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  • Markus Schlaich
Article

Plasma advanced glycation end products (AGEs) and NF-κB activity are independent determinants of diastolic and pulse pressure

Sourris, K. C., Lyons, J. G., Dougherty, S. L., Chand, V., Straznicky, N. E., Schlaich, M. P., Grima, M. T., Cooper, M. E., Kingwell, B. A., De Courten, M. P. J., Forbes, J. M. & De Courten, B., 2014, In : Clinical Chemistry and Laboratory Medicine. 52, 1, p. 129-138 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Point: Chronic activation of the sympathetic nervous system is the dominant contributor to systemic hypertension

Esler, M., Lambert, E. & Schlaich, M., Dec 2010, In : Journal of Applied Physiology. 109, 6, p. 1996-1998 3 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Potential future denervation targets

Gerard Leong, K. T., Walton, A., Krum, H. & Schlaich, M. P., 1 Dec 2014, In : Interventional Cardiology. 6, 6, p. 569-579 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Rationale and design of a large registry on renal denervation: The Global SYMPLICITY registry

Böhm, M., Mahfoud, F., Ukena, C., Bauer, A., Fleck, E., Hoppe, U. C., Kintscher, U., Narkiewicz, K., Negoita, M., Ruilope, L., Rump, L. C., Schlaich, M., Schmieder, R., Sievert, H., Weil, J., Williams, B., Zeymer, U. & Mancia, G., Aug 2013, In : EuroIntervention. 9, 4, p. 484-492 9 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Recurrent postural vasovagal syncope: Sympathetic nervous system phenotypes

Vaddadi, G., Guo, L., Esler, M., Socratous, F., Schlaich, M., Chopra, R., Eikelis, N., Lambert, G., Trauer, T. & Lambert, E., Oct 2011, In : Circulation: Arrhythmia and Electrophysiology. 4, 5, p. 711-718 8 p.

Research output: Contribution to journalArticle

Open Access
33 Citations (Scopus)

Reduction in basal nitric oxide activity causes albuminuria

Ott, C., Schneider, M. P., Delles, C., Schlaich, M. P. & Schmieder, R. E., Feb 2011, In : Diabetes. 60, 2, p. 572-576 5 p.

Research output: Contribution to journalArticle

Open Access
19 Citations (Scopus)

Reduction in peripheral vascular resistance predicts improvement in insulin clearance following weight loss

Straznicky, N. E., Grima, M. T., Sari, C. I., Lambert, E. A., Phillips, S. E., Eikelis, N., Kobayashi, D., Hering, D., Mariani, J. A., Dixon, J. B., Nestel, P. J., Karapanagiotidis, S., Schlaich, M. P. & Lambert, G. W., 22 Aug 2015, In : Cardiovascular Diabetology. 14, 1, 113.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Reinnervation following catheter-based radio-frequency renal denervation

Booth, L. C., Nishi, E. E., Yao, S. T., Ramchandra, R., Lambert, G. W., Schlaich, M. P. & May, C. N., 20 Apr 2015, In : Experimental Physiology. 100, 5, p. 485-490 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Reinnervation of renal afferent and efferent nerves at 5.5 and 11 months after catheter-based radiofrequency renal denervation in sheep

Booth, L. C., Nishi, E. E., Yao, S. T., Ramchandra, R., Lambert, G. W., Schlaich, M. P. & May, C. N., 21 Feb 2015, In : Hypertension. 65, 2, p. 393-400 8 p.

Research output: Contribution to journalArticle

Open Access
79 Citations (Scopus)

Relation between QT interval variability and cardiac sympathetic activity in hypertension

Baumert, M., Schlaich, M. P., Nalivaiko, E., Lambert, E., Sari, C. I., Kaye, D. M., Elser, M. D., Sanders, P. & Lambert, G., Apr 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 300, 4

Research output: Contribution to journalArticle

70 Citations (Scopus)

Relevance of sympathetic nervous system activation in obesity and metabolic syndrome

Thorp, A. A. & Schlaich, M., 2015, In : Journal of Diabetes Research. 2015, p. 1-11

Research output: Contribution to journalArticle

Open Access
File
138 Citations (Scopus)
210 Downloads (Pure)

