Find Research outputs — the UWA Profiles and Research Repository

2013

Crohn's disease and smoking: Is it ever too late to quit?

Lawrance, I., Murray, K., Batman, B., Gearry, R. B., Grafton, R., Krishnaprasad, K., Andrews, J. M., Prosser, R., Bampton, P. A., Cooke, S. E., Mahy, G., Radford-Smith, G., Croft, A. & Hanigan, K., 2013, In : JOURNAL OF CROHNS & COLITIS. 7, 12, p. e665-e671

Research output: Contribution to journal › Article

30 Citations (Scopus)

2014

The importance of validating proposed genetic profiles in IBD

Lawrance, I., May 2014, In : Journal of Internal Medicine.

Research output: Contribution to journal › Review article

2013

Prevention of cancer in IBD – a balancing act

Lawrance, I., Sep 2013, In : Minerva Gastroenterologica e Dietologica.

Research output: Contribution to journal › Review article

2014

Dose tailoring of anti-tumour necrosis factor-alpha therapy delivers useful clinical efficacy in Crohn disease patients experiencing loss of response

Ghaly, S., Costello, S., Beswick, L., Pudipeddi, A., Agarwal, A., Sechi, A., Antoniades, S., Headon, B., Connor, S., Lawrance, I., Sparrow, M., Walsh, A. & Andrews, J., 2014, In : Internal Medicine Journal. 45, 2, p. 170-177 8 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

2013

Oral tacrolimus for the treatment of refractory inflammatory bowel disease in the biologic era

Thin, L. W. Y., Murray, K. & Lawrance, I., 2013, In : Inflammatory Bowel Diseases. 19, 7, p. 1490-1498

Research output: Contribution to journal › Article

21 Citations (Scopus)

2016

Infliximab Reduces Endoscopic, but Not Clinical, Recurrence of Crohn's Disease after Ileocolonic Resection

Regueiro, M., Feagan, B. G., Zou, B., Johanns, J., Blank, M. A., Chevrier, M., Plevy, S., Popp, J., Cornillie, F. J., Lukas, M., Danese, S., Gionchetti, P., Hanauer, S. B., Reinisch, W., Sandborn, W. J., Sorrentino, D., Rutgeerts, P., Debinski, H., Florin, T., Hetzel, D. & 136 others, Lawrance, I., Radford-Smith, G., Sloss, A., Sorrentino, D., Gassner, S., Haas, T., Reicht, G., Reinisch, W., Strasser, M., Vogelsang, H., Bossuyt, P., Dewit, O., D'Haens, G., Franchimont, D., Louis, E., Vermeire, S., Bernstein, C. N., Bourdages, R., Chiba, N., Dhalla, S. S., Feagan, B. G., Fedorak, R. N., Lachance, J. R., Panaccione, R., Ropeleski, M., Singh Salh, B., Lukas, M., Colombel, J. F., Allez, M., Desreumaux, P., Dupas, J. L., Grimaud, J. C., Hebuterne, X., Laharie, D., Lerebours, E., Peyrin-Biroulet, L., Reimund, J. M., Viennot, S., Zerbib, F., Antoni, C., Atreya, R., Baumgart, D. C., Berg, C., Boecker, U., Bramkamp, G., Bünning, C., Ehehalt, R., Howaldt, S., Kucharzik, T., Lamprecht, H. G., Mudter, J., Preiss, J. C., Schreiber, S., Seidler, U., Altorjay, I., Banai, J., Lakatos, P. L., Varga, M., Vincze, A., Avni-Biron, I., Fishman, S., Fraser, G. M., Goldin, E., Rachmilewitz, D., Annese, V., Ardizzone, S., Biancone, L., Bossa, F., Danese, S., Fries, W., Gionchetti, P., Maconi, G., Terrosu, G., Usai, P., D'Haens, G. R., Gearry, R. B., Hill, J., Rowbotham, D. S., Schultz, M., Stubbs, R. S., Wallace, D., Walmsley, R. S., Wyeth, J., Malecka-Panas, E., Paradowski, L., Regula, J., Beales, I. P., Campbell, S., Hawthorne, A. B., Parkes, M., Travis, S. P., Achkar, J. P., Behm, B. W., Bickston, S. J., Brown, K. J., Chiorean, M. V., Devilliers, W. J. S., Elliott, D. E., Grunkmeier, D., Hamilton, J. W., Hanauer, S. B., Hanson, J. S., Hardi, R., Helper, D. J., Herfarth, H., Higgins, P. D. R., Holderman, W. H., Kottoor, R., Kreines, M. D., Leman, B. I., Li, X., Loftus, E. V., Noar, M., Oikonomou, I., Onken, J., Peterson, K. A., Phillips, R. P., Randall, C. W., Ricci, M., Ritter, T., Rubin, D. T., Safdi, M., Sandborn, W. J., Sauberman, L., Scherl, E., Schwarz, R. P., Sedghi, S., Shafran, I., Sninsky, C. A., Stein, I., Swoger, J., Vecchio, J., Weinberg, D. I., Wruble, L. D., Yajnik, V. & Younes, Z., 1 Jun 2016, In : Gastroenterology. 150, 7, p. 1568-1578 11 p.

