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  • Alex Hewitt
2017

Genome-wide association shows that pigmentation genes play a role in skin aging

Law, M. H., Medland, S. E., Zhu, G., Yazar, S., Viñuela, A., Wallace, L., Shekar, S. N., Duffy, D. L., Bataille, V., Glass, D., Spector, T. D., Wood, D., MuTHER Consortium, Gordon, S. D., Barbour, J. M., Henders, A. K., Hewitt, A. W., Montgomery, G. W., Sturm, R. A., Mackey, D. A. & 3 others, Green, A. C., Martin, N. G. & MacGregor, S., Sep 2017, In : Journal of Investigative Dermatology. 137, 9, p. 1887-1894

Research output: Contribution to journalArticle

17 Citations (Scopus)
Open Access
File
2 Citations (Scopus)
343 Downloads (Pure)
2015

WNT10A exonic variant increases the risk of keratoconus by decreasing corneal thickness

Cuellar-Partida, G., Springelkamp, H., Lucas, S. E. M., Yazar, S., Hewitt, A. W., Iglesias, A. I., Montgomery, G. W., Martin, N. G., Pennell, C., Van Leeuwen, E. M., Verhoeven, V. J. M., Hofman, A., Uitterlinden, A. G., Ramdas, W. D., Wolfs, R. C. W., Vingerling, J. R., Brown, M. A., Mills, R. A., Craig, J. E., Klaver, C. C. W. & 4 others, Van Duijn, C. M., Burdon, K. P., Macgregor, S. & Mackey, D., 1 Sep 2015, In : Human Molecular Genetics. 24, 17, p. 5060-5068

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
294 Downloads (Pure)
2020

Rationale and protocol for the 7- And 8-year longitudinal assessments of eye health in a cohort of young adults in the Raine Study

Lee, S. S. Y., Lingham, G., Yazar, S., Sanfilippo, P. G., Charng, J., Chen, F. K., Hewitt, A. W., Ng, F., Hammond, C., Straker, L. M., Eastwood, P. R., MacGregor, S., Rose, K. A., Lucas, R. M., Guggenheim, J. A., Saw, S. M., Coroneo, M. T., He, M. & MacKey, D. A., 25 Mar 2020, In : BMJ Open. 10, 3, e033440.

Research output: Contribution to journalArticle

Open Access
2019

Genome-wide association analysis of 95 549 individuals identifies novel loci and genes influencing optic disc morphology

Han, X., Qassim, A., An, J., Marshall, H., Zhou, T., Ong, J. S., Hassall, M. M., Hysi, P. G., Foster, P. J., Khaw, P. T., Mackey, D. A., Gharahkhani, P., Khawaja, A. P., Hewitt, A. W., Craig, J. E. & MacGregor, S., 1 Nov 2019, In : Human Molecular Genetics. 28, 21, p. 3680-3690 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2013

Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus

Lu, Y., Vitart, V., Burdon, K. P., Khor, C. C., Bykhovskaya, Y., Mirshahi, A., Hewitt, A., Koehn, D., Hysi, P. G., Ramdas, W. D., Zeller, T., Vithana, E. N., Cornes, B. K., Tay, W-T., Tai, E. S., Cheng, C-Y., Liu, J., Foo, J-N., Saw, S. M., Thorleifsson, G. & 70 others, Stefansson, K., Dimasi, D. P., Mills, R. A., Mountain, J., Ang, W., Hoehn, R., Verhoeven, V. J. M., Grus, F., Wolfs, R., Castagne, R., Lackner, K. J., Springelkamp, H., Yang, J., Jonasson, F., Leung, D. Y. L., Chen, L. J., Tham, C. C. Y., Rudan, I., Vatavuk, Z., Hayward, C., Gibson, J., Cree, A. J., Macleod, A., Ennis, S., Polasek, O., Campbell, H., Wilson, J. F., Viswanathan, A. C., Fleck, B., Li, X., Siscovick, D., Taylor, K. D., Rotter, J. I., Yazar, S., Ulmer, M., Li, J., Yaspan, B. L., Ozel, A. B., Richards, J. E., Moroi, S. E., Haines, J. L., Kang, J. H., Pasquale, L. R., Allingham, R. R., Ashley-Koch, A., Mitchell, P., Wang, J. J., Wright, A. F., Pennell, C., Spector, T. D., Young, T. L., Klaver, C. C. W., Martin, N. G., Montgomery, G. W., Anderson, M. G., Aung, T., Willoughby, C. E., Wiggs, J. L., Pang, C. P., Thorsteinsdottir, U., Lotery, A. J., Hammond, C. J., Van Duijn, C. M., Hauser, M. A., Rabinowitz, Y. S., Pfeiffer, N., Mackey, D., Craig, J. E., Macgregor, S. & Wong, T. Y., 2013, In : Nature Genetics. 45, p. 155