Renal artery anatomy affects the blood pressure response to renal denervation in patients with resistant hypertension

Hering, D., Marusic, P., Walton, A. S., Duval, J., Lee, R., Sata, Y., Krum, H., Lambert, E., Peter, K., Head, G., Lambert, G., Esler, M. D. & Schlaich, M., 1 Jan 2016, In : International Journal of Cardiology. 202, p. 388-393 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Renal artery anatomy assessed by quantitative analysis of selective renal angiography in 1,000 patients with hypertension

Lauder, L., Ewen, S., Tzafriri, A. R., Edelman, E. R., Lüscher, T. F., Blankestijn, P. J., Dörr, O., Schlaich, M., Sharif, F., Voskuil, M., Zeller, T., Ukena, C., Scheller, B., Böhm, M. & Mahfoud, F., 1 May 2018, In : EuroIntervention. 14, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Renal artery denervation for treatment of patients with self-reported obstructive sleep apnea and resistant hypertension: Results from the Global SYMPLICITY Registry

Linz, D., Mancia, G., Mahfoud, F., Narkiewicz, K., Ruilope, L., Schlaich, M., Kindermann, I., Schmieder, R. E., Ewen, S., Williams, B. & Bohm, M., 2017, In : Journal of Hypertension. 35, 1, p. 148-153 6 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Renal denervation: Current implications and future perspectives

Xu, J., Hering, D., Sata, Y., Walton, A., Krum, H., Esler, M. D. & Schlaich, M. P., 2014, In : Clinical Science. 126, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Renal denervation: A potential new treatment modality for polycystic ovary syndrome?

Schlaich, M. P., Straznicky, N., Grima, M., Ika-Sari, C., Dawood, T., Mahfoud, F., Lambert, E., Chopra, R., Socratous, F., Hennebry, S., Eikelis, N., Böhm, M., Krum, H., Lambert, G., Esler, M. D. & Sobotka, P. A., May 2011, In : Journal of Hypertension. 29, 5, p. 991-996 6 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

Renal denervation and hypertension

Schlaich, M. P., Krum, H., Sobotka, P. A. & Esler, M. D., Jun 2011, In : American Journal of Hypertension. 24, 6, p. 635-642 8 p.

Research output: Contribution to journalArticle

Open Access
46 Citations (Scopus)

Renal denervation in hypertensive patients not on blood pressure lowering drugs

De Jager, R. L., Sanders, M. F., Bots, M. L., Lobo, M. D., Ewen, S., Beeftink, M. M. A., Böhm, M., Daemen, J., Dörr, O., Hering, D., Mahfoud, F., Nef, H., Ott, C., Saxena, M., Schmieder, R. E., Schlaich, M., Spiering, W., Tonino, P. A. L., Verloop, W. L., Vink, E. E. & 4 others, Vonken, E. J., Voskuil, M., Worthley, S. G. & Blankestijn, P. J., 2016, In : Clinical Research in Cardiology. 105, 9, p. 755-762

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Renal Denervation Reduces Monocyte Activation and Monocyte-Platelet Aggregate Formation: An Anti-Inflammatory Effect Relevant for Cardiovascular Risk

Zaldivia, M. T. K., Rivera, J., Hering, D., Marusic, P., Sata, Y., Lim, B., Eikelis, N., Lee, R., Lambert, G. W., Esler, M. D., Htun, N. M., Duval, J., Hammond, L., Eisenhardt, S. U., Flierl, U., Schlaich, M. P. & Peter, K., 1 Feb 2017, In : Hypertension. 69, 2, p. 323-331 9 p.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
223 Downloads (Pure)

Renal denervation reduces office and ambulatory heart rate in patients with uncontrolled hypertension: 12-month outcomes fromthe global SYMPLICITY registry

Böhm, M., Ukena, C., Ewen, S., Linz, D., Zivanovic, I., Hoppe, U., Narkiewicz, K., Ruilope, L., Schlaich, M., Negoita, M., Schmieder, R., Williams, B., Zeymer, U., Zirlik, A., Mancia, G. & Mahfoud, F., 2016, In : Journal of Hypertension. 34, 12, p. 2480-2486 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Renal nerve ablation reduces augmentation index in patients with resistant hypertension

