteomic and bioinformatics analyses

Ye, D. P., Liang, W. G., Dai, L., Yao, Y., Chen, H., Zhou, Y. & Xu, J., 2017, In : International Journal of Clinical and Experimental Medicine. 10, 12, p. 16172-16180 9 p.

Research output: Contribution to journalArticle

Open Access
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59 Downloads (Pure)

Dihydroartemisinin, an Anti-Malaria Drug, Suppresses Estrogen Deficiency-Induced Osteoporosis, Osteoclast Formation, and RANKL-Induced Signaling Pathways

Zhou, L., Liu, Q., Yang, M., Wang, T., Yao, J., Cheng, J. W., Yuan, J., Lin, X., Zhao, J., Tickner, J. & Xu, J., May 2016, In : Journal of Bone and Mineral Research. 31, 5, p. 964-974

Research output: Contribution to journalArticle

Open Access
File
49 Citations (Scopus)
301 Downloads (Pure)

Dracorhodin perchlorate inhibits osteoclastogenesis through repressing RANKL-stimulated NFATc1 activity

Liu, Y., Wang, Z., Ma, C., Wei, Z., Chen, K., Wang, C., Zhou, C., Chen, L., Zhang, Q., Chen, Z., He, W. & Xu, J., 1 Mar 2020, In : Journal of Cellular and Molecular Medicine. 24, 6, p. 3303-3313 11 p.

Research output: Contribution to journalArticle

Open Access

Ellagic acid protects ovariectomy-induced bone loss in mice by inhibiting osteoclast differentiation and bone resorption

Lin, X., Yuan, G., Li, Z., Zhou, M., Hu, X., Song, F., Shao, S., Fu, F., Zhao, J., Xu, J., Liu, Q. & Feng, H., 1 Sep 2020, In : Journal of Cellular Physiology. 235, 9, p. 5951-5961 11 p.

Research output: Contribution to journalArticle

Eriodictyol Inhibits RANKL-Induced Osteoclast Formation and Function Via Inhibition of NFATc1 Activity

Song, F., Zhou, L., Zhao, J., Liu, Q., Yang, M., Tan, R., Xu, J., Zhang, G., Quinn, J. M. W., Tickner, J., Huang, Y. & Xu, J., Sep 2016, In : Journal of Cellular Physiology. 231, 9, p. 1983-1993

Research output: Contribution to journalArticle

21 Citations (Scopus)

Evaluation of N-phosphonium chitosan as a novel vaccine carrier for intramuscular immunization

Cai, J., Zhang, W., Xu, J., Xue, W. & Liu, Z., 1 Nov 2017, In : Journal of Biomaterials Applications. 32, 5, p. 677-685 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Folate-targeting redox hyperbranched poly(amido amine)s delivering MMP-9 siRNA for cancer therapy

Li, M., Zhou, X., Zeng, X., Wang, C., Xu, J., Ma, D. & Xue, W., 2016, In : Journal of Materials Chemistry B. 4, 3, p. 547-556

Research output: Contribution to journalArticle

32 Citations (Scopus)

Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways

Yuan, Y., Chen, K., Chen, X., Wang, C., Qiu, H., Cao, Z., Song, D., Sun, Y., Guo, J., Tickner, J., Xu, J. & Zou, J., 10 Mar 2020, In : Frontiers in Pharmacology. 11, 238.

Research output: Contribution to journalArticle

Open Access

Hederagenin protects mice against ovariectomy-induced bone loss by inhibiting RANKL-induced osteoclastogenesis and bone resorption

Tian, K., Su, Y., Ding, J., Wang, D., Zhan, Y., Li, Y., Liang, J., Lin, X., Song, F., Wang, Z., Xu, J., Liu, Q. & Zhao, J., 1 Mar 2020, In : Life Sciences. 244, 117336.

Research output: Contribution to journalArticle

Hemocompatibility evaluation in vitro of methoxy polyethyleneglycol-polycaprolactone copolymer solutions

Hu, Q., Zhang, Y., Wang, C., Xu, J., Wu, J., Liu, Z. & Xue, W., 2016, In : Journal of Biomedical Materials Research - Part A. 104, 3, p. 802-812

Research output: Contribution to journalArticle

7 Citations (Scopus)

Hemostasis mechanism and applications of N-alkylated chitosan sponge

Huang, Y., Feng, L., Zhang, Y., He, L., Wang, C., Xu, J., Wu, J., Kirk, T. B., Guo, R. & Xue, W., 1 Sep 2017, In : Polymers for Advanced Technologies. 28, 9, p. 1107-1114 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

High-resolution study of the 3D collagen fibrillary matrix of Achilles tendons without tissue labelling and dehydrating

