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  • Alan James
2019

Trends in smoking initiation in Australia over 70 years

Caliskan, G., Pesce, G., Abramson, M., Bui, D., James, A. L., Jarvis, D., Knuiman, M. W., Minelli, C., Musk, A. W., Accordini, S., Dharmage, S. C. & Marcon, A., 28 Sep 2019, In : European Respiratory Journal. 54, Supplement 63, 3 p., OA3312.

Research output: Contribution to journalAbstract/Meeting Abstract

2017

BODY MASS INDEX AND ADIPOSE TISSUE WITHIN THE AIRWAY WALL

Elliot, J. G., Green, F. H. Y., Noble, P. B. & James, A. L., Mar 2017, In : Respirology. 22, p. 102-102 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Australian Asthma Genetics Consortium Collaborators, 1 Jan 2018, In : Nature Genetics. 50, 1, p. 42-50 9 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)
2017

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Wain, L. V., Shrine, N., Artigas, M. S., Erzurumluoglu, A. M., Noyvert, B., Bossini-Castillo, L., Obeidat, ME., Henry, A. P., Portelli, M. A., Hall, R. J., Billington, C. K., Rimington, T. L., Fenech, A. G., John, C., Blake, T., Jackson, V. E., Allen, R. J., Prins, B. P., Campbell, A., Porteous, D. J. & 86 others, Jarvelin, M. R., Wielscher, M., James, A. L., Hui, J., Wareham, N. J., Zhao, J. H., Wilson, J. F., Joshi, P. K., Stubbe, B., Rawal, R., Schulz, H., Imboden, M., Probst-Hensch, N. M., Karrasch, S., Gieger, C., Deary, I. J., Harris, S. E., Marten, J., Rudan, I., Enroth, S., Gyllensten, U., Kerr, S. M., Polasek, O., Kähönen, M., Surakka, I., Vitart, V., Hayward, C., Lehtimäki, T., Raitakari, O. T., Evans, D. M., Henderson, A. J., Pennell, C. E., Wang, C. A., Sly, P. D., Wan, E. S., Busch, R., Hobbs, B. D., Litonjua, A. A., Sparrow, D. W., Gulsvik, A., Bakke, P. S., Crapo, J. D., Beaty, T. H., Hansel, N. N., Mathias, R. A., Ruczinski, I., Barnes, K. C., Bossé, Y., Joubert, P., Van Den Berge, M., Brandsma, C. A., Paré, P. D., Sin, D. D., Nickle, D. C., Hao, K., Gottesman, O., Dewey, F. E., Bruse, S. E., Carey, D. J., Kirchner, H. L., Jonsson, S., Thorleifsson, G., Jonsdottir, I., Gislason, T., Stefansson, K., Schurmann, C., Nadkarni, G., Bottinger, E. P., Loos, R. J. F., Walters, R. G., Chen, Z., Millwood, I. Y., Vaucher, J., Kurmi, O. P., Li, L., Hansell, A. L., Brightling, C., Zeggini, E., Cho, M. H., Silverman, E. K., Sayers, I., Trynka, G., Morris, A. P., Strachan, D. P., Hall, I. P. & Tobin, M. D., 1 Mar 2017, In : Nature Genetics. 49, 3, p. 416-425 10 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)
2019

Fatty airways: Implications for obstructive disease

Elliot, J. G., Donovan, G. M., Wang, K. C. W., Green, F. H. Y., James, A. L. & Noble, P. B., 1 Dec 2019, In : European Respiratory Journal. 54, 6, 1900857.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
3 Citations (Scopus)
2017