Hering, D., Lambert, E. A., Marusic, P., Ika-Sari, C., Walton, A. S., Krum, H., Sobotka, P. A., Mahfoud, F., Böhm, M., Lambert, G. W., Esler, M. D. & Schlaich, M. P., Sep 2013, In : Journal of Hypertension. 31, 9, p. 1893-1900 8 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Renal Nitric Oxide Deficiency and Chronic Kidney Disease in Young Sheep Born with a Solitary Functioning Kidney

Singh, R. R., Easton, L. K., Booth, L. C., Schlaich, M. P., Head, G. A., Moritz, K. M. & Denton, K. M., 26 May 2016, In : Scientific Reports. 6, 26777.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Renal oxygenation in acute renal ischemia-reperfusion injury

Abdelkader, A., Ho, J., Ow, C. P. C., Eppel, G. A., Rajapakse, N. W., Schlaich, M. P. & Evans, R. G., 1 May 2014, In : American Journal of Physiology - Renal Physiology. 306, 9

Research output: Contribution to journalArticle

47 Citations (Scopus)

Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): A randomised controlled trial

Esler, M. D., Krum, H., Sobotka, P. A., Schlaich, M. P., Schmieder, R. E., Böhm, M., Mahfoud, F., Sievert, H., Wunderlich, N., Rump, L. C., Vonend, O., Uder, M., Lobo, M., Caulfield, M., Erglis, A., Azizi, M., Sapoval, M., Thambar, S., Persu, A., Renkin, J. & 24 others, Schunkert, H., Weil, J., Hoppe, U. C., Walton, T., Scheinert, D., Binder, T., Januszewicz, A., Witkowski, A., Ruilope, L. M., Whitbourn, R., Bruck, H., Downes, M., Lüscher, T. F., Jardine, A. G., Webster, M. W., Zeller, T., Sadowski, J., Bartus, K., Straley, C. A., Barman, N. C., Lee, D. P., Witteles, R. M., Bhalla, V. & Massaro, J. M., 4 Dec 2010, In : The Lancet. 376, 9756, p. 1903-1909 7 p.

Research output: Contribution to journalArticle

1677 Citations (Scopus)

Renal sympathetic denervation restores aortic distensibility in patients with resistant hypertension: data from a multi-center trial

Stoiber, L., Mahfoud, F., Zamani, S. M., Lapinskas, T., Böhm, M., Ewen, S., Kulenthiran, S., Schlaich, M. P., Esler, M. D., Hammer, T., Stensæth, K. H., Pieske, B., Dreysse, S., Fleck, E., Kühne, T., Kelm, M., Stawowy, P. & Kelle, S., 1 Aug 2018, In : Clinical Research in Cardiology. 107, 8, p. 642-652 11 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Renal sympathetic nerve ablation for treatment-resistant hypertension

Krum, H., Schlaich, M. & Sobotka, P., Oct 2013, In : British Journal of Clinical Pharmacology. 76, 4, p. 495-503 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2 Citations (Scopus)

Reverse cardiac remodeling after renal denervation: Atrial electrophysiologic and structural changes associated with blood pressure lowering

Mclellan, A. J. A., Schlaich, M., Taylor, A. J., Prabhu, S. G. S., Hering, D., Hammond, L., Marusic, P., Duval, J., Sata, Y., Ellims, A. H., Esler, M. D., Peter, K., Shaw, J. A., Walton, A. S., Kalman, J. M. & Kistler, P. M., 1 May 2015, In : Heart Rhythm. 12, 5, p. 982-990

Research output: Contribution to journalArticle

37 Citations (Scopus)

Role of the sympathetic nervous system in regulation of the sodium glucose cotransporter 2

Matthews, V. B., Elliot, R. H., Rudnicka, C., Hricova, J., Herat, L. & Schlaich, M. P., 1 Oct 2017, In : Journal of Hypertension. 35, 10, p. 2059–2068

