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  • Alan James

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

the Million Veteran Program, 1 Oct 2018, In : Nature Genetics. 50, 10, p. 1412-1425 14 p.

Research output: Contribution to journalReview article

Open Access
89 Citations (Scopus)

Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling

Ferreira, M. A. R., Jansen, R., Willemsen, G., Penninx, B. W., Bain, L. M., Vicente, C. T., Revez, J. A., Matheson, M. C., Hui, J., Tung, J. Y., Baltic, S., Le Souëf, P., Montgomery, G. W., Martin, N. G., Robertson, C. F., James, A., Thompson, P. J., Boomsma, D. I., Hopper, J. L., Hinds, D. A. & 3 others, Werder, R. B., Phipps, S. & Australian Asthma Genetics Consortium Collaborators, 1 Apr 2017, In : Journal of Allergy and Clinical Immunology. 139, 4, p. 1148-1157 10 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
353 Downloads (Pure)

Foetal growth restriction in mice modifies postnatal airway responsiveness in an age and sex-dependent manner

Wang, K. C., Larcombe, A. N., Berry, L. J., Morton, J. S., Davidge, S. T., James, A. L. & Noble, P. B., 25 Jan 2018, In : Clinical Science. 132, 2, p. 273-284

Research output: Contribution to journalArticle

11 Citations (Scopus)
1 Downloads (Pure)

Fatty airways: Implications for obstructive disease

Elliot, J. G., Donovan, G. M., Wang, K. C. W., Green, F. H. Y., James, A. L. & Noble, P. B., 1 Dec 2019, In : European Respiratory Journal. 54, 6, 1900857.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

Aschard, H., Tobin, M. D., Hancock, D. B., Skurnik, D., Sood, A., James, A., Smith, A. V., Manichaikul, A. W., Campbell, A., Prins, B. P., Hayward, C., Loth, D. W., Porteous, D. J., Strachan, D. P., Zeggini, E., O'Connor, G. T., Brusselle, G. G., Boezen, H. M., Schulz, H., Deary, I. J. & 31 others, Hall, I. P., Rudan, I., Kaprio, J., Wilson, J. F., Wilk, J. B., Huffman, J. E., Zhao, J. H., de Jong, K., Lyytikäinen, L. P., Wain, L. V., Jarvelin, M. R., Kähönen, M., Fornage, M., Polasek, O., Cassano, P. A., Barr, R. G., Rawal, R., Harris, S. E., Gharib, S. A., Enroth, S., Heckbert, S. R., Lehtimäki, T., Gyllensten, U., Jackson, V. E., Gudnason, V., Tang, W., Dupuis, J., Artigas, M. S., Joshi, A. D., London, S. J. & Kraft, P., 1 Jun 2017, In : International Journal of Epidemiology. 46, 3, p. 894-904 11 p., dyw318.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)
4 Citations (Scopus)

Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial

Gibson, P. G., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Marks, G. B., Baraket, M., Powell, H., Taylor, S. L., Leong, L. E. X., Rogers, G. B. & Simpson, J. L., 12 Aug 2017, In : The Lancet. 390, 10095, p. 659-668 10 p.

Research output: Contribution to journalArticle

185 Citations (Scopus)

Early-life exposure to sibling modifies the relationship between CD14 polymorphisms and allergic sensitization

the investigators of the TAHS and MACS, 8 Aug 2019, In : Clinical and Experimental Allergy. 49, 3, p. 331-340 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access
File
12 Citations (Scopus)
264 Downloads (Pure)
Open Access
File
2 Citations (Scopus)
123 Downloads (Pure)

Cohort Profile: The Tasmanian Longitudinal Health STUDY (TAHS)

Matheson, M. C., Abramson, M. J., Allen, K., Benke, G., Burgess, J. A., Dowty, J. G., Erbas, B., Feather, I. H., Frith, P. A., Giles, G. G., Gurrin, L. C., Hamilton, G. S., Hopper, J. L., James, A. L., Jenkins, M. A., Johns, D. P., Lodge, C. J., Lowe, A. J., Markos, J., Morrison, S. C. & 8 others, Perret, J. L., Southey, M. C., Thomas, P. S., Thompson, B. R., Wood-Baker, R., Walters, E. H., Dharmage, S. C. & TAHS investigator group, Apr 2017, In : International Journal of Epidemiology. 46, 2, p. 407-408i 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Childhood respiratory risk factor profiles and middle-age lung function: A prospective cohort study from the first to sixth decade

