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• Abstract/Meeting Abstract

  Anti TNFα-induced Interstitial Pneumonitis in Inflammatory Bowel Disease Patients: A Multi-Centre Western Australia Case Series

  Lightowler, D., Thin, L. & Lawrance, I., 4 Sep 2019, In : Journal of Gastroenterology and Hepatology (Australia). 34, S2, p. 119-120

  Research output: Contribution to journal › Abstract/Meeting Abstract

• Antitumor necrosis factor-alpha induced interstitial pneumonitis in patients with inflammatory bowel disease: A multicenter Western Australia case series

  Lightowler, D., Thin, L. & Lawrance, I., Sep 2019, In : Journal of Gastroenterology and Hepatology. 34, p. 119-120 2 p.

  Research output: Contribution to journal › Abstract/Meeting Abstract

• Emu oil improves clinical indicators of disease in a mouse model of colitis-associated colorectal cancer

  Chartier, L. C., Howarth, G. S., Lawrance, I. C., Trinder, D., Barker, S. J. & Mashtoub, S., Aug 2017, In : Journal of Gastroenterology and Hepatology (Australia). 32, p. 56-56 1 p.

  Research output: Contribution to journal › Abstract/Meeting Abstract

• Emu Oil Reduces Colonic Damage Severity in a Mouse Model of Chronic Ulcerative Colitis

  Safaeian, R., Howarth, G. S., Lawrance, I. C., Trinder, D. & Mashtoub, S., Apr 2017, In : FASEB Journal. 31, 1 p.

  Research output: Contribution to journal › Abstract/Meeting Abstract

• NAFLD, the changing face of IBD

  Thin, L., Kava, J., Lawrance, I. & Olynyk, J., Oct 2012, In : Journal of Gastroenterology and Hepatology (Australia). 27, S4, p. 2 120 p.

  Research output: Contribution to journal › Abstract/Meeting Abstract

• OP007 A multi-centre double blind randomised placebo-controlled study of the use of rectal tacrolimus in the treatment of resistant ulcerative proctitis

  Lawrance, I., Baird, A., Lightowler, D., Radford-Smith, G., Andrews, J. M. & Connor, S., 26 Jan 2017, In : JOURNAL OF CROHNS & COLITIS. 11, 1

  Research output: Contribution to journal › Abstract/Meeting Abstract

  Open Access

• Vedolizumab (VDZ) real-world outcomes in ulcerative colitis (UC)

  Pulusu, S. S. R., Srinivasan, A., Krishnaprasad, K., Cheng, D., Mogilevski, T., Flanagan, E., Keung, C., Wu, C., Prosser, R., Sawyer, E., Rizvi, Q. U. A., Su, H., Leung, W., Edmundson, A., Cooke, S., Mahy, G., Thin, L., Radford-Smith, G., Sparrow, M. P., Andrews, J. M. & 10 others, Connor, S., Bampton, P. A., Ghaly, S., van Langenberg, D., Bell, S., De Cruz, P., Begun, J., Ng, S., Travis, S. & Lawrance, I., 1 Feb 2018, In : Journal of Crohn's and Colitis. 12, 1, P571.

  Research output: Contribution to journal › Abstract/Meeting Abstract
• Article

  Acute severe ulcerative colitis: Changing treatment paradigms

  Lawrance, I., 2016, In : Journal of Gastroenterology and Hepatology (Australia). 31, p. 16

  Research output: Contribution to journal › Article

• A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies

  Bodea, C. A., Neale, B. M., Ripke, S., International Inflammatory Bowel Disease Genetics Consortium, Lawrance, I., Daly, M. J., Devlin, B. & Roeder, K., 5 May 2016, In : American Journal of Human Genetics. 98, 5, p. 857-868 12 p.

  Research output: Contribution to journal › Article

  Open Access
  6 Citations (Scopus)

• Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

  International Inflammatory Bowel Disease Genetics Consortium, International Genetics of Ankylosing Spondylitis Consortium, International PSC Study Group, Genetic Analysis of Psoriasis Consortium & Psoriasis Association Genetics Extension, 1 May 2016, In : Nature Genetics. 48, 5, p. 510-518 9 p.

  Research output: Contribution to journal › Article

  • Sclerosing Cholangitis
  • Comorbidity
  • Chronic Disease
  • Inflammatory Bowel Diseases
  • Molecular Pathology
  260 Citations (Scopus)

• Anti-TNF therapeutic drug monitoring in postoperative Crohn's disease

  Wright, E. K., Kamm, M. A., De Cruz, P., Hamilton, A. L., Selvaraj, F., Princen, F., Gorelik, A., Liew, D., Prideaux, L., Lawrance, I. C., Andrews, J. M., Bampton, P. A., Jakobovits, S. L., Florin, T. H., Gibson, P. R., Debinski, H., Macrae, F. A., Samuel, D., Kronborg, I., Radford-Smith, G. & 5 others, Gearry, R. B., Selby, W., Bell, S. J., Brown, S. J. & Connell, W. R., 25 May 2018, In : Journal of Crohn's and Colitis. 12, 6, p. 653-661 9 p.

