Find Research Outputs

Search in all content

Filters for Research Output

Search concepts
Selected filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016

Author

  • Jiake Xu
2017

Molecular structure and differential function of choline kinases CHKα and CHKβ in musculoskeletal system and cancer

Chen, X., Qiu, H., Wang, C., Yuan, Y., Tickner, J., Xu, J. & Zou, J., Feb 2017, In : Cytokine and Growth Factor Reviews. 33, p. 65-72 8 p.

Research output: Contribution to journalReview article

Open Access
File
1 Citation (Scopus)
287 Downloads (Pure)
2020

The repair and autophagy mechanisms of hypoxia-regulated bFGF-modified primary embryonic neural stem cells in spinal cord injury

Zhu, S., Chen, M., Deng, L., Zhang, J., Ni, W., Wang, X., Yao, F., Li, X., Xu, H., Xu, J. & Xiao, J., 6 Feb 2020, In : Stem Cells Translational Medicine. 17 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2019

Cumambrin A prevents OVX-induced osteoporosis via the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways

Zhou, L., Liu, Q., Hong, G., Song, F., Zhao, J., Yuan, J., Xu, J., Tan, R. X., Tickner, J., Gu, Q. & Xu, J., 1 Jun 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 6, p. 6726-6735 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Natural Compounds for the Treatment of Psoriatic Arthritis: A Proposal Based on Multi-Targeted Osteoclastic Regulation and on a Preclinical Study

Deng, S., Cheng, J., Zhao, J., Yao, F. & Xu, J., 11 Jul 2017, In : JMIR Research Protocols. 6, 7, e132.

Research output: Contribution to journalArticle

Open Access
2016

Hemocompatibility evaluation in vitro of methoxy polyethyleneglycol-polycaprolactone copolymer solutions

Hu, Q., Zhang, Y., Wang, C., Xu, J., Wu, J., Liu, Z. & Xue, W., 2016, In : Journal of Biomedical Materials Research - Part A. 104, 3, p. 802-812

Research output: Contribution to journalArticle

7 Citations (Scopus)
2020

Asiatic Acid Inhibits OVX-Induced Osteoporosis and Osteoclastogenesis Via Regulating RANKL-Mediated NF-κb and Nfatc1 Signaling Pathways

Hong, G., Zhou, L., Han, X., Sun, P., Chen, Z., He, W., Tickner, J., Chen, L., Shi, X. & Xu, J., 27 Mar 2020, In : Frontiers in Pharmacology. 11, 331.

Research output: Contribution to journalArticle

Open Access
2018

Inhibitory effects of tubeimoside I on synoviocytes and collagen-induced arthritis in rats

Liu, Z., Zhou, L., Ma, X., Sun, S., Qiu, H., Li, H., Xu, J. & Liu, M., 1 Nov 2018, In : Journal of Cellular Physiology. 233, 11, p. 8740-8753 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2019

Molecular structure and the role of high-temperature requirement protein 1 in skeletal disorders and cancers

Li, Y., Yuan, J., Rothzerg, E., Wu, X., Xu, H., Zhu, S. & Xu, J., 22 Dec 2019, In : Cell Proliferation. e12746.

Research output: Contribution to journalReview article

Open Access

Connecting Versatile lncRNAs with Heterogeneous Nuclear Ribonucleoprotein K and Pathogenic Disorders

Zhu, S., Wang, Z. & Xu, J., 1 Sep 2019, In : Trends in Biochemical Sciences. 44, 9, p. 733-736 4 p.

Research output: Contribution to journalShort survey

1 Citation (Scopus)

The emerging roles of hnRNPK

Wang, Z., Qiu, H., He, J., Liu, L., Xue, W., Fox, A., Tickner, J. & Xu, J., 19 Sep 2019, In : Journal of Cellular Physiology.

