Find Research Outputs

Search results

• 2019

  Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

  International Inflammatory Bowel Disease Genetics Consortium (IIBDGC), 17 Jul 2019, In : Scientific Reports. 9, 1, 10351.

  Research output: Contribution to journal › Article

  Open Access

  • Machine Learning
  • Crohn Disease
  • Genome
  • Logistic Models
  • ROC Curve
  13 Citations (Scopus)
• 2013

  Vedolizumab as induction and maintenance therapy for Crohn's disease

  GEMINI 2 Study Group & Lawrance, I., 2013, In : New England Journal of Medicine. 369, 8, p. 711-721 11 p.

  Research output: Contribution to journal › Article

  • vedolizumab
  • Crohn Disease
  • Placebos
  • Therapeutics
  • Nasopharyngitis
  1025 Citations (Scopus)

• Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease

  International Inflammatory Bowel Disease Genetics Consortium & Lawrance, I. C., 6 Jun 2013, In : American Journal of Human Genetics. 92, 6, p. 1008-1012 5 p.

  Research output: Contribution to journal › Article

  Open Access

  • Machine Learning
  • Ulcerative Colitis
  • Crohn Disease
  • Inflammatory Bowel Diseases
  • Sample Size
  87 Citations (Scopus)
• 2016

  Acute severe ulcerative colitis: Changing treatment paradigms

  Lawrance, I., 2016, In : Journal of Gastroenterology and Hepatology (Australia). 31, p. 16

  Research output: Contribution to journal › Article

• High Vitamin D-Binding Protein Concentration, Low Albumin, and Mode of Remission Predict Relapse in Crohn's Disease

  Ghaly, S., Murray, K., Baird, A., Martin, K., Prosser, R., Mill, J., Simms, L. A., Hart, P. H., Radford-Smith, G., Bampton, P. A. & Lawrance, I. C., Oct 2016, In : Inflammatory Bowel Diseases. 22, 10, p. 2456-2464 9 p.

  Research output: Contribution to journal › Article

  • Vitamin D-Binding Protein
  • Crohn Disease
  • Albumins
  • Sunlight
  • Recurrence
  11 Citations (Scopus)

• A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies

  Bodea, C. A., Neale, B. M., Ripke, S., International Inflammatory Bowel Disease Genetics Consortium, Lawrance, I., Daly, M. J., Devlin, B. & Roeder, K., 5 May 2016, In : American Journal of Human Genetics. 98, 5, p. 857-868 12 p.

  Research output: Contribution to journal › Article

  Open Access
  6 Citations (Scopus)
• 2014

  The role of vitamin D in gastrointestinal inflammation

  Ghaly, S. & Lawrance, I., 2014, In : Expert Review of Gastroenterology and Hepatology. 8, 8, p. 909-923

  Research output: Contribution to journal › Review article

  • Vitamin D
  • Inflammation
  • Crohn Disease
  • Inflammatory Bowel Diseases
  • Adaptive Immunity
  24 Citations (Scopus)
• 2013

  Genetic susceptibility in IBD: Overlap between ulcerative Colitis and Crohn's disease

  Doecke, J. D., Simms, L. A., Zhao, Z., Huang, N., Hanigan, K., Krishnaprasad, K., Roberts, R. L., Andrews, J. M., Mahy, G., Bampton, P. A., Lewindon, P. J., Florin, T. H. J., Lawrance, I., Gearry, R. B., Montgomery, G. W. & Radford-Smith, G. L., 2013, In : Inflammatory Bowel Diseases. 19, 2, p. 240-245

  Research output: Contribution to journal › Article

  • Genetic Predisposition to Disease
  • Ulcerative Colitis
  • Crohn Disease
  • Single Nucleotide Polymorphism
  • Population Control
  26 Citations (Scopus)
• 2016

  Dysregulation of innate immunity in ulcerative colitis patients who fail anti-Tumor necrosis factor therapy Basic Study

  Baird, A., Mallon, D., Radford-Smith, G., Boyer, J., Piche, T., Prescott, S., Lawrance, I. & Tulic, M. K., 2016, In : World Journal of Gastroenterology. 22, 41, p. 9104-9116 13 p.

  Research output: Contribution to journal › Article

  Open Access

  • Ulcerative Colitis
  • Innate Immunity
  • Tumor Necrosis Factor-alpha
  • Toll-Like Receptors
  • Cytokines
  9 Citations (Scopus)
• 2019

  Level of UV Exposure, Skin Type, and Age Are More Important than Thiopurine Use for Keratinocyte Carcinoma Development in IBD Patients

  Wu, Y., Ghaly, S., Kerr, S., Jackson, B., Hanigan, K., Martins, D., Krishnaprasad, K., Mountifield, R. E., Whiteman, D. C., Bampton, P. A., Gearry, R. B., Radford-Smith, G. L. & Lawrance, I. C., 6 Sep 2019, In : Digestive Diseases and Sciences.

