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  • 2020
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Author

  • Mark Nicol

Highly sensitive sequence specific qPCR detection of Mycobacterium tuberculosis complex in respiratory specimens

Reed, J. L., Walker, Z. J., Basu, D., Allen, V., Nicol, M. P., Kelso, D. M. & McFall, S. M., 1 Dec 2016, In : Tuberculosis. 101, p. 114-124 11 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

HIV-exposure, early life feeding practices and delivery mode impacts on faecal bacterial profiles in a South African birth cohort

Claassen-Weitz, S., Gardner-Lubbe, S., Nicol, P., Botha, G., Mounaud, S., Shankar, J., Nierman, W. C., Mulder, N., Budree, S., Zar, H. J., Nicol, M. P. & Kaba, M., 1 Dec 2018, In : Scientific Reports. 8, 1, 5078.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

How should tuberculosis molecular diagnostics be adapted for use in seriously ill HIV patients?

Nicol, M. P., 1 Dec 2016, In : EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. 16, 12, p. 1237-1239 3 p.

Research output: Contribution to journalEditorial

Human breast milk bacteriome in health and disease

Ojo-Okunola, A., Nicol, M. & du Toit, E., 3 Nov 2018, In : Nutrients. 10, 11, 1643.

Research output: Contribution to journalReview article

Open Access
13 Citations (Scopus)

Human brucellosis in South Africa: Public health and diagnostic pitfalls

Wojno, J. M., Moodley, C., Pienaar, J., Beylis, N., Jacobsz, L., Nicol, M. P., Rossouw, J. & Bamford, C., 1 Jan 2016, In : South African Medical Journal. 106, 9, p. 883-885 3 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Impact of point-of-care xpert MTB/RIF on tuberculosis treatment initiation: A cluster-randomized trial

Lessells, R. J., Cooke, G. S., McGrath, N., Nicol, M. P., Newell, M. L. & Godfrey-Faussett, P., 1 Oct 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 7, p. 901-910 10 p.

Research output: Contribution to journalArticle

Open Access
19 Citations (Scopus)

Improved method for collection of sputum for tuberculosis testing to ensure adequate sample volumes for molecular diagnostic testing

Fisher, M., Dolby, T., Surtie, S., Omar, G., Hapeela, N., Basu, D., DeWalt, A., Kelso, D., Nicol, M. & McFall, S., 1 Apr 2017, In : Journal of Microbiological Methods. 135, p. 35-40 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Improving the design of studies evaluating the impact of diagnostic tests for tuberculosis on health outcomes: a qualitative study of perspectives of diverse stakeholders

Ochodo, E. A., Naidoo, S., Schumacher, S., Steingart, K., Deeks, J., Cobelens, F., Bossuyt, P. M., Young, T. & Nicol, M. P., 21 Nov 2019, In : Wellcome Open Research. 4, p. 183

Research output: Contribution to journalArticle

Open Access

Incidence and diagnosis of pertussis in South African children hospitalized with lower respiratory tract infection

Muloiwa, R., Dube, F. S., Nicol, M. P., Zar, H. J. & Hussey, G. D., 10 Mar 2016, In : Pediatric Infectious Disease Journal. 35, 6, p. 611-616 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Indoor air pollution and tobacco smoke exposure: impact on nasopharyngeal bacterial carriage in mothers and infants in an African birth cohort study

Vanker, A., Nduru, P. M., Barnett, W., Dube, F. S., Sly, P. D., Gie, R. P., Nicol, M. P. & Zar, H. J., Feb 2019, In : ERJ Open Research. 5, 1, 2 p.

Research output: Contribution to journalArticle

Open Access

Influence of Socio-Economic and Psychosocial Profiles on the Human Breast Milk Bacteriome of South African Women

Ojo-Okunola, A., Claassen-Weitz, S., Mwaikono, K. S., Gardner-Lubbe, S., Stein, D. J., Zar, H. J., Nicol, M. P. & du Toit, E., 20 Jun 2019, In : Nutrients. 11, 6

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Integrating environmental health and genomics research in Africa: challenges and opportunities identified during a Human Heredity and Health in Africa (H3Africa) Consortium workshop

Joubert, B. R., Berhane, K., Chevrier, J., Collman, G., Eskenazi, B., Fobil, J., Hoyo, C., John, C. C., Kumie, A., Nicol, M., Ramsay, M., Smith, J., Steyn, A., Tshala-Katumbay, D. & McAllister, K., Aug 2019, In : Gates Open Research. 2, p. 159

Research output: Contribution to journalArticle

Open Access

Key advances and remaining challenges in childhood and adolescent tuberculosis

Marais, B. J., Nicol, M. & Zar, H. J., 2020, In : Paediatric Respiratory Reviews.