Research output: Contribution to journalReview article

5 Citations (Scopus)
2018

GdX/UBL4A null mice exhibit mild kyphosis and scoliosis accompanied by dysregulation of osteoblastogenesis and chondrogenesis

Liang, J., Li, J., Fu, Y., Ren, F., Xu, J., Zhou, M., Li, P., Feng, H. & Wang, Y., 1 Apr 2018, In : Cell Biochemistry and Function. 36, 3, p. 129-136 8 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
237 Downloads (Pure)

Redox-responsive chemosensitive polyspermine delivers ursolic acid targeting to human breast tumor cells: The depletion of intracellular GSH contents arouses chemosensitizing effects

Ji, X., Tang, Q., Pang, P., Wu, J., Kirk, T. B., Xu, J., Ma, D. & Xue, W., 1 Oct 2018, In : Colloids and Surfaces B: Biointerfaces. 170, p. 293-302 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Green synthesis of lignin nanoparticle in aqueous hydrotropic solution toward broadening the window for its processing and application

Chen, L., Zhou, X., Shi, Y., Gao, B., Wu, J., Kirk, T. B., Xu, J. & Xue, W., 15 Aug 2018, In : Chemical Engineering Journal. 346, p. 217-225 9 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2017

Three-dimensional printing of shape memory hydrogels with internal structure for drug delivery

Wang, Y., Miao, Y., Zhang, J., Wu, J. P., Kirk, T. B., Xu, J., Ma, D. & Xue, W., 1 Mar 2017, In : Materials Science and Engineering C. 84, p. 44-51 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2019

Emerging Trend in the Pharmacotherapy of Osteoarthritis

Zhang, W., Robertson, W. B., Zhao, J., Chen, W. & Xu, J., 2 Jul 2019, In : Frontiers in Endocrinology. 10, 9 p., 431.

Research output: Contribution to journalReview article

Open Access
10 Citations (Scopus)

Astilbin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis

Jin, H., Wang, Q., Chen, K., Xu, K., Pan, H., Chu, F., Ye, Z., Wang, Z., Tickner, J., Qiu, H., Wang, C., Kenny, J., Xu, H., Wang, T. & Xu, J., 1 Dec 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8355-8368 14 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2016

Calmodulin interacts with Rab3D and modulates osteoclastic bone resorption

Zhu, S., Chim, S. M., Cheng, T., Ang, E., Ng, B., Lim, B., Chen, K., Qiu, H., Tickner, J., Xu, H., Pavlos, N. & Xu, J., 29 Nov 2016, In : Scientific Reports. 6, p. 1-9

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2018

Achyranthes bidentata polysaccharide suppresses osteoclastogenesis and bone resorption via inhibiting RANKL signaling

Song, D., Cao, Z., Huang, S., Tickner, J., Li, N., Qiu, H., Chen, X., Wang, C., Chen, K., Sun, Y., Dong, S. & Xu, J., 1 Jun 2018, In : Journal of Cellular Biochemistry. 119, 6, p. 4826-4835 10 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
330 Downloads (Pure)
2019

Helvolic acid attenuates osteoclast formation and function via suppressing RANKL-induced NFATc1 activation

Chen, K., Yuan, Y., Wang, Z., Song, D., Zhao, J., Cao, Z., Chen, J., Guo, Q., Chen, L., Tickner, J. & Xu, J., May 2019, In : Journal of Cellular Physiology. 234, 5, p. 6477-6488 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
34 Downloads (Pure)
2018

The emerging role of Hippo signaling pathway in regulating osteoclast formation

Yang, W., Han, W., Qin, A., Wang, Z., Xu, J. & Qian, Y., 1 Jun 2018, In : Journal of Cellular Physiology. 233, 6, p. 4606-4617 12 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)

Cistanche deserticola polysaccharide attenuates osteoclastogenesis and bone resorption via inhibiting RANKL signaling and reactive oxygen species production

Song, D., Cao, Z., Liu, Z., Tickner, J., Qiu, H., Wang, C., Chen, K., Wang, Z., Dong, S. & Xu, J., 1 Dec 2018, In : Journal of Cellular Physiology. 233, 12, p. 9674-9684 11 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
152 Downloads (Pure)
2019