Research output: Contribution to journal › Article

Open Access

115 Citations (Scopus)

2012

NAFLD, the changing face of IBD

Thin, L., Kava, J., Lawrance, I. & Olynyk, J., Oct 2012, In : Journal of Gastroenterology and Hepatology (Australia). 27, S4, p. 2 120 p.

Research output: Contribution to journal › Abstract/Meeting Abstract

2018

High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis

Ghaly, S., Kaakoush, N. O., Lloyd, F., McGonigle, T., Mok, D., Baird, A., Klopcic, B., Gordon, L., Gorman, S., Forest, C., Bouillon, R., Lawrance, I. C. & Hart, P. H., 1 Dec 2018, In : Scientific Reports. 8, 1, 11511.

Research output: Contribution to journal › Article

Open Access

19 Citations (Scopus)

2011

Bowel cleansing for colonoscopy: prospective randomized assessment of efficacy and of induced mucosal abnormality with three preparation agents

Lawrance, I., Willert, R. P. & Murray, K., 2011, In : Endoscopy. 43, 5, p. 412-418

Research output: Contribution to journal › Article

56 Citations (Scopus)

2017

A multi-centre double blind randomised placebo-controlled study of the use of rectal tacrolimus in the treatment of resistant ulcerative proctitis

Lawrance, I., Baird, A., Lightowler, D., Radford-Smith, G., Andrews, J. M. & Connor, S., Feb 2017.

Research output: Contribution to conference › Conference presentation/ephemera

2014

What is left when anti-tumour necrosis factor therapy in inflammatory bowel diseases fails?

Lawrance, I., 2014, In : World Journal of Gastroenterology. 20, 5, p. 1248-1258

Research output: Contribution to journal › Article

Open Access

9 Citations (Scopus)

2019

Vitamin D metabolites are lower with active Crohn’s disease and spontaneously recover with development of remission

Haifer, C., Lawrance, I. C., Center, J. R., Clarke, M. W., Hart, P. H., Eisman, J. A., Lucas, R. & Ghaly, S., 26 Jul 2019, In : Therapeutic Advances in Gastroenterology. 12, 12 p.

Research output: Contribution to journal › Article

Open Access

2014

Results of the 4th scientific workshop of the ECCO (I): Pathophysiology of intestinal fibrosis in IBD

Latella, G., Rogler, G., Bamias, G., Breynaert, C., Florholmen, J. R., Pellino, G., Reif, S. S., Speca, S. & Lawrance, I., 2014, In : Journal of Crohn's and Colitis. 8, 10, p. 1147-1165