Research output: Contribution to journalEditorial

Laboratory-acquired infections of Salmonella enterica serotype Typhi in South Africa: Phenotypic and genotypic analysis of isolates

GERMS-SA Surveillance Network & Nicol, M., 29 Sep 2017, In : BMC Infectious Diseases. 17, 1, 9 p., 656.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Longitudinal changes in the nasopharyngeal resistome of South African infants using shotgun metagenomic sequencing

Manenzhe, R. I., Dube, F. S., Wright, M., Lennard, K., Zar, H. J., Mounaud, S., Nierman, W. C., Nicol, M. P. & Moodley, C., 2020, In : PLoS One. 15, 4, p. e0231887

Research output: Contribution to journalArticle

Open Access

Longitudinal characterization of nasopharyngeal colonization with Streptococcus pneumoniae in a South African birth cohort post 13-valent pneumococcal conjugate vaccine implementation

Dube, F. S., Ramjith, J., Gardner-Lubbe, S., Nduru, P., Robberts, F. J. L., Wolter, N., Zar, H. J. & Nicol, M. P., 1 Dec 2018, In : Scientific Reports. 8, 1, 12497.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Longitudinal Population Dynamics of Staphylococcus aureus in the Nasopharynx During the First Year of Life

Abdulgader, S. M., Robberts, L., Ramjith, J., Nduru, P. M., Dube, F., Gardner-Lubbe, S., Zar, H. J. & Nicol, M. P., 15 Mar 2019, In : Frontiers in Genetics. 10, 10 p., 198.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Lymphadenopathy in a TB-Endemic Region: Employing Focused Techniques in a Rapid Access Lymph Node Biopsy Clinic

Antel, K. R., Verburgh, E., Louw, V. J., Oosthuizen, J., Malherbe, F., Gary, M. & Nicol, M., 29 Nov 2018, In : Blood. 132, 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Microbiological diagnosis of pulmonary tuberculosis in children by oral swab polymerase chain reaction

Nicol, M. P., Wood, R. C., Workman, L., Prins, M., Whitman, C., Ghebrekristos, Y., Mbhele, S., Olson, A., Jones-Engel, L. E., Zar, H. J. & Cangelosi, G. A., 25 Jul 2019, In : Scientific Reports. 9, 1, p. 10789

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Multicenter Study of the Accuracy of the BD MAX™ MDR-TB Assay for Detection of Mycobacterium tuberculosis Complex and Mutations Associated with Resistance to Rifampin and Isoniazid

Shah, M., Paradis, S., Betz, J., Beylis, N., Bharadwaj, R., Caceres, T., Gotuzzo, E., Joloba, M., Mave, V., Nakiyingi, L., Nicol, M. P., Pradhan, N., King, B., Armstrong, D., Knecht, D., Maus, C. E., Cooper, C. K., Dorman, S. E. & Manabe, Y. C., 27 Sep 2019, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Research output: Contribution to journalArticle

Nasopharyngeal carriage of antimicrobial-resistant pneumococci in an intensively sampled South African birth cohort

Manenzhe, R., Moodley, C., Abdulgader, S. M., Robberts, F. J. L., Zar, H. J., Nicol, M. P. & Dube, F. S., 27 Mar 2019, In : Frontiers in Microbiology. 10, 10 p., 610.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Novel lipoarabinomannan point-of-care tuberculosis test for people with HIV: a diagnostic accuracy study

Broger, T., Sossen, B., du Toit, E., Kerkhoff, A. D., Schutz, C., Ivanova Reipold, E., Ward, A., Barr, D. A., Macé, A., Trollip, A., Burton, R., Ongarello, S., Pinter, A., Lowary, T. L., Boehme, C., Nicol, M. P., Meintjes, G. & Denkinger, C. M., 30 May 2019, In : The Lancet Infectious Diseases. 10 p.

Research output: Contribution to journalArticle

Open Access
32 Citations (Scopus)

Optimizing 16S rRNA gene profile analysis from low biomass nasopharyngeal and induced sputum specimens

Claassen-Weitz, S., Gardner-Lubbe, S., Mwaikono, K. S., du Toit, E., Zar, H. J. & Nicol, M. P., 12 May 2020, In : BMC Microbiology. 20, 1, 26 p., 113.