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Warren, H. R., Evangelou, E., Cabrera, C. P., Gao, H., Ren, M., Mifsud, B., Ntalla, I., Surendran, P., Liu, C., Cook, J. P., Kraja, A. T., Drenos, F., Loh, M., Verweij, N., Marten, J., Karaman, I., Segura Lepe, M. P., O'Reilly, P., Knight, J., Snieder, H. & 249 others, Kato, N., He, J., Shyong Tai, E., Abdullah Said, M., Porteous, D., Alver, M., Poulter, N., Farrall, M., Gansevoort, R. T., Padmanabhan, S., Mägi, R., Stanton, A., Connell, J., Bakker, S. J. L., Metspalu, A., Shields, D. C., Thom, S., Brown, M., Sever, P., Esko, T., Hayward, C., van der Harst, P., Saleheen, D., Chowdhury, R., Chambers, J. C., Chasman, D. I., Chakravarti, A., Newton-Cheh, C., Lindgren, C. M., Levy, D., Kooner, J. S., Keavney, B. D., Tomaszewski, M., Samani, N. J., Howson, J. M. M., Tobin, M. D., Munroe, P. B., Ehret, G. B., Wain, V., Barnes, M. R., Tzoulaki, I., Caulfield, M. J., Elliott, P., Wain, V., Vaez, A., Jansen, R., Joehanes, R., van der Most, P. J., Mesut Erzurumluoglu, A., O'Reilly, P., Rose, L. M., Verwoert, G. C., Hottenga, J. J., Strawbridge, R. J., Esko, T., Arking, D. E., Hwang, S. J., Guo, X., Kutalik, Z., Trompet, S., Shrine, N., Teumer, A., Ried, J. S., Bis, J. C., Smith, A. V., Amin, N., Nolte, I. M., Lyytikäinen, L. P., Mahajan, A., Wareham, N. J., Hofer, E., Joshi, P. K., Kristiansson, K., Traglia, M., Havulinna, A. S., Goel, A., Nalls, M. A., Sõber, S., Vuckovic, D., Luan, J., Fabiola Del Greco, M., Ayers, K. L., Marrugat, J., Ruggiero, D., Lopez, L. M., Niiranen, T., Enroth, S., Jackson, A. U., Nelson, C. P., Huffman, J. E., Zhang, W., Gandin, I., Harris, S. E., Zemonik, T., Lu, Y., Shah, N., de Borst, M. H., Mangino, M., Prins, B. P., Campbell, A., Li-Gao, R., Chauhan, G., Oldmeadow, C., Abecasis, G., Abedi, M., Barbieri, C. M., Batini, C., Blake, T., Boehnke, M., Bottinger, E. P., Braund, P. S., Brumat, M., Campbell, H., Cocca, M., Collins, F., Cordell, H. J., Damman, J. J., Davies, G., de Geus, E. J., de Mutsert, R., Deelen, J., Demirkale, Y., Doney, A. S. F., Dörr, M., Ferreira, T., Frånberg, M., Giedraitis, V., Gieger, C., Giulianini, F., Gow, A. J., Hamsten, A., Harris, T. B., Hofman, A., Holliday, E. G., Jarvelin, M. R., Johansson, Å., Johnson, A. D., Jousilahti, P., Jula, A., Kähönen, M., Kathiresan, S., Khaw, K. T., Kolcic, I., Koskinen, S., Langenberg, C., Larson, M., Launer, L. J., Lehne, B., Liewald, D. C. M., Lin, L., Lind, L., Mach, F., Mamasoula, C., Menni, C., Milaneschi, Y., Morgan, A., Morris, A. D., Morrison, A. C., Munson, P. J., Nandakumar, P., Nguyen, Q. T., Nutile, T., Oldehinkel, A. J., Oostra, B. A., Org, E., Palotie, A., Paré, G., Pattie, A., Penninx, B. W. J. H., Pramstaller, P. P., Raitakari, O. T., Rice, K., Ridker, P. M., Riese, H., Ripatti, S., Robino, A., Rotter, J. I., Rudan, I., Saba, Y., Saint Pierre, A., Sala, C. F., Sarin, A. P., Schmidt, R., Scott, R., Seelen, M. A., Siscovick, D., Sorice, R., Stott, D. J., Sundström, J., Swertz, M., Taylor, K. D., Tzourio, C., Uitterlinden, A. G., Völker, U., Vollenweider, P., Wild, S., Willemsen, G., Wright, A. F., Yao, J., Thériault, S., Conen, D., John, A., Debette, S., Mook-Kanamori, D. O., Zeggini, E., Spector, T. D., Palmer, C. N. A., Vergnaud, A. C., Loos, R. J. F., Polasek, O., Starr, J. M., Girotto, G., Lindgren, C. M., Vitart, V., Tuomilehto, J., Gyllensten, U., Knekt, P., Deary, I. J., Ciullo, M., Elosua, R., Keavney, B. D., Hicks, A. A., Scott, R. A., Gasparini, P., Laan, M., Liu, Y. M., Watkins, H., Hartman, C. A., Salomaa, V., Toniolo, D., Perola, M., Wilson, J. F., Schmidt, H., Zhao, J. H., Lehtimäki, T., van Duijn, C. M., Gudnason, V., Psaty, B. M., Peters, A., Rettig, R., James, A., Wouter Jukema, J., Strachan, D. P., Palmas, W., Ingelsson, E., Boomsma, D. I., Franco, O. H., Bochud, M. & Morris, A. P., 1 Mar 2017, In : Nature Genetics. 49, 3, p. 403-415 13 p.