Research output: Contribution to journalArticle

163 Citations (Scopus)
2012

Common genetic determinants of intraocular pressure and primary open-angle Glaucoma

Van Koolwijk, L. M. E., Ramdas, W. D., Ikram, M. K., Jansonius, N. M., Pasutto, F., Hysi, P. G., Macgregor, S., Janssen, S. F., Hewitt, A., Viswanathan, A. C., Ten Brink, J. B., Hosseini, S. M., Amin, N., Despriet, D. D. G., Willemse-Assink, J. J. M., Kramer, R., Rivadeneira, F., Struchalin, M., Aulchenko, Y. S., Weisschuh, N. & 29 others, Zenkel, M., Mardin, C. Y., Gramer, E., Welge-Lüssen, U., Montgomery, G. W., Carbonaro, F., Young, T. L., Bellenguez, C., Mcguffin, P., Foster, P. J., Topouzis, F., Mitchell, P., Wang, J. J., Wong, T. Y., Czudowska, M. A., Hofman, A., Uitterlinden, A. G., Wolfs, R. C. W., De Jong, P. T. V. M., Oostra, B. A., Paterson, A. D., Mackey, D., Bergen, A. A. B., Reis, A., Hammond, C. J., Vingerling, J. R., Lemij, H. G., Klaver, C. C. W. & Van Duijn, C. M., 2012, In : PLoS Genetics. 8, 5, p. 14pp

Research output: Contribution to journalArticle

Open Access
113 Citations (Scopus)
2018

A RANZCO POSITION STATEMENT ON OCULAR STEM CELL THERAPY

Bobba, S., Di Girolamo, N., Munsie, M., Chen, F., Pebay, A., Harkin, D., Hewitt, A., O'Connor, M., McLenachan, S., Shadforth, A. & Watson, S., Nov 2018, In : Clinical and Experimental Ophthalmology. 46, p. 87-87 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2 Citations (Scopus)
2019

Molecular aspects of eye development and regeneration in the Australian redclaw crayfish, Cherax quadricarinatus

Ventura, T., Stewart, M. J., Chandler, J. C., Rotgans, B., Elizur, A. & Hewitt, A. W., 1 Jan 2019, In : Aquaculture and Fisheries. 4, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2014

Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma

Gharahkhani, P., Burdon, K. P., Fogarty, R. D., Sharma, S., Hewitt, A. W., Martin, S., Law, M. H., Cremin, K., Bailey, J. N. C., Loomis, S. J., Pasquale, L. R., Haines, J. L., Hauser, M. A., Viswanathan, A. C., Mcguffin, P. W., Topouzis, F., Foster, P. J. F., Graham, S. L. D., Casson, R. J., Chehade, M. J. & 21 others, White, A. J. R., Zhou, T., Souzeau, E., Landers, J., Fitzgerald, J. T., Klebe, S., Ruddle, J. B., Goldberg, I., Healey, P. R., Mills, R. A. D., Wang, J., Montgomery, G. W., Martin, N. G., Radford-Smith, G. L., Whiteman, D. C., Brown, M. A., Wiggs, J. L., Mackey, D., Mitchell, P., Macgregor, S. & Craig, J. E., Oct 2014, In : Nature Genetics. 46, 10, p. 1120-1125 6 p.

