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  • Jiake Xu
Abstract
Abstract/Meeting Abstract

PIP5k1 beta controls bone homeostasis through modulating both osteoclast and osteoblast differentiation

Zhao, X., Cui, P., Wang, C., Zhao, J., Zhang, X. & Xu, J., Dec 2019, In : Journal of Bone and Mineral Research. 34, p. 328-328 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Article

A005, a novel inhibitor of phosphatidylinositol 3-kinase/mammalian target of rapamycin, prevents osteosarcoma-induced osteolysis

Lian, Z., Han, J., Huang, L., Wei, C., Fan, Y., Xu, J., Zhou, M., Feng, H., Liu, Q., Chen, L., Li, Z., Cheng, H., Yuan, G., Lin, X., Song, F., Su, Y., Wang, C., Huang, G., Qin, A., Song, Y. & 1 others, Yao, G., 1 Jan 2019, In : Carcinogenesis. 40, 2, p. E1-E13

Research output: Contribution to journalArticle

2 Citations (Scopus)

Achyranthes bidentata polysaccharide suppresses osteoclastogenesis and bone resorption via inhibiting RANKL signaling

Song, D., Cao, Z., Huang, S., Tickner, J., Li, N., Qiu, H., Chen, X., Wang, C., Chen, K., Sun, Y., Dong, S. & Xu, J., 1 Jun 2018, In : Journal of Cellular Biochemistry. 119, 6, p. 4826-4835 10 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
322 Downloads (Pure)

A conceptual framework for computational models of Achilles tendon homeostasis

Smith, D., Rubenson, J., Lloyd, D., Zheng, M., Fernandez, J., Besier, T., Xu, J. & Gardiner, B., 2013, In : Wiley Interdisciplinary Reviews-Systems Biology and Medicine. 5, 5, p. 523-538

Research output: Contribution to journalArticle

20 Citations (Scopus)

A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation of microRNAs in osteoclasts

Liu, J., Dang, L., Li, D., Liang, C., He, X., Wu, H., Qian, A., Yang, Z., Au, D. W. T., Chiang, M. W. L., Zhang, B. T., Han, Q., Yue, K. K. M., Zhang, H., Lv, C., Pan, X., Xu, J., Bian, Z., Shang, P., Tan, W. & 4 others, Liang, Z., Guo, B., Lu, A. & Zhang, G., 2015, In : Biomaterials. 52, 1, p. 148-160

Research output: Contribution to journalArticle

38 Citations (Scopus)

Amyloid β peptide enhances RANKL-induced osteoclast activation through NF-κB, ERK, and calcium oscillation signaling

Li, S., Yang, B., Teguh, D., Zhou, L., Xu, J. & Rong, L., 1 Oct 2016, In : International Journal of Molecular Sciences. 17, 10, 1683.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Analysis of circulating microRNAs aberrantly expressed in alcohol-induced osteonecrosis of femoral head

Hong, G., Han, X., He, W., Xu, J., Sun, P., Shen, Y., Wei, Q. & Chen, Z., 1 Dec 2019, In : Scientific Reports. 9, 1, 18926.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Andrographolide inhibits ovariectomy-induced bone loss via the suppression of RANKL signaling pathways

Wang, T., Liu, Q., Zhou, L., Yuan, J., Lin, X., Zeng, R., Liang, X., Zhao, J. & Xu, J., 17 Nov 2015, In : International Journal of Molecular Sciences. 16, 11, p. 27470-27481 12 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

An overview of the regulation of bone remodelling at the cellular level

Kular, J., Tickner, J., Chim, S. & Xu, J., 2012, In : Clinical Biochemistry. 45, p. 863-873

Research output: Contribution to journalArticle

200 Citations (Scopus)

Anti-catabolic effect of caffeic acid phenethyl ester, an active component of honeybee propolis on bone loss in ovariectomized mice: a micro-computed tomography study and histological analysis

Duan, W., Wang, Q., Li, F., Xiang, C., Zhou, L., Xu, J., Feng, H. & Wei, X., 2014, In : Chinese Medical Journal. 127, p. 3932-3936

Research output: Contribution to journalArticle

2 Citations (Scopus)

A polyamidoamne dendrimer functionalized graphene oxide for DOX and MMP-9 shRNA plasmid co-delivery

Gu, Y., Guo, Y., Wang, C., Xu, J., Wu, J., Kirk, T. B., Ma, D. & Xue, W., 1 Jan 2017, In : Materials Science and Engineering C. 70, p. 572-585 14 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy

Liang, C., Guo, B., Wu, H., Shao, N., Li, D., Liu, J., Dang, L., Wang, C., Li, H., Li, S., Lau, W. K., Cao, Y., Yang, Z., Lu, C., He, X., Au, D. W. T., Pan, X., Zhang, B. T., Zhang, H., Yue, K. & 11 others, Qian, A., Shang, P., Xu, J., Xiao, L., Bian, Z., Tan, W., Liang, Z., He, F., Zhang, L., Lu, A. & Zhang, G., 2015, In : Nature Medicine. 21, 3, p. 288-296

Research output: Contribution to journalArticle

129 Citations (Scopus)

Artesunate inhibits RANKL-induced osteoclastogenesis and bone resorption in vitro and prevents LPS-induced bone loss in vivo

Wei, C. M., Liu, Q., Song, F. M., Lin, X. X., Su, Y. J., Xu, J., Huang, L., Zong, S. H. & Zhao, J. M., 1 Jan 2018, In : Journal of Cellular Physiology. 233, 1, p. 476-485 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Artesunate suppresses RANKL-induced osteoclastogenesis through inhibition of PLCγ1-Ca2+–NFATc1 signaling pathway and prevents ovariectomy-induced bone loss

Zeng, X., Zhang, Y., Wang, S., Wang, K., Tao, L., Zou, M., Chen, N., Xu, J., Liu, S. & Li, X., 15 Jan 2017, In : Biochemical Pharmacology. 124, p. 57-68 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Asiatic Acid Inhibits OVX-Induced Osteoporosis and Osteoclastogenesis Via Regulating RANKL-Mediated NF-κb and Nfatc1 Signaling Pathways

Hong, G., Zhou, L., Han, X., Sun, P., Chen, Z., He, W., Tickner, J., Chen, L., Shi, X. & Xu, J., 27 Mar 2020, In : Frontiers in Pharmacology. 11, 331.

Research output: Contribution to journalArticle

Open Access

Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-kappa B signaling pathways

He, L., Hong, G., Zhou, L., Zhang, J., Fang, J., He, W., Tickner, J., Han, X., Zhao, L. & Xu, J., Apr 2019, In : Journal of Cellular Physiology. 234, 4, p. 4267-4276 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Asperpyrone A attenuates RANKL-induced osteoclast formation through inhibiting NFATc1, Ca2+ signalling and oxidative stress

Chen, X., Wang, C., Qiu, H., Yuan, Y., Chen, K., Cao, Z., Xiang Tan, R., Tickner, J., Xu, J. & Zou, J., 1 Dec 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8269-8279 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Astilbin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis

Jin, H., Wang, Q., Chen, K., Xu, K., Pan, H., Chu, F., Ye, Z., Wang, Z., Tickner, J., Qiu, H., Wang, C., Kenny, J., Xu, H., Wang, T. & Xu, J., 1 Dec 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8355-8368 14 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Autologous tenocyte therapy for experimental achilles tendinopathy in a rabbit model

Chen, J., Yu, Q., Wu, B., Lin, Z., Pavlos, N., Xu, J., Ouyang, H., Wang, A. & Zheng, M., 2011, In : Tissue Engineering - Part A. 17, p. 2037-2049

Research output: Contribution to journalArticle

55 Citations (Scopus)
5 Citations (Scopus)

Bajijiasu abrogates osteoclast differentiation via the suppression of RANKL signaling pathways through NF-κB and NFAT

Hong, G., Zhou, L., Shi, X., He, W., Wang, H., Wei, Q., Chen, P., Qi, L., Tickner, J., Lin, L. & Xu, J., 19 Jan 2017, In : International Journal of Molecular Sciences. 18, 1, 12 p., 203.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Berberine Sulfate Attenuates Osteoclast Differentiation through RANKL Induced NF-B and NFAT Pathways

Zhou, L., Song, F., Liu, Q., Yang, M., Zhao, J., Tan, R., Xu, J., Zhang, G., Quinn, J. M. W., Tickner, J. & Xu, J., 2015, In : International Journal of Molecular Sciences. 16, 11, p. 27087-27096

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Biocompatibility and cellular uptake mechanisms of poly(N -isopropylacrylamide) in different cells

Guo, Z., Li, S., Wang, C., Xu, J., Kirk, B., Wu, J., Liu, Z. & Xue, W., 1 Jan 2017, In : Journal of Bioactive and Compatible Polymers. 32, 1, p. 17-31 15 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Biocompatible hyperbranched polyglycerol modified β-cyclodextrin derivatives for docetaxel delivery