  Research output: Contribution to journal › Article

  • Adalimumab
  • Drug Monitoring
  • Crohn Disease
  • Recurrence
  • Anti-Idiotypic Antibodies
  5 Citations (Scopus)

• A Validated Bowel-Preparation Tolerability Questionnaire and Assessment of Three Commonly Used Bowel-Cleansing Agents

  Lawrance, I., Willert, R. P. & Murray, K., 2013, In : Digestive Diseases and Sciences. 58, 4, p. 926-935

  Research output: Contribution to journal › Article
  11 Citations (Scopus)

• Bowel cleansing for colonoscopy: prospective randomized assessment of efficacy and of induced mucosal abnormality with three preparation agents

  Lawrance, I., Willert, R. P. & Murray, K., 2011, In : Endoscopy. 43, 5, p. 412-418

  Research output: Contribution to journal › Article
  56 Citations (Scopus)

• Cellular and Molecular Mediators of Intestinal Fibrosis

  Lawrance, I., Rogler, G., Bamias, G., Breynaert, C., Florholmen, J., Pellino, G., Reif, S., Speca, S. & Latella, G., Dec 2017, In : Journal of Crohn's and Colitis. 11, 12, p. 1491–1503 13 p.

  Research output: Contribution to journal › Article

  Open Access

  • Fibrosis
  • Inflammatory Bowel Diseases
  • Inflammation
  • Anti-Inflammatory Agents
  50 Citations (Scopus)

• Clinical features and HLA association of 5-aminosalicylate (5-ASA)-induced nephrotoxicity in inflammatory bowel disease

  Heap, G. A., So, K., Weedon, M., Edney, N., Bewshea, C., Singh, A., Annese, V., Beckly, J., Buurman, D., Chaudhary, R., Cole, A. T., Cooper, S. C., Creed, T., Cummings, F., de Boer, N. K., D'Inca, R., Daneshmend, T. K., Delaney, M., Dhar, A., Direkze, N. & 43 others, Dunckley, P., Gaya, D. R., Gearry, R., Gore, S., Halfvarson, J., Hart, A., Hawkey, C. J., Hoentjen, F., Iqbal, T., Irving, P., Lal, S., Lawrence, I., Lees, C. W., Lewis, S., Lockett, M., Mann, S., Mansfield, J., Mowat, C., Muller, F., Murray, C., Orchard, T., Parkes, M., Phillips, R., Pollok, R., Radford-Smith, G., Sebastian, S., Sen, S., Shirazi, T., Silverberg, M., Solomon, L., Sturniolo, G. C., Thomas, M., Tremelling, M., Tsianos, E. V., Watts, D., Weaver, S., Wesley, E., Holden, A., D'Souza, R., Mulgrew, C. J., Oram, R., Weersma, R. K. & Ahmad, T., 1 Feb 2016, In : Journal of Crohn's and Colitis. 10, 2, p. 149-158 10 p.

  Research output: Contribution to journal › Article

  • Mesalamine
  • Inflammatory Bowel Diseases
  • Kidney
  • Genome-Wide Association Study
  • Pharmaceutical Preparations
  40 Citations (Scopus)

• Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

  International Inflammatory Bowel Disease Genetics Consortium (IIBDGC), 17 Jul 2019, In : Scientific Reports. 9, 1, 10351.

  Research output: Contribution to journal › Article

  Open Access

  • Machine Learning
  • Crohn Disease
  • Genome
  • Logistic Models
  • ROC Curve
  13 Citations (Scopus)

• Concentrations of Adalimumab and Infliximab in Mothers and Newborns, and Effects on Infection

  Julsgaard, M., Christensen, L. A., Gibson, P. R., Gearry, R. B., Fallingborg, J., Hvas, C. L., Bibby, B. M., Uldbjerg, N., Connell, W. R., Rosella, O., Grosen, A., Brown, S. J., Kjeldsen, J., Wildt, S., Svenningsen, L., Sparrow, M. P., Walsh, A., Connor, S. J., Radford-Smith, G., Lawrance, I. & 3 others, Andrews, J. M., Ellard, K. & Bell, S. J., 2016, In : Gastroenterology. 151, 1, p. 110-119

  Research output: Contribution to journal › Article

  • Adalimumab
  • Infliximab
  • Newborn Infant
  • Necrosis
  • Umbilical Cord
  137 Citations (Scopus)

• Crohn's disease and smoking: Is it ever too late to quit?

  Lawrance, I., Murray, K., Batman, B., Gearry, R. B., Grafton, R., Krishnaprasad, K., Andrews, J. M., Prosser, R., Bampton, P. A., Cooke, S. E., Mahy, G., Radford-Smith, G., Croft, A. & Hanigan, K., 2013, In : JOURNAL OF CROHNS & COLITIS. 7, 12, p. e665-e671

  Research output: Contribution to journal › Article
  30 Citations (Scopus)

• Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

  National Institute of Diabetes and Digestive Kidney Diseases Inflammatory Bowel Disease Genetics Consortium, United Kingdom Inflammatory Bowel Disease Genetics Consortium, International Inflammatory Bowel Disease Genetics Consortium & Lawrance, I., Nov 2011, In : Nature Genetics. 43, 11, p. 1066-1073 8 p.