Bui, D. S., Walters, H. E., Burgess, J. A., Perret, J. L., Bui, M. Q., Bowatte, G., Lowe, A. J., Russell, M. A., Thompson, B. R., Hamilton, G. S., James, A. L., Giles, G. G., Thomas, P. S., Jarvis, D., Svanes, C., Garcia-Aymerich, J., Erbas, B., Frith, P. A., Allen, K. J., Abramson, M. J. & 2 others, Lodge, C. J. & Dharmage, S. C., 1 Sep 2018, In : Annals of the American Thoracic Society. 15, 9, p. 1057-1066 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma

Asai, Y., Eslami, A., van Ginkel, C. D., Akhabir, L., Wan, M., Yin, D., Ellis, G., Ben-Shoshan, M., Marenholz, I., Martino, D., Ferreira, M. A., Allen, K., Mazer, B., de Groot, H., de Jong, N. W., Gerth van Wijk, R., Dubois, A. E. J., Grosche, S., Ashley, S., Rüschendorf, F. & 20 others, Kalb, B., Beyer, K., Nöthen, M. M., Lee, Y-A., Chin, R., Cheuk, S., Hoffman, J., Jorgensen, E., Witte, J. S., Melles, R. B., Hong, X., Wang, X., Hui, J., Musk, A. W. B., Hunter, M., James, A. L., Koppelman, G. H., Sandford, A. J., Clarke, A. E. & Daley, D., 1 Apr 2018, In : The Journal of Allergy and Clinical Immunology. 141, 4, p. 1513-1516

Research output: Contribution to journalLetter

Open Access
File
11 Citations (Scopus)
312 Downloads (Pure)

BODY MASS INDEX AND ADIPOSE TISSUE WITHIN THE AIRWAY WALL

Elliot, J. G., Green, F. H. Y., Noble, P. B. & James, A. L., Mar 2017, In : Respirology. 22, p. 102-102 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Blood cytotoxic/inflammatory mediators in non-eosinophilic asthma

Hodge, S., Hodge, G., Simpson, J. L., Yang, I. A., Upham, J., James, A., Gibson, P. G. & Reynolds, P. N., 1 Jan 2016, In : Clinical and Experimental Allergy. 46, 1, p. 60-70 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Azithromycin reduces exacerbations in adults with persistent symptomatic eosinophilic asthma

Gibson, P. G., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Marks, G. B., Baraket, M., Powell, H. & Simpson, J. L., Mar 2017, In : Respirology. 22, p. 24-24 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Azithromycin add-on therapy reduces airway inflammation and extracellular DNA: An AMAZES sub-study

Simpson, J., Barker, D., Yang, I., Upham, J., Reynolds, P., Hodge, S., James, A., Jenkins, C., Peters, M., Marks, G., Baraket, M. & Gibson, P., 28 Sep 2019, In : European Respiratory Journal. 54, 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Atopy in people aged 40 years and over: Relation to airflow limitation

Guevara-Rattray, E. M., Garden, F. L., James, A. L., Wood-Baker, R., Abramson, M. J., Johns, D. P., Sonia Buist, A., Burney, P. G. J., Haydn Walters, E., Toelle, B. G. & Marks, G. B., 1 Dec 2017, In : Clinical and Experimental Allergy. 47, 12, p. 1625-1630 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Asthma: Pharmacological degradation of the airway smooth muscle layer

Wang, K., Donovan, G. M., James, A. & Noble, P., 21 Jul 2020, In : The International Journal of Biochemistry & Cell Biology. 126, 2020, p. 105818

Research output: Contribution to journalArticle

Association of Forced Vital Capacity with the Developmental Gene NCOR2

CHARGE consortium & SpiroMeta consortium, 2016, In : PLoS One. 11, 2, 17 p., e0147388.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Assessment of the depression, anxiety, and stress scale (DASS-21) in untreated obstructive sleep apnea (OSA)