Xu, Z., Zhang, Y., Hu, Q., Tang, Q., Xu, J., Wu, J., Kirk, T. B., Ma, D. & Xue, W., 1 Feb 2017, In : Materials Science and Engineering C. 71, p. 965-972 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Caffeic Acid Phenethyl Ester Abrogates Bone Resorption in a Murine Calvarial Model of Polyethylene Particle-Induced Osteolysis

Zawawi, M. S. F., Perilli, E., Stansborough, R. L., Marino, V., Cantley, M. D., Xu, J., Dharmapatni, A. A. S. S. K., Haynes, D. R., Gibson, R. J. & Crotti, T. N., 2015, In : Calcified Tissue International. 96, 6, p. 565-574

Research output: Contribution to journalArticle

7 Citations (Scopus)

Cajaninstilbene acid inhibits osteoporosis through suppressing osteoclast formation and RANKL-induced signaling pathways

Sun, Y., Liu, Y., He, W., Wang, C., Tickner, J., Kuek, V., Zhou, C., Wang, H., Zou, X., Hong, Z., Yang, F., Shao, M., Chen, L. & Xu, J., 1 Jul 2019, In : Journal of Cellular Physiology. 234, 7, p. 11792-11804 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Calmodulin interacts with Rab3D and modulates osteoclastic bone resorption

Zhu, S., Chim, S. M., Cheng, T., Ang, E., Ng, B., Lim, B., Chen, K., Qiu, H., Tickner, J., Xu, H., Pavlos, N. & Xu, J., 29 Nov 2016, In : Scientific Reports. 6, p. 1-9

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Carnosic acid inhibits inflammation response and joint destruction on osteoclasts, fibroblast-like synoviocytes, and collagen-induced arthritis rats

Liu, M., Zhou, X., Zhou, L., Liu, Z., Yuan, J., Cheng, J., Zhao, J., Wu, L., Li, H., Qiu, H. & Xu, J., 1 Aug 2018, In : Journal of Cellular Physiology. 233, 8, p. 6291-6303 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Cepharanthine suppresses osteoclast formation by modulating the nuclear factor-κB and nuclear factor of activated T-cell signaling pathways

Lin, X., Song, F., Zhou, L., Wang, Z., Wei, C., Xu, J., Zhao, J. & Liu, Q., 1 Feb 2019, In : Journal of Cellular Biochemistry. 120, 2, p. 1990-1996 7 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
49 Downloads (Pure)

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts

Mullin, B., Tickner, J., Zhu, K., Kenny, J., Mullin, S., Brown, S. J., Dudbridge, F., Pavlos, N., Mocarski, E. S., Walsh, J. P., Xu, J. & Wilson, S., 26 Mar 2020, In : Genome Biology. 21, 80.

Research output: Contribution to journalArticle

Open Access

CHIP/Stub1 functions as a tumor suppressor and represses NF-κB-mediated signaling in colorectal cancer

Wang, Y., Ren, F., Feng, Y., Wang, D., Jia, B., Qiu, Y., Wang, S., Yu, J., Sung, J., Xu, J., Zeps, N. & Chang, Z., 2014, In : Carcinogenesis. 35, 5, p. 983-991

Research output: Contribution to journalArticle

50 Citations (Scopus)

CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma

Shang, Y., He, J., Wang, Y., Feng, Q., Zhang, Y., Guo, J., Li, J., Li, S., Wang, Y., Yan, G., Ren, F., Shi, Y., Xu, J., Zeps, N., Zhai, Y., He, D. & Chang, Z., 20 Jul 2017, In : Oncogene. 36, 29, p. 4191-4200 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Choline kinase β mutant mice exhibit reduced phosphocholine, elevated osteoclast activity, and low bone mass

Kular, J., Tickner, J., Pavlos, N., Viola, H., Abel, T., Lim, B., Yang, X., Chen, H., Cook, R., Hool, L., Zheng, M. & Xu, J., 16 Jan 2015, In : Journal of Biological Chemistry. 290, 3, p. 1729-1742

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

Cistanche deserticola polysaccharide attenuates osteoclastogenesis and bone resorption via inhibiting RANKL signaling and reactive oxygen species production

Song, D., Cao, Z., Liu, Z., Tickner, J., Qiu, H., Wang, C., Chen, K., Wang, Z., Dong, S. & Xu, J., 1 Dec 2018, In : Journal of Cellular Physiology. 233, 12, p. 9674-9684 11 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
135 Downloads (Pure)

Comparative and quantitative proteomic analysis of normal and degenerated human annulus fibrosus cells

