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  • Patrick Holt
2013

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Bønnelykke, K., Matheson, M. C., Pers, T. H., Granell, R., Strachan, D. P., Alves, A. C., Linneberg, A., Curtin, J. A., Warrington, N. M., Standl, M., Kerkhof, M., Jonsdottir, I., Bukvic, B. K., Kaakinen, M., Sleimann, P., Thorleifsson, G., Thorsteinsdottir, U., Schramm, K., Baltic, S., Møller, E. K. & 46 others, Simpson, A., St Pourcain, B., Coin, L., Hui, J., Walters, E. H., Tiesler, C. M. T., Duffy, D. L., Jones, G., Ring, S. M., Mcardle, W. L., Price, L., Robertson, C. F., Pekkanen, J., Tang, C. S., Thiering, E., Montgomery, G. W., Hartikainen, A-L., Dharmage, S. C., Husemoen, L. L., Herder, C., Kemp, J. P., Elliot, P., James, A., Waldenberger, M., Abramson, M. J., Fairfax, B. P., Knight, C. J., Gupta, R., Thompson, P., Holt, P., Sly, P., Hirschhorn, J. N., Blekic, M., Weidinger, S., Hakonarsson, H., Stefansson, K., Heinrich, J., Postma, D. S., Custovic, A., Pennell, C., Jarvelin, M-R., Koppelman, G. H., Timpson, N., Ferreira, M. A., Bisgaard, H. & Henderson, A. J., 2013, In : Nature Genetics. 45, p. 902-908

Research output: Contribution to journalArticle

150 Citations (Scopus)
2012

T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergy

Martino, D., Bosco, A., Mckenna, K., Hollams, E., Mok, D., Holt, P. & Prescott, S., 2012, In : Allergy. 67, 2, p. 191-200

Research output: Contribution to journalArticle

28 Citations (Scopus)
2014
31 Citations (Scopus)
2013

Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, does not influence susceptibility to asthma

Le Page, M. E. L., Goodridge, J. P., Zhang, B., Holt, P., Sly, P. & Witt, C. S., 2013, In : Tissue Antigens. 82, p. 276-279

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Protection against maternal infection-associated fetal growth restriction: proof-of-concept with a microbial-derived immunomodulator

Scott, N. M., Lauzon-Joset, J. F., Jones, A. P., Mincham, K., Troy, N., Leffler, J., Serralha, M., Prescott, S. L., Robertson, S. A., Pasquali, C., Bosco, A., Holt, P. G. & Strickland, D. H., 2017, In : Mucosal Immunology. 10, 3, p. 789 801 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2016

Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults

Black, L., Burrows, S., Lucas, R. M., Marshall, C., Huang, R-C., Chan She Ping-Delfos, W., Beilin, L., Holt, P., Hart, P., Oddy, W. & Mori, T., Jun 2016, In : British Journal of Nutrition. 115, 11, p. 1994-2002

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
430 Downloads (Pure)
2012

Anti-bacterial antibody reponses associated with the development of asthma in house dust mite-sensitised and non-sensitised children

Hales, B., Chai, L. Y., Elliot, C. E., Pearce, L., Zhang, B., Heinrich, T., Smith, W-A., Kusel, M., Holt, P., Sly, P. & Thomas, W., 2012, In : Thorax. 67, p. 321-327

Research output: Contribution to journalArticle

38 Citations (Scopus)
2013

Safety and Immunogenicity of Neonatal Pneumococcal Conjugate Vaccination in Papua New Guinean Children: A Randomised Controlled Trial

Pomat, W. S., Van Den Biggelaar, A., Phuanukoonnon, S., Francis, J., Jacoby, P., Siba, P. M., Alpers, M. P., Reeder, J. C., Holt, P., Richmond, P. & Lehmann, D., 2013, In : PLoS One. 8, 2, p. 12pp