Research output: Contribution to journalArticle

Open Access

Optimizing Tuberculosis Diagnosis in Human Immunodeficiency Virus-Infected Inpatients Meeting the Criteria of Seriously Ill in the World Health Organization Algorithm

Griesel, R., Stewart, A., van der Plas, H., Sikhondze, W., Rangaka, M. X., Nicol, M. P., Kengne, A. P., Mendelson, M. & Maartens, G., 6 Nov 2017, In : Clinical Infectious Diseases. 66, 9, p. 1419-1426 8 p.

Research output: Contribution to journalArticle

Precision medicine for drug-resistant tuberculosis in high-burden countries: is individualised treatment desirable and feasible?

Cox, H., Hughes, J., Black, J. & Nicol, M. P., 1 Sep 2018, In : The Lancet Infectious Diseases. 18, 9, p. e282-e287

Research output: Contribution to journalReview article

17 Citations (Scopus)

Prevalence and antibiotic susceptibility patterns of enteric bacterial pathogens in human and non-human sources in an urban informal settlement in Cape Town, South Africa

Kalule, J. B., Smith, A. M., Vulindhlu, M., Tau, N. P., Nicol, M. P., Keddy, K. H. & Robberts, L., 6 Nov 2019, In : BMC Microbiology. 19, 1, 244.

Research output: Contribution to journalArticle

Open Access

Preventing tuberculosis-related death in children with HIV

Tootla, H. D. & Nicol, M. P., 1 Feb 2018, In : The lancet. HIV. 5, 2, p. e62-e64

Research output: Contribution to journalComment/debate

Proteomic comparison of three clinical diarrhoeagenic drug-resistant Escherichia coli isolates grown on CHROMagar™STEC media

Kalule, J. B., Fortuin, S., Calder, B., Robberts, L., Keddy, K. H., Nel, A. J. M., Garnett, S., Nicol, M., Warner, D. F., Soares, N. C. & Blackburn, J. M., 30 May 2018, In : Journal of Proteomics. 180, p. 25-35 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Recent developments in the diagnosis of drug-resistant tuberculosis

Nicol, M. P. & Cox, H., 1 Jan 2019, In : Microbiology Australia. 40, 2, p. 82-86 5 p.

Research output: Contribution to journalArticle

Regulatory T cells and pro-inflammatory responses predominate in children with tuberculosis

Whittaker, E., Nicol, M., Zar, H. J. & Kampmann, B., 25 Apr 2017, In : Frontiers in Immunology. 8, APR, 448.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Remembering the basics: interventions to improve sputum collection for tuberculosis diagnosis

Centner, C. M. & Nicol, M. P., 1 Aug 2017, In : The Lancet Global Health. 5, 8, p. e728-e729

Research output: Contribution to journalComment/debate

Respiratory microbes present in the nasopharynx of children hospitalised with suspected pulmonary tuberculosis in Cape Town, South Africa

Dube, F. S., Kaba, M., Robberts, F. J. L., Tow, L. A., Lubbe, S., Zar, H. J. & Nicol, M. P., 24 Oct 2016, In : BMC Infectious Diseases. 16, 1, 12 p., 597.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Serologic Responses in Childhood Pulmonary Tuberculosis

Nonyane, B. A. S., Nicol, M. P., Andreas, N. J., Rimmele, S., Schneiderhan-Marra, N., Workman, L. J., Perkins, M. D., Joos, T., Broger, T., Ellner, J. J., Alland, D., Kampmann, B., Dorman, S. E. & Zar, H. J., 1 Jan 2018, In : Pediatric Infectious Disease Journal. 37, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

'SILVAMP TB LAM' rapid urine tuberculosis test predicts mortality in hospitalized HIV patients in South Africa

Sossen, B., Broger, T., Kerkhoff, A. D., Schutz, C., Trollip, A., Moreau, E., Schumacher, S. G., Burton, R., Ward, A., Wilkinson, R. J., Barr, D. A., Nicol, M. P., Denkinger, C. M. & Meintjes, G., 9 Jan 2020, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Research output: Contribution to journalReview article

Open Access

Strengthening Diagnosis of Pulmonary Tuberculosis in Children: The Role of Xpert MTB/RIF Ultra

