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• Fine-mapping inflammatory bowel disease loci to single-variant resolution

  Huang, H., Fang, M., Jostins, L., Umićević Mirkov, M., Boucher, G., Anderson, C. A., Andersen, V., Cleynen, I., Cortes, A., Crins, F., D'Amato, M., Deffontaine, V., Dmitrieva, J., Docampo, E., Elansary, M., Farh, K. K-H., Franke, A., Gori, A-S., Goyette, P., Halfvarson, J. & 27 others, Haritunians, T., Knight, J., Lawrance, I. C., Lees, C. W., Louis, E., Mariman, R., Meuwissen, T., Mni, M., Momozawa, Y., Parkes, M., Spain, S. L., Théâtre, E., Trynka, G., Satsangi, J., van Sommeren, S., Vermeire, S., Xavier, R. J., Weersma, R. K., Duerr, R. H., Mathew, C. G., Rioux, J. D., McGovern, D. P. B., Cho, J. H., Georges, M., Daly, M. J., Barrett, J. C. & International Inflammatory Bowel Disease Genetics Consortium, 13 Jul 2017, In : Nature. 547, 7662, p. 173-178 6 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Inflammatory Bowel Diseases
  • Genome-Wide Association Study
  • Ulcerative Colitis
  • Crohn Disease
  • Epigenomics
  186 Citations (Scopus)

  428 Downloads (Pure)

• European evidence based consensus for endoscopy in inflammatory bowel disease

  ECCO & Lawrance, I., 15 Dec 2013, In : Journal of Crohn's and Colitis. 7, 12, p. 982-1018 37 p.

  Research output: Contribution to journal › Article

  Open Access
  442 Citations (Scopus)

• Emu Oil reduces disease severity in a mouse model of chronic ulcerative colitis

  Safaeian, R., Howarth, G. S., Lawrance, I. C., Trinder, D. & Mashtoub, S., 4 Mar 2019, In : Scandinavian Journal of Gastroenterology. 54, 3, p. 273-280 8 p.

  Research output: Contribution to journal › Article

  • emu Oil
  • Ulcerative Colitis
  • Peroxidase
  • Water
  • Dextran Sulfate
  3 Citations (Scopus)

• Emu Oil Reduces Colonic Damage Severity in a Mouse Model of Chronic Ulcerative Colitis

  Safaeian, R., Howarth, G. S., Lawrance, I. C., Trinder, D. & Mashtoub, S., Apr 2017, In : FASEB Journal. 31, 1 p.

  Research output: Contribution to journal › Abstract/Meeting Abstract

• Emu Oil Improves Clinical Indicators of Disease in a Mouse Model of Colitis-Associated Colorectal Cancer

  Chartier, L. C., Howarth, G. S., Lawrance, I. C., Trinder, D., Barker, S. J. & Mashtoub, S., 2018, In : Digestive Diseases and Sciences. 63, 1, p. 135–145 11 p.

  Research output: Contribution to journal › Article

  • emu Oil
  • Colitis
  • Colorectal Neoplasms
  • Dextran Sulfate
  • Azoxymethane
  11 Citations (Scopus)

• Emu oil improves clinical indicators of disease in a mouse model of colitis-associated colorectal cancer

  Chartier, L. C., Howarth, G. S., Lawrance, I. C., Trinder, D., Barker, S. J. & Mashtoub, S., Aug 2017, In : Journal of Gastroenterology and Hepatology (Australia). 32, p. 56-56 1 p.

  Research output: Contribution to journal › Abstract/Meeting Abstract

• Efficacy of rectal tacrolimus for induction therapy in patients with resistant ulcerative proctitis

  Lawrance, I. C., Baird, A., Lightowler, D., Radford-Smith, G., Andrews, J. M. & Connor, S., 1 Aug 2017, In : Clinical Gastroenterology and Hepatology. 15, 8, p. 1248-1255 8 p.