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
115 Downloads (Pure)
2019

Personalized Transcriptomics Reveals Heterogeneous Immunophenotypes in Children with Viral Bronchiolitis

Jones, A. C., Anderson, D., Galbraith, S., Fantino, E., Cardenas, D. G., Read, J. F., Serralha, M., Holt, B. J., Strickland, D. H., Sly, P. D., Bosco, A. & Holt, P. G., 15 Jun 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1537-1549 13 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2016

Distinguishing benign from pathologic TH2 immunity in atopic children

Holt, P., Strickland, D., Bosco, A., Belgrave, D., Hales, B., Simpson, A., Hollams, E., Holt, B., Kusel, M., Ahlstedt, S., Sly, P. D. & Custovic, A., Feb 2016, In : Journal of Allergy and Clinical Immunology. 137, 2, p. 379-387 9 p.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
269 Downloads (Pure)
2011

Th2 cyokine levels distort the association of IL-10 and IFN-y with allergic phenotypes

Zhang, B., Hayden, C., Goldblatt, J., Holt, P. & Le Souef, P., 2011, In : ISRN Allergy. 28 November 2011, p. 6 pages

Research output: Contribution to journalArticle

Open Access

Environmental Factors in Children's Asthma and Respiratory Effects

Sly, P., Kusel, M., Franklin, P. & Holt, P., 2011, Encyclopedia of Environmental Health, Five-Volume Set. Jerome, O. N. (ed.). Burlington: Elsevier, p. 367-379

Research output: Chapter in Book/Conference paperEntry for encyclopedia/dictionary

5 Citations (Scopus)
2012

Airway Epithelial Cells Condition Dendritic Cells to Express Multiple Immune Surveillance Genes

Rate, A., Bosco, A., Mckenna, K., Holt, P. & Upham, J. W., 11 Sep 2012, In : PLoS One. 7, 9, p. e44941.1-10

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)
2019

Risk factors and prognosis of recurrent wheezing in Chinese young children: A prospective cohort study

Guo, J., Zhu, W., Wang, H., Holt, P. G., Zhang, G. & Liu, C., 18 Jun 2019, In : Allergy, Asthma and Clinical Immunology. 15, 1, 38.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2020

Assessing the strength of evidence for a causal effect of respiratory syncytial virus lower respiratory tract infections on subsequent wheezing illness: a systematic review and meta-analysis

Brunwasser, S. M., Snyder, B. M., Driscoll, A. J., Fell, D. B., Savitz, D. A., Feikin, D. R., Skidmore, B., Bhat, N., Bont, L. J., Dupont, W. D., Wu, P., Gebretsadik, T., Holt, P. G., Zar, H. J., Ortiz, J. R. & Hartert, T. V., Aug 2020, In : The Lancet Respiratory Medicine. 8, 8, p. 795-806 12 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2019

Relationship Between Vitamin D Status From Childhood to Early Adulthood With Body Composition in Young Australian Adults

Zhu, K., Oddy, W. H., Holt, P., Ping-Delfos, W. C. S., McVeigh, J., Straker, L., Mori, T. A., Lye, S., Pennell, C. & Walsh, J. P., Mar 2019, In : Journal of the Endocrine Society. 3, 3, p. 563-576 14 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Whole-cell versus acellular pertussis vaccination and risk of food allergy: case-control study

Snelling, T., Estcourt, M. J., Marsh, J., Campbell, D. E., Gold, M. S., Allen, K. J., Richmond, P., Holt, P. & Waddington, C., Jun 2018.

Research output: Contribution to conferenceAbstract

2011

Pneumococcal conjugate vaccination at birth in a high-risk setting: No evidence for neonatal T-cell tolerance

Van Den Biggelaar, A. H. J., Pomat, W., Bosco, A., Phuanukoonnon, S., Devitt, C. J., Nadal-Sims, M. A., Siba, P. M., Richmond, P., Lehmann, D. & Holt, P., 2011, In : Vaccine. 29, 33, p. 5414-5420

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)

Restricted aeroallergen access to airway mucosal dendritic cells in vivo limits allergen-specific CD4 + T cell proliferation during the induction of inhalation tolerance

Fear, V., Burchell, J., Lai, S. P., Wikstrom, M., Blank, F., Von Garnier, C., Turner, D., Sly, P., Holt, P., Strickland, D. & Stumbles, P., 2011, In : Journal of Immunology. 187, 9, p. 4561-4570

Research output: Contribution to journalArticle

11 Citations (Scopus)
2015

Meta-analysis identifies seven susceptibility loci involved in the atopic March

Marenholz, I., Esparza-Gordillo, J., Rüschendorf, F., Bauerfeind, A., Strachan, D. P., Spycher, B. D., Baurecht, H., Margaritte-Jeannin, P., Sääf, A., Kerkhof, M., Ege, M., Baltic, S., Matheson, M. C., Li, J., Michel, S., Ang, W., Mcardle, W., Arnold, A., Homuth, G., Demenais, F. & 53 others, Bouzigon, E., Söderhäll, C., Pershagen, G., De Jongste, J. C., Postma, D. S., Braun-Fahrländer, C., Horak, E., Ogorodova, L. M., Puzyrev, V. P., Bragina, E. Y., Hudson, T. J., Morin, C., Duffy, D. L., Marks, G. B., Robertson, C. F., Montgomery, G. W., Musk, B., Thompson, P., Martin, N. G., James, A., Sleiman, P., Toskala, E., Rodriguez, E., Fölster-Holst, R., Franke, A., Lieb, W., Gieger, C., Heinzmann, A., Rietschel, E., Keil, T., Cichon, S., Nöthen, M. M., Pennell, C., Sly, P. D., Schmidt, C. O., Matanovic, A., Schneider, V., Heinig, M., Hübner, N., Holt, P., Lau, S., Kabesch, M., Weidinger, S., Hakonarson, H., Ferreira, M. A. R., Laprise, C., Freidin, M. B., Genuneit, J., Koppelman, G. H., Melén, E., Dizier, M. H., Henderson, A. J. & Lee, Y. A., 2015, In : Nature Communications. 6, p. Article 8804

Research output: Contribution to journalArticle

Open Access
70 Citations (Scopus)
2012

A genomics-based approach to assessment of vaccine safety and immunogenicity in children

White, O., Mckenna, K., Bosco, A., Van Den Biggelaar, A., Richmond, P. & Holt, P., 2012, In : Vaccine. 30, 10, p. 1865-1874

Research output: Contribution to journalArticle

16 Citations (Scopus)
2014

Global allergy forum and second davos declaration 2013 allergy: Barriers to cure - Challenges and actions to be taken

Ring, J., Akdis, C., Lauener, R., Schäppi, G., Traidl-Hoffmann, C., Akdis, M., Ammann, W., Behrendt, H., Bieber, T., Biedermann, T., Bienenstock, J., Blaser, K., Braun-Fahrländer, C., Brockow, K., Buters, J., Crameri, R., Darsow, U., Denburg, J. A., Eyerich, K., Frei, R. & 21 others, Galli, S. J., Gutermuth, J., Holt, P., Koren, H., Leung, D., Müller, U., Muraro, A., Ollert, M., O'Mahony, L., Pawankar, R., Platts-Mills, T., Rhyner, C., Rosenwasser, L. J., Schmid-Grendelmeier, P., Schmidt-Weber, C. B., Schmutz, W., Simon, D., Simon, H. U., Sofiev, M., Van Hage, M. & Van Ree, R., 2014, In : Allergy: European Journal of Allergy and Clinical Immunology. 69, 8, p. 978-982

Research output: Contribution to journalLetter

18 Citations (Scopus)
2011

Risk factors for bronchial hyperresponsiveness in teenagers differ with sex and atopic status