Ye, D., Liang, W., Dai, L., Zhou, L., Yao, Y., Zhong, X., Chen, H. & Xu, J., 2015, In : Clinical and Experimental Pharmacology and Physiology. 42, 5, p. 530-536

Research output: Contribution to journalArticle

8 Citations (Scopus)

Construction and biomechanical properties of polyaxial self-locking anatomical plate based on the geometry of distal tibia

Liang, W., Ye, W., Ye, D., Zhou, Z., Chen, Z., Li, A., Xie, Z., Zhang, L. & Xu, J., 2014, In : BioMed Research International. 2014, p. 1-7

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
18 Citations (Scopus)

Coupling factors and exosomal packaging microRNAs involved in the regulation of bone remodelling

Zhu, S., Yao, F., Qiu, H., Zhang, G., Xu, H. & Xu, J., Feb 2018, In : Biological Reviews. 93, 1, p. 469-480 12 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
456 Downloads (Pure)

Cumambrin A prevents OVX-induced osteoporosis via the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways

Zhou, L., Liu, Q., Hong, G., Song, F., Zhao, J., Yuan, J., Xu, J., Tan, R. X., Tickner, J., Gu, Q. & Xu, J., 1 Jun 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 6, p. 6726-6735 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Cyanidin Chloride inhibits ovariectomy-induced osteoporosis by suppressing RANKL-mediated osteoclastogenesis and associated signaling pathways

Cheng, J., Zhou, L., Liu, Q., Tickner, J., Tan, Z., Li, X., Liu, M., Lin, X., Wang, T., Pavlos, N. J., Zhao, J. & Xu, J., 1 Mar 2018, In : Journal of Cellular Physiology. 233, 3, p. 2502-2512 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Cytochalasin Z11 inhibits RANKL-induced osteoclastogenesis: Via suppressing NFATc1 activation

Wang, L., Chen, K., He, J., Kenny, J., Yuan, Y., Chen, J., Liu, Q., Tan, R., Zhao, J. & Xu, J., 25 Nov 2019, In : RSC Advances. 9, 66, p. 38438-38446 9 p.

Research output: Contribution to journalArticle

Open Access

Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation

Fan, X., Xiong, H., Wei, J., Gao, X., Feng, Y., Liu, X., Zhang, G., He, Q. Y., Xu, J. & Liu, L., 2015, In : Scientific Reports. 5, p. Article 17732

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Daphnetin attenuates LPS-induced osteolysis and RANKL mediated osteoclastogenesis through suppression of ERK and NFATc1 pathways

Wu, Z., Wu, H., Li, C., Fu, F., Ding, J., Shao, S., Li, K., Yu, X., Su, Y., Liang, J., Lin, X., Yuan, G., Zhou, J., Song, F., Zhao, J., Xu, J., Liu, Q. & Xu, F., 1 Oct 2019, In : Journal of Cellular Physiology. 234, 10, p. 17812-17823 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation

Zhou, C., You, Y., Shen, W., Zhu, Y. Z., Peng, J., Feng, H. T., Wang, Y., Li, D., Shao, W. W., Li, C. X., Li, W. Z., Xu, J. & Shen, X., 2016, In : Annals of the Rheumatic Diseases. n/a, p. 1-8

Research output: Contribution to journalArticle

14 Citations (Scopus)

Dehydrocostus lactone (DHC) suppresses estrogen deficiency-induced osteoporosis

Li, Z., Yuan, G., Lin, X., Liu, Q., Xu, J., Lian, Z., Song, F., Zheng, J., Xie, D., Chen, L., Wang, X., Feng, H., Zhou, M. & Yao, G., 1 May 2019, In : Biochemical Pharmacology. 163, p. 279-289 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Dexamethasone shifts bone marrow stromal cells from osteoblasts to adipocytes by C/EBPαlpha promoter methylation

Li, J., Zhang, N., Huang, X., Xu, J., Fernandes, J. C., Dai, K. & Zhang, X., 2013, In : Cell Death & Disease. 4, p. 11pp

Research output: Contribution to journalArticle

Open Access
80 Citations (Scopus)

Differential expression of extracellular-Signal-Regulated kinase 5 (ERK5) in normal and degenerated human nucleus pulposus tissues and cells

Liang, W., Fang, D., Ye, D., Zou, L., Shen, Y., Dai, L. & Xu, J., 2014, In : Biochemical and Biophysical Research Communications. 449, 4, p. 466-470

Research output: Contribution to journalArticle

3 Citations (Scopus)