Pectolinarigenin prevents bone loss in ovariectomized mice and inhibits RANKL-induced osteoclastogenesis via blocking activation of MAPK and NFATc1 signaling

Xiao, Y., Li, K., Wang, Z., Fu, F., Shao, S., Song, F., Zhao, J., Chen, W., Liu, Q. & Xu, J., 1 Aug 2019, In : Journal of Cellular Physiology. 234, 8, p. 13959-13968 10 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
4 Downloads (Pure)
2016

NPNT is expressed by osteoblasts and mediates angiogenesis via the activation of extracellular signal-regulated kinase

Kuek, V., Yang, Z., Chim, S., Zhu, S., Xu, H., Chow, S. T., Tickner, J., Rosen, V., Erber, W., Li, X., An, Q., Qian, Y. & Xu, J., 26 Oct 2016, In : Scientific Reports. 6, p. 1-13 13 p., 36210.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
361 Downloads (Pure)
2018

Artesunate inhibits RANKL-induced osteoclastogenesis and bone resorption in vitro and prevents LPS-induced bone loss in vivo

Wei, C. M., Liu, Q., Song, F. M., Lin, X. X., Su, Y. J., Xu, J., Huang, L., Zong, S. H. & Zhao, J. M., 1 Jan 2018, In : Journal of Cellular Physiology. 233, 1, p. 476-485 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2016

Nitidine chloride prevents OVX-induced bone loss via suppressing NFATc1-mediated osteoclast differentiation

Liu, Q., Wang, T., Zhou, L., Song, F., Qin, A., Feng, H. T., Lin, X. X., Lin, Z., Yuan, J. B., Tickner, J., Liu, H. G., Zheng, M. H., Xu, J. & Zhao, J. M., 8 Nov 2016, In : Scientific Reports. 6, p. 1-10 36662 .

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)
2019

Cajaninstilbene acid inhibits osteoporosis through suppressing osteoclast formation and RANKL-induced signaling pathways

Sun, Y., Liu, Y., He, W., Wang, C., Tickner, J., Kuek, V., Zhou, C., Wang, H., Zou, X., Hong, Z., Yang, F., Shao, M., Chen, L. & Xu, J., 1 Jul 2019, In : Journal of Cellular Physiology. 234, 7, p. 11792-11804 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Madecassoside inhibits estrogen deficiency-induced osteoporosis by suppressing RANKL-induced osteoclastogenesis

Wang, Q., Yao, L., Xu, K., Jin, H., Chen, K., Wang, Z., Liu, Q., Cao, Z., Kenny, J., Liu, Y., Tickner, J., Xu, H. & Xu, J., Jan 2019, In : Journal of Cellular and Molecular Medicine. 23, 1, p. 380-394 15 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Evodiamine inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in mice

Jin, H., Yao, L., Chen, K., Liu, Y., Wang, Q., Wang, Z., Liu, Q., Cao, Z., Kenny, J., Tickner, J., Wang, X. & Xu, J., Jan 2019, In : Journal of Cellular and Molecular Medicine. 23, 1, p. 522-534 13 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Therapeutic anabolic and anticatabolic benefits of natural Chinese medicines for the treatment of osteoporosis

He, J., Li, X., Wang, Z., Bennett, S., Chen, K., Xiao, Z., Zhan, J., Chen, S., Hou, Y., Chen, J., Wang, S., Xu, J. & Lin, D., 25 Nov 2019, In : Frontiers in Pharmacology. 10, 1344.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Pseurotin A inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppressing reactive oxygen species

Chen, K., Qiu, P., Yuan, Y., Zheng, L., He, J., Wang, C., Guo, Q., Kenny, J., Liu, Q., Zhao, J., Chen, J., Tickner, J., Fan, S., Lin, X. & Xu, J., 28 Feb 2019, In : Theranostics. 9, 6, p. 1634-1650

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
455 Downloads (Pure)
2020

Arctiin abrogates osteoclastogenesis and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation

Chen, D., Ye, Z., Wang, C., Wang, Q., Wang, H., Kuek, V., Wang, Z., Qiu, H., Yuan, J., Kenny, J., Yang, F., He, J., Liu, Y., Wang, G., Zhang, M., Zhang, G., Wang, J., Chen, P. & Xu, J., Sep 2020, In : Pharmacological Research. 159, 104944.