Research output: Contribution to journal › Review article

96 Citations (Scopus)

2013

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis

Beaudoin, M., Goyette, P., Boucher, G., Lo, K., Rivas, M. A., Stevens, C. R., Alikashani, A., Ladouceur, M. G., Ellinghaus, D., Törkvist, L., Goel, G., Lagacé, C., Annese, V., Bitton, A., Begun, J., Brant, S. R., Bresso, F., Cho, J., Duerr, R. H., Halfvarson, J. & 97 others, Mcgovern, D. P. B., Radford-Smith, G. L., Schreiber, S., Schumm, P. L., Sharma, Y., Silverberg, M. S., Weersma, R. K., D'Amato, M., Vermeire, S., Franke, A., Lettre, G., Xavier, R. J., Daly, M. J., Rioux, J. D., Aumais, G., Bernard, E. J., Cohen, A. Y., Deslandres, C., Lahaie, R. G., Paré, P., Cho, J. H., Targan, S. R., Schumm, P. P., Rutgeerts, P. J., Vermeire, S. A. F. A., Steinhart, A. H., Ahmad, T., Anderson, C. A., Baldassano, R. N., Balschun, T., Barclay, M. L., Barrett, J. C., Bayless, T. M., Bis, J. C. M., Brand, S., Bumpstead, S., Büning, C., Cohen, A., Colombel -, J. F., Cottone, M., D'Incà, R., Denson, T., Dubinsky, M. C., Edwards, C. M., Florin, T. H. J., Franchimont, D. P., Gearry, R. B., Georges, M. A. J. A. J., Glas, J., Van Gossum, A., Griffiths, A. M., Guthery, S. L., Hákonarson, H. H., Haritunians, T., Hugot, J. P., De Jong, D. J., Jostins, L., Kugathasan, S., Kullak- Ublick, G. A., Latiano, A., Laukens, D., Lawrance, I., Lee, J., Lees, C. W., Lémann, M., Levine, A. D., Libioulle, C., Louis, É. J., Mansfield, J. C., Mathew, C. G. P., Mitrovič, M., Montgomery, G. W., Mowat, C. E., Newman, W. G., Palmieri, O., Panés, J., Parkes, M., Phillips, A. M., Ponsioen, C. Y. J., Potočnik, U., Prescott, N. J., Proctor, D. D., Regueiro, M. D., Roberts, R. L., Rotter, J. I., Sanderson, J. D., Sans, M., Satsangi, J., Seibold, F., Simms, L. A., Taylor, K. D., Verspaget, H. W., De Vos, M. P., Walters, T. D., Wang, K., Whiteman, D. C. & Wijmenga, C., 2013, In : PLoS Genetics. 9, 9, p. 11 pp.

Research output: Contribution to journal › Article

Open Access

114 Citations (Scopus)

2014

HLA-DQA1–HLA-DRB1variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants

Heap, G. A., Weedon, M. N., Bewshea, C., Singh, A., Chen, M., Satchwell, J. B., Vivian, J. P., So, K., Dubois, P. C., Andrews, J. M., Annese, V., Bampton, P., Barnardo, M., Bell, S., Cole, A., Connor, S. J., Creed, T., Cummings, F. R., D'Amato, M., Daneshmend, T. K. & 38 others, Fedorak, R. N., Florin, T. H., Gaya, D. R., Greig, E., Halfvarson, J., Hart, A., Irving, P., Jones, G., Karban, A., Lawrance, I., Lee, J. C., Lees, C., Lev-Tzion, R., Lindsay, J. O., Mansfield, J., Mawdsley, J., Mazhar, Z., Parkes, M., Parnell, K., Orchard, T. R., Radford-Smith, G., Russell, R. K., Reffitt, D., Satsangi, J., Silverberg, M. S., Sturniolo, G. C., Tremelling, M., Tsianos, V., Van Heel, D. A., Walsh, A., Watermeyer, G., Weersma, R. K., Zeissig, S., Rossjohn, J., Holden, A. L., International Serious Adverse Events Consortium, I. S. A. E. C., Ibd Pharmacogenetics Study Group, IBD. P. S. G. & Ahmad, T., 2014, In : Nature Genetics. 46, 10, p. 1131-1136

Research output: Contribution to journal › Article

107 Citations (Scopus)

2017

Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method

Chen, G. B., Lee, S. H., Montgomery, G. W., Wray, N. R., Visscher, P. M., Gearry, R. B., Lawrance, I. C., Andrews, J. M., Bampton, P., Mahy, G., Bell, S., Walsh, A., Connor, S., Sparrow, M., Bowdler, L. M., Simms, L. A., Krishnaprasad, K., Radford-Smith, G. L. & Moser, G., 29 Aug 2017, In : BMC Medical Genetics. 18, 1, 94.

