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PIP5k1 beta controls bone homeostasis through modulating both osteoclast and osteoblast differentiation

Zhao, X., Cui, P., Wang, C., Zhao, J., Zhang, X. & Xu, J., Dec 2019, In : Journal of Bone and Mineral Research. 34, p. 328-328 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Article
1 Citation (Scopus)

A005, a novel inhibitor of phosphatidylinositol 3-kinase/mammalian target of rapamycin, prevents osteosarcoma-induced osteolysis

Lian, Z., Han, J., Huang, L., Wei, C., Fan, Y., Xu, J., Zhou, M., Feng, H., Liu, Q., Chen, L., Li, Z., Cheng, H., Yuan, G., Lin, X., Song, F., Su, Y., Wang, C., Huang, G., Qin, A., Song, Y. & 1 othersYao, G., 1 Jan 2019, In : Carcinogenesis. 40, 2, p. E1-E13

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Osteolysis
Osteosarcoma
Sirolimus
RANK Ligand
6 Citations (Scopus)
266 Downloads (Pure)

Achyranthes bidentata polysaccharide suppresses osteoclastogenesis and bone resorption via inhibiting RANKL signaling

Song, D., Cao, Z., Huang, S., Tickner, J., Li, N., Qiu, H., Chen, X., Wang, C., Chen, K., Sun, Y., Dong, S. & Xu, J., 1 Jun 2018, In : Journal of Cellular Biochemistry. 119, 6, p. 4826-4835 10 p.

Research output: Contribution to journalArticle

Open Access
File
Achyranthes
Bone Resorption
Osteogenesis
Osteoclasts
Polysaccharides
8 Citations (Scopus)

Amyloid β peptide enhances RANKL-induced osteoclast activation through NF-κB, ERK, and calcium oscillation signaling

Li, S., Yang, B., Teguh, D., Zhou, L., Xu, J. & Rong, L., 1 Oct 2016, In : International Journal of Molecular Sciences. 17, 10, 1683.

Research output: Contribution to journalArticle

Open Access
Calcium Signaling
Extracellular Signal-Regulated MAP Kinases
Osteoclasts
Amyloid
Peptides

Analysis of circulating microRNAs aberrantly expressed in alcohol-induced osteonecrosis of femoral head

Hong, G., Han, X., He, W., Xu, J., Sun, P., Shen, Y., Wei, Q. & Chen, Z., 1 Dec 2019, In : Scientific Reports. 9, 1, 18926.

Research output: Contribution to journalArticle

Open Access
Osteonecrosis
Thigh
MicroRNAs
Alcohols
Bone and Bones
36 Citations (Scopus)

A polyamidoamne dendrimer functionalized graphene oxide for DOX and MMP-9 shRNA plasmid co-delivery

Gu, Y., Guo, Y., Wang, C., Xu, J., Wu, J., Kirk, T. B., Ma, D. & Xue, W., 1 Jan 2017, In : Materials Science and Engineering C. 70, p. 572-585 14 p.

Research output: Contribution to journalArticle

Dendrimers
Polyetherimides
plasmids
Graphite
dendrimers
14 Citations (Scopus)

Artesunate inhibits RANKL-induced osteoclastogenesis and bone resorption in vitro and prevents LPS-induced bone loss in vivo

Wei, C. M., Liu, Q., Song, F. M., Lin, X. X., Su, Y. J., Xu, J., Huang, L., Zong, S. H. & Zhao, J. M., 1 Jan 2018, In : Journal of Cellular Physiology. 233, 1, p. 476-485 10 p.

Research output: Contribution to journalArticle

Bone Resorption
Osteogenesis
Lipopolysaccharides
Bone
Bone and Bones
16 Citations (Scopus)

Artesunate suppresses RANKL-induced osteoclastogenesis through inhibition of PLCγ1-Ca2+–NFATc1 signaling pathway and prevents ovariectomy-induced bone loss

Zeng, X., Zhang, Y., Wang, S., Wang, K., Tao, L., Zou, M., Chen, N., Xu, J., Liu, S. & Li, X., 15 Jan 2017, In : Biochemical Pharmacology. 124, p. 57-68 12 p.