Research output: Contribution to journalArticle

182 Citations (Scopus)
2018
Open Access
File
22 Citations (Scopus)
224 Downloads (Pure)
2017

Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney

Wain, L. V., Vaez, A., Jansen, R., Joehanes, R., Van Der Most, P. J., Erzurumluoglu, A. M., O'Reilly, P. F., Cabrera, C. P., Warren, H. R., Rose, L. M., Verwoert, G. C., Hottenga, J. J., Strawbridge, R. J., Esko, T., Arking, D. E., Hwang, S. J., Guo, X., Kutalik, Z., Trompet, S., Shrine, N. & 223 others, Teumer, A., Ried, J. S., Bis, J. C., Smith, A. V., Amin, N., Nolte, I. M., Lyytikäinen, L. P., Mahajan, A., Wareham, N. J., Hofer, E., Joshi, P. K., Kristiansson, K., Traglia, M., Havulinna, A. S., Goel, A., Nalls, M. A., Sõber, S., Vuckovic, D., Luan, JA., Del Greco, F. M., Ayers, K. L., Marrugat, J., Ruggiero, D., Lopez, L. M., Niiranen, T., Enroth, S., Jackson, A. U., Nelson, C. P., Huffman, J. E., Zhang, W., Marten, J., Gandin, I., Harris, S. E., Zemunik, T., Lu, Y., Evangelou, E., Shah, N., De Borst, M. H., Mangino, M., Prins, B. P., Campbell, A., Li-Gao, R., Chauhan, G., Oldmeadow, C., Abecasis, G., Abedi, M., Barbieri, C. M., Barnes, M. R., Batini, C., Beilby, J., Blake, T., Boehnke, M., Bottinger, E. P., Braund, P. S., Brown, M. J., Brumat, M., Campbell, H., Chambers, J. C., Cocca, M., Collins, F. S., Connell, J., Cordell, H. J., Damman, J. J., Davies, G., De Geus, E. J. C. N., De Mutsert, R., Deelen, J., Demirkale, Y., Doney, A. S. F., Dörr, M., Farrall, M., Ferreira, T., Frånberg, M., Gao, H., Giedraitis, V., Gieger, C., Giulianini, F., Gow, A. J., Hamsten, A., Harris, T. B., Hofman, A., Holliday, E. G., Hui, J., Jarvelin, M. R., Johansson, Å., Johnson, A. D., Jousilahti, P., Jula, A., Kähönen, M., Kathiresan, S., Khaw, K. T., Kolcic, I., Koskinen, S., Langenberg, C., Larson, M., Launer, L. J., Lehne, B., Liewald, D. C. M., Lin, L., Lind, L., Mach, F., Mamasoula, C., Menni, C., Mifsud, B., Milaneschi, Y., Morgan, A., Morris, A. D., Morrison, A. C., Munson, P. J., Nandakumar, P., Nguyen, Q. T., Nutile, T., Oldehinkel, A. J., Oostra, B. A., Org, E., Padmanabhan, S., Palotie, A., Paré, G., Pattie, A., Penninx, B. W. J. H., Poulter, N., Pramstaller, P. P., Raitakari, O. T., Ren, M., Rice, K. M., Ridker, P. M., Riese, H., Ripatti, S., Robino, A., Rotter, J. I., Rudan, I., Saba, Y., Saint-Pierre, A., Sala, C. F., Sarin, A. P., Schmidt, R., Scott, R., Seelen, M. A., Shields, D. C., Siscovick, D. S., Sorice, R., Stanton, A., Stott, D. J., Sundström, J., Swertz, M. A., Taylor, K. D., Thom, S., Tzoulaki, I., Tzourio, C., Uitterlinden, A. G., Völker, U., Vollenweider, P., Wild, S. H., Willemsen, G., Wright, A. F., Yao, J., Thériault, S., Conen, D., Attia, J., Sever, P., Debette, S., Mook-Kanamori, D. O., Zeggini, E., Spector, T. D., Van der Harst, P., Palmer, C. N. A., Vergnaud, A. C., Loos, R. J. F., Polasek, O., Starr, J. M., Girotto, G., Hayward, C., Kooner, J. S., Lindgren, C. M., Vitart, V., Samani, N. J., Tuomilehto, J., Gyllensten, U., Knekt, P. B., Deary, I. J., Ciullo, M., Elosua, R., Keavney, B. D., Hicks, A. A., Scott, R. A., Gasparini, P., Laan, M., Liu, Y., Watkins, H., Hartman, C. A., Salomaa, V., Toniolo, D., Perola, M., Wilson, J. F., Schmidt, H., Zhao, J. H., Lehtimäki, T., van Duijn, C. M., Gudnason, V., Psaty, B. M., Peters, A., Rettig, R., James, A., Jukema, J. W., Strachan, D. P., Palmas, W., Metspalu, A., Ingelsson, E., Boomsma, D. I., Franco, O. H., Bochud, M., Newton-Cheh, C., Munroe, P. B., Elliott, P., Chasman, D. I., Chakravarti, A., Knight, J., Morris, A. P., Levy, D., Tobin, M. D., Snieder, H., Caulfield, M. J. & Ehret, G. B., 1 Sep 2017, In : Hypertension. 70, 3, p. e4-e19

