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  • Alan James
2017

Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling

Ferreira, M. A. R., Jansen, R., Willemsen, G., Penninx, B. W., Bain, L. M., Vicente, C. T., Revez, J. A., Matheson, M. C., Hui, J., Tung, J. Y., Baltic, S., Le Souëf, P., Montgomery, G. W., Martin, N. G., Robertson, C. F., James, A., Thompson, P. J., Boomsma, D. I., Hopper, J. L., Hinds, D. A. & 3 others, Werder, R. B., Phipps, S. & Australian Asthma Genetics Consortium Collaborators, 1 Apr 2017, In : Journal of Allergy and Clinical Immunology. 139, 4, p. 1148-1157 10 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
353 Downloads (Pure)
2019

Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

Liu, C. T., Merino, J., Rybin, D., DiCorpo, D., Benke, K. S., Bragg-Gresham, J. L., Canouil, M., Corre, T., Grallert, H., Isaacs, A., Kutalik, Z., Lahti, J., Marullo, L., Marzi, C., Rasmussen-Torvik, L. J., Rocheleau, G., Rueedi, R., Scapoli, C., Verweij, N., Vogelzangs, N. & 30 others, Willems, S. M., Yengo, L., Bakker, S. J. L., Beilby, J., Hui, J., Kajantie, E., Müller-Nurasyid, M., Rathmann, W., Balkau, B., Bergmann, S., Eriksson, J. G., Florez, J. C., Froguel, P., Harris, T., Hung, J., James, A. L., Kavousi, M., Miljkovic, I., Musk, A. W., Palmer, L. J., Peters, A., Roussel, R., van der harst, P., van Duijn, C. M., Vollenweider, P., Barroso, I., Prokopenko, I., Dupuis, J., Meigs, J. B. & Bouatia-Naji, N., Jul 2019, In : Scientific Reports. 9, 1, 9439.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma

Asai, Y., Eslami, A., van Ginkel, C. D., Akhabir, L., Wan, M., Yin, D., Ellis, G., Ben-Shoshan, M., Marenholz, I., Martino, D., Ferreira, M. A., Allen, K., Mazer, B., de Groot, H., de Jong, N. W., Gerth van Wijk, R., Dubois, A. E. J., Grosche, S., Ashley, S., Rüschendorf, F. & 20 others, Kalb, B., Beyer, K., Nöthen, M. M., Lee, Y-A., Chin, R., Cheuk, S., Hoffman, J., Jorgensen, E., Witte, J. S., Melles, R. B., Hong, X., Wang, X., Hui, J., Musk, A. W. B., Hunter, M., James, A. L., Koppelman, G. H., Sandford, A. J., Clarke, A. E. & Daley, D., 1 Apr 2018, In : The Journal of Allergy and Clinical Immunology. 141, 4, p. 1513-1516

Research output: Contribution to journalLetter

Open Access
File
12 Citations (Scopus)
312 Downloads (Pure)
2017

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

Aschard, H., Tobin, M. D., Hancock, D. B., Skurnik, D., Sood, A., James, A., Smith, A. V., Manichaikul, A. W., Campbell, A., Prins, B. P., Hayward, C., Loth, D. W., Porteous, D. J., Strachan, D. P., Zeggini, E., O'Connor, G. T., Brusselle, G. G., Boezen, H. M., Schulz, H., Deary, I. J. & 31 others, Hall, I. P., Rudan, I., Kaprio, J., Wilson, J. F., Wilk, J. B., Huffman, J. E., Zhao, J. H., de Jong, K., Lyytikäinen, L. P., Wain, L. V., Jarvelin, M. R., Kähönen, M., Fornage, M., Polasek, O., Cassano, P. A., Barr, R. G., Rawal, R., Harris, S. E., Gharib, S. A., Enroth, S., Heckbert, S. R., Lehtimäki, T., Gyllensten, U., Jackson, V. E., Gudnason, V., Tang, W., Dupuis, J., Artigas, M. S., Joshi, A. D., London, S. J. & Kraft, P., 1 Jun 2017, In : International Journal of Epidemiology. 46, 3, p. 894-904 11 p., dyw318.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Assessment of the depression, anxiety, and stress scale (DASS-21) in untreated obstructive sleep apnea (OSA)

Nanthakumar, S., Bucks, R. S., Skinner, T. C., Starkstein, S., Hillman, D., James, A. & Hunter, M., 1 Oct 2017, In : Psychological Assessment. 29, 10, p. 1201-1209 9 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
508 Downloads (Pure)
2018