Research output: Contribution to journal › Article

Open Access

10 Citations (Scopus)

2016

Concentrations of Adalimumab and Infliximab in Mothers and Newborns, and Effects on Infection

Julsgaard, M., Christensen, L. A., Gibson, P. R., Gearry, R. B., Fallingborg, J., Hvas, C. L., Bibby, B. M., Uldbjerg, N., Connell, W. R., Rosella, O., Grosen, A., Brown, S. J., Kjeldsen, J., Wildt, S., Svenningsen, L., Sparrow, M. P., Walsh, A., Connor, S. J., Radford-Smith, G., Lawrance, I. & 3 others, Andrews, J. M., Ellard, K. & Bell, S. J., 2016, In : Gastroenterology. 151, 1, p. 110-119

Research output: Contribution to journal › Article

137 Citations (Scopus)

2012

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Jostins, L., Ripke, S., Weersma, R. K., Duerr, R. H., Mcgovern, D. P., Hui, K. Y., Lee, J. C., Philip Schumm, L., Sharma, Y., Anderson, C. A., Essers, J., Mitrovic, M., Ning, K., Cleynen, I., Theatre, E., Spain, S. L., Raychaudhuri, S., Goyette, P., Wei, Z., Abraham, C. & 86 others, Achkar, J-P., Ahmad, T., Amininejad, L., Ananthakrishnan, A. N., Andersen, V., Andrews, J. M., Baidoo, L., Balschun, T., Bampton, P. A., Bitton, A., Boucher, G., Brand, S., Büning, C., Cohain, A., Cichon, S., D'Amato, M., De Jong, D., Devaney, K. L., Dubinsky, M., Edwards, C., Ellinghaus, D., Ferguson, L. R., Franchimont, D., Fransen, K., Gearry, R., Georges, M., Gieger, C., Glas, J., Haritunians, T., Hart, A., Hawkey, C., Hedl, M., Hu, X., Karlsen, T. H., Kupcinskas, L., Kugathasan, S., Latiano, A., Laukens, D., Lawrance, I., Lees, C. W., Louis, E., Mahy, G., Mansfield, J., Morgan, A. R., Mowat, C., Newman, W., Palmieri, O., Ponsioen, C. Y., Potocnik, U., Prescott, N. J., Regueiro, M., Rotter, J. I., Russell, R. K., Sanderson, J. D., Sans, M., Satsangi, J., Schreiber, S., Simms, L. A., Sventoraityte, J., Targan, S. R., Taylor, K. D., Tremelling, M., Verspaget, H. W., De Vos, M., Wijmenga, C., Wilson, D. C., Winkelmann, J., Xavier, R. J., Zeissig, S., Zhang, B., Zhang, C. K., Zhao, H., Silverberg, M. S., Annese, V., Hakonarson, H., Brant, S. R., Radford-Smith, G., Mathew, C. G., Rioux, J. D., Schadt, E. E., Daly, M. J., Franke, A., Parkes, M., Vermeire, S., Barrett, J. C. & Cho, J. H., 1 Nov 2012, In : Nature. 491, 7422, p. 119-124

Research output: Contribution to journal › Article

2659 Citations (Scopus)

2013

Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease

International Inflammatory Bowel Disease Genetics Consortium & Lawrance, I. C., 6 Jun 2013, In : American Journal of Human Genetics. 92, 6, p. 1008-1012 5 p.

Research output: Contribution to journal › Article

Open Access

89 Citations (Scopus)

2016

A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies

Bodea, C. A., Neale, B. M., Ripke, S., International Inflammatory Bowel Disease Genetics Consortium, Lawrance, I., Daly, M. J., Devlin, B. & Roeder, K., 5 May 2016, In : American Journal of Human Genetics. 98, 5, p. 857-868 12 p.

Research output: Contribution to journal › Article

Open Access

7 Citations (Scopus)

2019

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

International Inflammatory Bowel Disease Genetics Consortium (IIBDGC), 17 Jul 2019, In : Scientific Reports. 9, 1, 10351.

Research output: Contribution to journal › Article

Open Access

13 Citations (Scopus)

2016

Clinical features and HLA association of 5-aminosalicylate (5-ASA)-induced nephrotoxicity in inflammatory bowel disease