  Research output: Contribution to journal › Article

  • Genome-Wide Association Study
  • Crohn Disease
  • Inflammatory Bowel Diseases
  • Ulcerative Colitis
  • Genes
  505 Citations (Scopus)

• Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis

  Beaudoin, M., Goyette, P., Boucher, G., Lo, K., Rivas, M. A., Stevens, C. R., Alikashani, A., Ladouceur, M. G., Ellinghaus, D., Törkvist, L., Goel, G., Lagacé, C., Annese, V., Bitton, A., Begun, J., Brant, S. R., Bresso, F., Cho, J., Duerr, R. H., Halfvarson, J. & 97 others, Mcgovern, D. P. B., Radford-Smith, G. L., Schreiber, S., Schumm, P. L., Sharma, Y., Silverberg, M. S., Weersma, R. K., D'Amato, M., Vermeire, S., Franke, A., Lettre, G., Xavier, R. J., Daly, M. J., Rioux, J. D., Aumais, G., Bernard, E. J., Cohen, A. Y., Deslandres, C., Lahaie, R. G., Paré, P., Cho, J. H., Targan, S. R., Schumm, P. P., Rutgeerts, P. J., Vermeire, S. A. F. A., Steinhart, A. H., Ahmad, T., Anderson, C. A., Baldassano, R. N., Balschun, T., Barclay, M. L., Barrett, J. C., Bayless, T. M., Bis, J. C. M., Brand, S., Bumpstead, S., Büning, C., Cohen, A., Colombel -, J. F., Cottone, M., D'Incà, R., Denson, T., Dubinsky, M. C., Edwards, C. M., Florin, T. H. J., Franchimont, D. P., Gearry, R. B., Georges, M. A. J. A. J., Glas, J., Van Gossum, A., Griffiths, A. M., Guthery, S. L., Hákonarson, H. H., Haritunians, T., Hugot, J. P., De Jong, D. J., Jostins, L., Kugathasan, S., Kullak- Ublick, G. A., Latiano, A., Laukens, D., Lawrance, I., Lee, J., Lees, C. W., Lémann, M., Levine, A. D., Libioulle, C., Louis, É. J., Mansfield, J. C., Mathew, C. G. P., Mitrovič, M., Montgomery, G. W., Mowat, C. E., Newman, W. G., Palmieri, O., Panés, J., Parkes, M., Phillips, A. M., Ponsioen, C. Y. J., Potočnik, U., Prescott, N. J., Proctor, D. D., Regueiro, M. D., Roberts, R. L., Rotter, J. I., Sanderson, J. D., Sans, M., Satsangi, J., Seibold, F., Simms, L. A., Taylor, K. D., Verspaget, H. W., De Vos, M. P., Walters, T. D., Wang, K., Whiteman, D. C. & Wijmenga, C., 2013, In : PLoS Genetics. 9, 9, p. 11 pp.

  Research output: Contribution to journal › Article

  Open Access

  • colitis
  • Genome-Wide Association Study
  • Ulcerative Colitis
  • Crohn disease
  • loci
  114 Citations (Scopus)

• Detection of liver injury in IBD using transient elastography

  Thin, L. W. Y., Lawrance, I., Spilsbury, K., Kava, J. & Olynyk, J. K., 2014, In : JOURNAL OF CROHNS & COLITIS. 8, 7, p. 671-677

  Research output: Contribution to journal › Article

  • Elasticity Imaging Techniques
  • Inflammatory Bowel Diseases
  • Liver
  • Wounds and Injuries
  • Inflammatory Bowel Disease 5
  9 Citations (Scopus)

• Dietary Iron Enhances Colonic Inflammation and IL-6/IL-11-Stat3 Signalling Promoting Colonic Tumor Development in Mice

  Chua, A., Klopcic, B., Ho, D., Fu, S., Forrest, C., Croft, K., Olynyk, J., Lawrance, I. & Trinder, D., 2013, In : PLoS One. 8, 11, p. 12pp

  Research output: Contribution to journal › Article

  Open Access
  40 Citations (Scopus)

• Dose tailoring of anti-tumour necrosis factor-alpha therapy delivers useful clinical efficacy in Crohn disease patients experiencing loss of response

  Ghaly, S., Costello, S., Beswick, L., Pudipeddi, A., Agarwal, A., Sechi, A., Antoniades, S., Headon, B., Connor, S., Lawrance, I., Sparrow, M., Walsh, A. & Andrews, J., 2014, In : Internal Medicine Journal. 45, 2, p. 170-177 8 p.

  Research output: Contribution to journal › Article

  • Crohn Disease
  • Tumor Necrosis Factor-alpha
  • Adrenal Cortex Hormones
  • Physicians
  • Steroids
  1 Citation (Scopus)

• Dysregulation of innate immunity in ulcerative colitis patients who fail anti-Tumor necrosis factor therapy Basic Study

  Baird, A., Mallon, D., Radford-Smith, G., Boyer, J., Piche, T., Prescott, S., Lawrance, I. & Tulic, M. K., 2016, In : World Journal of Gastroenterology. 22, 41, p. 9104-9116 13 p.