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

LifeLines Cohort Study & CHARGE Inflammation Working Group, 1 Nov 2018, In : American Journal of Human Genetics. 103, 5, p. 691-706 16 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2016

Identification of STOML2 as a putative novel asthma risk gene associated with IL6R

Revez, J. A., Matheson, M. C., Hui, J., Baltic, S., James, A., Upham, J. W., Dharmage, S., Thompson, P., Martin, N. G., Hopper, J. L. & Ferreira, M. A. R., 14 Jun 2016, In : Allergy: European Journal of Allergy and Clinical Immunology. 71, 7, p. 1020-1030 11 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Periostin levels and eosinophilic inflammation in poorly-controlled asthma

Simpson, J. L., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A., Jenkins, C., Peters, M. J., Jia, G., Holweg, C. T. J. & Gibson, P. G., 30 Apr 2016, In : BMC Pulmonary Medicine. 16, p. 1-7 7 p., 67.

Research output: Contribution to journalArticle

Open Access
38 Citations (Scopus)
2018

No association between sleep apnoea and macular telangiectasia type 2 and its markers of severity and progression: a case–control study and retrospective cohort study

Lee, M. G., Marshall, N. S., Clemons, T. E., Hunter, M. L., James, A. L., Grunstein, R. R., Nguyen, V., Campain, A. & Gillies, M. C., 19 Aug 2018, In : Clinical and Experimental Ophthalmology. 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

Blood cytotoxic/inflammatory mediators in non-eosinophilic asthma

Hodge, S., Hodge, G., Simpson, J. L., Yang, I. A., Upham, J., James, A., Gibson, P. G. & Reynolds, P. N., 1 Jan 2016, In : Clinical and Experimental Allergy. 46, 1, p. 60-70 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

Atopy in people aged 40 years and over: Relation to airflow limitation

Guevara-Rattray, E. M., Garden, F. L., James, A. L., Wood-Baker, R., Abramson, M. J., Johns, D. P., Sonia Buist, A., Burney, P. G. J., Haydn Walters, E., Toelle, B. G. & Marks, G. B., 1 Dec 2017, In : Clinical and Experimental Allergy. 47, 12, p. 1625-1630 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

Pleiotropy of cardiometabolic syndrome with obesity-related anthropometric traits determined using empirically derived kinships from the Busselton Health Study

Cadby, G., Melton, P. E., McCarthy, N. S., Almeida, M., Williams-Blangero, S., Curran, J. E., VandeBerg, J. L., Hui, J., Beilby, J., Musk, A. W., James, A. L., Hung, J., Blangero, J. & Moses, E. K., 2018, In : Human Genetics. 137, 1, p. 45–53 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016

Genetic Correlation of Lung Function with Anthropometric Measures in the Busselton Health Study

Cadby, G., Melton, P. E., McCarthy, N. S., Hui, J., Beilby, J., Musk, A. B., James, A. L., Hung, J., Blangero, J. & Moses, E. K., Nov 2016, In : Genetic Epidemiology. 40, 7, p. 625-626 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Secular trends in COPD over five decades in 46-65 year-olds in Busselton, Western Australia

Musk, A., Hunter, M., Hui, J., Knuiman, M., Divitini, M. & James, A., Apr 2016, In : Respirology. 21, p. 134-134 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2018
Open Access
File
2 Citations (Scopus)
123 Downloads (Pure)
2020

Asthma: Pharmacological degradation of the airway smooth muscle layer

Wang, K., Donovan, G. M., James, A. & Noble, P., 21 Jul 2020, In : The International Journal of Biochemistry & Cell Biology. 126, 2020, p. 105818

Research output: Contribution to journalArticle

2019
4 Citations (Scopus)
2016

Airflow obstruction is associated with increased smooth muscle extracellular matrix

Jones, R. L., Noble, P. B., Elliot, J. G., Mitchell, H. W., McFawn, P. K., Hogg, J. C. & James, A. L., 2016, In : European Respiratory Journal. 47, 6, p. 1855-1857 3 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Airway remodelling in COPD: It's not asthma!

Jones, R. L., Noble, P. B., Elliot, J. G. & James, A. L., 1 Nov 2016, In : Respirology. 21, 8, p. 1347-1356 10 p.