Heap, G. A., So, K., Weedon, M., Edney, N., Bewshea, C., Singh, A., Annese, V., Beckly, J., Buurman, D., Chaudhary, R., Cole, A. T., Cooper, S. C., Creed, T., Cummings, F., de Boer, N. K., D'Inca, R., Daneshmend, T. K., Delaney, M., Dhar, A., Direkze, N. & 43 others, Dunckley, P., Gaya, D. R., Gearry, R., Gore, S., Halfvarson, J., Hart, A., Hawkey, C. J., Hoentjen, F., Iqbal, T., Irving, P., Lal, S., Lawrence, I., Lees, C. W., Lewis, S., Lockett, M., Mann, S., Mansfield, J., Mowat, C., Muller, F., Murray, C., Orchard, T., Parkes, M., Phillips, R., Pollok, R., Radford-Smith, G., Sebastian, S., Sen, S., Shirazi, T., Silverberg, M., Solomon, L., Sturniolo, G. C., Thomas, M., Tremelling, M., Tsianos, E. V., Watts, D., Weaver, S., Wesley, E., Holden, A., D'Souza, R., Mulgrew, C. J., Oram, R., Weersma, R. K. & Ahmad, T., 1 Feb 2016, In : Journal of Crohn's and Colitis. 10, 2, p. 149-158 10 p.

Research output: Contribution to journal › Article

41 Citations (Scopus)

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

International Inflammatory Bowel Disease Genetics Consortium, International Genetics of Ankylosing Spondylitis Consortium, International PSC Study Group, Genetic Analysis of Psoriasis Consortium & Psoriasis Association Genetics Extension, 1 May 2016, In : Nature Genetics. 48, 5, p. 510-518 9 p.

Research output: Contribution to journal › Article

263 Citations (Scopus)

2017

Serologic antibodies in relation to outcome in postoperative Crohn's disease

Hamilton, A. L., Kamm, M. A., De Cruz, P., Wright, E. K., Selvaraj, F., Princen, F., Gorelik, A., Liew, D., Lawrance, I. C., Andrews, J. M., Bampton, P. A., Sparrow, M. P., Florin, T. H., Gibson, P. R., Debinski, H., Gearry, R. B., Macrae, F. A., Leong, R. W., Kronborg, I., Radford-Smith, G. & 4 others, Selby, W., Bell, S. J., Brown, S. J. & Connell, W. R., 1 Jun 2017, In : Journal of Gastroenterology and Hepatology (Australia). 32, 6, p. 1195-1203 9 p.

Research output: Contribution to journal › Article

10 Citations (Scopus)

2018

Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease

Roberts, R. L., Wallace, M. C., Seinen, M. L., van Bodegraven, A. A., Krishnaprasad, K., Jones, G. T., van Rij, A. M., Baird, A., Lawrance, I. C., Prosser, R., Bampton, P., Grafton, R., Simms, L. A., Studd, C., Bell, S. J., Kennedy, M. A., Halliwell, J., Gearry, R. B., Radford-Smith, G., Andrews, J. M. & 2 others, McHugh, P. C. & Barclay, M. L., 29 Nov 2018, In : Inflammatory Bowel Diseases. 24, 12, p. 2606-2612 7 p.

Research output: Contribution to journal › Article

2013

European evidence based consensus for endoscopy in inflammatory bowel disease

ECCO & Lawrance, I., 15 Dec 2013, In : Journal of Crohn's and Colitis. 7, 12, p. 982-1018 37 p.

Research output: Contribution to journal › Article

Open Access

441 Citations (Scopus)

2017

Fine-mapping inflammatory bowel disease loci to single-variant resolution

Huang, H., Fang, M., Jostins, L., Umićević Mirkov, M., Boucher, G., Anderson, C. A., Andersen, V., Cleynen, I., Cortes, A., Crins, F., D'Amato, M., Deffontaine, V., Dmitrieva, J., Docampo, E., Elansary, M., Farh, K. K-H., Franke, A., Gori, A-S., Goyette, P., Halfvarson, J. & 27 others, Haritunians, T., Knight, J., Lawrance, I. C., Lees, C. W., Louis, E., Mariman, R., Meuwissen, T., Mni, M., Momozawa, Y., Parkes, M., Spain, S. L., Théâtre, E., Trynka, G., Satsangi, J., van Sommeren, S., Vermeire, S., Xavier, R. J., Weersma, R. K., Duerr, R. H., Mathew, C. G., Rioux, J. D., McGovern, D. P. B., Cho, J. H., Georges, M., Daly, M. J., Barrett, J. C. & International Inflammatory Bowel Disease Genetics Consortium, 13 Jul 2017, In : Nature. 547, 7662, p. 173-178 6 p.

Research output: Contribution to journal › