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  • Markus Schlaich

Obesity-Associated Organ Damage and Sympathetic Nervous Activity: A Target for Treatment?

Lambert, E. A., Esler, M. D., Schlaich, M. P., Dixon, J., Eikelis, N. & Lambert, G. W., Jun 2019, In : Hypertension. 73, 6, p. 1150-1159 10 p.

Research output: Contribution to journalReview article

Opposing effects of shear-mediated dilation and myogenic constriction on artery diameter in response to handgrip exercise in humans

Atkinson, C., Carter, H., Naylor, L., Dawson, E. A., Marusic, P., Hering, D., Schlaich, M., Thijssen, D. H. J. & Green, D. J., 15 Oct 2015, In : Journal of Applied Physiology. 119, 8, p. 858-864 7 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
361 Downloads (Pure)

Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer

Rudnicka, C., Mochizuki, S., Okada, Y., McLaughlin, C., Leedman, P. J., Stuart, L., Epis, M., Hoyne, G., Boulos, S., Johnson, L., Schlaich, M. & Matthews, V., 2016, In : Medicine (United States). 95, 40, p. 1-8 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Percutaneous renal denervation in patients with treatment-resistant hypertension: Final 3-year report of the Symplicity HTN-1 study

Krum, H., Schlaich, M. P., Sobotka, P. A., Böhm, M., Mahfoud, F., Rocha-Singh, K., Katholi, R. & Esler, M. D., 2014, In : The Lancet. 383, 9917, p. 622-629 8 p.

Research output: Contribution to journalArticle

427 Citations (Scopus)

Percutaneous transluminal renal denervation: A potential treatment option for polycystic kidney disease-related pain?

Shetty, S., Roberts, T. J. & Schlaich, M. P., 2013, In : International Journal of Cardiology. 162, 3, p. e58-e59

Research output: Contribution to journalLetter

18 Citations (Scopus)

Pioglitazone treatment enhances the sympathetic nervous system response to oral carbohydrate load in obese individuals with metabolic syndrome

Straznicky, N. E., Grima, M. T., Sari, C. I., Eikelis, N., Lambert, G. W., Nestel, P. J., Richards, K., Dixon, J. B., Schlaich, M. P. & Lambert, E. A., 1 Jul 2015, In : Metabolism: clinical and experimental. 64, 7, p. 797-803 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Plasma advanced glycation end products (AGEs) and NF-κB activity are independent determinants of diastolic and pulse pressure

Sourris, K. C., Lyons, J. G., Dougherty, S. L., Chand, V., Straznicky, N. E., Schlaich, M. P., Grima, M. T., Cooper, M. E., Kingwell, B. A., De Courten, M. P. J., Forbes, J. M. & De Courten, B., 2014, In : Clinical Chemistry and Laboratory Medicine. 52, 1, p. 129-138 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Postchallenge hyperglycemia is closely related with early vascular damage in overweight and obese patients

Schneider, M. P., Ott, C., Ritt, M., Raff, U., Schlaich, M. P. & Schmieder, R. E., 2012, In : Journal of Hypertension. 30, 1, p. 147-152 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Potential future denervation targets

Gerard Leong, K. T., Walton, A., Krum, H. & Schlaich, M. P., 1 Dec 2014, In : Interventional Cardiology. 6, 6, p. 569-579 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Preferred Fourth-Line Pharmacotherapy for Resistant Hypertension: Are We There Yet?

Prosser, H. C., Gregory, C., Hering, D., Hillis, G. S., Perry, G., Rosman, J., Schultz, C., Thomas, M., Watts, G. F. & Schlaich, M. P., 1 Apr 2017, In : Current Hypertension Reports. 19, 4, 30.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Rationale and design of a large registry on renal denervation: The Global SYMPLICITY registry

Böhm, M., Mahfoud, F., Ukena, C., Bauer, A., Fleck, E., Hoppe, U. C., Kintscher, U., Narkiewicz, K., Negoita, M., Ruilope, L., Rump, L. C., Schlaich, M., Schmieder, R., Sievert, H., Weil, J., Williams, B., Zeymer, U. & Mancia, G., Aug 2013, In : EuroIntervention. 9, 4, p. 484-492 9 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Rebuttal from Markus P. Schlaich, Yusuke Sata and Murray D. Esler

Schlaich, M. P., Sata, Y. & Esler, M. D., 2014, In : Journal of Physiology. 592, 18, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Reduction in blood pressure following renal denervation for patients with differing baseline cardiovascular risk