  Research output: Contribution to journal › Article

  Open Access

  • Ulcerative Colitis
  • Innate Immunity
  • Tumor Necrosis Factor-alpha
  • Toll-Like Receptors
  • Cytokines
  10 Citations (Scopus)

• Efficacy of rectal tacrolimus for induction therapy in patients with resistant ulcerative proctitis

  Lawrance, I. C., Baird, A., Lightowler, D., Radford-Smith, G., Andrews, J. M. & Connor, S., 1 Aug 2017, In : Clinical Gastroenterology and Hepatology. 15, 8, p. 1248-1255 8 p.

  Research output: Contribution to journal › Article

  • Proctitis
  • Tacrolimus
  • Placebos
  • Therapeutics
  • Ulcerative Colitis
  25 Citations (Scopus)

• Emu Oil Improves Clinical Indicators of Disease in a Mouse Model of Colitis-Associated Colorectal Cancer

  Chartier, L. C., Howarth, G. S., Lawrance, I. C., Trinder, D., Barker, S. J. & Mashtoub, S., 2018, In : Digestive Diseases and Sciences. 63, 1, p. 135–145 11 p.

  Research output: Contribution to journal › Article

  • emu Oil
  • Colitis
  • Colorectal Neoplasms
  • Dextran Sulfate
  • Azoxymethane
  10 Citations (Scopus)

• Emu Oil reduces disease severity in a mouse model of chronic ulcerative colitis

  Safaeian, R., Howarth, G. S., Lawrance, I. C., Trinder, D. & Mashtoub, S., 4 Mar 2019, In : Scandinavian Journal of Gastroenterology. 54, 3, p. 273-280 8 p.

  Research output: Contribution to journal › Article

  • emu Oil
  • Ulcerative Colitis
  • Peroxidase
  • Water
  • Dextran Sulfate
  3 Citations (Scopus)

• European evidence based consensus for endoscopy in inflammatory bowel disease

  ECCO & Lawrance, I., 15 Dec 2013, In : Journal of Crohn's and Colitis. 7, 12, p. 982-1018 37 p.

  Research output: Contribution to journal › Article

  Open Access
  439 Citations (Scopus)

• Fine-mapping inflammatory bowel disease loci to single-variant resolution

  Huang, H., Fang, M., Jostins, L., Umićević Mirkov, M., Boucher, G., Anderson, C. A., Andersen, V., Cleynen, I., Cortes, A., Crins, F., D'Amato, M., Deffontaine, V., Dmitrieva, J., Docampo, E., Elansary, M., Farh, K. K-H., Franke, A., Gori, A-S., Goyette, P., Halfvarson, J. & 27 others, Haritunians, T., Knight, J., Lawrance, I. C., Lees, C. W., Louis, E., Mariman, R., Meuwissen, T., Mni, M., Momozawa, Y., Parkes, M., Spain, S. L., Théâtre, E., Trynka, G., Satsangi, J., van Sommeren, S., Vermeire, S., Xavier, R. J., Weersma, R. K., Duerr, R. H., Mathew, C. G., Rioux, J. D., McGovern, D. P. B., Cho, J. H., Georges, M., Daly, M. J., Barrett, J. C. & International Inflammatory Bowel Disease Genetics Consortium, 13 Jul 2017, In : Nature. 547, 7662, p. 173-178 6 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Inflammatory Bowel Diseases
  • Genome-Wide Association Study
  • Ulcerative Colitis
  • Crohn Disease
  • Epigenomics
  178 Citations (Scopus)

  405 Downloads (Pure)

• Genetic susceptibility in IBD: Overlap between ulcerative Colitis and Crohn's disease

  Doecke, J. D., Simms, L. A., Zhao, Z., Huang, N., Hanigan, K., Krishnaprasad, K., Roberts, R. L., Andrews, J. M., Mahy, G., Bampton, P. A., Lewindon, P. J., Florin, T. H. J., Lawrance, I., Gearry, R. B., Montgomery, G. W. & Radford-Smith, G. L., 2013, In : Inflammatory Bowel Diseases. 19, 2, p. 240-245

  Research output: Contribution to journal › Article

  • Genetic Predisposition to Disease
  • Ulcerative Colitis
  • Crohn Disease
  • Single Nucleotide Polymorphism
  • Population Control
  27 Citations (Scopus)

• High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis

  Ghaly, S., Kaakoush, N. O., Lloyd, F., McGonigle, T., Mok, D., Baird, A., Klopcic, B., Gordon, L., Gorman, S., Forest, C., Bouillon, R., Lawrance, I. C. & Hart, P. H., 1 Dec 2018, In : Scientific Reports. 8, 1, 11511.