Wu, J. P., Swift, B. J., Becker, T., Squelch, A., Wang, A., Zheng, Y. C., Zhao, X., Xu, J., Xue, W., Zheng, M., Lloyd, D. & Kirk, T. B., Jun 2017, In : Journal of Microscopy. 266, 3, p. 237-287

Research output: Contribution to journalArticle

3 Citations (Scopus)

Injectable supramolecular hydrogel formed from α-cyclodextrin and PEGylated arginine-functionalized poly(L-lysine) dendron for sustained MMP-9 shRNA plasmid delivery

Lin, Q., Yang, Y., Hu, Q., Guo, Z., Liu, T., Xu, J., Wu, J., Kirk, T. B., Ma, D. & Xue, W., 1 Feb 2017, In : Acta Biomaterialia. 49, p. 456-471 16 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Jatrophane Diterpenoids from Euphorbia esula as Inhibitors of RANKL-Induced Osteoclastogenesis

Yuan, S., Hua, P., Zhao, C., Zhou, H., Xu, J., Xu, J. & Gu, Q., 1 Apr 2020, In : Journal of Natural Products. 83, 4, p. 1005–1017

Research output: Contribution to journalArticle

Mechanical Stress Regulates Bone Metabolism Through MicroRNAs

Yuan, Y., Zhang, L., Tong, X., Zhang, M., Zhao, Y., Guo, J., Lei, L., Chen, X., Tickner, J., Xu, J. & Zou, J., 1 Jun 2017, In : Journal of Cellular Physiology. 232, 6, p. 1239-1245 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Melphalan modifies the bone microenvironment by enhancing osteoclast formation

Chai, R. C., McDonald, M. M., Terry, R. L., Kovacic, N., Down, J. M., Pettitt, J. A., Mohanty, S. T., Shah, S., Haffari, G., Xu, J., Gillespie, M. T., Rogers, M. J., Price, J. T., Croucher, P. I. & Quinn, J. M. W., 15 Sep 2017, In : Oncotarget. 8, 40, p. 68047-68058 12 p.

Research output: Contribution to journalArticle

Open Access
Open Access
10 Citations (Scopus)

Natural Compounds for the Treatment of Psoriatic Arthritis: A Proposal Based on Multi-Targeted Osteoclastic Regulation and on a Preclinical Study

Deng, S., Cheng, J., Zhao, J., Yao, F. & Xu, J., 11 Jul 2017, In : JMIR Research Protocols. 6, 7, e132.

Research output: Contribution to journalArticle

Open Access

Neohesperidin suppresses osteoclast differentiation, bone resorption and ovariectomised-induced osteoporosis in mice

Tan, Z., Cheng, J., Liu, Q., Zhou, L., Kenny, J., Wang, T., Lin, X., Yuan, J., Quinn, J. M. W., Tickner, J., Hong, G., Qin, A., Zhao, J. & Xu, J., 5 Jan 2017, In : Molecular and Cellular Endocrinology. 439, p. 369-378 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats

Su, Y., Chung, R., Ruan, C., Chim, S., Kuek, V., Dwivedi, P., Hassanshahi, M., Chen, K., Xie, Y., Chen, L., Foster, B., Rosen, V., Zhou, X., Xu, J. & Xian, C., Jun 2016, In : Journal of Bone & Mineral Research. 31, 6, p. 1258-1274

Research output: Contribution to journalArticle

25 Citations (Scopus)

Nitidine chloride prevents OVX-induced bone loss via suppressing NFATc1-mediated osteoclast differentiation

Liu, Q., Wang, T., Zhou, L., Song, F., Qin, A., Feng, H. T., Lin, X. X., Lin, Z., Yuan, J. B., Tickner, J., Liu, H. G., Zheng, M. H., Xu, J. & Zhao, J. M., 8 Nov 2016, In : Scientific Reports. 6, p. 1-10 36662 .

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

NPNT is expressed by osteoblasts and mediates angiogenesis via the activation of extracellular signal-regulated kinase

Kuek, V., Yang, Z., Chim, S., Zhu, S., Xu, H., Chow, S. T., Tickner, J., Rosen, V., Erber, W., Li, X., An, Q., Qian, Y. & Xu, J., 26 Oct 2016, In : Scientific Reports. 6, p. 1-13 13 p., 36210.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
361 Downloads (Pure)

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Li, D., Liu, J., Guo, B., Liang, C., Dang, L., Lu, C., He, X., Cheung, H. Y. S., Xu, L., He, B., Liu, B., Shaikh, A. B., Li, F., Wang, L., Yang, Z., Au, D. W. T., Peng, S., Zhang, Z., Zhang, B. T., Pan, X. & 13 others, Qian, A., Shang, P., Xiao, L., Jiang, B., Wong, C. K. C., Xu, J., Bian, Z., Liang, Z., Guo, D. A., Zhu, H., Tan, W., Lu, A. & Zhang, G., 2016, In : Nature Communications. 7