Mahfoud, F., Mancia, G., Schmieder, R., Narkiewicz, K., Ruilope, L., Schlaich, M., Williams, B., Fahy, M. & Bohm, M., Oct 2019, In : European Heart Journal. 40, p. 663-663 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

10 Citations (Scopus)

Reduction in peripheral vascular resistance predicts improvement in insulin clearance following weight loss

Straznicky, N. E., Grima, M. T., Sari, C. I., Lambert, E. A., Phillips, S. E., Eikelis, N., Kobayashi, D., Hering, D., Mariani, J. A., Dixon, J. B., Nestel, P. J., Karapanagiotidis, S., Schlaich, M. P. & Lambert, G. W., 22 Aug 2015, In : Cardiovascular Diabetology. 14, 1, 113.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Regulation of the sympathetic nervous system by the kidney

Larsen, R., Thorp, A. & Schlaich, M., 2014, In : Current Opinion in Nephrology and Hypertension. 23, 1, p. 61-68 8 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Reinnervation following catheter-based radio-frequency renal denervation

Booth, L. C., Nishi, E. E., Yao, S. T., Ramchandra, R., Lambert, G. W., Schlaich, M. P. & May, C. N., 20 Apr 2015, In : Experimental Physiology. 100, 5, p. 485-490 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Reinnervation of renal afferent and efferent nerves at 5.5 and 11 months after catheter-based radiofrequency renal denervation in sheep

Booth, L. C., Nishi, E. E., Yao, S. T., Ramchandra, R., Lambert, G. W., Schlaich, M. P. & May, C. N., 21 Feb 2015, In : Hypertension. 65, 2, p. 393-400 8 p.

Research output: Contribution to journalArticle

Open Access
80 Citations (Scopus)

Relevance of sympathetic nervous system activation in obesity and metabolic syndrome

Thorp, A. A. & Schlaich, M., 2015, In : Journal of Diabetes Research. 2015, p. 1-11

Research output: Contribution to journalArticle

Open Access
File
146 Citations (Scopus)
224 Downloads (Pure)
Open Access

Renal artery anatomy affects the blood pressure response to renal denervation in patients with resistant hypertension

Hering, D., Marusic, P., Walton, A. S., Duval, J., Lee, R., Sata, Y., Krum, H., Lambert, E., Peter, K., Head, G., Lambert, G., Esler, M. D. & Schlaich, M., 1 Jan 2016, In : International Journal of Cardiology. 202, p. 388-393 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Renal artery denervation for treatment of patients with self-reported obstructive sleep apnea and resistant hypertension: Results from the Global SYMPLICITY Registry

Linz, D., Mancia, G., Mahfoud, F., Narkiewicz, K., Ruilope, L., Schlaich, M., Kindermann, I., Schmieder, R. E., Ewen, S., Williams, B. & Bohm, M., 2017, In : Journal of Hypertension. 35, 1, p. 148-153 6 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Renal denervation: Potential future implications beyond resistant hypertension

Schlaich, M. P., 2015, Renal Denervation: A New Approach to Treatment of Resistant Hypertension. New York: Springer-Verlag London Ltd., p. 155-161 7 p.

Research output: Chapter in Book/Conference paperChapter

Renal denervation: Current opinions and practice

Schlaich, M. P., 31 Jul 2017, Cardio-Nephrology: Confluence of the Heart and Kidney in Clinical Practice. USA: Springer International Publishing AG, p. 419-426 8 p.

Research output: Chapter in Book/Conference paperChapter

Renal denervation: Current implications and future perspectives

Xu, J., Hering, D., Sata, Y., Walton, A., Krum, H., Esler, M. D. & Schlaich, M. P., 2014, In : Clinical Science. 126, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Renal denervation: A new approach to treatment of resistant hypertension

Heuser, R. R. (ed.), Schlaich, M. (ed.) & Sievert, H. (ed.), 2015, New York: Springer-Verlag London Ltd. 201 p.

Research output: Book/ReportBook

Renal Denervation After the SPYRAL HTN-OFF MED Trial Putting a Complex Study Into Context

Schlaich, M. P. & Esler, M. D., Dec 2017, In : Hypertension. 70, 6, p. 1076-1079 4 p.