  Research output: Contribution to journal › Article

  • Keratinocytes
  • Inflammatory Bowel Diseases
  • Carcinoma
  • Solar System
  • Skin
• 2020

  The role of a plant-based diet in the pathogenesis, etiology and management of the inflammatory bowel diseases

  Grosse, C. S. J., Christophersen, C. T., Devine, A. & Lawrance, I. C., 3 Mar 2020, In : Expert Review of Gastroenterology and Hepatology. 14, 3, p. 137-145 9 p.

  Research output: Contribution to journal › Review article

  • Inflammatory Bowel Diseases
  • Diet
  • Symbiosis
  • Diet Therapy
  • Expert Testimony
  2 Citations (Scopus)

• Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford

  Pulusu, S. S. R., Srinivasan, A., Krishnaprasad, K., Cheng, D., Begun, J., Keung, C., van Langenberg, D., Thin, L., Mogilevski, T., De Cruz, P., Radford-Smith, G., Flanagan, E., Bell, S., Kashkooli, S., Sparrow, M. P., Ghaly, S., Bampton, P. A., Sawyer, E., Connor, S., Rizvi, Q-U-A. & 4 others, Andrews, J. M., Mahy, G., Chivers, P. & Lawrance, I., 14 Aug 2020, In : World Journal of Gastroenterology. 26, 30, p. 4428-4441

  Research output: Contribution to journal › Article

  Open Access

  • vedolizumab
  • Ulcerative Colitis
  • integrin beta7
  • Integrin alpha4
  • Antibodies, Monoclonal, Humanized
• 2017

  Emu Oil Reduces Colonic Damage Severity in a Mouse Model of Chronic Ulcerative Colitis

  Safaeian, R., Howarth, G. S., Lawrance, I. C., Trinder, D. & Mashtoub, S., Apr 2017, In : FASEB Journal. 31, 1 p.

  Research output: Contribution to journal › Abstract/Meeting Abstract
• 2019

  Anti TNFα-induced Interstitial Pneumonitis in Inflammatory Bowel Disease Patients: A Multi-Centre Western Australia Case Series

  Lightowler, D., Thin, L. & Lawrance, I., 4 Sep 2019, In : Journal of Gastroenterology and Hepatology (Australia). 34, S2, p. 119-120

  Research output: Contribution to journal › Abstract/Meeting Abstract
• 2011

  Understanding the Use of Immunosuppressive Agents in the Clinical Management of IBD

  Waters, O. R. & Lawrance, I., 2011, In : Current Drug Targets. 12, 9, p. 1364-1371

  Research output: Contribution to journal › Article

  8 Citations (Scopus)

• Topical agents for idiopathic distal colitis and proctitis

  Lawrance, I., 2011, In : Journal of Gastroenterology and Hepatology. 26, 1, p. 36-43

  Research output: Contribution to journal › Article
  19 Citations (Scopus)

• Predictors of fibrostenotic Crohn's Disease

  Rieder, F., Lawrance, I., Leite, A. & Sans, M., 2011, In : Inflammatory Bowel Diseases. 17, 9, p. 2000-2007

  Research output: Contribution to journal › Article
  47 Citations (Scopus)

• SPARC, FOXP3, CD8 and CD45 Correlation with Disease Recurrence and Long-Term Disease-Free Survival in Colorectal Cancer

  Chew, A., Salama, P., Robbshaw, A., Klopcic, B., Zeps, N., Platell, C. & Lawrance, I., 2011, In : PLoS One. 6, 7, p. 13pp

  Research output: Contribution to journal › Article

  Open Access
  45 Citations (Scopus)
• 2013

  A Validated Bowel-Preparation Tolerability Questionnaire and Assessment of Three Commonly Used Bowel-Cleansing Agents

  Lawrance, I., Willert, R. P. & Murray, K., 2013, In : Digestive Diseases and Sciences. 58, 4, p. 926-935

  Research output: Contribution to journal › Article
  11 Citations (Scopus)
• 2019

  Inflammatory bowel diseases: interrelationships between dietary vitamin D, exposure to UV radiation and the fecal microbiome

  Ghaly, S., Hart, P. H. & Lawrance, I. C., 2 Nov 2019, In : Expert Review of Gastroenterology and Hepatology. 13, 11, p. 1039-1048 10 p.