Collins, R. A., Parsons, F., Deverell, M., Hollams, E., Holt, P. & Sly, P., 2011, In : Journal of Allergy and Clinical Immunology. 128, 2, p. 301-307

Research output: Contribution to journalArticle

20 Citations (Scopus)
2014
Open Access
70 Citations (Scopus)
2015

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children

Hong, X., Hao, K., Ladd-Acosta, C. M., Hansen, K. D., Tsai, H., Liu, X., Xu, X., Thornton, T. A., Caruso, D. M., Keet, C. A., Sun, Y., Wang, G., Luo, W., Kumar, R., Fuleihan, R. L., Singh, A. M., Kim, J. S., Story, R. E., Gupta, R. S., Gao, P. & 12 others, Chen, Z., Walker, S. O., Bartell, T. R., Beaty, T. H., Fallin, M. D., Schleimer, R. P., Holt, P., Nadeau, K. C., Wood, R. A., Pongracic, J. A., Weeks, D. E. & Wang, X., 2015, In : Nature Communications. 6, p. Article 6304

Research output: Contribution to journalArticle

111 Citations (Scopus)
2014

Antibody and cell-mediated immunity to pertussis 4 years after monovalent acellular pertussis vaccine at birth

Wood, N., Marshall, H., White, O., Holt, P. & Mcintyre, P., May 2014, In : Pediatric Infectious Disease Journal. 33, 5, p. 511-517

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
2011

T regulatory cells in childhood asthma

Strickland, D. & Holt, P., 2011, In : Trends in Immunology. 32, 9, p. 420-427

Research output: Contribution to journalLiterature review

36 Citations (Scopus)
2017

Childhood atopy and mental health: A prospective, longitudinal investigation

Goodwin, R. D., Robinson, M., Sly, P. D. & Holt, P. G., 1 Jan 2017, In : Psychological Medicine. 47, 2, p. 317-325 9 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2018

Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children

Brealey, J. C., Chappell, K. J., Galbraith, S., Fantino, E., Gaydon, J., Tozer, S., Young, P. R., Holt, P. G. & Sly, P. D., 1 Feb 2018, In : Respirology. 23, 2, p. 220-227 8 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
114 Downloads (Pure)
2017

Identification and characterization of a dendritic cell precursor in parenchymal lung tissue

Von Garnier, C., Blank, F., Rothen-Rutishauser, B., Goethert, J. R., Holt, P. G., Stumbles, P. A. & Strickland, D. H., 1 Mar 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 3, p. 353-361 9 p.

Research output: Contribution to journalArticle

2015

The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development

Teo, S. M., Mok, D., Pham, K., Kusel, M., Serralha, M., Troy, N., Holt, B. J., Hales, B., Walker, M. L., Hollams, E., Bochkov, Y. A., Grindle, K., Johnston, S. L., Gern, J. E., Sly, P. D., Holt, P., Holt, K. E. & Inouye, M., 2015, In : Cell Host and Microbe. 17, 5, p. 704-715

Research output: Contribution to journalArticle

Open Access
336 Citations (Scopus)

Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages

Tarique, A. A., Logan, J., Thomas, E., Holt, P., Sly, P. D. & Fantino, E., Nov 2015, In : American Journal of Respiratory Cell and Molecular Biology. 53, 5, p. 676-688 13 p.

Research output: Contribution to journalArticle

Open Access
133 Citations (Scopus)
2017

Tracking of Vitamin D status from childhood to early adulthood and its association with peak bone mass

Zhu, K., Oddy, W. H., Holt, P., Ping-Delfos, W. C. S., Mountain, J., Lye, S., Pennell, C., Hart, P. H. & Walsh, J. P., 1 Jul 2017, In : American Journal of Clinical Nutrition. 106, 1, p. 276-283 8 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
187 Downloads (Pure)
2011

Infection and the development of allergic disease

Holt, P., 2011, In : Allergy. 66, SUPPL. 95, p. 13-15

Research output: Contribution to journalArticle

9 Citations (Scopus)
2016

Benign versus pathologic Th2-immunity in atopic children

Holt, P. G., Strickland, D., Bosco, A., Belgrave, D., Hales, B. J., Simpson, A., Hollams, E., Holt, B., Kusel, M., Ahlstedt, S., Sly, P. D. & Custovic, A., 2016, Allergies: Current Challenges and Solutions: Proceedings of the 30th Symposium of the Collegium Internationale Allergologicum. Maurer, M. & Behrendt, H. (eds.). Italy: Pacini Editore Medicina, p. 155-159 5 p.

Research output: Chapter in Book/Conference paperConference paper

2019
3 Citations (Scopus)
2014

Anti-infective proteins in breast milk and asthma-associated phenotypes during early childhood

Zhang, G., Lai, C., Hartmann, P., Oddy, W., Kusel, M. M. H., Sly, P. D. & Holt, P., 2014, In : Pediatric Allergy and Immunology. 25, 6, p. 544-551

Research output: Contribution to journalArticle

7 Citations (Scopus)
2011

Gene polymorphisms, breast-feeding, and development of food sensitization in early childhood

Hong, X., Wang, G., Liu, X., Kumar, R., Tsai, H-J., Arguelles, L., Hao, K., Pearson, C., Ortiz, K., Bonzagni, A., Apollon, S., Fu, L., Caruso, D., Pongracic, J. A., Schleimer, R., Holt, P., Bauchner, H. & Wang, X., 2011, In : Journal of Allergy and Clinical Immunology. 128, 2, p. 374-381.e2

Research output: Contribution to journalArticle

54 Citations (Scopus)
2012

Ontogeny of toll-like and NOD-like receptor-mediated innate immune responses in Papua New Guinean infants

Lisciandro, J., Prescott, S., Nadal-Sims, M. G., Devitt, C. J., Pomat, W., Siba, P. M., Tulic, M., Holt, P., Strickland, D. & Van Den Biggelaar, A., 2012, In : PLoS One. 7, 5, p. 9pp

Research output: Contribution to journalArticle

Open Access
35 Citations (Scopus)
2018

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

the 23andMe Research Team & AAGC collaborators, 1 Aug 2018, In : Nature Genetics. 50, 8, p. 1072-1080 9 p.

Research output: Contribution to journalLetter

22 Citations (Scopus)
2015
Open Access
30 Citations (Scopus)
2011

Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control

Strickland, D., Judd, S., Thomas, W., Larcombe, A., Sly, P. & Holt, P., 2011, In : Mucosal Immunology. 4, 1, p. 43-52

Research output: Contribution to journalArticle

43 Citations (Scopus)
2015

Environmental microbial exposure and protection against asthma

Holt, P. & Sly, P. D., 2015, In : New England Journal of Medicine. 373, 26, p. 2576-2578

Research output: Contribution to journalReview article

10 Citations (Scopus)
2014

Elucidation of pathways driving asthma pathogenesis: Development of a systems-level analytic strategy

Walker, M. L., Holt, K. E., Anderson, G. P., Teo, S. M., Sly, P. D. L., Holt, P. & Inouye, M., 2014, In : Frontiers in Immunology. 5, SEP, p. 447

Research output: Contribution to journalReview article

Open Access
11 Citations (Scopus)
2013

Size-dependent uptake of particles by pulmonary antigen-presenting cell populations and trafficking to regional lymph nodes

Blank, F., Stumbles, P., Seydoux, E., Holt, P., Fink, A., Rothen-Rutishauser, B., Strickland, D. & Von Garnier, C., 2013, In : American Journal of Respiratory Cell and Molecular Biology. 49, 1, p. 67-77

Research output: Contribution to journalArticle

62 Citations (Scopus)