Research output: Contribution to journalArticle

2017

Biocompatibility and cellular uptake mechanisms of poly(N -isopropylacrylamide) in different cells

Guo, Z., Li, S., Wang, C., Xu, J., Kirk, B., Wu, J., Liu, Z. & Xue, W., 1 Jan 2017, In : Journal of Bioactive and Compatible Polymers. 32, 1, p. 17-31 15 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2016

Sinomenine down-regulates TLR4/TRAF6 expression and attenuates lipopolysaccharide-induced osteoclastogenesis and osteolysis

He, L., Duan, H., Li, X., Wang, S., Zhang, Y., Lei, L., Xu, J. & Liu, S., 2016, In : European Journal of Pharmacology. 779, p. 66-79

Research output: Contribution to journalArticle

13 Citations (Scopus)
2018

Macrophages release plasma membrane-derived particles rich in accessible cholesterol

He, C., Hu, X., Weston, T. A., Jung, R. S., Sandhu, J., Huang, S., Heizer, P., Kim, J., Ellison, R., Xu, J., Kilburn, M., Bensinger, S. J., Riezman, H., Tontonoz, P., Fong, L. G., Jiang, H. & Young, S. G., 4 Sep 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 36, p. E8499-E8508

Research output: Contribution to journalArticle

8 Citations (Scopus)
2016

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Li, D., Liu, J., Guo, B., Liang, C., Dang, L., Lu, C., He, X., Cheung, H. Y. S., Xu, L., He, B., Liu, B., Shaikh, A. B., Li, F., Wang, L., Yang, Z., Au, D. W. T., Peng, S., Zhang, Z., Zhang, B. T., Pan, X. & 13 others, Qian, A., Shang, P., Xiao, L., Jiang, B., Wong, C. K. C., Xu, J., Bian, Z., Liang, Z., Guo, D. A., Zhu, H., Tan, W., Lu, A. & Zhang, G., 2016, In : Nature Communications. 7

Research output: Contribution to journalArticle

152 Citations (Scopus)
2019

Discovery of new inhibitors against both NF-κB and osteoclastogenesis from in-house library with α, β-unsaturated-enone fragment

Zhao, C., Huang, D., Li, R., Xu, J., Gu, Q. & Xu, J., 1 Jun 2019, In : Bioorganic Chemistry. 87, p. 638-646 9 p.

Research output: Contribution to journalArticle

Sclareol prevents ovariectomy-induced bone loss: In vivo and inhibits osteoclastogenesis in vitro via suppressing NF-κB and MAPK/ERK signaling pathways

Jin, H., Shao, Z., Wang, Q., Miao, J., Bai, X., Liu, Q., Qiu, H., Wang, C., Zhang, Z., Jennifer, T., Wang, X. & Xu, J., 1 Oct 2019, In : Food and Function. 10, 10, p. 6556-6567 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2020

Hederagenin protects mice against ovariectomy-induced bone loss by inhibiting RANKL-induced osteoclastogenesis and bone resorption

Tian, K., Su, Y., Ding, J., Wang, D., Zhan, Y., Li, Y., Liang, J., Lin, X., Song, F., Wang, Z., Xu, J., Liu, Q. & Zhao, J., 1 Mar 2020, In : Life Sciences. 244, 117336.