  Research output: Contribution to journal › Review article

  • Ultraviolet Rays
  • Microbiota
  • Inflammatory Bowel Diseases
  • Vitamin D
  • Gastrointestinal Microbiome
  1 Citation (Scopus)
• 2018

  Vedolizumab (VDZ) real-world outcomes in ulcerative colitis (UC)

  Pulusu, S. S. R., Srinivasan, A., Krishnaprasad, K., Cheng, D., Mogilevski, T., Flanagan, E., Keung, C., Wu, C., Prosser, R., Sawyer, E., Rizvi, Q. U. A., Su, H., Leung, W., Edmundson, A., Cooke, S., Mahy, G., Thin, L., Radford-Smith, G., Sparrow, M. P., Andrews, J. M. & 10 others, Connor, S., Bampton, P. A., Ghaly, S., van Langenberg, D., Bell, S., De Cruz, P., Begun, J., Ng, S., Travis, S. & Lawrance, I., 1 Feb 2018, In : Journal of Crohn's and Colitis. 12, 1, P571.

  Research output: Contribution to journal › Abstract/Meeting Abstract

• High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis

  Ghaly, S., Kaakoush, N. O., Lloyd, F., McGonigle, T., Mok, D., Baird, A., Klopcic, B., Gordon, L., Gorman, S., Forest, C., Bouillon, R., Lawrance, I. C. & Hart, P. H., 1 Dec 2018, In : Scientific Reports. 8, 1, 11511.

  Research output: Contribution to journal › Article

  Open Access

  • Colitis
  • Microbiota
  • Vitamin D
  • Dextran Sulfate
  • Serum Albumin
  18 Citations (Scopus)
• 2014

  The importance of validating proposed genetic profiles in IBD

  Lawrance, I., May 2014, In : Journal of Internal Medicine.

  Research output: Contribution to journal › Review article

• Mechanisms of initiation and progression of intestinal fibrosis in IBD

  Latella, G., Di Gregorio, J., Flati, V., Rieder, F. & Lawrance, I., 2014, In : Scandinavian Journal of Gastroenterology. 50, p. 53-65

  Research output: Contribution to journal › Review article
  73 Citations (Scopus)
• 2017

  Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method

  Chen, G. B., Lee, S. H., Montgomery, G. W., Wray, N. R., Visscher, P. M., Gearry, R. B., Lawrance, I. C., Andrews, J. M., Bampton, P., Mahy, G., Bell, S., Walsh, A., Connor, S., Sparrow, M., Bowdler, L. M., Simms, L. A., Krishnaprasad, K., Radford-Smith, G. L. & Moser, G., 29 Aug 2017, In : BMC Medical Genetics. 18, 1, 94.

  Research output: Contribution to journal › Article

  Open Access

  • Inflammatory Bowel Diseases
  • Genome-Wide Association Study
  • Single Nucleotide Polymorphism
  • Crohn Disease
  • Ulcerative Colitis
  9 Citations (Scopus)
• 2011

  Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

  Anderson, C. A., Boucher, G., Lees, C. W., Franke, A., D’amato, M., Taylor, K. D., Lee, J. C., Goyette, P., Imielinski, M., Latiano, A., Lagacé, C., Scott, R., Amininejad, L., Bumpstead, S., Baidoo, L., Baldassano, R. N., Barclay, M., Bayless, T. M., Brand, S., Büning, C. & 93 others, Colombel, J-F., Denson, L. A., De Vos, M., Dubinsky, M., Edwards, C., Ellinghaus, D., Fehrmann, R. S. N., Floyd, J. A. B., Florin, T., Franchimont, D., Franke, L., Georges, M., Glas, J., Glazer, N. L., Guthery, S. L., Haritunians, T., Hayward, N. K., Hugot, J-P., Jobin, G., Laukens, D., Lawrance, I., Lémann, M., Levine, A., Libioulle, C., Louis, E., Mcgovern, D. P., Milla, M., Montgomery, G. W., Morley, K. I., Mowat, C., Ng, A., Newman, W., Ophoff, R. A., Papi, L., Palmieri, O., Peyrin-Biroulet, L., Panés, J., Phillips, A., Prescott, N. J., Proctor, D. D., Roberts, R., Russell, R., Rutgeerts, P., Sanderson, J., Sans, M., Schumm, P., Seibold, F., Sharma, Y., Simms, L., Seielstad, M., Hillary Steinhart, A., Targan, S. R., Van Den Berg, L. H., Vatn, M., Verspaget, H., Walters, T., Wijmenga, C., Wilson, D. C., Westra, H-J., Xavier, R. J., Zhao, Z. Z., Ponsioen, C. Y., Andersen, V., Torkvist, L., Gazouli, M., Anagnou, N. P., Karlsen, T. H., Kupcinskas, L., Sventoraityte, J., Mansfield, J. C., Kugathasan, S., Silverberg, M. S., Halfvarson, J., Rotter, J. I., Mathew, C. G., Griffiths, A. M., Gearry, R., Ahmad, T., Brant, S. R., Chamaillard, M., Satsangi, J., Cho, J. H., Schreiber, S., Daly, M. J., Barrett, J. C., Parkes, M., Annese, V., Hakonarson, H., Radford-Smith, G., Duerr, R. H., Vermeire, S., Weersma, R. K. & Rioux, J. D., 2011, In : Nature Genetics. 43, 3, p. 246-252