Research output: Contribution to journalArticle

152 Citations (Scopus)

Sinomenine down-regulates TLR4/TRAF6 expression and attenuates lipopolysaccharide-induced osteoclastogenesis and osteolysis

He, L., Duan, H., Li, X., Wang, S., Zhang, Y., Lei, L., Xu, J. & Liu, S., 2016, In : European Journal of Pharmacology. 779, p. 66-79

Research output: Contribution to journalArticle

13 Citations (Scopus)

Star-Shaped Amphiphilic Hyperbranched Polyglycerol Conjugated with Dendritic Poly(L-lysine) for the Codelivery of Docetaxel and MMP-9 siRNA in Cancer Therapy

Zhou, X., Zheng, Q., Wang, C., Xu, J., Wu, J. P., Kirk, T. B., Ma, D. & Xue, W., 2016, In : ACS Applied Materials and Interfaces. 8, 20, p. 12609-12619 11 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

The Emerging Role of MORC Family Proteins in Cancer Development and Bone Homeostasis

Hong, G., Qiu, H., Wang, C., Jadhav, G., Wang, H., Tickner, J., He, W. & Xu, J., 1 May 2017, In : Journal of Cellular Physiology. 232, 5, p. 928-934 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The repair and autophagy mechanisms of hypoxia-regulated bFGF-modified primary embryonic neural stem cells in spinal cord injury

Zhu, S., Chen, M., Deng, L., Zhang, J., Ni, W., Wang, X., Yao, F., Li, X., Xu, H., Xu, J. & Xiao, J., 6 Feb 2020, In : Stem Cells Translational Medicine. 17 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

The y6 receptor suppresses bone resorption and stimulates bone formation in mice via a suprachiasmatic nucleus relay

Khor, E. C., Yulyaningsih, E., Driessler, F., Kovaĉić, N., Wee, N. K. Y., Kulkarni, R. N., Lee, N. J., Enriquez, R. F., Xu, J., Zhang, L., Herzog, H. & Baldock, P. A., Mar 2016, In : Bone. 84, p. 139-147 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Three dimensional microstructural network of elastin, collagen, and cells in Achilles tendons

Pang, X., Wu, J-P., Allison, G. T., Xu, J., Rubenson, J., Zheng, M-H., Lloyd, D. G., Gardiner, B., Wang, A. & Kirk, T. B., Jun 2017, In : Journal of Orthopaedic Research. 35, 6, p. 1203-1214

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
151 Downloads (Pure)

Three-dimensional printing of shape memory hydrogels with internal structure for drug delivery

Wang, Y., Miao, Y., Zhang, J., Wu, J. P., Kirk, T. B., Xu, J., Ma, D. & Xue, W., 1 Mar 2017, In : Materials Science and Engineering C. 84, p. 44-51 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Treadmill running exercise prevents senile osteoporosis and upregulates the Wnt signaling pathway in SAMP6 mice

Chen, X., Li, L., Guo, J., Zhang, L., Yuan, Y., Chen, B., Sun, Z., Xu, J. & Zou, J., 2016, In : Oncotarget. 7, 44, p. 71072-71086 15 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
Review article

Current research on pharmacologic and regenerative therapies for osteoarthritis

Zhang, W., Ouyang, H., Dass, C. R. & Xu, J., 1 Mar 2016, In : Bone Research. 4, p. 1-14 14 p., 15040 .

Research output: Contribution to journalReview article

Open Access
140 Citations (Scopus)

Endothelial cells produce angiocrine factors to regulate bone and cartilage via versatile mechanisms

Zhu, S., Bennett, S., Kuek, V., Xiang, C., Xu, H., Rosen, V. & Xu, J., 1 May 2020, In : Theranostics. 10, 13, p. 5957-5965 9 p.

Research output: Contribution to journalReview article

Open Access

Massage alleviates delayed onset muscle soreness after strenuous exercise: A systematic review and meta-analysis

Guo, J., Li, L., Gong, Y., Zhu, R., Xu, J., Zou, J. & Chen, X., 27 Sep 2017, In : Frontiers in Physiology. 8, 747.

Research output: Contribution to journalReview article

Open Access
10 Citations (Scopus)

Molecular structure and differential function of choline kinases CHKα and CHKβ in musculoskeletal system and cancer

Chen, X., Qiu, H., Wang, C., Yuan, Y., Tickner, J., Xu, J. & Zou, J., Feb 2017, In : Cytokine and Growth Factor Reviews. 33, p. 65-72 8 p.

Research output: Contribution to journalReview article

Open Access
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1 Citation (Scopus)
287 Downloads (Pure)