Research output: Contribution to journalReview article

33 Citations (Scopus)

Airway dysbiosis: Haemophilus influenza and Tropheryma in poorly controlled asthma

Simpson, J. L., Daly, J., Baines, K. J., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A., Hugenholtz, P., Willner, D. & Gibson, P. G., 2016, In : European Respiratory Journal. 47, 3, p. 792-800 9 p.

Research output: Contribution to journalArticle

Open Access
67 Citations (Scopus)
2017
Open Access
File
12 Citations (Scopus)
264 Downloads (Pure)
2018

Airway smooth muscle proliferation and inflammation in asthma

James, A. L., Noble, P. B., Drew, S. A., Mauad, T., Bai, T. R., Abramson, M. J., McKay, K. O., Green, F. H. Y. & Elliot, J. G., 1 Oct 2018, In : Journal of Applied Physiology. 125, 4, p. 1090-1096 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2019

Patient-specific targeted bronchial thermoplasty: predictions of improved outcomes with structure-guided treatment

Donovan, G. M., Elliot, J. G., Boser, S. R., Green, F. H. Y., James, A. L. & Noble, P. B., Mar 2019, In : Journal of Applied Physiology. 126, 3, p. 599-606 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

Myofibroblasts are increased in the lung parenchyma in asthma

Boser, S. R., Mauad, T., de Araujo-Paulino, B. B., Mitchell, I., Shrestha, G., Chiu, A., Butt, J., Kelly, M. M., Caldini, E., James, A. & Green, F., 7 Aug 2017, In : PLoS One. 12, 8, 14 p., e0182378.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)
2019

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Understanding Society Scientific Group, 1 Mar 2019, In : Nature Genetics. 51, 3, p. 481-493 13 p.

Research output: Contribution to journalArticle

Open Access
File
30 Citations (Scopus)
66 Downloads (Pure)
2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Australian Asthma Genetics Consortium Collaborators, 1 Jan 2018, In : Nature Genetics. 50, 1, p. 42-50 9 p.

Research output: Contribution to journalArticle

103 Citations (Scopus)
2019

Early-life exposure to sibling modifies the relationship between CD14 polymorphisms and allergic sensitization

the investigators of the TAHS and MACS, 8 Aug 2019, In : Clinical and Experimental Allergy. 49, 3, p. 331-340 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney

Wain, L. V., Vaez, A., Jansen, R., Joehanes, R., Van Der Most, P. J., Erzurumluoglu, A. M., O'Reilly, P. F., Cabrera, C. P., Warren, H. R., Rose, L. M., Verwoert, G. C., Hottenga, J. J., Strawbridge, R. J., Esko, T., Arking, D. E., Hwang, S. J., Guo, X., Kutalik, Z., Trompet, S., Shrine, N. & 223 others, Teumer, A., Ried, J. S., Bis, J. C., Smith, A. V., Amin, N., Nolte, I. M., Lyytikäinen, L. P., Mahajan, A., Wareham, N. J., Hofer, E., Joshi, P. K., Kristiansson, K., Traglia, M., Havulinna, A. S., Goel, A., Nalls, M. A., Sõber, S., Vuckovic, D., Luan, JA., Del Greco, F. M., Ayers, K. L., Marrugat, J., Ruggiero, D., Lopez, L. M., Niiranen, T., Enroth, S., Jackson, A. U., Nelson, C. P., Huffman, J. E., Zhang, W., Marten, J., Gandin, I., Harris, S. E., Zemunik, T., Lu, Y., Evangelou, E., Shah, N., De Borst, M. H., Mangino, M., Prins, B. P., Campbell, A., Li-Gao, R., Chauhan, G., Oldmeadow, C., Abecasis, G., Abedi, M., Barbieri, C. M., Barnes, M. R., Batini, C., Beilby, J., Blake, T., Boehnke, M., Bottinger, E. P., Braund, P. S., Brown, M. J., Brumat, M., Campbell, H., Chambers, J. C., Cocca, M., Collins, F. S., Connell, J., Cordell, H. J., Damman, J. J., Davies, G., De Geus, E. J. C. N., De Mutsert, R., Deelen, J., Demirkale, Y., Doney, A. S. F., Dörr, M., Farrall, M., Ferreira, T., Frånberg, M., Gao, H., Giedraitis, V., Gieger, C., Giulianini, F., Gow, A. J., Hamsten, A., Harris, T. B., Hofman, A., Holliday, E. G., Hui, J., Jarvelin, M. R., Johansson, Å., Johnson, A. D., Jousilahti, P., Jula, A., Kähönen, M., Kathiresan, S., Khaw, K. T., Kolcic, I., Koskinen, S., Langenberg, C., Larson, M., Launer, L. J., Lehne, B., Liewald, D. C. M., Lin, L., Lind, L., Mach, F., Mamasoula, C., Menni, C., Mifsud, B., Milaneschi, Y., Morgan, A., Morris, A. D., Morrison, A. C., Munson, P. J., Nandakumar, P., Nguyen, Q. T., Nutile, T., Oldehinkel, A. J., Oostra, B. A., Org, E., Padmanabhan, S., Palotie, A., Paré, G., Pattie, A., Penninx, B. W. J. H., Poulter, N., Pramstaller, P. P., Raitakari, O. T., Ren, M., Rice, K. M., Ridker, P. M., Riese, H., Ripatti, S., Robino, A., Rotter, J. I., Rudan, I., Saba, Y., Saint-Pierre, A., Sala, C. F., Sarin, A. P., Schmidt, R., Scott, R., Seelen, M. A., Shields, D. C., Siscovick, D. S., Sorice, R., Stanton, A., Stott, D. J., Sundström, J., Swertz, M. A., Taylor, K. D., Thom, S., Tzoulaki, I., Tzourio, C., Uitterlinden, A. G., Völker, U., Vollenweider, P., Wild, S. H., Willemsen, G., Wright, A. F., Yao, J., Thériault, S., Conen, D., Attia, J., Sever, P., Debette, S., Mook-Kanamori, D. O., Zeggini, E., Spector, T. D., Van der Harst, P., Palmer, C. N. A., Vergnaud, A. C., Loos, R. J. F., Polasek, O., Starr, J. M., Girotto, G., Hayward, C., Kooner, J. S., Lindgren, C. M., Vitart, V., Samani, N. J., Tuomilehto, J., Gyllensten, U., Knekt, P. B., Deary, I. J., Ciullo, M., Elosua, R., Keavney, B. D., Hicks, A. A., Scott, R. A., Gasparini, P., Laan, M., Liu, Y., Watkins, H., Hartman, C. A., Salomaa, V., Toniolo, D., Perola, M., Wilson, J. F., Schmidt, H., Zhao, J. H., Lehtimäki, T., van Duijn, C. M., Gudnason, V., Psaty, B. M., Peters, A., Rettig, R., James, A., Jukema, J. W., Strachan, D. P., Palmas, W., Metspalu, A., Ingelsson, E., Boomsma, D. I., Franco, O. H., Bochud, M., Newton-Cheh, C., Munroe, P. B., Elliott, P., Chasman, D. I., Chakravarti, A., Knight, J., Morris, A. P., Levy, D., Tobin, M. D., Snieder, H., Caulfield, M. J. & Ehret, G. B., 1 Sep 2017, In : Hypertension. 70, 3, p. e4-e19

Research output: Contribution to journalArticle

58 Citations (Scopus)

Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial

Gibson, P. G., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Marks, G. B., Baraket, M., Powell, H., Taylor, S. L., Leong, L. E. X., Rogers, G. B. & Simpson, J. L., 12 Aug 2017, In : The Lancet. 390, 10095, p. 659-668 10 p.

Research output: Contribution to journalArticle

186 Citations (Scopus)
2016

Association of Forced Vital Capacity with the Developmental Gene NCOR2

CHARGE consortium & SpiroMeta consortium, 2016, In : PLoS One. 11, 2, 17 p., e0147388.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)
2018

Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy

Asai, Y., Eslami, A., van Ginkel, C. D., Akhabir, L., Wan, M., Ellis, G., Ben-Shoshan, M., Martino, D., Ferreira, M. A., Allen, K., Mazer, B., de Groot, H., de Jong, N. W., Gerth van Wijk, R. N., Dubois, A. E. J., Chin, R., Cheuk, S., Hoffman, J., Jorgensen, E., Witte, J. S. & 11 others, Melles, R. B., Hong, X., Wang, X., Hui, J., Musk, A. W., Hunter, M., James, A. L., Koppelman, G. H., Sandford, A. J., Clarke, A. E. & Daley, D., Mar 2018, In : Journal of Allergy and Clinical Immunology. 141, 3, p. 991-1001

Research output: Contribution to journalArticle

Open Access
27 Citations (Scopus)
2020