Nanthakumar, S., Bucks, R. S., Skinner, T. C., Starkstein, S., Hillman, D., James, A. & Hunter, M., 1 Oct 2017, In : Psychological Assessment. 29, 10, p. 1201-1209 9 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
508 Downloads (Pure)

A sputum 6-gene signature predicts future exacerbations of poorly controlled asthma

Fricker, M., Gibson, P. G., Powell, H., Simpson, J. L., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Marks, G. B., Baraket, M. & Baines, K. J., 1 Jul 2019, In : Journal of Allergy and Clinical Immunology. 144, 1, p. 51-60.e11

Research output: Contribution to journalArticle

10 Citations (Scopus)

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Ried, J. S., Jeff, J. M., Chu, A. Y., Bragg-Gresham, J. L., Van Dongen, J., Huffman, J. E., Ahluwalia, T. S., Cadby, G., Eklund, N., Eriksson, J., Esko, T., Feitosa, M. F., Goel, A., Gorski, M., Hayward, C., Heard-Costa, N. L., Jackson, A. U., Jokinen, E., Kanoni, S., Kristiansson, K. & 256 others, Kutalik, Z., Lahti, J., Luan, JA., Mägi, R., Mahajan, A., Mangino, M., Medina-Gomez, C., Monda, K. L., Nolte, I. M., Pérusse, L., Prokopenko, I., Qi, L., Rose, L. M., Salvi, E., Smith, M. T., Snieder, H., Standáková, A., Ju Sung, Y., Tachmazidou, I., Teumer, A., Thorleifsson, G., Van Der Harst, P., Walker, R. W., Wang, S. R., Wild, S. H., Willems, S. M., Wong, A., Zhang, W., Albrecht, E., Couto Alves, A., Bakker, S. J. L., Barlassina, C., Bartz, T. M., Beilby, J., Bellis, C., Bergman, R. N., Bergmann, S., Blangero, J., Blüher, M., Boerwinkle, E., Bonnycastle, L. L., Bornstein, S. R., Bruinenberg, M., Campbell, H., Chen, Y. D. I., Chiang, C. W. K., Chines, P. S., Collins, F. S., Cucca, F., Cupples, L. A., D'avila, F., De Geus, E. J. C. N., Dedoussis, G. V., Dimitriou, M., Döring, A., Eriksson, J. G., Farmaki, A. E., Farrall, M., Ferreira, T., Fischer, K., Forouhi, N. G., Friedrich, N., Gjesing, A. P., Glorioso, N., Graff, M., Grallert, H., Grarup, N., Gräßler, J., Grewal, J., Hamsten, A., Harder, M. N., Hartman, C. A., Hassinen, M., Hastie, N., Hattersley, A. T., Havulinna, A. S., Heliövaara, M., Hillege, H., Hofman, A., Holmen, O. L., Homuth, G., Hottenga, J. J., Hui, J., Husemoen, L. L., Hysi, P. G., Isaacs, A., Ittermann, T., Jalilzadeh, S., James, A. L., Jørgensen, T., Jousilahti, P., Jula, A., Marie Justesen, J., Justice, A. E., Kähönen, M., Karaleftheri, M., Tee Khaw, K., Keinanen-Kiukaanniemi, S. M., Kinnunen, L., Knekt, P. B., Koistinen, H. A., Kolcic, I., Kooner, I. K., Koskinen, S., Kovacs, P., Kyriakou, T., Laitinen, T., Langenberg, C., Lewin, A. M., Lichtner, P., Lindgren, C. M., Lindström, J., Linneberg, A., Lorbeer, R., Lorentzon, M., Luben, R., Lyssenko, V., Männistö, S., Manunta, P., Leach, I. M., Mcardle, W. L., Mcknight, B., Mohlke, K. L., Mihailov, E., Milani, L., Mills, R., Montasser, M. E., Morris, A. P., Müller, G., Musk, A. W., Narisu, N., Ong, K. K., Oostra, B. A., Osmond, C., Palotie, A., Pankow, J. S., Paternoster, L., Penninx, B. W., Pichler, I., Pilia, M. G., Polašek, O., Pramstaller, P. P., Raitakari, O. T., Rankinen, T., Rao, D. C., Rayner, N. W., Ribel-Madsen, R., Rice, T. K., Richards, M., Ridker, P. M., Rivadeneira, F., Ryan, K. A., Sanna, S., Sarzynski, M. A., Scholtens, S., Scott, R. A., Sebert, S., Southam, L., Sparsø, T. H., Steinthorsdottir, V., Stirrups, K., Stolk, R. P., Strauch, K., Stringham, H. M., Swertz, M. A., Swift, A. J., Tönjes, A., Tsafantakis, E., Van Der Most, P. J., Van Vliet-Ostaptchouk, J. V., Vandenput, L., Vartiainen, E., Venturini, C., Verweij, N., Viikari, J. S., Vitart, V., Vohl, M. C., Vonk, J. M., Waeber, G., Widén, E., Willemsen, G., Wilsgaard, T., Winkler, T. W., Wright, A. F., Yerges-Armstrong, L. M., Zhao, J. H., Carola Zillikens, M., Boomsma, D. I., Bouchard, C., Chambers, J. C., Chasman, D. I., Cusi, D., Gansevoort, R. T., Gieger, C., Hansen, T., Hicks, A. A., Hu, F., Hveem, K., Jarvelin, M. R., Kajantie, E., Kooner, J. S., Kuh, D., Kuusisto, J., Laakso, M., Lakka, T. A., Lehtimäki, T., Metspalu, A., Njølstad, I., Ohlsson, C., Oldehinkel, A. J., Palmer, L. J., Pedersen, O., Perola, M., Peters, A., Psaty, B. M., Puolijoki, H., Rauramaa, R., Rudan, I., Salomaa, V., Schwarz, P. E. H., Shudiner, A. R., Smit, J. H., Sørensen, T. I. A., Spector, T. D., Stefansson, K., Stumvoll, M., Tremblay, A., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., Völker, U., Vollenweider, P., Wareham, N. J., Watkins, H., Wilson, J. F., Zeggini, E., Abecasis, G. R., Boehnke, M., Borecki, I. B., Deloukas, P., van Duijn, C. M., Fox, C., Groop, L. C., Heid, I. M., Hunter, D. J., Kaplan, R. C., McCarthy, M. I., North, K. E., O'connell, J. R., Schlessinger, D., Thorsteinsdottir, U., Strachan, D. P., Frayling, T. M., Hirschhorn, J. N., Müller-Nurasyid, M. & Loos, R. J. F., 23 Nov 2016, In : Nature Communications. 7, 13357.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)

