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  • 2020
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Author

  • Ursula Kees
Article

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Somers, K., Wen, V. W., Middlemiss, S. M. C., Osborne, B., Forgham, H., Jung, M., Karsa, M., Clifton, M., Bongers, A., Gao, J., Mayoh, C., Raoufi-Rad, N., Kusnadi, E. P., Hannan, K. M., Scott, D. A., Kwek, A., Liu, B., Flemming, C., Chudakova, D. A., Pandher, R. & 17 others, Failes, T. W., Lim, J., Angeli, A., Osterman, A. L., Imamura, T., Kees, U. R., Supuran, C. T., Pearson, R. B., Hannan, R. D., Davis, T. P., McCarroll, J., Kavallaris, M., Turner, N., Gudkov, A. V., Haber, M., Norris, M. D. & Henderson, M. J., 16 May 2019, In : Oncogene. 38, 20, p. 3824-3842 19 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements

Somers, K., Chudakova, D. A., Middlemiss, S. M. C., Wen, V. W., Clifton, M., Kwek, A., Liu, B., Mayoh, C., Bongers, A., Karsa, M., Pan, S., Cruikshank, S., Scandlyn, M., Hoang, W., Imamura, T., Kees, U., Gudkov, A. V., Chernova, O. B., Haber, M., Norris, M. D. & 1 others, Henderson, M. J., 14 Jun 2016, In : Oncotarget. 7, 29, p. 46067-46087 21 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Effective targeting of NAMPT in patient-derived xenograft models of high-risk pediatric acute lymphoblastic leukemia

Somers, K., Evans, K., Cheung, L., Karsa, M., Pritchard, T., Kosciolek, A., Bongers, A., El-Ayoubi, A., Forgham, H., Middlemiss, S., Mayoh, C., Jones, L., Gupta, M., Kees, U. R., Chernova, O., Korotchkina, L., Gudkov, A. V., Erickson, S. W., Teicher, B., Smith, M. A. & 4 others, Norris, M. D., Haber, M., Lock, R. B. & Henderson, M. J., 1 Jun 2020, In : Leukemia. 34, 6, p. 1524-1539 16 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia

Yadav, B. D., Samuels, A. L., Wells, J. E., Sutton, R., Venn, N. C., Bendak, K., Anderson, D., Marshall, G. M., Cole, C. H., Beesley, A. H., Kees, U. R. & Lock, R. B., Sep 2016, In : Oncotarget. 7, 37, p. 58728-58742

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

High expression of connective tissue growth factor accelerates dissemination of leukaemia

Wells, J., Howlett, M., Halse, H. N., Heng, J., Ford, J., Cheung, L. C., Samuels, A. L., Crook, M., Charles, A. K., Cole, C. H. & Kees, U., 2016, In : Oncogene. 35, p. 4591–4600 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Identifying the optimal donor for natural killer cell adoptive therapy to treat paediatric B- and T-cell acute lymphoblastic leukaemia

Foley, B., Ta, C., Barnes, S., de Jong, E., Nguyen, M., Cheung, L. C., Buzzai, A., Wagner, T., Wylie, B., Fernandez, S., Cruickshank, M., Endersby, R., Kees, U. & Waithman, J., 1 Jan 2020, In : Clinical and Translational Immunology. 9, 7, e1151.

Research output: Contribution to journalArticle

Open Access

Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma-an aggressive and fatal disease

Stirnweiss, A., Oommen, J., Kotecha, R. S., Kees, U. R. & Beesley, A. H., 22 Dec 2017, In : Oncotarget. 8, 68, p. 112313-112329 17 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Potent antileukemic activity of curaxin CBL0137 against MLL-rearranged leukemia

Somers, K., Kosciolek, A., Bongers, A., El-Ayoubi, A., Karsa, M., Mayoh, C., Wadham, C., Middlemiss, S., Neznanov, N., Kees, U. R., Lock, R. B., Gudkov, A., Sutton, R., Gurova, K., Haber, M., Norris, M. D. & Henderson, M. J., 20 Jul 2019, In : International Journal of Cancer.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Silencing of GATA3 defines a novel stem cell-like subgroup of ETP-ALL

Fransecky, L., Neumann, M., Heesch, S., Schlee, C., Ortiz-Tanchez, J., Heller, S., Mossner, M., Schwartz, S., Mochmann, L. H., Isaakidis, K., Bastian, L., Kees, U. R., Herold, T., Spiekermann, K., Gökbuget, N. & Baldus, C. D., 2016, In : Journal of Hematology & Oncology. 9, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin

Cruickshank, M. N., Ford, J., Cheung, L. C., Heng, J., Singh, S., Wells, J., Failes, T. W., Arndt, G. M., Smithers, N., Prinjha, R. K., Anderson, D., Carter, K. W., Gout, A. M., Lassmann, T., O'Reilly, J., Cole, C. H., Kotecha, R. S. & Kees, U. R., 1 Jan 2017, In : Leukemia. 31, 1, p. 40-50 11 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
Letter

Romidepsin enhances the efficacy of cytarabine in vivo, revealing histone deacetylase inhibition as a promising therapeutic strategy for KMT2A-rearranged infant acute lymphoblastic leukemia

Cheung, L. C., Cruickshank, M. N., Hughes, A. M., Singh, S., Chua, G-A., Ford, J., Ferrari, E., Oommen, J., Malinge, S., Lock, R. B., Kees, U. R. & Kotecha, R. S., 30 Jun 2019, In : Haematologica. 104, 7, 4 p.

Research output: Contribution to journalLetter

Open Access
1 Citation (Scopus)