Research output: Contribution to journalArticle

Ovariectomy
Osteogenesis
Bone
Bone and Bones
Calcineurin
4 Citations (Scopus)

Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-kappa B signaling pathways

He, L., Hong, G., Zhou, L., Zhang, J., Fang, J., He, W., Tickner, J., Han, X., Zhao, L. & Xu, J., Apr 2019, In : Journal of Cellular Physiology. 234, 4, p. 4267-4276 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Asperpyrone A attenuates RANKL-induced osteoclast formation through inhibiting NFATc1, Ca2+ signalling and oxidative stress

Chen, X., Wang, C., Qiu, H., Yuan, Y., Chen, K., Cao, Z., Xiang Tan, R., Tickner, J., Xu, J. & Zou, J., 1 Dec 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8269-8279 11 p.

Research output: Contribution to journalArticle

Open Access
Osteoclasts
Osteogenesis
Osteoporosis
Oxidative Stress
Messenger RNA
1 Citation (Scopus)

Astilbin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis

Jin, H., Wang, Q., Chen, K., Xu, K., Pan, H., Chu, F., Ye, Z., Wang, Z., Tickner, J., Qiu, H., Wang, C., Kenny, J., Xu, H., Wang, T. & Xu, J., 1 Dec 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8355-8368 14 p.

Research output: Contribution to journalArticle

Open Access
Osteogenesis
Bone and Bones
Osteoclasts
Osteoporosis
Bone Diseases
3 Citations (Scopus)
Acidification
Osteoclasts
Adenosine Triphosphatases
Proton Pumps
Proteins
12 Citations (Scopus)

Bajijiasu abrogates osteoclast differentiation via the suppression of RANKL signaling pathways through NF-κB and NFAT

Hong, G., Zhou, L., Shi, X., He, W., Wang, H., Wei, Q., Chen, P., Qi, L., Tickner, J., Lin, L. & Xu, J., 19 Jan 2017, In : International Journal of Molecular Sciences. 18, 1, 12 p., 203.

Research output: Contribution to journalArticle

Open Access
Osteoclasts
bones
Bone
retarding
Bone Resorption
7 Citations (Scopus)

Biocompatibility and cellular uptake mechanisms of poly(N -isopropylacrylamide) in different cells

Guo, Z., Li, S., Wang, C., Xu, J., Kirk, B., Wu, J., Liu, Z. & Xue, W., 1 Jan 2017, In : Journal of Bioactive and Compatible Polymers. 32, 1, p. 17-31 15 p.

Research output: Contribution to journalArticle

Biocompatibility
Endothelial cells
Cells
Macrophages
Switching systems
16 Citations (Scopus)

Biocompatible hyperbranched polyglycerol modified β-cyclodextrin derivatives for docetaxel delivery

Xu, Z., Zhang, Y., Hu, Q., Tang, Q., Xu, J., Wu, J., Kirk, T. B., Ma, D. & Xue, W., 1 Feb 2017, In : Materials Science and Engineering C. 71, p. 965-972 8 p.

Research output: Contribution to journalArticle

docetaxel
Chemotherapy
Cyclodextrins
Drug delivery
Biocompatibility
2 Citations (Scopus)

Cajaninstilbene acid inhibits osteoporosis through suppressing osteoclast formation and RANKL-induced signaling pathways

Sun, Y., Liu, Y., He, W., Wang, C., Tickner, J., Kuek, V., Zhou, C., Wang, H., Zou, X., Hong, Z., Yang, F., Shao, M., Chen, L. & Xu, J., 1 Jul 2019, In : Journal of Cellular Physiology. 234, 7, p. 11792-11804 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteoporosis
Bone
Bone and Bones
Osteogenesis
4 Citations (Scopus)