Research output: Contribution to journalArticle

Open Access
98 Citations (Scopus)
2019

Myocilin Gene Gln368Ter Variant Penetrance and Association With Glaucoma in Population-Based and Registry-Based Studies

Han, X., Souzeau, E., Ong, J-S., An, J., Siggs, O. M., Bunion, K. P., Best, S., Goldberg, I., Healey, P. R., Graham, S. L., Ruddle, J. B., Mills, R. A., Landers, J., Galanopoulos, A., White, A. J. R., Casson, R., Mackey, D. A., Hewitt, A. W., Gharahkhani, P., Craig, J. E. & 1 others, MacGregor, S., Jan 2019, In : JAMA Ophthalmology. 137, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2014

Replication of genetic loci implicated in diabetic retinopathy

McAuley, A. K., Wang, J. J., Dirani, M., Connell, P. P., Lamoureux, E. & Hewitt, A. W., Mar 2014, In : Investigative ophthalmology & visual science. 55, 3, p. 1666-1671 6 p.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)
2015

ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure

Springelkamp, H., Iglesias, A. I., Cuellar-Partida, G., Amin, N., Burdon, K. P., Van Leeuwen, E. M., Gharahkhani, P., Mishra, A., Van Der Lee, S. J., Hewitt, A. W., Rivadeneira, F., Viswanathan, A. C., Wolfs, R. C. W., Martin, N. G., Ramdas, W. D., Van Koolwijk, L. M., Pennell, C., Vingerling, J. R., Mountain, J., Uitterlinden, A. G. & 9 others, Hofman, A., Mitchell, P., Lemij, H. G., Wang, J. J., Klaver, C. C. W., Mackey, D., Craig, J. E., Van Duijn, C. M. & Macgregor, S., 2015, In : Human Molecular Genetics. 24, 9, p. 2689-2699

Research output: Contribution to journalArticle

Open Access
42 Citations (Scopus)
2014

TLR4 polymorphism is not associated with biopsy proven giant cell arteritis

Dunstan, E., Lester, S. L., Rischmueller, M., Chan, H., Hewitt, A. & Hill, C. L., 2014, In : Clinical and Experimental Rheumatology. 32, SUPPL.82, p. S26-S29

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients

Ashworth-Briggs, E. L., Toh, T., Eri, R., Hewitt, A. & Cook, A. L., 2015, In : Molecular Vision. 21, p. 1162-1172

Research output: Contribution to journalArticle

25 Citations (Scopus)
2012

The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma.

Wiggs, JL., Hewitt, A., Fan, BJ., Wang, DY., Figueiredo Sena, DR., O'Brien, C., Realini, A., Craig, JE., Dimasi, DP., Mackey, D., Haines, JL. & Pasquale, LR., 26 Sep 2012, In : PLoS One. 7, 9, p. 7pp

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)
2013

Genetic Loci for Retinal Arteriolar Microcirculation

Sim, X., Jensen, R. A., Ikram, M. K., Cotch, M. F., Li, X., Macgregor, S., Xie, J., Smith, A. V., Boerwinkle, E., Mitchell, P., Klein, R., Klein, B. E. K., Glazer, N. L., Lumley, T., Mcknight, B., Psaty, B. M., De Jong, P. T. V. M., Hofman, A., Rivadeneira, F., Uitterlinden, A. G. & 36 others, Van Duijn, C. M., Aspelund, T., Eiríksdóttir, G., Harris, T. B., Jónasson, F., Launer, L. J., Attia, J., Baird, P. N., Harrap, S., Holliday, E. G., Inouye, M., Rochtchina, E., Scott, R. J., Viswanathan, A., Li, G., Smith, N. L., Wiggins, K. L., Kuo, J. Z., Taylor, K. D., Hewitt, A., Martin, N. G., Montgomery, G. W., Sun, C., Young, T. L., Mackey, D., Van Zuydam, N. R., Doney, A. S. F., Palmer, C. N. A., Morris, A. D., Rotter, J. I., Tai, E. S., Gudnason, V., Vingerling, J. R., Siscovick, D. S., Wang, J. J. & Wong, T. Y., 2013, In : PLoS One. 8, 6, p. 12pp

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
2011

The role of toll-like receptor variants in acute anterior uveitis

Pratap, DS., Lim, LL., Wang, JJ., Mackey, D., Kearns, LS., Stawell, RJ., Burdon, KP., Mitchell, P., Craig, JE., Hall, AJ. & Hewitt, AW., 2011, In : Molecular Vision. 17, p. 2970-2977