  Research output: Contribution to journal › Article
  928 Citations (Scopus)
• 2017

  Fine-mapping inflammatory bowel disease loci to single-variant resolution

  Huang, H., Fang, M., Jostins, L., Umićević Mirkov, M., Boucher, G., Anderson, C. A., Andersen, V., Cleynen, I., Cortes, A., Crins, F., D'Amato, M., Deffontaine, V., Dmitrieva, J., Docampo, E., Elansary, M., Farh, K. K-H., Franke, A., Gori, A-S., Goyette, P., Halfvarson, J. & 27 others, Haritunians, T., Knight, J., Lawrance, I. C., Lees, C. W., Louis, E., Mariman, R., Meuwissen, T., Mni, M., Momozawa, Y., Parkes, M., Spain, S. L., Théâtre, E., Trynka, G., Satsangi, J., van Sommeren, S., Vermeire, S., Xavier, R. J., Weersma, R. K., Duerr, R. H., Mathew, C. G., Rioux, J. D., McGovern, D. P. B., Cho, J. H., Georges, M., Daly, M. J., Barrett, J. C. & International Inflammatory Bowel Disease Genetics Consortium, 13 Jul 2017, In : Nature. 547, 7662, p. 173-178 6 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Inflammatory Bowel Diseases
  • Genome-Wide Association Study
  • Ulcerative Colitis
  • Crohn Disease
  • Epigenomics
  171 Citations (Scopus)

  384 Downloads (Pure)
• 2011

  Proteins Encoded in Genomic Regions Associated with Immune-Mediated Disease Physically Interact and Suggest Underlying Biology

  Rossin, E. J., Lage, K., Raychaudhuri, S., Xavier, R. J., Tatar, D., Benita, Y., Lawrance, I., Cotsapas, C., Daly, M. J., Franke, A., Mcgovern, D. P. B., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., Lees, C. W., Balschun, T., Lee, J., Roberts, R., Anderson, C. A. & 78 others, Bis, J. C., Bumpstead, S., Ellinghaus, D., Festen, E. M., Georges, M., Haritunians, T., Jostins, L., Latiano, A., Mathew, C. G., Montgomery, G. W., Prescott, N. J., Rotter, J. I., Schumm, P., Sharma, Y., Simms, L. A., Taylor, K. D., Whiteman, D., Wijmenga, C., Baldassano, R. N., Barclay, M., Bayless, T. M., Brand, S., Bunning, C., Cohen, A., Colombel, J-F., Cottone, M., Stronati, L., Denson, T., De Vos, M., D'Inca, R., Dubinsky, M., Edwards, C., Florin, T., Franchimont, D., Gearry, R., Glas, J., Van Gossum, A., Guthery, S. L., Halfvarson, J., Hommes, D., Hugot, J-P., Laukens, D., Lemann, M., Levine, A., Libioulle, C., Louis, E., Mowat, C., Newman, W., Panes, J., Phillips, A., Proctor, D. D., Regueiro, M., Rutgeerts, P., Sanderson, J., Sans, M., Seibold, F., Steinhart, A. H., Stokkers, P. C. F., Torkvist, L., Kullak-Ublick, G., Walters, T., Targan, S. R., Brant, S. R., Rioux, J. D., D'Amato, M., Weersma, R., Kutharthasan, S., Griffiths, A. M., Mansfield, J. C., Vermeire, S., Duerr, R. H., Silverberg, M. S., Satsangi, J., Schreiber, S., Cho, J. H., Annese, V., Hakonarson, H. & Parkes, M., 2011, In : PLoS Genetics. 7, 1, p. 13pp

  Research output: Contribution to journal › Article

  Open Access
  349 Citations (Scopus)
• 2017

  Cellular and Molecular Mediators of Intestinal Fibrosis

  Lawrance, I., Rogler, G., Bamias, G., Breynaert, C., Florholmen, J., Pellino, G., Reif, S., Speca, S. & Latella, G., Dec 2017, In : Journal of Crohn's and Colitis. 11, 12, p. 1491–1503 13 p.

  Research output: Contribution to journal › Article

  Open Access

  • Fibrosis
  • Inflammatory Bowel Diseases
  • Inflammation
  • Anti-Inflammatory Agents
  49 Citations (Scopus)
• 2018

  IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

  The International IBD Genetics Consortium, 1 Dec 2018, In : Nature Communications. 9, 1, 2427.

  Research output: Contribution to journal › Article

  Open Access

  • genes
  • loci
  • Inflammatory Bowel Diseases
  • Genes
  • modules
  28 Citations (Scopus)