Calmodulin interacts with Rab3D and modulates osteoclastic bone resorption

Zhu, S., Chim, S. M., Cheng, T., Ang, E., Ng, B., Lim, B., Chen, K., Qiu, H., Tickner, J., Xu, H., Pavlos, N. & Xu, J., 29 Nov 2016, In : Scientific Reports. 6, p. 1-9

Research output: Contribution to journalArticle

Open Access
Calmodulin
Bone Resorption
Osteoclasts
Calcium
calmidazolium
7 Citations (Scopus)

Carnosic acid inhibits inflammation response and joint destruction on osteoclasts, fibroblast-like synoviocytes, and collagen-induced arthritis rats

Liu, M., Zhou, X., Zhou, L., Liu, Z., Yuan, J., Cheng, J., Zhao, J., Wu, L., Li, H., Qiu, H. & Xu, J., 1 Aug 2018, In : Journal of Cellular Physiology. 233, 8, p. 6291-6303 13 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Osteoclasts
Fibroblasts
Rats
Collagen
2 Citations (Scopus)
9 Downloads (Pure)

Cepharanthine suppresses osteoclast formation by modulating the nuclear factor-κB and nuclear factor of activated T-cell signaling pathways

Lin, X., Song, F., Zhou, L., Wang, Z., Wei, C., Xu, J., Zhao, J. & Liu, Q., 1 Feb 2019, In : Journal of Cellular Biochemistry. 120, 2, p. 1990-1996 7 p.

Research output: Contribution to journalArticle

Open Access
File
NFATC Transcription Factors
Cell signaling
Osteoclasts
Bone
Bone Diseases
13 Citations (Scopus)

CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma

Shang, Y., He, J., Wang, Y., Feng, Q., Zhang, Y., Guo, J., Li, J., Li, S., Wang, Y., Yan, G., Ren, F., Shi, Y., Xu, J., Zeps, N., Zhai, Y., He, D. & Chang, Z., 20 Jul 2017, In : Oncogene. 36, 29, p. 4191-4200 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
66 Downloads (Pure)

Cistanche deserticola polysaccharide attenuates osteoclastogenesis and bone resorption via inhibiting RANKL signaling and reactive oxygen species production

Song, D., Cao, Z., Liu, Z., Tickner, J., Qiu, H., Wang, C., Chen, K., Wang, Z., Dong, S. & Xu, J., 1 Dec 2018, In : Journal of Cellular Physiology. 233, 12, p. 9674-9684 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cistanche
Osteoclasts
Bone Resorption
Osteogenesis
Polysaccharides
15 Citations (Scopus)
Cyclodextrins
Grafts
Genes
Doxorubicin
Derivatives
18 Citations (Scopus)
344 Downloads (Pure)

Coupling factors and exosomal packaging microRNAs involved in the regulation of bone remodelling

Zhu, S., Yao, F., Qiu, H., Zhang, G., Xu, H. & Xu, J., Feb 2018, In : Biological Reviews. 93, 1, p. 469-480 12 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)

Cumambrin A prevents OVX-induced osteoporosis via the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways

Zhou, L., Liu, Q., Hong, G., Song, F., Zhao, J., Yuan, J., Xu, J., Tan, R. X., Tickner, J., Gu, Q. & Xu, J., 1 Jun 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 6, p. 6726-6735 10 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Resorption
Osteogenesis
Osteoporosis
Bone
18 Citations (Scopus)

Cyanidin Chloride inhibits ovariectomy-induced osteoporosis by suppressing RANKL-mediated osteoclastogenesis and associated signaling pathways

Cheng, J., Zhou, L., Liu, Q., Tickner, J., Tan, Z., Li, X., Liu, M., Lin, X., Wang, T., Pavlos, N. J., Zhao, J. & Xu, J., 1 Mar 2018, In : Journal of Cellular Physiology. 233, 3, p. 2502-2512 11 p.

Research output: Contribution to journalArticle

Ovariectomy
Osteogenesis
Osteoporosis
Osteoclasts
Bone

Cytochalasin Z11 inhibits RANKL-induced osteoclastogenesis: Via suppressing NFATc1 activation

Wang, L., Chen, K., He, J., Kenny, J., Yuan, Y., Chen, J., Liu, Q., Tan, R., Zhao, J. & Xu, J., 25 Nov 2019, In : RSC Advances. 9, 66, p. 38438-38446 9 p.

Research output: Contribution to journalArticle

Open Access
Chemical activation
Bone
Cytochalasins
Cytology
Metabolites
4 Citations (Scopus)

Daphnetin attenuates LPS-induced osteolysis and RANKL mediated osteoclastogenesis through suppression of ERK and NFATc1 pathways

Wu, Z., Wu, H., Li, C., Fu, F., Ding, J., Shao, S., Li, K., Yu, X., Su, Y., Liang, J., Lin, X., Yuan, G., Zhou, J., Song, F., Zhao, J., Xu, J., Liu, Q. & Xu, F., 1 Oct 2019, In : Journal of Cellular Physiology. 234, 10, p. 17812-17823 12 p.

Research output: Contribution to journalArticle

Osteolysis
MAP Kinase Signaling System
Osteogenesis
Bone
Prosthetics
13 Citations (Scopus)

Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation

Zhou, C., You, Y., Shen, W., Zhu, Y. Z., Peng, J., Feng, H. T., Wang, Y., Li, D., Shao, W. W., Li, C. X., Li, W. Z., Xu, J. & Shen, X., 2016, In : Annals of the Rheumatic Diseases. n/a, p. 1-8

Research output: Contribution to journalArticle

1 Citation (Scopus)

Dehydrocostus lactone (DHC) suppresses estrogen deficiency-induced osteoporosis

Li, Z., Yuan, G., Lin, X., Liu, Q., Xu, J., Lian, Z., Song, F., Zheng, J., Xie, D., Chen, L., Wang, X., Feng, H., Zhou, M. & Yao, G., 1 May 2019, In : Biochemical Pharmacology. 163, p. 279-289 11 p.

Research output: Contribution to journalArticle

Osteoporosis
Osteoclasts
Bone
Estrogens
Bone Resorption
45 Downloads (Pure)

Differential protein expression between normal and degenerated human nucleus pulposus cells by proteomic and bioinformatics analyses

Ye, D. P., Liang, W. G., Dai, L., Yao, Y., Chen, H., Zhou, Y. & Xu, J., 2017, In : International Journal of Clinical and Experimental Medicine. 10, 12, p. 16172-16180 9 p.

Research output: Contribution to journalArticle

Open Access
File
Bioinformatics
Computational Biology
Proteomics
Intervertebral Disc
Protein Isoforms
42 Citations (Scopus)
241 Downloads (Pure)

Dihydroartemisinin, an Anti-Malaria Drug, Suppresses Estrogen Deficiency-Induced Osteoporosis, Osteoclast Formation, and RANKL-Induced Signaling Pathways

Zhou, L., Liu, Q., Yang, M., Wang, T., Yao, J., Cheng, J. W., Yuan, J., Lin, X., Zhao, J., Tickner, J. & Xu, J., May 2016, In : Journal of Bone and Mineral Research. 31, 5, p. 964-974

Research output: Contribution to journalArticle

Open Access
File
dihydroartemisinin
Osteoclasts
Malaria
Osteoporosis
Estrogens
2 Citations (Scopus)

Diosmetin inhibits osteoclast formation and differentiation and prevents LPS-induced osteolysis in mice

Shao, S., Fu, F., Wang, Z., Song, F., Li, C., Wu, Z. X., Ding, J., Li, K., Xiao, Y., Su, Y., Lin, X., Yuan, G., Zhao, J., Liu, Q. & Xu, J., 1 Aug 2019, In : Journal of Cellular Physiology. 234, 8, p. 12701-12713 13 p.

Research output: Contribution to journalArticle

Osteolysis
Osteoclasts
RANK Ligand
Bone
NFATC Transcription Factors

Discovery of new inhibitors against both NF-κB and osteoclastogenesis from in-house library with α, β-unsaturated-enone fragment

Zhao, C., Huang, D., Li, R., Xu, J., Gu, Q. & Xu, J., 1 Jun 2019, In : Bioorganic Chemistry. 87, p. 638-646 9 p.

Research output: Contribution to journalArticle

Osteogenesis
Scaffolds
Libraries
Signal transduction
Phosphorylation
5 Citations (Scopus)

Double network shape memory hydrogels activated by near-infrared with high mechanical toughness, nontoxicity, and 3D printability

Dai, W., Guo, H., Gao, B., Ruan, M., Xu, L., Wu, J., Kirk, T. B., Xu, J., Ma, D. & Xue, W., 15 Jan 2019, In : Chemical Engineering Journal. 356, p. 934-949 16 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Eriodictyol Inhibits RANKL-Induced Osteoclast Formation and Function Via Inhibition of NFATc1 Activity

Song, F., Zhou, L., Zhao, J., Liu, Q., Yang, M., Tan, R., Xu, J., Zhang, G., Quinn, J. M. W., Tickner, J., Huang, Y. & Xu, J., Sep 2016, In : Journal of Cellular Physiology. 231, 9, p. 1983-1993

Research output: Contribution to journalArticle

RANK Ligand
Osteoclasts
Cathepsin K
Transcription Factor AP-1
Plant Extracts
2 Citations (Scopus)

Evaluation of N-phosphonium chitosan as a novel vaccine carrier for intramuscular immunization

Cai, J., Zhang, W., Xu, J., Xue, W. & Liu, Z., 1 Nov 2017, In : Journal of Biomaterials Applications. 32, 5, p. 677-685 9 p.

Research output: Contribution to journalArticle

Immunization
Vaccines
Chitosan
Antigens
Water
6 Citations (Scopus)

Evodiamine inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in mice

Jin, H., Yao, L., Chen, K., Liu, Y., Wang, Q., Wang, Z., Liu, Q., Cao, Z., Kenny, J., Tickner, J., Wang, X. & Xu, J., Jan 2019, In : Journal of Cellular and Molecular Medicine. 23, 1, p. 522-534 13 p.

Research output: Contribution to journalArticle

Open Access
Ovariectomy
Osteogenesis
Bone and Bones
Osteoclasts
Postmenopausal Osteoporosis
5 Citations (Scopus)
292 Downloads (Pure)

Expression quantitative trait locus study of bone mineral density GWAS variants in human osteoclasts

Mullin, B. H., Zhu, K., Xu, J., Brown, S. J., Mullin, S., Tickner, J., Pavlos, N. J., Dudbridge, F., Walsh, J. P. & Wilson, S. G., Jun 2018, In : Journal of Bone & Mineral Research. 33, 6, p. 1044-1051

Research output: Contribution to journalArticle

Open Access
File
Quantitative Trait Loci
Genome-Wide Association Study
Osteoclasts
Bone Density
Single Nucleotide Polymorphism
31 Citations (Scopus)

Folate-targeting redox hyperbranched poly(amido amine)s delivering MMP-9 siRNA for cancer therapy

Li, M., Zhou, X., Zeng, X., Wang, C., Xu, J., Ma, D. & Xue, W., 2016, In : Journal of Materials Chemistry B. 4, 3, p. 547-556

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Folic Acid
Small Interfering RNA
Oxidation-Reduction
Amines
3 Citations (Scopus)
173 Downloads (Pure)

GdX/UBL4A null mice exhibit mild kyphosis and scoliosis accompanied by dysregulation of osteoblastogenesis and chondrogenesis

Liang, J., Li, J., Fu, Y., Ren, F., Xu, J., Zhou, M., Li, P., Feng, H. & Wang, Y., 1 Apr 2018, In : Cell Biochemistry and Function. 36, 3, p. 129-136 8 p.