Research output: Contribution to journalArticle

58 Citations (Scopus)
2018

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

LifeLines Cohort Study & CHARGE Inflammation Working Group, 1 Nov 2018, In : American Journal of Human Genetics. 103, 5, p. 691-706 16 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2017

The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics

Rosner, S. R., Pascoe, C. D., Blankman, E., Jensen, C. C., Krishnan, R., James, A. L., Elliot, J. G., Green, F. H., Liu, J. C., Seow, C. Y., Park, J-A., Beckerle, M. C., Pare, P. D., Fredberg, J. J. & Smith, M. A., 9 Mar 2017, In : PLoS One. 12, 3, 16 p., 0171728.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)
2018

No association between sleep apnoea and macular telangiectasia type 2 and its markers of severity and progression: a case–control study and retrospective cohort study

Lee, M. G., Marshall, N. S., Clemons, T. E., Hunter, M. L., James, A. L., Grunstein, R. R., Nguyen, V., Campain, A. & Gillies, M. C., 19 Aug 2018, In : Clinical and Experimental Ophthalmology. 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

Periostin levels and eosinophilic inflammation in poorly-controlled asthma

Simpson, J. L., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A., Jenkins, C., Peters, M. J., Jia, G., Holweg, C. T. J. & Gibson, P. G., 30 Apr 2016, In : BMC Pulmonary Medicine. 16, p. 1-7 7 p., 67.

Research output: Contribution to journalArticle

Open Access
37 Citations (Scopus)
2019

A sputum 6-gene signature predicts future exacerbations of poorly controlled asthma

Fricker, M., Gibson, P. G., Powell, H., Simpson, J. L., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Marks, G. B., Baraket, M. & Baines, K. J., 1 Jul 2019, In : Journal of Allergy and Clinical Immunology. 144, 1, p. 51-60.e11

Research output: Contribution to journalArticle

10 Citations (Scopus)
2017

Severe asthma: Current management, targeted therapies and future directions—A roundtable report

McDonald, V. M., Maltby, S., Reddel, H. K., King, G. G., Wark, P. A. B., Smith, L., Upham, J. W., James, A. L., Marks, G. B. & Gibson, P. G., 1 Jan 2017, In : Respirology. 22, 1, p. 53-60 8 p.

Research output: Contribution to journalReview article

Open Access
26 Citations (Scopus)

SEX DEPENDENT EFFECTS ON AIRWAY RESPONSIVENESS OF MATERNAL HYPOXIA-INDUCED INTRAUTERINE GROWTH RESTRICTED JUVENILE MICE

Wang, K. C., Larcombe, A. N., Morton, J. S., Davidge, S. T., James, A. L. & Noble, P. B., Mar 2017, In : Respirology. 22, p. 36-36 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

Aschard, H., Tobin, M. D., Hancock, D. B., Skurnik, D., Sood, A., James, A., Smith, A. V., Manichaikul, A. W., Campbell, A., Prins, B. P., Hayward, C., Loth, D. W., Porteous, D. J., Strachan, D. P., Zeggini, E., O'Connor, G. T., Brusselle, G. G., Boezen, H. M., Schulz, H., Deary, I. J. & 31 others, Hall, I. P., Rudan, I., Kaprio, J., Wilson, J. F., Wilk, J. B., Huffman, J. E., Zhao, J. H., de Jong, K., Lyytikäinen, L. P., Wain, L. V., Jarvelin, M. R., Kähönen, M., Fornage, M., Polasek, O., Cassano, P. A., Barr, R. G., Rawal, R., Harris, S. E., Gharib, S. A., Enroth, S., Heckbert, S. R., Lehtimäki, T., Gyllensten, U., Jackson, V. E., Gudnason, V., Tang, W., Dupuis, J., Artigas, M. S., Joshi, A. D., London, S. J. & Kraft, P., 1 Jun 2017, In : International Journal of Epidemiology. 46, 3, p. 894-904 11 p., dyw318.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)
2018
Open Access
File
2 Citations (Scopus)
113 Downloads (Pure)
2017

Airway remodeling in asthma: Is it fixed or variable?