  Research output: Contribution to journal › Article

  Open Access

  • Colitis
  • Microbiota
  • Vitamin D
  • Dextran Sulfate
  • Serum Albumin
  19 Citations (Scopus)

• High Vitamin D-Binding Protein Concentration, Low Albumin, and Mode of Remission Predict Relapse in Crohn's Disease

  Ghaly, S., Murray, K., Baird, A., Martin, K., Prosser, R., Mill, J., Simms, L. A., Hart, P. H., Radford-Smith, G., Bampton, P. A. & Lawrance, I. C., Oct 2016, In : Inflammatory Bowel Diseases. 22, 10, p. 2456-2464 9 p.

  Research output: Contribution to journal › Article

  • Vitamin D-Binding Protein
  • Crohn Disease
  • Albumins
  • Sunlight
  • Recurrence
  12 Citations (Scopus)

• HLA-DQA1–HLA-DRB1variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants

  Heap, G. A., Weedon, M. N., Bewshea, C., Singh, A., Chen, M., Satchwell, J. B., Vivian, J. P., So, K., Dubois, P. C., Andrews, J. M., Annese, V., Bampton, P., Barnardo, M., Bell, S., Cole, A., Connor, S. J., Creed, T., Cummings, F. R., D'Amato, M., Daneshmend, T. K. & 38 others, Fedorak, R. N., Florin, T. H., Gaya, D. R., Greig, E., Halfvarson, J., Hart, A., Irving, P., Jones, G., Karban, A., Lawrance, I., Lee, J. C., Lees, C., Lev-Tzion, R., Lindsay, J. O., Mansfield, J., Mawdsley, J., Mazhar, Z., Parkes, M., Parnell, K., Orchard, T. R., Radford-Smith, G., Russell, R. K., Reffitt, D., Satsangi, J., Silverberg, M. S., Sturniolo, G. C., Tremelling, M., Tsianos, V., Van Heel, D. A., Walsh, A., Watermeyer, G., Weersma, R. K., Zeissig, S., Rossjohn, J., Holden, A. L., International Serious Adverse Events Consortium, I. S. A. E. C., Ibd Pharmacogenetics Study Group, IBD. P. S. G. & Ahmad, T., 2014, In : Nature Genetics. 46, 10, p. 1131-1136

  Research output: Contribution to journal › Article
  106 Citations (Scopus)

• Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

  Jostins, L., Ripke, S., Weersma, R. K., Duerr, R. H., Mcgovern, D. P., Hui, K. Y., Lee, J. C., Philip Schumm, L., Sharma, Y., Anderson, C. A., Essers, J., Mitrovic, M., Ning, K., Cleynen, I., Theatre, E., Spain, S. L., Raychaudhuri, S., Goyette, P., Wei, Z., Abraham, C. & 86 others, Achkar, J-P., Ahmad, T., Amininejad, L., Ananthakrishnan, A. N., Andersen, V., Andrews, J. M., Baidoo, L., Balschun, T., Bampton, P. A., Bitton, A., Boucher, G., Brand, S., Büning, C., Cohain, A., Cichon, S., D'Amato, M., De Jong, D., Devaney, K. L., Dubinsky, M., Edwards, C., Ellinghaus, D., Ferguson, L. R., Franchimont, D., Fransen, K., Gearry, R., Georges, M., Gieger, C., Glas, J., Haritunians, T., Hart, A., Hawkey, C., Hedl, M., Hu, X., Karlsen, T. H., Kupcinskas, L., Kugathasan, S., Latiano, A., Laukens, D., Lawrance, I., Lees, C. W., Louis, E., Mahy, G., Mansfield, J., Morgan, A. R., Mowat, C., Newman, W., Palmieri, O., Ponsioen, C. Y., Potocnik, U., Prescott, N. J., Regueiro, M., Rotter, J. I., Russell, R. K., Sanderson, J. D., Sans, M., Satsangi, J., Schreiber, S., Simms, L. A., Sventoraityte, J., Targan, S. R., Taylor, K. D., Tremelling, M., Verspaget, H. W., De Vos, M., Wijmenga, C., Wilson, D. C., Winkelmann, J., Xavier, R. J., Zeissig, S., Zhang, B., Zhang, C. K., Zhao, H., Silverberg, M. S., Annese, V., Hakonarson, H., Brant, S. R., Radford-Smith, G., Mathew, C. G., Rioux, J. D., Schadt, E. E., Daly, M. J., Franke, A., Parkes, M., Vermeire, S., Barrett, J. C. & Cho, J. H., 1 Nov 2012, In : Nature. 491, 7422, p. 119-124

  Research output: Contribution to journal › Article

  • Host Microbial Interactions
  • Inflammatory Bowel Diseases
  • Genome-Wide Association Study
  • Ulcerative Colitis
  • Crohn Disease
  2659 Citations (Scopus)

• IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

  The International IBD Genetics Consortium, 1 Dec 2018, In : Nature Communications. 9, 1, 2427.