Research output: Contribution to journalArticle

Open Access
File
Chondrogenesis
Kyphosis
Scoliosis
Knockout Mice
Bone
2 Citations (Scopus)
Open Access
Osteitis Deformans
Osteoclasts
Quantitative Trait Loci
Genome-Wide Association Study
Genes
15 Citations (Scopus)

Green synthesis of lignin nanoparticle in aqueous hydrotropic solution toward broadening the window for its processing and application

Chen, L., Zhou, X., Shi, Y., Gao, B., Wu, J., Kirk, T. B., Xu, J. & Xue, W., 15 Aug 2018, In : Chemical Engineering Journal. 346, p. 217-225 9 p.

Research output: Contribution to journalArticle

Lignin
lignin
aqueous solution
Nanoparticles
drug
3 Citations (Scopus)

Helvolic acid attenuates osteoclast formation and function via suppressing RANKL-induced NFATc1 activation

Chen, K., Yuan, Y., Wang, Z., Song, D., Zhao, J., Cao, Z., Chen, J., Guo, Q., Chen, L., Tickner, J. & Xu, J., May 2019, In : Journal of Cellular Physiology. 234, 5, p. 6477-6488 12 p.

Research output: Contribution to journalArticle

NFATC Transcription Factors
Osteoclasts
Chemical activation
Bone
Osteoporosis
7 Citations (Scopus)

Hemocompatibility evaluation in vitro of methoxy polyethyleneglycol-polycaprolactone copolymer solutions

Hu, Q., Zhang, Y., Wang, C., Xu, J., Wu, J., Liu, Z. & Xue, W., 2016, In : Journal of Biomedical Materials Research - Part A. 104, 3, p. 802-812

Research output: Contribution to journalArticle

Polycaprolactone
Copolymers
Blood
Platelets
Fibrinogen
5 Citations (Scopus)

Hemostasis mechanism and applications of N-alkylated chitosan sponge

Huang, Y., Feng, L., Zhang, Y., He, L., Wang, C., Xu, J., Wu, J., Kirk, T. B., Guo, R. & Xue, W., 1 Sep 2017, In : Polymers for Advanced Technologies. 28, 9, p. 1107-1114 8 p.

Research output: Contribution to journalArticle

Chitosan
Hemostatics
Platelets
Fibrinogen
Assays
3 Citations (Scopus)

High-resolution study of the 3D collagen fibrillary matrix of Achilles tendons without tissue labelling and dehydrating

Wu, J. P., Swift, B. J., Becker, T., Squelch, A., Wang, A., Zheng, Y. C., Zhao, X., Xu, J., Xue, W., Zheng, M., Lloyd, D. & Kirk, T. B., Jun 2017, In : Journal of Microscopy. 266, 3, p. 237-287

Research output: Contribution to journalArticle

Achilles Tendon
Collagen
Tendons
Tensile Strength
Atomic Force Microscopy
3 Citations (Scopus)

Inhibitory effects of tubeimoside I on synoviocytes and collagen-induced arthritis in rats

Liu, Z., Zhou, L., Ma, X., Sun, S., Qiu, H., Li, H., Xu, J. & Liu, M., 1 Nov 2018, In : Journal of Cellular Physiology. 233, 11, p. 8740-8753 14 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Rats
Collagen
Rheumatoid Arthritis
Down-Regulation
36 Citations (Scopus)

Injectable supramolecular hydrogel formed from α-cyclodextrin and PEGylated arginine-functionalized poly(L-lysine) dendron for sustained MMP-9 shRNA plasmid delivery

Lin, Q., Yang, Y., Hu, Q., Guo, Z., Liu, T., Xu, J., Wu, J., Kirk, T. B., Ma, D. & Xue, W., 1 Feb 2017, In : Acta Biomaterialia. 49, p. 456-471 16 p.

Research output: Contribution to journalArticle

Arginine
Hydrogel
Cyclodextrins
Matrix Metalloproteinases
Hydrogels