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  • Jiake Xu
Article

GdX/UBL4A null mice exhibit mild kyphosis and scoliosis accompanied by dysregulation of osteoblastogenesis and chondrogenesis

Liang, J., Li, J., Fu, Y., Ren, F., Xu, J., Zhou, M., Li, P., Feng, H. & Wang, Y., 1 Apr 2018, In : Cell Biochemistry and Function. 36, 3, p. 129-136 8 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
245 Downloads (Pure)
Open Access
6 Citations (Scopus)

Green synthesis of lignin nanoparticle in aqueous hydrotropic solution toward broadening the window for its processing and application

Chen, L., Zhou, X., Shi, Y., Gao, B., Wu, J., Kirk, T. B., Xu, J. & Xue, W., 15 Aug 2018, In : Chemical Engineering Journal. 346, p. 217-225 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Hederagenin protects mice against ovariectomy-induced bone loss by inhibiting RANKL-induced osteoclastogenesis and bone resorption

Tian, K., Su, Y., Ding, J., Wang, D., Zhan, Y., Li, Y., Liang, J., Lin, X., Song, F., Wang, Z., Xu, J., Liu, Q. & Zhao, J., 1 Mar 2020, In : Life Sciences. 244, 117336.

Research output: Contribution to journalArticle

Helvolic acid attenuates osteoclast formation and function via suppressing RANKL-induced NFATc1 activation

Chen, K., Yuan, Y., Wang, Z., Song, D., Zhao, J., Cao, Z., Chen, J., Guo, Q., Chen, L., Tickner, J. & Xu, J., May 2019, In : Journal of Cellular Physiology. 234, 5, p. 6477-6488 12 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
44 Downloads (Pure)

Hemocompatibility evaluation in vitro of methoxy polyethyleneglycol-polycaprolactone copolymer solutions

Hu, Q., Zhang, Y., Wang, C., Xu, J., Wu, J., Liu, Z. & Xue, W., 2016, In : Journal of Biomedical Materials Research - Part A. 104, 3, p. 802-812

Research output: Contribution to journalArticle

7 Citations (Scopus)

Hemostasis mechanism and applications of N-alkylated chitosan sponge

Huang, Y., Feng, L., Zhang, Y., He, L., Wang, C., Xu, J., Wu, J., Kirk, T. B., Guo, R. & Xue, W., 1 Sep 2017, In : Polymers for Advanced Technologies. 28, 9, p. 1107-1114 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

High-resolution study of the 3D collagen fibrillary matrix of Achilles tendons without tissue labelling and dehydrating

Wu, J. P., Swift, B. J., Becker, T., Squelch, A., Wang, A., Zheng, Y. C., Zhao, X., Xu, J., Xue, W., Zheng, M., Lloyd, D. & Kirk, T. B., Jun 2017, In : Journal of Microscopy. 266, 3, p. 237-287

Research output: Contribution to journalArticle

3 Citations (Scopus)

Hymenialdisine: A Marine Natural Product That Acts on Both Osteoblasts and Osteoclasts and Prevents Estrogen-Dependent Bone Loss in Mice

Wang, Q., Chen, D., Jin, H., Ye, Z., Wang, C., Chen, K., Kuek, V., Xu, K., Qiu, H., Chen, P., Song, D., Zhao, J., Liu, Q., Davis, R. A., Song, F. & Xu, J., 1 Aug 2020, In : Journal of Bone and Mineral Research. 35, 8, p. 1582-1596 15 p.

Research output: Contribution to journalArticle

Inhibitory effects of tubeimoside I on synoviocytes and collagen-induced arthritis in rats

Liu, Z., Zhou, L., Ma, X., Sun, S., Qiu, H., Li, H., Xu, J. & Liu, M., 1 Nov 2018, In : Journal of Cellular Physiology. 233, 11, p. 8740-8753 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Injectable supramolecular hydrogel formed from α-cyclodextrin and PEGylated arginine-functionalized poly(L-lysine) dendron for sustained MMP-9 shRNA plasmid delivery

Lin, Q., Yang, Y., Hu, Q., Guo, Z., Liu, T., Xu, J., Wu, J., Kirk, T. B., Ma, D. & Xue, W., 1 Feb 2017, In : Acta Biomaterialia. 49, p. 456-471 16 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Jatrophane Diterpenoids from Euphorbia esula as Inhibitors of RANKL-Induced Osteoclastogenesis

Yuan, S., Hua, P., Zhao, C., Zhou, H., Xu, J., Xu, J. & Gu, Q., 1 Apr 2020, In : Journal of Natural Products. 83, 4, p. 1005–1017

Research output: Contribution to journalArticle

1 Citation (Scopus)

Light-Triggered Biomimetic Nanoerythrocyte for Tumor-Targeted Lung Metastatic Combination Therapy of Malignant Melanoma

Liu, W., Ruan, M., Wang, Y., Song, R., Ji, X., Xu, J., Dai, J. & Xue, W., 20 Sep 2018, In : Small. 14, 38, 1801754.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Loureirin B suppresses RANKL-induced osteoclastogenesis and ovariectomized osteoporosis via attenuating NFATc1 and ROS activities

Liu, Y., Wang, C., Wang, G., Sun, Y., Deng, Z., Chen, L., Chen, K., Tickner, J., Kenny, J., Song, D., Zhang, Q., Wang, H., Chen, Z., Zhou, C., He, W. & Xu, J., 2019, In : Theranostics. 9, 16, p. 4648-4662 15 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Lumichrome inhibits osteoclastogenesis and bone resorption through suppressing RANKL-induced NFAT activation and calcium signaling

Liu, C., Cao, Z., Zhang, W., Tickner, J., Qiu, H., Wang, C., Chen, K., Wang, Z., Tan, R., Dong, S. & Xu, J., 1 Nov 2018, In : Journal of Cellular Physiology. 233, 11, p. 8971-8983 13 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
163 Downloads (Pure)

Luteoloside prevents lipopolysaccharide-induced osteolysis and suppresses RANKL-induced osteoclastogenesis through attenuating RANKL signaling cascades

Song, F., Wei, C., Zhou, L., Qin, A., Yang, M., Tickner, J., Huang, Y., Zhao, J. & Xu, J., 1 Feb 2018, In : Journal of Cellular Physiology. 233, 2, p. 1723-1735 13 p.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
250 Downloads (Pure)

Macrophages release plasma membrane-derived particles rich in accessible cholesterol

He, C., Hu, X., Weston, T. A., Jung, R. S., Sandhu, J., Huang, S., Heizer, P., Kim, J., Ellison, R., Xu, J., Kilburn, M., Bensinger, S. J., Riezman, H., Tontonoz, P., Fong, L. G., Jiang, H. & Young, S. G., 4 Sep 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 36, p. E8499-E8508

Research output: Contribution to journalArticle

9 Citations (Scopus)

Madecassoside inhibits estrogen deficiency-induced osteoporosis by suppressing RANKL-induced osteoclastogenesis

Wang, Q., Yao, L., Xu, K., Jin, H., Chen, K., Wang, Z., Liu, Q., Cao, Z., Kenny, J., Liu, Y., Tickner, J., Xu, H. & Xu, J., Jan 2019, In : Journal of Cellular and Molecular Medicine. 23, 1, p. 380-394 15 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Mechanical Stress Regulates Bone Metabolism Through MicroRNAs

Yuan, Y., Zhang, L., Tong, X., Zhang, M., Zhao, Y., Guo, J., Lei, L., Chen, X., Tickner, J., Xu, J. & Zou, J., 1 Jun 2017, In : Journal of Cellular Physiology. 232, 6, p. 1239-1245 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Melphalan modifies the bone microenvironment by enhancing osteoclast formation

Chai, R. C., McDonald, M. M., Terry, R. L., Kovacic, N., Down, J. M., Pettitt, J. A., Mohanty, S. T., Shah, S., Haffari, G., Xu, J., Gillespie, M. T., Rogers, M. J., Price, J. T., Croucher, P. I. & Quinn, J. M. W., 15 Sep 2017, In : Oncotarget. 8, 40, p. 68047-68058 12 p.

Research output: Contribution to journalArticle

Open Access

MiR-214 Attenuates the Osteogenic Effects of Mechanical Loading on Osteoblasts

Yuan, Y., Guo, J., Zhang, L., Tong, X., Zhang, S., Zhou, X., Zhang, M., Chen, X., Lei, L., Li, H., Liu, T. C. Y., Xu, J. & Zou, J., Dec 2019, In : International Journal of Sports Medicine. 40, 14, p. 931-940 10 p.

Research output: Contribution to journalArticle

Modulating calcium-mediated NFATc1 and mitogen-activated protein kinase deactivation underlies the inhibitory effects of kavain on osteoclastogenesis and bone resorption

Guo, Q., Cao, Z., Wu, B., Chen, F., Tickner, J., Wang, Z., Qiu, H., Wang, C., Chen, K., Tan, R., Gao, Q. & Xu, J., Jan 2019, In : Journal of Cellular Physiology. 234, 1, p. 789-801 13 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
246 Downloads (Pure)

Monocrotaline Suppresses RANKL-Induced Osteoclastogenesis in Vitro and Prevents LPS-Induced Bone Loss in Vivo

Wei, C. M., Su, Y. J., Qin, X., Ding, J. X., Liu, Q., Song, F. M., Zong, S. H., Xu, J., Zhou, B. & Zhao, J. M., 1 Aug 2018, In : Cellular Physiology and Biochemistry. 48, 2, p. 644-656 13 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
Open Access
10 Citations (Scopus)

Natural Compounds for the Treatment of Psoriatic Arthritis: A Proposal Based on Multi-Targeted Osteoclastic Regulation and on a Preclinical Study

Deng, S., Cheng, J., Zhao, J., Yao, F. & Xu, J., 11 Jul 2017, In : JMIR Research Protocols. 6, 7, e132.

Research output: Contribution to journalArticle

Open Access

Neohesperidin suppresses osteoclast differentiation, bone resorption and ovariectomised-induced osteoporosis in mice

Tan, Z., Cheng, J., Liu, Q., Zhou, L., Kenny, J., Wang, T., Lin, X., Yuan, J., Quinn, J. M. W., Tickner, J., Hong, G., Qin, A., Zhao, J. & Xu, J., 5 Jan 2017, In : Molecular and Cellular Endocrinology. 439, p. 369-378 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats

Su, Y., Chung, R., Ruan, C., Chim, S., Kuek, V., Dwivedi, P., Hassanshahi, M., Chen, K., Xie, Y., Chen, L., Foster, B., Rosen, V., Zhou, X., Xu, J. & Xian, C., Jun 2016, In : Journal of Bone & Mineral Research. 31, 6, p. 1258-1274

Research output: Contribution to journalArticle

26 Citations (Scopus)

Nitidine chloride prevents OVX-induced bone loss via suppressing NFATc1-mediated osteoclast differentiation

Liu, Q., Wang, T., Zhou, L., Song, F., Qin, A., Feng, H. T., Lin, X. X., Lin, Z., Yuan, J. B., Tickner, J., Liu, H. G., Zheng, M. H., Xu, J. & Zhao, J. M., 8 Nov 2016, In : Scientific Reports. 6, p. 1-10 36662 .

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

NPNT is expressed by osteoblasts and mediates angiogenesis via the activation of extracellular signal-regulated kinase

Kuek, V., Yang, Z., Chim, S., Zhu, S., Xu, H., Chow, S. T., Tickner, J., Rosen, V., Erber, W., Li, X., An, Q., Qian, Y. & Xu, J., 26 Oct 2016, In : Scientific Reports. 6, p. 1-13 13 p., 36210.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
368 Downloads (Pure)

Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats

Su, Y. W., Chim, S. M., Zhou, L., Hassanshahi, M., Chung, R., Fan, C., Song, Y., Foster, B. K., Prestidge, C. A., Peymanfar, Y., Tang, Q., Butler, L. M., Gronthos, S., Chen, D., Xie, Y., Chen, L., Zhou, X. F., Xu, J. & Xian, C. J., 1 Nov 2018, In : Bone. 116, p. 232-247 16 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Li, D., Liu, J., Guo, B., Liang, C., Dang, L., Lu, C., He, X., Cheung, H. Y. S., Xu, L., He, B., Liu, B., Shaikh, A. B., Li, F., Wang, L., Yang, Z., Au, D. W. T., Peng, S., Zhang, Z., Zhang, B. T., Pan, X. & 13 others, Qian, A., Shang, P., Xiao, L., Jiang, B., Wong, C. K. C., Xu, J., Bian, Z., Liang, Z., Guo, D. A., Zhu, H., Tan, W., Lu, A. & Zhang, G., 2016, In : Nature Communications. 7

Research output: Contribution to journalArticle

158 Citations (Scopus)

Osthole inhibits osteoclasts formation and bone resorption by regulating NF-κB signaling and NFATc1 activations stimulated by RANKL

Ma, Y., Wang, L., Zheng, S., Xu, J., Pan, Y., Tu, P., Sun, J. & Guo, Y., 1 Sep 2019, In : Journal of Cellular Biochemistry. 120, 9, p. 16052-16061 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Pectolinarigenin prevents bone loss in ovariectomized mice and inhibits RANKL-induced osteoclastogenesis via blocking activation of MAPK and NFATc1 signaling

Xiao, Y., Li, K., Wang, Z., Fu, F., Shao, S., Song, F., Zhao, J., Chen, W., Liu, Q. & Xu, J., 1 Aug 2019, In : Journal of Cellular Physiology. 234, 8, p. 13959-13968 10 p.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
11 Downloads (Pure)

Poria cocos polysaccharide attenuates RANKL-induced osteoclastogenesis by suppressing NFATc1 activity and phosphorylation of ERK and STAT3

Song, D., Cao, Z., Tickner, J., Qiu, H., Wang, C., Chen, K., Wang, Z., Guo, C., Dong, S. & Xu, J., 1 Jun 2018, In : Archives of Biochemistry and Biophysics. 647, p. 76-83 8 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
233 Downloads (Pure)

Pseurotin A inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppressing reactive oxygen species

Chen, K., Qiu, P., Yuan, Y., Zheng, L., He, J., Wang, C., Guo, Q., Kenny, J., Liu, Q., Zhao, J., Chen, J., Tickner, J., Fan, S., Lin, X. & Xu, J., 28 Feb 2019, In : Theranostics. 9, 6, p. 1634-1650

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
515 Downloads (Pure)

Redox-responsive chemosensitive polyspermine delivers ursolic acid targeting to human breast tumor cells: The depletion of intracellular GSH contents arouses chemosensitizing effects

Ji, X., Tang, Q., Pang, P., Wu, J., Kirk, T. B., Xu, J., Ma, D. & Xue, W., 1 Oct 2018, In : Colloids and Surfaces B: Biointerfaces. 170, p. 293-302 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Reduction-Responsive Codelivery System Based on a Metal-Organic Framework for Eliciting Potent Cellular Immune Response

Yang, Y., Chen, Q., Wu, J-P., Kirk, T. B., Xu, J., Liu, Z. & Xue, W., 18 Apr 2018, In : ACS APPLIED MATERIALS & INTERFACES. 10, 15, p. 12463-12473 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways

Liao, S., Song, F., Feng, W., Ding, X., Yao, J., Song, H., Liu, Y., Ma, S., Wang, Z., Lin, X., Xu, J., Zhao, J. & Liu, Q., 1 Oct 2019, In : Journal of Cellular Physiology. 234, 10, p. 17600-17611 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Salidroside promotes rat spinal cord injury recovery by inhibiting inflammatory cytokine expression and NF-κB and MAPK signaling pathways

Su, Y., Zong, S., Wei, C., Song, F., Feng, H., Qin, A., Lian, Z., Fu, F., Shao, S., Fang, F., Wu, T., Xu, J., Liu, Q. & Zhao, J., 1 Aug 2019, In : Journal of Cellular Physiology. 234, 8, p. 14259-14269 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Sclareol prevents ovariectomy-induced bone loss: In vivo and inhibits osteoclastogenesis in vitro via suppressing NF-κB and MAPK/ERK signaling pathways