Research output: Contribution to journalArticle

8 Citations (Scopus)

Pediatric cataract, myopic astigmatism, familial exudative vitreoretinopathy and primary open-angle glaucoma co-segregating in a family

Mackey, D., Hewitt, AW., Ruddle, JB., Vote, B., Buttery, RG., Toomes, C., Metlapally, R., Li, YJ., Tran-Viet, KN., Malecaze, F., Calvas, P., Rosenberg, T., Guggenheim, JA. & Young, TL., 2011, In : Molecular Vision. 17, p. 2118-2128

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

Accurate imputation-based screening of Gln368Ter myocilin variant in primary open-angle glaucoma

Gharahkhani, P., Burdon, K. P., Hewitt, A. W., Law, M. H., Souzeau, E., Montgomery, G. W., Radford-Smith, G., Mackey, D., Craig, J. E. & Macgregor, S., 2015, In : Investigative Ophthalmology and Visual Science. 56, 9, p. 5087-5093

Research output: Contribution to journalArticle

9 Citations (Scopus)
2011

Best's macular dystrophy in Australia: phenotypic profile and identification of novel BEST1 mutation

Cohn, A. C., Turnbull, C., Ruddle, J. B., Guymer, R. H., Kearns, L. S., Staffieri, S., Daggett, H. T., Hewitt, A. W. & Mackey, D., 2011, In : Eye. PMID: 21109774, 26 November 2010, p. 208-217

Research output: Contribution to journalArticle

11 Citations (Scopus)
2012

Authors’ response: Approach to evaluating the reliability and validity of conjunctival ultraviolet autofluorescence measurement

Sherwin, JC., Hewitt, A., Mcknight, C. M., Griffiths, LR., Coroneo, MT. & Mackey, D., 2012, In : British Journal of Ophthalmology. 96, p. 1271

Research output: Contribution to journalLetter

2011

Ophthalmic Phenotypes and the Representativeness of Twin Data for the General Population

Sanfilippo, PG., Medland, SE., Hewitt, AW., Kearns, LS., Ruddle, JB., Sun, C., Hammond, CJ., Young, TL., Martin, NG. & Mackey, D., 2011, In : Investigative ophthalmology & visual science. 52, p. 5565-5572

Research output: Contribution to journalArticle

11 Citations (Scopus)

Distribution of conjunctival ultraviolet autofluorescence in a population-based study: the Norfolk Island Eye Study

Sherwin, JC., Hewitt, AW., Kearns, LS., Coroneo, MT., Griffiths, LR. & Mackey, D., 2011, In : Eye. 25, p. 893-900

Research output: Contribution to journalArticle

17 Citations (Scopus)
2013

Research: Keep PubMed running at all costs

Hewitt, A. W. & Mackey, D. A., 22 Oct 2013, In : Nature. 502, 7471, 1 p.

Research output: Contribution to journalLetter

2015

Occurrence of CYP1B1 mutations in juvenile open-angle glaucoma with advanced visual field loss

Souzeau, E., Hayes, M., Zhou, T., Siggs, O. M., Ridge, B., Awadalla, M. S., Smith, J. E. H., Ruddle, J. B., Elder, J. E., Mackey, D., Hewitt, A., Healey, P. R., Goldberg, I., Morgan, W., Landers, J., Dubowsky, A., Burdon, K. P. & Craig, J. E., Jul 2015, In : JAMA Ophthalmology. 133, 7, p. 826-833 8 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)
2011

Prevalence and predictors of refractive error in a genetically isolated population: the Norfolk Island Eye Study

Sherwin, JC., Kelly, J., Hewitt, AW., Kearns, LS., Griffiths, LR. & Mackey, D., 2011, In : Clinical and Experimental Ophthalmology. 39, p. 734-742

Research output: Contribution to journalArticle

13 Citations (Scopus)
2015

Don't it make your brown eyes blue? A comparison of iris colour across latitude in Australian twins

Sanfilippo, P., Wilkinson, C. H., Ruddle, J. B., Zhu, G., Martin, N. G., Hewitt, A. & Mackey, D., Mar 2015, In : Clinical and Experimental Optometry. 98, 2, p. 172-176

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
362 Downloads (Pure)

Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium

Li, Q., Wojciechowski, R., Simpson, C. L., Hysi, P. G., Verhoeven, V. J. M., Ikram, M. K., Höhn, R., Vitart, V., Hewitt, A., Oexle, K., Mäkelä, K. M., Macgregor, S., Pirastu, M., Fan, Q., Cheng, C. Y., St Pourcain, B., Mcmahon, G., Kemp, J. P., Northstone, K., Rahi, J. S. & 47 others, Cumberland, P. M., Martin, N. G., Sanfilippo, P., Lu, Y., Wang, Y. X., Hayward, C., Polašek, O., Campbell, H., Bencic, G., Wright, A. F., Wedenoja, J., Zeller, T., Schillert, A., Mirshahi, A., Lackner, K., Yip, S. P., Yap, M. K. H., Ried, J. S., Gieger, C., Murgia, F., Wilson, J. F., Fleck, B., Yazar, S., Vingerling, J. R., Hofman, A., Uitterlinden, A., Rivadeneira, F., Amin, N., Karssen, L., Oostra, B. A., Zhou, X., Teo, Y. Y., Tai, E. S., Vithana, E., Barathi, V., Zheng, Y., Siantar, R. G., Neelam, K., Shin, Y., Lam, J., Yonova-Doing, E., Venturini, C., Hosseini, S. M., Wong, H. S., Lehtimäki, T., Kähönen, M. & Raitakari, O., 2015, In : Human Genetics. 134, 2, p. 131-146

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Swimming goggle wear is not associated with an increased prevalence of glaucoma

Franchina, M., Yazar, S., Booth, L., Wan, S. L., Cox, K., Kang, M., Hewitt, A. & Mackey, D., 2015, In : British Journal of Ophthalmology. 99, 2, p. 255-257

Research output: Contribution to journalArticle

7 Citations (Scopus)

Genetic and environmental factors in conjunctival UV autofluorescence

Yazar, S., Cuellar Partida, G., Mcknight, C. M., Quach-Thanissorn, P., Mountain, J., Coroneo, M. T., Pennell, C., Hewitt, A. W., Macgregor, S. & Mackey, D., 2015, In : JAMA Ophthalmology. 133, 4, p. 406-412

Research output: Contribution to journalArticle

15 Citations (Scopus)
2013

Recessive mutations in SLC38A8 cause foveal hypoplasia and optic nerve misrouting without albinism

Poulter, J. A., Al-Araimi, M., Conte, I., Van Genderen, M. M., Sheridan, E., Carr, I. M., Parry, D. A., Shires, M., Carrella, S., Bradbury, J., Khan, K., Lakeman, P., Sergouniotis, P. I., Webster, A. R., Moore, A. T., Pal, B., Mohamed, M. D., Venkataramana, A., Ramprasad, V., Shetty, R. & 9 others, Saktivel, M., Kumaramanickavel, G., Tan, A., Mackey, D., Hewitt, A., Banfi, S., Ali, M., Inglehearn, C. F. & Toomes, C., 2013, In : American Journal of Human Genetics. 93, 6, p. 1143-1150

Research output: Contribution to journalArticle

Open Access
33 Citations (Scopus)
2016
4 Citations (Scopus)
2015

Copy number variations of TBK1 in Australian patients with primary open-angle glaucoma

Awadalla, M. S., Fingert, J. H., Roos, B. E., Chen, S., Holmes, R., Graham, S. L., Chehade, M., Galanopolous, A., Ridge, B., Souzeau, E., Zhou, T., Siggs, O. M., Hewitt, A., Mackey, D., Burdon, K. P. & Craig, J. E., Jan 2015, In : American Journal of Ophthalmology. 159, 1, p. 124-130.e1

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)
2014

Comparison of monochromatic aberrations in young adults with different visual acuity and refractive errors

Yazar, S., Hewitt, A., Forward, H., Mcknight, C. M., Tan, A., Mountain, J. & Mackey, D., 2014, In : Journal of Cataract and Refractive Surgery. 40, 3, p. 441-449