Research output: Contribution to journalEditorial

4 Citations (Scopus)

Renal denervation and pulmonary vein isolation in patients with drug resistant hypertension and symptomatic atrial fibrillation

Wilson, S., Kistler, P. M., Mclellan, A. J. A., Hering, D. & Schlaich, M., 2014, In : JOURNAL OF ATRIAL FIBRILLATION. 7, 4, p. 69-74

Research output: Contribution to journalReview article

1 Citation (Scopus)

Renal denervation as a synergistic tool for the treatment of polymorphic ventricular ectopic beats: A case report

Kiuchi, M. G., Chen, S., Villacorta, H., Carnagarin, R., Nolde, J. M., Matthews, V. B. & Schlaich, M. P., 17 Jul 2020, In : Medicine. 99, 29, p. e21098

Research output: Contribution to journalArticle

Open Access

Renal denervation for resistant hypertension: Closing in on potential confounders

Schlaich, M. P., Schultz, C. & Shetty, S., 2016, In : Journal of Hypertension. 34, 8, p. 1505-1506 2 p.

Research output: Contribution to journalLetter

Renal denervation for resistant hypertension—the Symplicity HTN-1 study – Authors' reply

Krum, H., Sobotka, P., Schlaich, M., Bohm, M. & Esler, M., 1 May 2014, In : The Lancet. 383, 9932, p. 1885-1886

Research output: Contribution to journalLetter

Renal Denervation for Treating Hypertension Current Scientific and Clinical Evidence

Weber, M. A., Mahfoud, F., Schmieder, R. E., Kandzari, D. E., Tsioufis, K. P., Townsend, R. R., Kario, K., Bohm, M., Sharp, A. S. P., Davies, J. E., Osborn, J. W., Fink, G. D., Euler, D. E., Cohen, D. L., Schlaich, M. P. & Esler, M. D., 24 Jun 2019, In : JACC: Cardiovascular Interventions. 12, 12, p. 1095-1105 11 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)

Renal Denervation in High-Risk Patients With Hypertension

Mahfoud, F., Mancia, G., Schmieder, R., Narkiewicz, K., Ruilope, L., Schlaich, M., Whitbourn, R., Zirlik, A., Zeller, T., Stawowy, P., Cohen, S. A., Fahy, M. & Böhm, M., 16 Jun 2020, In : Journal of the American College of Cardiology. 75, 23, p. 2879-2888 10 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Renal denervation in human hypertension: Mechanisms, current findings, and future prospects

Schlaich, M. P., Hering, D., Sobotka, P. A., Krum, H. & Esler, M. D., 1 Jun 2012, In : Current Hypertension Reports. 14, 3, p. 247-253 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Renal denervation in hypertensive patients not on blood pressure lowering drugs

De Jager, R. L., Sanders, M. F., Bots, M. L., Lobo, M. D., Ewen, S., Beeftink, M. M. A., Böhm, M., Daemen, J., Dörr, O., Hering, D., Mahfoud, F., Nef, H., Ott, C., Saxena, M., Schmieder, R. E., Schlaich, M., Spiering, W., Tonino, P. A. L., Verloop, W. L., Vink, E. E. & 4 others, Vonken, E. J., Voskuil, M., Worthley, S. G. & Blankestijn, P. J., 2016, In : Clinical Research in Cardiology. 105, 9, p. 755-762

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Renal denervation in less severe forms of (resistant) hypertension—Quo vadis?

Schlaich, M. P., Hering, D. & Sata, Y., 1 Apr 2017, In : Journal of Clinical Hypertension. 19, 4, p. 369-370 2 p.

Research output: Contribution to journalComment/debate

Renal denervation in moderate to severe CKD

Hering, D., Mahfoud, F., Walton, A. S., Krum, H., Lambert, G. W., Lambert, E. A., Sobotka, P. A., Böhm, M., Cremers, B., Esler, M. D. & Schlaich, M. P., 1 Jul 2012, In : Journal of the American Society of Nephrology. 23, 7, p. 1250-1257 8 p.

Research output: Contribution to journalArticle

Open Access
272 Citations (Scopus)

Renal Denervation Reduces Monocyte Activation and Monocyte-Platelet Aggregate Formation: An Anti-Inflammatory Effect Relevant for Cardiovascular Risk

Zaldivia, M. T. K., Rivera, J., Hering, D., Marusic, P., Sata, Y., Lim, B., Eikelis, N., Lee, R., Lambert, G. W., Esler, M. D., Htun, N. M., Duval, J., Hammond, L., Eisenhardt, S. U., Flierl, U., Schlaich, M. P. & Peter, K., 1 Feb 2017, In : Hypertension. 69, 2, p. 323-331 9 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
237 Downloads (Pure)

Renal denervation reduces office and ambulatory heart rate in patients with uncontrolled hypertension: 12-month outcomes fromthe global SYMPLICITY registry

Böhm, M., Ukena, C., Ewen, S., Linz, D., Zivanovic, I., Hoppe, U., Narkiewicz, K., Ruilope, L., Schlaich, M., Negoita, M., Schmieder, R., Williams, B., Zeymer, U., Zirlik, A., Mancia, G. & Mahfoud, F., 2016, In : Journal of Hypertension. 34, 12, p. 2480-2486 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Renal Denervation Update From the International Sympathetic Nervous System Summit

Kiuchi, M. G., Esler, M. D., Fink, G. D., Osborn, J. W., Banek, C. T., Boehm, M., Denton, K. M., DiBona, G. F., Everett, T. H., Grassi, G., Katholi, R. E., Knuepfer, M. M., Kopp, U. C., Lefer, D. J., Lohmeier, T. E., May, C. N., Mahfoud, F., Paton, J. F. R., Schmieder, R. E., Pellegrino, P. R. & 2 others, Sharabi, Y. & Schlaich, M. P., 18 Jun 2019, In : Journal of the American College of Cardiology. 73, 23, p. 3006-3017 12 p.

Research output: Contribution to journalReview article

Open Access
9 Citations (Scopus)

Renal hemodynamics and renal function after catheter-based renal sympathetic denervation in patients with resistant hypertension

Mahfoud, F., Cremers, B., Janker, J., Link, B., Vonend, O., Ukena, C., Linz, D., Schmieder, R., Rump, L. C., Kindermann, I., Sobotka, P. A., Krum, H., Scheller, B., Schlaich, M., Laufs, U. & Böhm, M., 1 Aug 2012, In : Hypertension. 60, 2, p. 419-424 6 p.

Research output: Contribution to journalArticle

Open Access
241 Citations (Scopus)

Renal nerve ablation reduces augmentation index in patients with resistant hypertension

Hering, D., Lambert, E. A., Marusic, P., Ika-Sari, C., Walton, A. S., Krum, H., Sobotka, P. A., Mahfoud, F., Böhm, M., Lambert, G. W., Esler, M. D. & Schlaich, M. P., Sep 2013, In : Journal of Hypertension. 31, 9, p. 1893-1900 8 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Renal nerve ablation reduces blood pressure in a patient with renovascular hypertension resistant to drug and revascularisation therapies

Hering, D., Walton, A., Krum, H., Lambert, G. W., Esler, M. D. & Schlaich, M. P., 23 Aug 2012, In : International Journal of Cardiology. 159, 2

Research output: Contribution to journalArticle

9 Citations (Scopus)

Renal Nitric Oxide Deficiency and Chronic Kidney Disease in Young Sheep Born with a Solitary Functioning Kidney

Singh, R. R., Easton, L. K., Booth, L. C., Schlaich, M. P., Head, G. A., Moritz, K. M. & Denton, K. M., 26 May 2016, In : Scientific Reports. 6, 26777.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Renal oxygenation in acute renal ischemia-reperfusion injury

Abdelkader, A., Ho, J., Ow, C. P. C., Eppel, G. A., Rajapakse, N. W., Schlaich, M. P. & Evans, R. G., 1 May 2014, In : American Journal of Physiology - Renal Physiology. 306, 9

Research output: Contribution to journalArticle

47 Citations (Scopus)

Renal sympathetic denervation: a viable option for treating resistant hypertension

Schlaich, M. P., Sep 2017, In : American Journal of Hypertension. 30, 9, p. 847-856 10 p.

Research output: Contribution to journalReview article

10 Citations (Scopus)

Renal Sympathetic Denervation

Schlaich, M., 2015, Chronic Kidney Disease and Hypertension. Weir, M. R. & Lerma, E. V. (eds.). New York: Humana Press, p. 69-81

Research output: Chapter in Book/Conference paperChapter

Renal sympathetic denervation for treatment of drug-resistant hypertension: One-year results from the symplicity htn-2 randomized, controlled trial

Esler, M. D., Krum, H., Schlaich, M., Schmieder, R. E., Böhm, M. & Sobotka, P. A., 18 Dec 2012, In : Circulation. 126, 25, p. 2976-2982 7 p.

Research output: Contribution to journalArticle

Open Access
357 Citations (Scopus)

Renal sympathetic nerve ablation for the management of resistant hypertension: An update

Thorp, A. A., Larsen, R. N. & Schlaich, M. P., Nov 2013, In : Current Opinion in Nephrology and Hypertension. 22, 6, p. 607-614 8 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)

Renal sympathetic nerve ablation for treatment-resistant hypertension

Krum, H., Schlaich, M. & Sobotka, P., Oct 2013, In : British Journal of Clinical Pharmacology. 76, 4, p. 495-503 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)