Zar, H. J. & Nicol, M. P., 1 Nov 2019, In : Pediatrics. 144, 5

Research output: Contribution to journalArticle

1 Citation (Scopus)

The Determinants of the Human Milk Metabolome and Its Role in Infant Health

Ojo-Okunola, A., Cacciatore, S., Nicol, M. P. & du Toit, E., 20 Feb 2020, In : Metabolites. 10, 2

Research output: Contribution to journalReview article

Open Access

The Influence of DNA Extraction and Lipid Removal on Human Milk Bacterial Profiles

Ojo-Okunola, A., Claassen-Weitz, S., Mwaikono, K. S., Gardner-Lubbe, S., Zar, H. J., Nicol, M. P. & du Toit, E., 15 May 2020, In : Methods and protocols. 3, 2

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

The Influence of HIV on the Evolution of Mycobacterium tuberculosis

Koch, A. S., Brites, D., Stucki, D., Evans, J. C., Seldon, R., Heekes, A., Mulder, N., Nicol, M., Oni, T., Mizrahi, V., Warner, D. F., Parkhill, J., Gagneux, S., Martin, D. P. & Wilkinson, R. J., 1 Jul 2017, In : Molecular Biology and Evolution. 34, 7, p. 1654-1668 15 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Treatment of bronchiectasis exacerbations in children: which antibiotic?

Zar, H. J. & Nicol, M. P., 6 Oct 2018, In : The Lancet. 392, 10154, p. 1169-1170 2 p.

Research output: Contribution to journalComment/debate

Tuberculin skin test conversion and primary progressive tuberculosis disease in the first 5 years of life: a birth cohort study from Cape Town, South Africa

Martinez, L., le Roux, D. M., Barnett, W., Stadler, A., Nicol, M. P. & Zar, H. J., 1 Jan 2018, In : The Lancet Child & Adolescent Health. 2, 1, p. 46-55 10 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Tuberculosis Diagnosis in Children Using Xpert Ultra on Different Respiratory Specimens

Zar, H. J., Workman, L. J., Prins, M., Bateman, L. J., Mbhele, S. P., Whitman, C. B., Denkinger, C. M. & Nicol, M. P., 15 Dec 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 12, p. 1531-1538

Research output: Contribution to journalArticle

11 Citations (Scopus)

Tuberculosis diagnostics: State of the art and future directions

Pai, M., Nicol, M. P. & Boehme, C. C., 1 Jan 2016, In : Microbiology Spectrum. 4, 5, TBTB2-0019-2016.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)

Tuberculosis eradication: renewed commitment and global investment required

Cox, H. & Nicol, M. P., 1 Mar 2018, In : The Lancet Infectious Diseases. 18, 3, p. 228-229 2 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Utility of second-generation line probe assay (Hain MTBDRplus) directly on 2-month sputum specimens for monitoring tuberculosis treatment response

Rockwood, N., Wojno, J., Ghebrekristos, Y., Nicol, M. P., Meintjes, G. & Wilkinson, R. J., 1 May 2017, In : Journal of Clinical Microbiology. 55, 5, p. 1508-1515 8 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Variation in the observed effect of Xpert MTB/RIF testing for tuberculosis on mortality: A systematic review and analysis of trial design considerations

Ochodo, E. A., Kalema, N., Schumacher, S., Steingart, K., Young, T., Mallett, S., Deeks, J., Cobelens, F., Bossuyt, P. M., Nicol, M. P. & Cattamanchi, A., 2019, In : Wellcome Open Research. 4, p. 173

Research output: Contribution to journalReview article

Open Access

What causes symptoms suggestive of tuberculosis in HIV-positive people with negative initial investigations?

Hanifa, Y., Toro Silva, S., Karstaedt, A., Sahid, F., Charalambous, S., Chihota, V. N., Churchyard, G. J., von Gottberg, A., McCarthy, K., Nicol, M. P., Ndlovu, N. T., Stevens, W., Fielding, K. L. & Grant, A. D., 1 Feb 2019, In : International Journal of Tuberculosis & Lung Disease. 23, 2, p. 157-165 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Xpert MTB/RIF Ultra: a gamechanger for tuberculous meningitis?

Khonga, M. & Nicol, M. P., 1 Jan 2018, In : The Lancet Infectious Diseases. 18, 1, p. 6-8 3 p.

Research output: Contribution to journalComment/debate

8 Citations (Scopus)