Research output: Contribution to journalArticle

9 Citations (Scopus)
2015

A common variant near TGFBR3 is associated with primary open angle glaucoma

Li, Z., Allingham, R. R., Nakano, M., Jia, L., Chen, Y., Ikeda, Y., Mani, B., Chen, L. J., Kee, C., Garway-Heath, D. F., Sripriya, S., Fuse, N., Abu-Amero, K. K., Huang, C., Namburi, P., Burdon, K., Perera, S. A., Gharahkhani, P., Lin, Y., Ueno, M. & 91 others, Ozaki, M., Mizoguchi, T., Krishnadas, S. R., Osman, E. A., Lee, M. C., Chan, A. S. Y., Tajudin, L. S. A., Do, T., Goncalves, A., Reynier, P., Zhang, H., Bourne, R., Goh, D., Broadway, D., Husain, R., Negi, A. K., Su, D. H., Ho, C. L., Blanco, A. A., Leung, C. K. S., Wong, T. T., Yakub, A., Liu, Y., Nongpiur, M. E., Han, J. C., Hon, D. N., Shantha, B., Zhao, B., Sang, J., Zhang, N., Sato, R., Yoshii, K., Panda-Jonas, S., Ashley Koch, A. E., Herndon, L. W., Moroi, S. E., Challa, P., Foo, J. N., Bei, J. X., Zeng, Y. X., Simmons, C. P., Bich Chau, T. N., Sharmila, P. F., Chew, M., Lim, B., Tam, P. O. S., Chua, E., Ng, X. Y., Yong, V. H. K., Chong, Y. F., Meah, W. Y., Vijayan, S., Seongsoo, S., Xu, W., Teo, Y. Y., Cooke Bailey, J. N., Kang, J. H., Haines, J. L., Cheng, C. Y., Saw, S. M., Tai, E. S., Richards, J. E., Ritch, R., Gaasterland, D. E., Pasquale, L. R., Liu, J., Jonas, J. B., Milea, D., George, R., Al-Obeidan, S. A., Mori, K., Macgregor, S., Hewitt, A. W., Girkin, C. A., Zhang, M., Sundaresan, P., Vijaya, L., Mackey, D., Wong, T. Y., Craig, J. E., Sun, X., Kinoshita, S., Wiggs, J. L., Khor, C. C., Yang, Z., Pang, C. P., Wang, N., Hauser, M. A., Tashiro, K., Aung, T. & Vithana, E. N., 2015, In : Human Molecular Genetics. 24, 13, p. 3880-3892 13 p.

Research output: Contribution to journalArticle

Open Access
58 Citations (Scopus)

Pterygium and conjunctival ultraviolet autofluorescence in young Australian adults: the Raine study

Mcknight, C., Sherwin, J., Yazar, S., Forward, H., Tan, A., Hewitt, A., Smith, E., Turton, D., Byrd, P., Pennell, C., Coroneo, T. & Mackey, D., May 2015, In : Clinical and Experimental Ophthalmology. 43, 4, p. 300-307

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
443 Downloads (Pure)
2014

Multiple prenatal ultrasound scans and ocular development: 20-year follow-up of a randomized controlled trial

Forward, H., Yazar, S., Hewitt, A., Khan, J., Mountain, J. A., Pesudovs, K., Mcknight, C. M., Tan, A., Pennell, C., Mackey, D. & Newnham, J., 4 Aug 2014, In : Ultrasound in Obstetrics & Gynecology. 44, 2, p. 166-170 5 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
245 Downloads (Pure)
2015

Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology

Springelkamp, H., Mishra, A., Hysi, P. G., Gharahkhani, P., Höhn, R., Khor, C. C., Cooke Bailey, J. N., Luo, X., Ramdas, W. D., Vithana, E. N. I., Koh, V., Yazar, S., Xu, L., Forward, H., Kearns, L. S., Amin, N., Iglesias, A. I., Sim, K., Van Leeuwen, E. M., Demirkan, A. & 65 others, Van Der Lee, S. J., Loon, S. C., Rivadeneira, F. F., Nag, A., Sanfilippo, P., Schillert, A., De Jong, P. T. V. M., Oostra, B. A., Uitterlinden, A. G., Hofman, A. F., Zhou, T., Burdon, K. P., Spector, T. D., Lackner, K. J., Saw, S., Vingerling, J. R., Teo, Y. Y. I., Pasquale, L. R., Wolfs, R. C. W., Lemij, H. G., Tai, E. S., Jonas, J. B., Cheng, C., Aung, T., Jansonius, N. M., Klaver, C. C. W., Craig, J. E., Young, T. L., Haines, J. L., Macgregor, S., Mackey, D., Pfeiffer, N., Wong, T., Wiggs, J. L., Hewitt, A. W., Van Duijn, C. M., Hammond, C. J., Allingham, R. R., Brilliant, M. H., Budenz, D. L., Bailey, J. N. C., Christen, W. G., Fingert, J. H., Gaasterland, D. E., Gaasterland, T. M., Hauser, M. A., Kang, J., Kraft, P. L., Lee, R. K., Lichter, P. A., Liu, Y., Loomis, S. J., Moroi, S. E., Pericak-Vance, M. A., Realini, A. T., Richards, J. E., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Weinréb, R. N., Wollstein, G., Zack, D. J. & Zhang, K., 2015, In : Genetic Epidemiology. 39, 3, p. 207-216