  Research output: Contribution to journal › Article

  • Proctitis
  • Tacrolimus
  • Placebos
  • Therapeutics
  • Ulcerative Colitis
  26 Citations (Scopus)

• Dysregulation of innate immunity in ulcerative colitis patients who fail anti-Tumor necrosis factor therapy Basic Study

  Baird, A., Mallon, D., Radford-Smith, G., Boyer, J., Piche, T., Prescott, S., Lawrance, I. & Tulic, M. K., 2016, In : World Journal of Gastroenterology. 22, 41, p. 9104-9116 13 p.

  Research output: Contribution to journal › Article

  Open Access

  • Ulcerative Colitis
  • Innate Immunity
  • Tumor Necrosis Factor-alpha
  • Toll-Like Receptors
  • Cytokines
  11 Citations (Scopus)

• Dysplasia and colorectal cancer surveillance in inflammatory bowel disease

  Pulusu, S. S. R. & Lawrance, I. C., 3 Aug 2017, In : Expert Review of Gastroenterology and Hepatology. 11, 8, p. 711-722 12 p.

  Research output: Contribution to journal › Review article

  • Inflammatory Bowel Diseases
  • Colorectal Neoplasms
  • Mesalamine
  • Needs Assessment
  • Chemoprevention
  9 Citations (Scopus)

• Dose tailoring of anti-tumour necrosis factor-alpha therapy delivers useful clinical efficacy in Crohn disease patients experiencing loss of response

  Ghaly, S., Costello, S., Beswick, L., Pudipeddi, A., Agarwal, A., Sechi, A., Antoniades, S., Headon, B., Connor, S., Lawrance, I., Sparrow, M., Walsh, A. & Andrews, J., 2014, In : Internal Medicine Journal. 45, 2, p. 170-177 8 p.

  Research output: Contribution to journal › Article

  • Crohn Disease
  • Tumor Necrosis Factor-alpha
  • Adrenal Cortex Hormones
  • Physicians
  • Steroids
  1 Citation (Scopus)

• Dietary Iron Enhances Colonic Inflammation and IL-6/IL-11-Stat3 Signalling Promoting Colonic Tumor Development in Mice

  Chua, A., Klopcic, B., Ho, D., Fu, S., Forrest, C., Croft, K., Olynyk, J., Lawrance, I. & Trinder, D., 2013, In : PLoS One. 8, 11, p. 12pp

  Research output: Contribution to journal › Article

  Open Access
  42 Citations (Scopus)

• Detection of liver injury in IBD using transient elastography

  Thin, L. W. Y., Lawrance, I., Spilsbury, K., Kava, J. & Olynyk, J. K., 2014, In : JOURNAL OF CROHNS & COLITIS. 8, 7, p. 671-677

  Research output: Contribution to journal › Article

  • Elasticity Imaging Techniques
  • Inflammatory Bowel Diseases
  • Liver
  • Wounds and Injuries
  • Inflammatory Bowel Disease 5
  9 Citations (Scopus)

• Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis

  Beaudoin, M., Goyette, P., Boucher, G., Lo, K., Rivas, M. A., Stevens, C. R., Alikashani, A., Ladouceur, M. G., Ellinghaus, D., Törkvist, L., Goel, G., Lagacé, C., Annese, V., Bitton, A., Begun, J., Brant, S. R., Bresso, F., Cho, J., Duerr, R. H., Halfvarson, J. & 97 others, Mcgovern, D. P. B., Radford-Smith, G. L., Schreiber, S., Schumm, P. L., Sharma, Y., Silverberg, M. S., Weersma, R. K., D'Amato, M., Vermeire, S., Franke, A., Lettre, G., Xavier, R. J., Daly, M. J., Rioux, J. D., Aumais, G., Bernard, E. J., Cohen, A. Y., Deslandres, C., Lahaie, R. G., Paré, P., Cho, J. H., Targan, S. R., Schumm, P. P., Rutgeerts, P. J., Vermeire, S. A. F. A., Steinhart, A. H., Ahmad, T., Anderson, C. A., Baldassano, R. N., Balschun, T., Barclay, M. L., Barrett, J. C., Bayless, T. M., Bis, J. C. M., Brand, S., Bumpstead, S., Büning, C., Cohen, A., Colombel -, J. F., Cottone, M., D'Incà, R., Denson, T., Dubinsky, M. C., Edwards, C. M., Florin, T. H. J., Franchimont, D. P., Gearry, R. B., Georges, M. A. J. A. J., Glas, J., Van Gossum, A., Griffiths, A. M., Guthery, S. L., Hákonarson, H. H., Haritunians, T., Hugot, J. P., De Jong, D. J., Jostins, L., Kugathasan, S., Kullak- Ublick, G. A., Latiano, A., Laukens, D., Lawrance, I., Lee, J., Lees, C. W., Lémann, M., Levine, A. D., Libioulle, C., Louis, É. J., Mansfield, J. C., Mathew, C. G. P., Mitrovič, M., Montgomery, G. W., Mowat, C. E., Newman, W. G., Palmieri, O., Panés, J., Parkes, M., Phillips, A. M., Ponsioen, C. Y. J., Potočnik, U., Prescott, N. J., Proctor, D. D., Regueiro, M. D., Roberts, R. L., Rotter, J. I., Sanderson, J. D., Sans, M., Satsangi, J., Seibold, F., Simms, L. A., Taylor, K. D., Verspaget, H. W., De Vos, M. P., Walters, T. D., Wang, K., Whiteman, D. C. & Wijmenga, C., 2013, In : PLoS Genetics. 9, 9, p. 11 pp.

  Research output: Contribution to journal › Article

  Open Access

  • colitis
  • Genome-Wide Association Study
  • Ulcerative Colitis
  • Crohn disease
  • loci
  116 Citations (Scopus)

• Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

  National Institute of Diabetes and Digestive Kidney Diseases Inflammatory Bowel Disease Genetics Consortium, United Kingdom Inflammatory Bowel Disease Genetics Consortium, International Inflammatory Bowel Disease Genetics Consortium & Lawrance, I., Nov 2011, In : Nature Genetics. 43, 11, p. 1066-1073 8 p.

  Research output: Contribution to journal › Article

  • Genome-Wide Association Study
  • Crohn Disease
  • Inflammatory Bowel Diseases
  • Ulcerative Colitis
  • Genes
  512 Citations (Scopus)

• Crohn's disease and smoking: Is it ever too late to quit?

  Lawrance, I., Murray, K., Batman, B., Gearry, R. B., Grafton, R., Krishnaprasad, K., Andrews, J. M., Prosser, R., Bampton, P. A., Cooke, S. E., Mahy, G., Radford-Smith, G., Croft, A. & Hanigan, K., 2013, In : JOURNAL OF CROHNS & COLITIS. 7, 12, p. e665-e671

  Research output: Contribution to journal › Article
  30 Citations (Scopus)

• Concentrations of Adalimumab and Infliximab in Mothers and Newborns, and Effects on Infection

  Julsgaard, M., Christensen, L. A., Gibson, P. R., Gearry, R. B., Fallingborg, J., Hvas, C. L., Bibby, B. M., Uldbjerg, N., Connell, W. R., Rosella, O., Grosen, A., Brown, S. J., Kjeldsen, J., Wildt, S., Svenningsen, L., Sparrow, M. P., Walsh, A., Connor, S. J., Radford-Smith, G., Lawrance, I. & 3 others, Andrews, J. M., Ellard, K. & Bell, S. J., 2016, In : Gastroenterology. 151, 1, p. 110-119

  Research output: Contribution to journal › Article

  • Adalimumab
  • Infliximab
  • Newborn Infant
  • Necrosis
  • Umbilical Cord
  144 Citations (Scopus)

• Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

  International Inflammatory Bowel Disease Genetics Consortium (IIBDGC), 17 Jul 2019, In : Scientific Reports. 9, 1, 10351.

  Research output: Contribution to journal › Article

  Open Access

  • Machine Learning
  • Crohn Disease
  • Genome
  • Logistic Models
  • ROC Curve
  16 Citations (Scopus)

• Clinical features and HLA association of 5-aminosalicylate (5-ASA)-induced nephrotoxicity in inflammatory bowel disease

  Heap, G. A., So, K., Weedon, M., Edney, N., Bewshea, C., Singh, A., Annese, V., Beckly, J., Buurman, D., Chaudhary, R., Cole, A. T., Cooper, S. C., Creed, T., Cummings, F., de Boer, N. K., D'Inca, R., Daneshmend, T. K., Delaney, M., Dhar, A., Direkze, N. & 43 others, Dunckley, P., Gaya, D. R., Gearry, R., Gore, S., Halfvarson, J., Hart, A., Hawkey, C. J., Hoentjen, F., Iqbal, T., Irving, P., Lal, S., Lawrence, I., Lees, C. W., Lewis, S., Lockett, M., Mann, S., Mansfield, J., Mowat, C., Muller, F., Murray, C., Orchard, T., Parkes, M., Phillips, R., Pollok, R., Radford-Smith, G., Sebastian, S., Sen, S., Shirazi, T., Silverberg, M., Solomon, L., Sturniolo, G. C., Thomas, M., Tremelling, M., Tsianos, E. V., Watts, D., Weaver, S., Wesley, E., Holden, A., D'Souza, R., Mulgrew, C. J., Oram, R., Weersma, R. K. & Ahmad, T., 1 Feb 2016, In : Journal of Crohn's and Colitis. 10, 2, p. 149-158 10 p.

  Research output: Contribution to journal › Article

  • Mesalamine
  • Inflammatory Bowel Diseases
  • Kidney
  • Genome-Wide Association Study
  • Pharmaceutical Preparations
  42 Citations (Scopus)

• Certolizumab pegol in the treatment of Crohn's disease: evidence from the PRECiSE clinical trial program

  Lawrance, I., 2011, In : CLINICAL INVESTIGATION. 1, 3, p. 459-465

  Research output: Contribution to journal › Review article

• Cellular and Molecular Mediators of Intestinal Fibrosis

  Lawrance, I., Rogler, G., Bamias, G., Breynaert, C., Florholmen, J., Pellino, G., Reif, S., Speca, S. & Latella, G., Dec 2017, In : Journal of Crohn's and Colitis. 11, 12, p. 1491–1503 13 p.

  Research output: Contribution to journal › Article

  Open Access

  • Fibrosis
  • Inflammatory Bowel Diseases
  • Inflammation
  • Anti-Inflammatory Agents
  53 Citations (Scopus)

• Bowel cleansing for colonoscopy: prospective randomized assessment of efficacy and of induced mucosal abnormality with three preparation agents

  Lawrance, I., Willert, R. P. & Murray, K., 2011, In : Endoscopy. 43, 5, p. 412-418

  Research output: Contribution to journal › Article
  56 Citations (Scopus)

• A Validated Bowel-Preparation Tolerability Questionnaire and Assessment of Three Commonly Used Bowel-Cleansing Agents

  Lawrance, I., Willert, R. P. & Murray, K., 2013, In : Digestive Diseases and Sciences. 58, 4, p. 926-935

  Research output: Contribution to journal › Article
  12 Citations (Scopus)

• Antitumor necrosis factor-alpha induced interstitial pneumonitis in patients with inflammatory bowel disease: A multicenter Western Australia case series

  Lightowler, D., Thin, L. & Lawrance, I., Sep 2019, In : Journal of Gastroenterology and Hepatology. 34, p. 119-120 2 p.

  Research output: Contribution to journal › Abstract/Meeting Abstract

• Anti TNFα-induced Interstitial Pneumonitis in Inflammatory Bowel Disease Patients: A Multi-Centre Western Australia Case Series

  Lightowler, D., Thin, L. & Lawrance, I., 4 Sep 2019, In : Journal of Gastroenterology and Hepatology (Australia). 34, S2, p. 119-120

  Research output: Contribution to journal › Abstract/Meeting Abstract

• Anti-TNF Therapy in Pregnant Women with Inflammatory Bowel Disease: Effects of Therapeutic Strategies on Disease Behavior and Birth Outcomes

  Julsgaard, M., Hvas, C. L., Gearry, R. B., Gibson, P. R., Fallingborg, J., Sparrow, M. P., Bibby, B. M., Connell, W. R., Brown, S. J., Kamm, M. A., Lawrance, I. C., Vestergaard, T., Svenningsen, L., Baekdal, M., Kammerlander, H., Walsh, A., Boysen, T., Bampton, P., Radford-Smith, G., Kjeldsen, J. & 10 others, Andrews, J. M., Subramaniam, K., Moore, G. T., Jensen, N. M., Connor, S. J., Wildt, S., Wilson, B., Ellard, K., Christensen, L. A. & Bell, S. J., Jan 2020, In : Inflammatory Bowel Diseases. 26, 1, p. 93-102 10 p.

  Research output: Contribution to journal › Article

  • Inflammatory Bowel Diseases
  • Therapeutic Uses
  • Pregnant Women
  • Tumor Necrosis Factor-alpha
  • Parturition
  5 Citations (Scopus)

• Anti-TNF therapeutic drug monitoring in postoperative Crohn's disease

  Wright, E. K., Kamm, M. A., De Cruz, P., Hamilton, A. L., Selvaraj, F., Princen, F., Gorelik, A., Liew, D., Prideaux, L., Lawrance, I. C., Andrews, J. M., Bampton, P. A., Jakobovits, S. L., Florin, T. H., Gibson, P. R., Debinski, H., Macrae, F. A., Samuel, D., Kronborg, I., Radford-Smith, G. & 5 others, Gearry, R. B., Selby, W., Bell, S. J., Brown, S. J. & Connell, W. R., 25 May 2018, In : Journal of Crohn's and Colitis. 12, 6, p. 653-661 9 p.

  Research output: Contribution to journal › Article

  • Adalimumab
  • Drug Monitoring
  • Crohn Disease
  • Recurrence
  • Anti-Idiotypic Antibodies
  6 Citations (Scopus)

• Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

  International Inflammatory Bowel Disease Genetics Consortium, International Genetics of Ankylosing Spondylitis Consortium, International PSC Study Group, Genetic Analysis of Psoriasis Consortium & Psoriasis Association Genetics Extension, 1 May 2016, In : Nature Genetics. 48, 5, p. 510-518 9 p.

  Research output: Contribution to journal › Article

  • Sclerosing Cholangitis
  • Comorbidity
  • Chronic Disease
  • Inflammatory Bowel Diseases
  • Molecular Pathology
  275 Citations (Scopus)

• A multi-centre double blind randomised placebo-controlled study of the use of rectal tacrolimus in the treatment of resistant ulcerative proctitis

  Lawrance, I., Baird, A., Lightowler, D., Radford-Smith, G., Andrews, J. M. & Connor, S., Feb 2017.

  Research output: Contribution to conference › Conference presentation/ephemera

• A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies

  Bodea, C. A., Neale, B. M., Ripke, S., International Inflammatory Bowel Disease Genetics Consortium, Lawrance, I., Daly, M. J., Devlin, B. & Roeder, K., 5 May 2016, In : American Journal of Human Genetics. 98, 5, p. 857-868 12 p.

  Research output: Contribution to journal › Article

  Open Access
  7 Citations (Scopus)

• Acute Severe Ulcerative Colitis: Evidence Based Consensus Statements

  Lawrance, I., Jul 2016, In : Alimentary Pharmacology and Therapeutics.

  Research output: Contribution to journal › Editorial

  Open Access
  35 Citations (Scopus)

• Acute severe ulcerative colitis: Changing treatment paradigms

  Lawrance, I., 2016, In : Journal of Gastroenterology and Hepatology (Australia). 31, p. 16

  Research output: Contribution to journal › Article