Research output: Contribution to journalArticle

2019
Open Access
4 Citations (Scopus)

PIP5k1 beta controls bone homeostasis through modulating both osteoclast and osteoblast differentiation

Zhao, X., Cui, P., Wang, C., Zhao, J., Zhang, X. & Xu, J., Dec 2019, In : Journal of Bone and Mineral Research. 34, p. 328-328 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2020

Ellagic acid protects ovariectomy-induced bone loss in mice by inhibiting osteoclast differentiation and bone resorption

Lin, X., Yuan, G., Li, Z., Zhou, M., Hu, X., Song, F., Shao, S., Fu, F., Zhao, J., Xu, J., Liu, Q. & Feng, H., 1 Sep 2020, In : Journal of Cellular Physiology. 235, 9, p. 5951-5961 11 p.

Research output: Contribution to journalArticle

2016

Folate-targeting redox hyperbranched poly(amido amine)s delivering MMP-9 siRNA for cancer therapy

Li, M., Zhou, X., Zeng, X., Wang, C., Xu, J., Ma, D. & Xue, W., 2016, In : Journal of Materials Chemistry B. 4, 3, p. 547-556

Research output: Contribution to journalArticle

32 Citations (Scopus)
2019

Osthole inhibits osteoclasts formation and bone resorption by regulating NF-κB signaling and NFATc1 activations stimulated by RANKL

Ma, Y., Wang, L., Zheng, S., Xu, J., Pan, Y., Tu, P., Sun, J. & Guo, Y., 1 Sep 2019, In : Journal of Cellular Biochemistry. 120, 9, p. 16052-16061 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Dehydrocostus lactone (DHC) suppresses estrogen deficiency-induced osteoporosis

Li, Z., Yuan, G., Lin, X., Liu, Q., Xu, J., Lian, Z., Song, F., Zheng, J., Xie, D., Chen, L., Wang, X., Feng, H., Zhou, M. & Yao, G., 1 May 2019, In : Biochemical Pharmacology. 163, p. 279-289 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2018

TNF-α inhibits SATB2 expression and osteoblast differentiation through NF-κB and MAPK pathways

Zuo, C., Zhao, X., Shi, Y., Wu, W., Zhang, N., Xu, J., Wang, C., Hu, G. & Zhang, X., 1 Jan 2018, In : Oncotarget. 9, 4, p. 4833-4850 18 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42

Xu, S., Zhang, Y., Wang, J., Li, K., Tan, K., Liang, K., Shen, J., Cai, D., Jin, D., Li, M., Xiao, G., Xu, J., Jiang, Y. & Bai, X., Sep 2018, In : Cell Death and Differentiation. 25, 9, p. 1549–1566

Research output: Contribution to journalArticle

3 Citations (Scopus)
2016

Amyloid β peptide enhances RANKL-induced osteoclast activation through NF-κB, ERK, and calcium oscillation signaling

Li, S., Yang, B., Teguh, D., Zhou, L., Xu, J. & Rong, L., 1 Oct 2016, In : International Journal of Molecular Sciences. 17, 10, 1683.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)
2019

MiR-214 Attenuates the Osteogenic Effects of Mechanical Loading on Osteoblasts

Yuan, Y., Guo, J., Zhang, L., Tong, X., Zhang, S., Zhou, X., Zhang, M., Chen, X., Lei, L., Li, H., Liu, T. C. Y., Xu, J. & Zou, J., Dec 2019, In : International Journal of Sports Medicine. 40, 14, p. 931-940 10 p.

Research output: Contribution to journalArticle

2017

Melphalan modifies the bone microenvironment by enhancing osteoclast formation

Chai, R. C., McDonald, M. M., Terry, R. L., Kovacic, N., Down, J. M., Pettitt, J. A., Mohanty, S. T., Shah, S., Haffari, G., Xu, J., Gillespie, M. T., Rogers, M. J., Price, J. T., Croucher, P. I. & Quinn, J. M. W., 15 Sep 2017, In : Oncotarget. 8, 40, p. 68047-68058 12 p.

Research output: Contribution to journalArticle

Open Access