  Research output: Contribution to journal › Article

  Open Access

  • genes
  • loci
  • Inflammatory Bowel Diseases
  • Genes
  • modules
  33 Citations (Scopus)

• Implementing guidelines on the prevention of opportunistic infections in inflammatory bowel disease

  Walsh, A. J., Weltman, M., Burger, D., Vivekanandarajah, S., Connor, S., Howlett, M., Radford-Smith, G., Selby, W., Veillard, A. S., Grimm, M. C., Travis, S. P. L. & Lawrance, I., 2013, In : JOURNAL OF CROHNS & COLITIS. 7, p. e449-e456

  Research output: Contribution to journal › Article
  31 Citations (Scopus)

• Infliximab Reduces Endoscopic, but Not Clinical, Recurrence of Crohn's Disease after Ileocolonic Resection

  Regueiro, M., Feagan, B. G., Zou, B., Johanns, J., Blank, M. A., Chevrier, M., Plevy, S., Popp, J., Cornillie, F. J., Lukas, M., Danese, S., Gionchetti, P., Hanauer, S. B., Reinisch, W., Sandborn, W. J., Sorrentino, D., Rutgeerts, P., Debinski, H., Florin, T., Hetzel, D. & 136 others, Lawrance, I., Radford-Smith, G., Sloss, A., Sorrentino, D., Gassner, S., Haas, T., Reicht, G., Reinisch, W., Strasser, M., Vogelsang, H., Bossuyt, P., Dewit, O., D'Haens, G., Franchimont, D., Louis, E., Vermeire, S., Bernstein, C. N., Bourdages, R., Chiba, N., Dhalla, S. S., Feagan, B. G., Fedorak, R. N., Lachance, J. R., Panaccione, R., Ropeleski, M., Singh Salh, B., Lukas, M., Colombel, J. F., Allez, M., Desreumaux, P., Dupas, J. L., Grimaud, J. C., Hebuterne, X., Laharie, D., Lerebours, E., Peyrin-Biroulet, L., Reimund, J. M., Viennot, S., Zerbib, F., Antoni, C., Atreya, R., Baumgart, D. C., Berg, C., Boecker, U., Bramkamp, G., Bünning, C., Ehehalt, R., Howaldt, S., Kucharzik, T., Lamprecht, H. G., Mudter, J., Preiss, J. C., Schreiber, S., Seidler, U., Altorjay, I., Banai, J., Lakatos, P. L., Varga, M., Vincze, A., Avni-Biron, I., Fishman, S., Fraser, G. M., Goldin, E., Rachmilewitz, D., Annese, V., Ardizzone, S., Biancone, L., Bossa, F., Danese, S., Fries, W., Gionchetti, P., Maconi, G., Terrosu, G., Usai, P., D'Haens, G. R., Gearry, R. B., Hill, J., Rowbotham, D. S., Schultz, M., Stubbs, R. S., Wallace, D., Walmsley, R. S., Wyeth, J., Malecka-Panas, E., Paradowski, L., Regula, J., Beales, I. P., Campbell, S., Hawthorne, A. B., Parkes, M., Travis, S. P., Achkar, J. P., Behm, B. W., Bickston, S. J., Brown, K. J., Chiorean, M. V., Devilliers, W. J. S., Elliott, D. E., Grunkmeier, D., Hamilton, J. W., Hanauer, S. B., Hanson, J. S., Hardi, R., Helper, D. J., Herfarth, H., Higgins, P. D. R., Holderman, W. H., Kottoor, R., Kreines, M. D., Leman, B. I., Li, X., Loftus, E. V., Noar, M., Oikonomou, I., Onken, J., Peterson, K. A., Phillips, R. P., Randall, C. W., Ricci, M., Ritter, T., Rubin, D. T., Safdi, M., Sandborn, W. J., Sauberman, L., Scherl, E., Schwarz, R. P., Sedghi, S., Shafran, I., Sninsky, C. A., Stein, I., Swoger, J., Vecchio, J., Weinberg, D. I., Wruble, L. D., Yajnik, V. & Younes, Z., 1 Jun 2016, In : Gastroenterology. 150, 7, p. 1568-1578 11 p.

  Research output: Contribution to journal › Article

  Open Access

  • Infliximab
  • Crohn Disease
  • Recurrence
  • Placebos
  • Numbers Needed To Treat
  115 Citations (Scopus)

• Infliximab vs. adalimumab in Crohn's disease: results from 327 patients in an Australian and New Zealand observational cohort study

  the Australian and New Zealand Inflammatory Bowel Disease Consortium, 1 Feb 2017, In : Alimentary Pharmacology and Therapeutics. 45, 4, p. 542-552 11 p.

  Research output: Contribution to journal › Article

  • Adalimumab
  • Infliximab
  • New Zealand
  • Crohn Disease
  • Observational Studies
  23 Citations (Scopus)

• Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: A genetic association study

  Cleynen, I., Boucher, G., Jostins, L., Schumm, L. P., Zeissig, S., Ahmad, T., Andersen, V., Andrews, J. M., Annese, V., Brand, S., Brant, S. R., Cho, J. H., Daly, M. J., Dubinsky, M., Duerr, R. H., Ferguson, L. R., Franke, A., Gearry, R. B., Goyette, P., Hakonarson, H. & 22 others, Halfvarson, J., Hov, J. R., Huang, H., Kennedy, N. A., Kupcinskas, L., Lawrance, I., Lee, J. C., Satsangi, J., Schreiber, S., Théâtre, E., Van Der Meulen-De Jong, A. E., Weersma, R. K., Wilson, D. C., Parkes, M., Vermeire, S., Rioux, J. D., Mansfield, J., Silverberg, M. S., Radford-Smith, G., Mcgovern, D. P. B., Barrett, J. C. & Lees, C. W., 9 Jan 2016, In : The Lancet. 387, 10014, p. 156-167 12 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Genetic Association Studies
  • Ulcerative Colitis
  • Crohn Disease
  • Inflammatory Bowel Diseases
  • Phenotype
  330 Citations (Scopus)

  431 Downloads (Pure)

• Inter-observer agreement for Crohn's disease subphenotypes using the Montreal Classification: How good are we? A multi-centre Australasian study

  Krishnaprasad, K., Andrews, J. M., Lawrance, I., Florin, T., Gearry, R. B., Leong, R. W. L., Mahy, G., Bampton, P., Prosser, R., Leach, P., Chitti, L., Cock, C., Grafton, R., Croft, A. R., Cooke, S., Doecke, J. D. & Radford-Smith, G. L., 2012, In : JOURNAL OF CROHNS & COLITIS. 6, p. 287-293

  Research output: Contribution to journal › Article
  13 Citations (Scopus)

• Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease

  International Inflammatory Bowel Disease Genetics Consortium & Lawrance, I. C., 6 Jun 2013, In : American Journal of Human Genetics. 92, 6, p. 1008-1012 5 p.

  Research output: Contribution to journal › Article

  Open Access

  • Machine Learning
  • Ulcerative Colitis
  • Crohn Disease
  • Inflammatory Bowel Diseases
  • Sample Size
  88 Citations (Scopus)

• Level of UV Exposure, Skin Type, and Age Are More Important than Thiopurine Use for Keratinocyte Carcinoma Development in IBD Patients

  Wu, Y., Ghaly, S., Kerr, S., Jackson, B., Hanigan, K., Martins, D., Krishnaprasad, K., Mountifield, R. E., Whiteman, D. C., Bampton, P. A., Gearry, R. B., Radford-Smith, G. L. & Lawrance, I. C., 6 Sep 2019, In : Digestive Diseases and Sciences.

  Research output: Contribution to journal › Article

  • Keratinocytes
  • Inflammatory Bowel Diseases
  • Carcinoma
  • Solar System
  • Skin

• Mesenchymal cell proliferation and programmed cell death: key players in fibrogenesis and new targets for therapeutic intervention

  Luna, J., Masamunt, M. C., Lawrance, I. & Sans, M., 2011, In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 300, p. G703-G708

  Research output: Contribution to journal › Article

  Open Access
  9 Citations (Scopus)

• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

  Anderson, C. A., Boucher, G., Lees, C. W., Franke, A., D’amato, M., Taylor, K. D., Lee, J. C., Goyette, P., Imielinski, M., Latiano, A., Lagacé, C., Scott, R., Amininejad, L., Bumpstead, S., Baidoo, L., Baldassano, R. N., Barclay, M., Bayless, T. M., Brand, S., Büning, C. & 93 others, Colombel, J-F., Denson, L. A., De Vos, M., Dubinsky, M., Edwards, C., Ellinghaus, D., Fehrmann, R. S. N., Floyd, J. A. B., Florin, T., Franchimont, D., Franke, L., Georges, M., Glas, J., Glazer, N. L., Guthery, S. L., Haritunians, T., Hayward, N. K., Hugot, J-P., Jobin, G., Laukens, D., Lawrance, I., Lémann, M., Levine, A., Libioulle, C., Louis, E., Mcgovern, D. P., Milla, M., Montgomery, G. W., Morley, K. I., Mowat, C., Ng, A., Newman, W., Ophoff, R. A., Papi, L., Palmieri, O., Peyrin-Biroulet, L., Panés, J., Phillips, A., Prescott, N. J., Proctor, D. D., Roberts, R., Russell, R., Rutgeerts, P., Sanderson, J., Sans, M., Schumm, P., Seibold, F., Sharma, Y., Simms, L., Seielstad, M., Hillary Steinhart, A., Targan, S. R., Van Den Berg, L. H., Vatn, M., Verspaget, H., Walters, T., Wijmenga, C., Wilson, D. C., Westra, H-J., Xavier, R. J., Zhao, Z. Z., Ponsioen, C. Y., Andersen, V., Torkvist, L., Gazouli, M., Anagnou, N. P., Karlsen, T. H., Kupcinskas, L., Sventoraityte, J., Mansfield, J. C., Kugathasan, S., Silverberg, M. S., Halfvarson, J., Rotter, J. I., Mathew, C. G., Griffiths, A. M., Gearry, R., Ahmad, T., Brant, S. R., Chamaillard, M., Satsangi, J., Cho, J. H., Schreiber, S., Daly, M. J., Barrett, J. C., Parkes, M., Annese, V., Hakonarson, H., Radford-Smith, G., Duerr, R. H., Vermeire, S., Weersma, R. K. & Rioux, J. D., 2011, In : Nature Genetics. 43, 3, p. 246-252