Research output: Contribution to journalArticle

41 Citations (Scopus)
2016

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

Fan, Q., Verhoeven, V. J. M. J. M., Wojciechowski, R., Barathi, V. A. A., Hysi, P. G. G., Guggenheim, J. A. A., Hohn, R., Vitart, V., Khawaja, A. P. P., Yamashiro, K., Hosseini, S. M. M., Lehtimaki, T., Lu, Y., Haller, T., Xie, J., Delcourt, C., Pirastu, M., Wedenoja, J., Gharahkhani, P., Venturini, C. & 134 others, Miyake, M., Hewitt, A. W. W., Guo, X., Mazur, J., Huffman, J. E. E., Williams, K. M. M., Polasek, O., Campbell, H., Rudan, I., Vatavuk, Z., Wilson, J. F. F., Joshi, P. K. K., McMahon, G., St Pourcain, B., Evans, D. M. M., Simpson, C. L. L., Schwantes-An, T-H. -H., Igo, R. P. P., Mirshahi, A., Cougnard-Gregoire, A., Bellenguez, C., Blettner, M., Raitakari, O., Kahonen, M., Seppala, I., Zeller, T., Meitinger, T., Ried, J. S. S., Gieger, C., Portas, L., Van Leeuwen, E. M. M., Amin, N., Uitterlinden, A. G. G., Rivadeneira, F., Hofman, A., Vingerling, J. R. R., Wang, Y. X. X., Wang, X., Tai-Hui Boh, E., Ikram, M. K. K., Sabanayagam, C., Gupta, P., Tan, V., Zhou, L., Ho, C. E. H. E. H., Lim, W., Beuerman, R. W. W., Siantar, R., Tai, E-S. -S., Vithana, E., Mihailov, E., Khor, C-C. -C., Hayward, C., Luben, R. N. N., Foster, P. J. J., Klein, B. E. K. E. K., Klein, R., Wong, H-S. -S., Mitchell, P., Metspalu, A., Aung, T., Young, T. L. L., He, M., Parssinen, O., Van Duijn, C. M. M., Jin Wang, J., Williams, C., Jonas, J. B. B., Teo, Y-Y. -Y., MacKey, D. A., Oexle, K., Yoshimura, N., Paterson, A. D. D., Pfeiffer, N., Wong, T-Y. -Y., Baird, P. N. N., Stambolian, D., Wilson, J. E. B. E. B., Cheng, C-Y. -Y., Hammond, C. J. J., Klaver, C. C. W. C. W., Saw, S-M. -M., Rahi, J. S. S., Korobelnik, J-F. -F., Kemp, J. P. P., Timpson, N. J. J., Smith, G. D. D., Craig, J. E. E., Burdon, K. P. P., Fogarty, R. D. D., Iyengar, S. K. K., Chew, E., Janmahasatian, S., Martin, N. G. G., MacGregor, S., Xu, L., Schache, M., Nangia, V., Panda-Jonas, S., Wright, A. F. F., Fondran, J. R. R., Lass, J. H. H., Feng, S., Zhao, J. H. H., Khaw, K-T. -T., Wareham, N. J. J., Rantanen, T., Kaprio, J., Pang, C. P. P., Chen, L. J. J., Tam, P. O. O., Jhanji, V., Young, A. L. L., Doring, A., Raffel, L. J. J., Cotch, M-F. -F., Li, X., Yip, S. P. P., Yap, M. K. H. K. H., Biino, G., Vaccargiu, S., Fossarello, M., Fleck, B., Yazar, S., Tideman, J. W. L. W. L., Tedja, M., Deangelis, M. M. M., Morrison, M., Farrer, L., Zhou, X., Chen, W., Mizuki, N., Meguro, A. & Makela, K. M. M., 2016, In : Nature Communications. 7