James, A., 15 Apr 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 8, p. 968-970 3 p.

Research output: Contribution to journalEditorial

4 Citations (Scopus)
2016

Airway dysbiosis: Haemophilus influenza and Tropheryma in poorly controlled asthma

Simpson, J. L., Daly, J., Baines, K. J., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A., Hugenholtz, P., Willner, D. & Gibson, P. G., 2016, In : European Respiratory Journal. 47, 3, p. 792-800 9 p.

Research output: Contribution to journalArticle

Open Access
67 Citations (Scopus)
2019
2017
Open Access
File
11 Citations (Scopus)
256 Downloads (Pure)
2020
2016

Genetic Correlation of Lung Function with Anthropometric Measures in the Busselton Health Study

Cadby, G., Melton, P. E., McCarthy, N. S., Hui, J., Beilby, J., Musk, A. B., James, A. L., Hung, J., Blangero, J. & Moses, E. K., Nov 2016, In : Genetic Epidemiology. 40, 7, p. 625-626 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2017

Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling

Ferreira, M. A. R., Jansen, R., Willemsen, G., Penninx, B. W., Bain, L. M., Vicente, C. T., Revez, J. A., Matheson, M. C., Hui, J., Tung, J. Y., Baltic, S., Le Souëf, P., Montgomery, G. W., Martin, N. G., Robertson, C. F., James, A., Thompson, P. J., Boomsma, D. I., Hopper, J. L., Hinds, D. A. & 3 others, Werder, R. B., Phipps, S. & Australian Asthma Genetics Consortium Collaborators, 1 Apr 2017, In : Journal of Allergy and Clinical Immunology. 139, 4, p. 1148-1157 10 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
343 Downloads (Pure)
2020

Airway remodelling with spatial correlations: Implications for asthma pathogenesis

Pascoe, C. D., Green, F. H. Y., Elliot, J. G., James, A. L., Noble, P. B. & Donovan, G. M., 27 May 2020, In : Respiratory Physiology & Neurobiology. p. 103469

Research output: Contribution to journalArticle

2018

Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy

Asai, Y., Eslami, A., van Ginkel, C. D., Akhabir, L., Wan, M., Ellis, G., Ben-Shoshan, M., Martino, D., Ferreira, M. A., Allen, K., Mazer, B., de Groot, H., de Jong, N. W., Gerth van Wijk, R. N., Dubois, A. E. J., Chin, R., Cheuk, S., Hoffman, J., Jorgensen, E., Witte, J. S. & 11 others, Melles, R. B., Hong, X., Wang, X., Hui, J., Musk, A. W., Hunter, M., James, A. L., Koppelman, G. H., Sandford, A. J., Clarke, A. E. & Daley, D., Mar 2018, In : Journal of Allergy and Clinical Immunology. 141, 3, p. 991-1001

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

the Million Veteran Program, 1 Oct 2018, In : Nature Genetics. 50, 10, p. 1412-1425 14 p.

Research output: Contribution to journalReview article

Open Access
80 Citations (Scopus)
2019

Patient-specific targeted bronchial thermoplasty: predictions of improved outcomes with structure-guided treatment

Donovan, G. M., Elliot, J. G., Boser, S. R., Green, F. H. Y., James, A. L. & Noble, P. B., Mar 2019, In : Journal of Applied Physiology. 126, 3, p. 599-606 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2018

Airway smooth muscle proliferation and inflammation in asthma

James, A. L., Noble, P. B., Drew, S. A., Mauad, T., Bai, T. R., Abramson, M. J., McKay, K. O., Green, F. H. Y. & Elliot, J. G., 1 Oct 2018, In : Journal of Applied Physiology. 125, 4, p. 1090-1096 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology

Taylor, S. L., Leong, L. E. X., Choo, J. M., Wesselingh, S., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Baraket, M., Marks, G. B., Gibson, P. G., Simpson, J. L. & Rogers, G. B., 1 Jan 2018, In : Journal of Allergy and Clinical Immunology. 141, 1, p. 94-103.e15

Research output: Contribution to journalArticle

Open Access
61 Citations (Scopus)