Research output: Contribution to journalArticle

39 Citations (Scopus)

Serum uric acid and the relationship with subclinical organ damage in adults

Lambert, E. A., Hachem, M., Hemmes, R., Straznicky, N. E., Eikelis, N., Sari, C. I., Schlaich, M. P., Lambert, G. W. & Dixon, J. B., 1 Apr 2017, In : Journal of Hypertension. 35, 4, p. 745-752 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Shining LIGHT on the metabolic role of the cytokine TNFSF14 and the implications on hepatic IL-6 production

Saunders, B. M., Rudnicka, C., Filipovska, A., Davies, S., Ward, N., Hricova, J., Schlaich, M. P. & Matthews, V. B., 1 Jan 2018, In : Immunology and Cell Biology. 96, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Short-term effects of catheter-based renal denervation on cardiac sympathetic drive and cardiac baroreflex function in heart failure

Booth, L. C., Schlaich, M. P., Nishi, E. E., Yao, S. T., Xu, J., Ramchandra, R., Lambert, G. W. & May, C. N., 1 Jul 2015, In : International Journal of Cardiology. 190, 1, p. 220-226 7 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
61 Downloads (Pure)

Single-unit muscle sympathetic nervous activity and its relation to cardiac noradrenaline spillover

Lambert, E. A., Schlaich, M. P., Dawood, T., Sari, C., Chopra, R., Barton, D. A., Kaye, D. M., Elam, M., Esler, M. D. & Lambert, G. W., May 2011, In : Journal of Physiology. 589, 10, p. 2597-2605 9 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Soluble vascular endothelial growth factor receptor-1 is reduced in patients with resistant hypertension after renal denervation

Eikelis, N., Hering, D., Marusic, P., Walton, A. S., Lambert, E. A., Sata, Y., Krum, H., Lambert, G. W., Esler, M. D. & Schlaich, M. P., 1 Apr 2017, In : Journal of Human Hypertension. 31, 4, p. 248-252 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Substantial reduction in single sympathetic nerve firing after renal denervation in patients with resistant hypertension

Hering, D., Lambert, E. A., Marusic, P., Walton, A. S., Krum, H., Lambert, G. W., Esler, M. D. & Schlaich, M. P., 1 Feb 2013, In : Hypertension. 61, 2, p. 457-464 8 p.

Research output: Contribution to journalArticle

Open Access
247 Citations (Scopus)

Sustained sympathetic and blood pressure reduction 1 year after renal denervation in patients with resistant hypertension

Hering, D., Marusic, P., Walton, A. S., Lambert, E. A., Krum, H., Narkiewicz, K., Lambert, G. W., Esler, M. D. & Schlaich, M. P., 2014, In : Hypertension. 64, 1, p. 118-124 7 p.

Research output: Contribution to journalArticle

Open Access
98 Citations (Scopus)

Sympathetic activation and endothelial dysfunction in polycystic ovary syndrome are not explained by either obesity or insulin resistance

Lambert, E. A., Teede, H., Sari, C. I., Jona, E., Shorakae, S., Woodington, K., Hemmes, R., Eikelis, N., Straznicky, N. E., De Courten, B., Dixon, J. B., Schlaich, M. P. & Lambert, G. W., Dec 2015, In : Clinical Endocrinology. 83, 6, p. 812-819 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Sympathetic activity and markers of cardiovascular risk in nondiabetic severely obese patients: The effect of the initial 10% weight loss

Lambert, E. A., Rice, T., Eikelis, N., Straznicky, N. E., Lambert, G. W., Head, G. A., Hensman, C., Schlaich, M. P. & Dixon, J. B., 2014, In : American Journal of Hypertension. 27, 10, p. 1308-1315 8 p.

Research output: Contribution to journalArticle

Open Access
23 Citations (Scopus)

Sympathetic and vascular dysfunction in adult patients with Fontan circulation

Lambert, E., D'Udekem, Y., Cheung, M., Sari, C. I., Inman, J., Ahimastos, A., Eikelis, N., Pathak, A., King, I., Grigg, L., Schlaich, M. & Lambert, G., 20 Aug 2013, In : International Journal of Cardiology. 167, 4, p. 1333-1338 6 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Sympathetic nervous response to ischemia-reperfusion injury in humans is altered with remote ischemic preconditioning

Lambert, E. A., Thomas, C. J., Hemmes, R., Eikelis, N., Pathak, A., Schlaich, M. & Lambert, G. W., 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 2, p. H364-H370

Research output: Contribution to journalArticle

27 Citations (Scopus)

Sympathetic nervous system activity is associated with obesity-induced subclinical organ damage in young adults

Lambert, E., Sari, C. I., Dawood, T., Nguyen, J., McGrane, M., Eikelis, N., Chopra, R., Wong, C., Chatzivlastou, K., Head, G., Straznicky, N., Esler, M., Schlaich, M. & Lambert, G., 1 Sep 2010, In : Hypertension. 56, 3, p. 351-358 8 p.

Research output: Contribution to journalArticle

Open Access
136 Citations (Scopus)

Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects

Straznicky, N. E., Lambert, E. A., Nestel, P. J., McGrane, M. T., Dawood, T., Schlaich, M. P., Masuo, K., Eikelis, N., De Courten, B., Mariani, J. A., Esler, M. D., Socratous, F., Chopra, R., Sari, C. I., Paul, E. & Lambert, G. W., 2010, In : Diabetes. 59, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

Open Access
69 Citations (Scopus)

Sympathetic Response and Outcomes Following Renal Denervation in Patients With Chronic Heart Failure: 12-Month Outcomes From the Symplicity HF Feasibility Study

Hopper, I., Gronda, E., Hoppe, U. C., Rundqvist, B., Marwick, T. H., Shetty, S., Hayward, C., Lambert, T., Hering, D., Esler, M., Schlaich, M., Walton, A., Airoldi, F., Brandt, M. C., Cohen, S. A., Reiters, P. & Krum, H., 1 Sep 2017, In : Journal of Cardiac Failure. 23, 9, p. 702-707 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The effect of renal denervation on plasma adipokine profile in patients with treatment resistant hypertension

Eikelis, N., Hering, D., Marusic, P., Duval, J., Hammond, L. J., Walton, A. S., Lambert, E. A., Esler, M. D., Lambert, G. W. & Schlaich, M. P., 30 May 2017, In : Frontiers in Physiology. 8, MAY, 369.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

The effects of dietary weight loss on indices of norepinephrine turnover: Modulatory influence of hyperinsulinemia

Straznicky, N. E., Lambert, E. A., Grima, M. T., Eikelis, N., Richards, K., Nestel, P. J., Dawood, T., Masuo, K., Sari, C. I., Dixon, J. B., Esler, M. D., Paul, E., Schlaich, M. P. & Lambert, G. W., 2014, In : Obesity. 22, 3, p. 652-662 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The effects of weight loss versus weight loss maintenance on sympathetic nervous system activity and metabolic syndrome components

Straznicky, N. E., Grima, M. T., Eikelis, N., Nestel, P. J., Dawood, T., Schlaich, M. P., Chopra, R., Masuo, K., Esler, M. D., Sari, C. I., Lambert, G. W. & Lambert, E. A., Mar 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 3

Research output: Contribution to journalArticle

Open Access
72 Citations (Scopus)

The metalloproteinase ADAM28 promotes metabolic dysfunction in mice

Herat, L., Rudnicka, C., Okada, Y., Mochizuki, S., Schlaich, M. & Matthews, V., 21 Apr 2017, In : International Journal of Molecular Sciences. 18, 4, 12 p., 884.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

The relation of glucose metabolism to left ventricular mass and function and sympathetic nervous system activity in obese subjects with metabolic syndrome

Straznicky, N. E., Grima, M. T., Sari, C. I., Karapanagiotidis, S., Wong, C., Eikelis, N., Richards, K. L., Lee, G., Nestel, P. J., Dixon, J. B., Lambert, G. W., Schlaich, M. P. & Lambert, E. A., 1 Feb 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 2

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)
Open Access
File
5 Citations (Scopus)
418 Downloads (Pure)

Three-year changes of prothrombotic factors in a cohort of South Africans with a high clinical suspicion of obstructive sleep apnea

Von Känel, R., Malan, N. T., Hamer, M., Lambert, G. W., Schlaich, M., Reimann, M. & Malan, L., 2016, In : Thrombosis and Haemostasis. 115, 1, p. 63-72

Research output: Contribution to journalArticle

5 Citations (Scopus)