Research output: Contribution to journalArticle

Open Access
52 Citations (Scopus)
2017

Drusen in patient-derived hiPSC-RPE models of macular dystrophies

Galloway, C. A., Dalvi, S., Hung, S. S. C., MacDonald, L. A., Latchney, L. R., Wong, R. C. B., Guymer, R. H., Mackey, D. A., Williams, D. S., Chung, M. M., Gamm, D. M., Pébay, A., Hewitt, A. W. & Singh, R., 26 Sep 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 39, p. E8214-E8223

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)
2016

Gene-Based Therapies for Leber Hereditary Optic Neuropathy. Hype or Hope?

Mackey, D. A., Kearns, LS. & Hewitt, A., 2016, In : Asia Pacific Journal of Opthalmology. 5, 4, p. 253-255 3 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)
2018

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

Melanoma GWAS Consortium, 1 Dec 2018, In : Nature Communications. 9, 1, 4774.

Research output: Contribution to journalArticle

Open Access
23 Citations (Scopus)
2020

Age-dependent regional retinal nerve fibre changes in SIX1/SIX6 polymorphism

Charng, J., Simcoe, M., Sanfilippo, P. G., Allingham, R. R., Hewitt, A. W., Hammond, C. J., Mackey, D. A. & Yazar, S., 1 Dec 2020, In : Scientific Reports. 10, 1, 12485.

Research output: Contribution to journalArticle

Open Access
2017

Glaucoma spectrum and age-related prevalence of individuals with FOXC1 and PITX2 variants

Souzeau, E., Siggs, O. M., Zhou, T., Galanopoulos, A., Hodson, T., Taranath, D., Mills, R. A., Landers, J., Pater, J., Smith, J. E., Elder, J. E., Rait, J. L., Giles, P., Phakey, V., Staffieri, S. E., Kearns, L. S., Dubowsky, A., Mackey, D. A., Hewitt, A. W., Ruddle, J. B. & 2 others, Burdon, K. P. & Craig, J. E., Jun 2017, In : European Journal of Human Genetics. 25, 7, p. 839-847 9 p.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)
2018

Mitochondrial DNA variation and disease susceptibility in primary open-angle glaucoma

Singh, L. N., Crowston, J. G., Lopez Sanchez, M. I. G., Van Bergen, N. J., Kearns, L. S., Hewitt, A. W., Yazar, S., Mackey, D. A., Wallace, D. C. & Trounce, I. A., 1 Sep 2018, In : Investigative Ophthalmology and Visual Science. 59, 11, p. 4598-4602 5 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2016

Ethical Considerations for the Return of Incidental Findings in Ophthalmic Genomic Research

Souzeau, E., Burdon, KP., Mackey, D. A., Hewitt, A., Savarirayan, R., Otlowski, M. & Craig, JE., 2016, In : Translational Vision Science and Technology. 5, 1, 11 p., 3.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2018
Open Access
2019

A need for better understanding is the major determinant for public perceptions of human gene editing

McCaughey, T., Budden, D. M., Sanfilippo, P. G., Gooden, G. E. C., Fan, L., Fenwick, E., Rees, G., Macgregor, C., Si, L., Chen, C., Liang, H. H., Pébay, A., Baldwin, T. & Hewitt, A. W., 10 Jan 2019, In : Human Gene Therapy. 30, 1, p. 36-43 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

High-throughput genetic screening of 51 pediatric cataract genes identifies causative mutations in inherited pediatric cataract in South Eastern Australia

Javadiyan, S., Craig, J. E., Souzeau, E., Sharma, S., Lower, K. M., Mackey, D. A., Staffieri, S. E., Elder, J. E., Taranath, D., Straga, T., Black, J., Pater, J., Casey, T., Hewitt, A. W. & Burdon, K. P., 1 Oct 2017, In : G3: Genes, Genomes, Genetics. 7, 10, p. 3257-3268 12 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)