  Research output: Contribution to journal › Article
  932 Citations (Scopus)

• Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease

  Roberts, R. L., Wallace, M. C., Seinen, M. L., van Bodegraven, A. A., Krishnaprasad, K., Jones, G. T., van Rij, A. M., Baird, A., Lawrance, I. C., Prosser, R., Bampton, P., Grafton, R., Simms, L. A., Studd, C., Bell, S. J., Kennedy, M. A., Halliwell, J., Gearry, R. B., Radford-Smith, G., Andrews, J. M. & 2 others, McHugh, P. C. & Barclay, M. L., 29 Nov 2018, In : Inflammatory Bowel Diseases. 24, 12, p. 2606-2612 7 p.

  Research output: Contribution to journal › Article

  • 6-methylthiopurine
  • Guanine
  • Ligases
  • 6-thioguanylic acid
  • Inflammatory Bowel Diseases

• Oral tacrolimus for the treatment of refractory inflammatory bowel disease in the biologic era

  Thin, L. W. Y., Murray, K. & Lawrance, I., 2013, In : Inflammatory Bowel Diseases. 19, 7, p. 1490-1498

  Research output: Contribution to journal › Article

  • Tacrolimus
  • Inflammatory Bowel Diseases
  • Crohn Disease
  • Necrosis
  • Therapeutics
  21 Citations (Scopus)

• Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method

  Chen, G. B., Lee, S. H., Montgomery, G. W., Wray, N. R., Visscher, P. M., Gearry, R. B., Lawrance, I. C., Andrews, J. M., Bampton, P., Mahy, G., Bell, S., Walsh, A., Connor, S., Sparrow, M., Bowdler, L. M., Simms, L. A., Krishnaprasad, K., Radford-Smith, G. L. & Moser, G., 29 Aug 2017, In : BMC Medical Genetics. 18, 1, 94.

  Research output: Contribution to journal › Article

  Open Access

  • Inflammatory Bowel Diseases
  • Genome-Wide Association Study
  • Single Nucleotide Polymorphism
  • Crohn Disease
  • Ulcerative Colitis
  9 Citations (Scopus)

• Predictors of fibrostenotic Crohn's Disease

  Rieder, F., Lawrance, I., Leite, A. & Sans, M., 2011, In : Inflammatory Bowel Diseases. 17, 9, p. 2000-2007

  Research output: Contribution to journal › Article
  48 Citations (Scopus)

• Prostaglandin E2 and polyenylphosphatidylcholine protect against intestinal fibrosis and regulate myofibroblast function

  Baird, A., Lloyd, F. & Lawrance, I., 2014, In : Digestive Diseases & Sciences. 60, p. 1603–1616

  Research output: Contribution to journal › Article
  5 Citations (Scopus)

• Proteins Encoded in Genomic Regions Associated with Immune-Mediated Disease Physically Interact and Suggest Underlying Biology

  Rossin, E. J., Lage, K., Raychaudhuri, S., Xavier, R. J., Tatar, D., Benita, Y., Lawrance, I., Cotsapas, C., Daly, M. J., Franke, A., Mcgovern, D. P. B., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., Lees, C. W., Balschun, T., Lee, J., Roberts, R., Anderson, C. A. & 78 others, Bis, J. C., Bumpstead, S., Ellinghaus, D., Festen, E. M., Georges, M., Haritunians, T., Jostins, L., Latiano, A., Mathew, C. G., Montgomery, G. W., Prescott, N. J., Rotter, J. I., Schumm, P., Sharma, Y., Simms, L. A., Taylor, K. D., Whiteman, D., Wijmenga, C., Baldassano, R. N., Barclay, M., Bayless, T. M., Brand, S., Bunning, C., Cohen, A., Colombel, J-F., Cottone, M., Stronati, L., Denson, T., De Vos, M., D'Inca, R., Dubinsky, M., Edwards, C., Florin, T., Franchimont, D., Gearry, R., Glas, J., Van Gossum, A., Guthery, S. L., Halfvarson, J., Hommes, D., Hugot, J-P., Laukens, D., Lemann, M., Levine, A., Libioulle, C., Louis, E., Mowat, C., Newman, W., Panes, J., Phillips, A., Proctor, D. D., Regueiro, M., Rutgeerts, P., Sanderson, J., Sans, M., Seibold, F., Steinhart, A. H., Stokkers, P. C. F., Torkvist, L., Kullak-Ublick, G., Walters, T., Targan, S. R., Brant, S. R., Rioux, J. D., D'Amato, M., Weersma, R., Kutharthasan, S., Griffiths, A. M., Mansfield, J. C., Vermeire, S., Duerr, R. H., Silverberg, M. S., Satsangi, J., Schreiber, S., Cho, J. H., Annese, V., Hakonarson, H. & Parkes, M., 2011, In : PLoS Genetics. 7, 1, p. 13pp

  Research output: Contribution to journal › Article

  Open Access
  349 Citations (Scopus)