Jin, H., Shao, Z., Wang, Q., Miao, J., Bai, X., Liu, Q., Qiu, H., Wang, C., Zhang, Z., Jennifer, T., Wang, X. & Xu, J., 1 Oct 2019, In : Food and Function. 10, 10, p. 6556-6567 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Scutellarein inhibits RANKL-induced osteoclast formation in vitro and prevents LPS-induced bone loss in vivo

Fu, F., Shao, S., Wang, Z., Song, F., Lin, X., Ding, J., Li, C., Wu, Z., Li, K., Xiao, Y., Su, Y., Zhao, J., Liu, Q. & Xu, J., 1 Jul 2019, In : Journal of Cellular Physiology. 234, 7, p. 11951-11959 9 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
148 Downloads (Pure)

Sinomenine down-regulates TLR4/TRAF6 expression and attenuates lipopolysaccharide-induced osteoclastogenesis and osteolysis

He, L., Duan, H., Li, X., Wang, S., Zhang, Y., Lei, L., Xu, J. & Liu, S., 2016, In : European Journal of Pharmacology. 779, p. 66-79

Research output: Contribution to journalArticle

13 Citations (Scopus)

Star-Shaped Amphiphilic Hyperbranched Polyglycerol Conjugated with Dendritic Poly(L-lysine) for the Codelivery of Docetaxel and MMP-9 siRNA in Cancer Therapy

Zhou, X., Zheng, Q., Wang, C., Xu, J., Wu, J. P., Kirk, T. B., Ma, D. & Xue, W., 2016, In : ACS Applied Materials and Interfaces. 8, 20, p. 12609-12619 11 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts

Chen, K., Liu, Y., He, J., Pavlos, N., Wang, C., Kenny, J., Yuan, J., Zhang, Q., Xu, J. & He, W., 2020, In : International Journal of Biological Sciences. 16, 11, p. 1888-1900 13 p.

Research output: Contribution to journalArticle

Open Access

Synthesis of Janus Au nanorods/polydivinylbenzene hybrid nanoparticles for chemo-photothermal therapy

Wang, Y., Ji, X., Pang, P., Shi, Y., Dai, J., Xu, J., Wu, J., Kirk, T. B. & Xue, W., 28 Apr 2018, In : Journal of Materials Chemistry B. 6, 16, p. 2481-2488 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The Emerging Role of MORC Family Proteins in Cancer Development and Bone Homeostasis

Hong, G., Qiu, H., Wang, C., Jadhav, G., Wang, H., Tickner, J., He, W. & Xu, J., 1 May 2017, In : Journal of Cellular Physiology. 232, 5, p. 928-934 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Therapeutic anabolic and anticatabolic benefits of natural Chinese medicines for the treatment of osteoporosis

He, J., Li, X., Wang, Z., Bennett, S., Chen, K., Xiao, Z., Zhan, J., Chen, S., Hou, Y., Chen, J., Wang, S., Xu, J. & Lin, D., 25 Nov 2019, In : Frontiers in Pharmacology. 10, 1344.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

The repair and autophagy mechanisms of hypoxia-regulated bFGF-modified primary embryonic neural stem cells in spinal cord injury

Zhu, S., Chen, M., Deng, L., Zhang, J., Ni, W., Wang, X., Yao, F., Li, X., Xu, H., Xu, J. & Xiao, J., 6 Feb 2020, In : Stem Cells Translational Medicine. 17 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

The y6 receptor suppresses bone resorption and stimulates bone formation in mice via a suprachiasmatic nucleus relay

Khor, E. C., Yulyaningsih, E., Driessler, F., Kovaĉić, N., Wee, N. K. Y., Kulkarni, R. N., Lee, N. J., Enriquez, R. F., Xu, J., Zhang, L., Herzog, H. & Baldock, P. A., Mar 2016, In : Bone. 84, p. 139-147 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Three dimensional microstructural network of elastin, collagen, and cells in Achilles tendons

Pang, X., Wu, J-P., Allison, G. T., Xu, J., Rubenson, J., Zheng, M-H., Lloyd, D. G., Gardiner, B., Wang, A. & Kirk, T. B., Jun 2017, In : Journal of Orthopaedic Research. 35, 6, p. 1203-1214

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
213 Downloads (Pure)