Airway smooth muscle proliferation and inflammation in asthma

James, A. L., Noble, P. B., Drew, S. A., Mauad, T., Bai, T. R., Abramson, M. J., McKay, K. O., Green, F. H. Y. & Elliot, J. G., 1 Oct 2018, In : Journal of Applied Physiology. 125, 4, p. 1090-1096 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Airway remodelling with spatial correlations: Implications for asthma pathogenesis

Pascoe, C. D., Green, F. H. Y., Elliot, J. G., James, A. L., Noble, P. B. & Donovan, G. M., Aug 2020, In : Respiratory Physiology & Neurobiology. 279, p. 103469

Research output: Contribution to journalArticle

Airway remodelling in COPD: It's not asthma!

Jones, R. L., Noble, P. B., Elliot, J. G. & James, A. L., 1 Nov 2016, In : Respirology. 21, 8, p. 1347-1356 10 p.

Research output: Contribution to journalReview article

33 Citations (Scopus)

Airway remodeling in asthma: Is it fixed or variable?

James, A., 15 Apr 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 8, p. 968-970 3 p.

Research output: Contribution to journalEditorial

4 Citations (Scopus)

Airway dysbiosis: Haemophilus influenza and Tropheryma in poorly controlled asthma

Simpson, J. L., Daly, J., Baines, K. J., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A., Hugenholtz, P., Willner, D. & Gibson, P. G., 2016, In : European Respiratory Journal. 47, 3, p. 792-800 9 p.

Research output: Contribution to journalArticle

Open Access
67 Citations (Scopus)

Airflow obstruction is associated with increased smooth muscle extracellular matrix

Jones, R. L., Noble, P. B., Elliot, J. G., Mitchell, H. W., McFawn, P. K., Hogg, J. C. & James, A. L., 2016, In : European Respiratory Journal. 47, 6, p. 1855-1857 3 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)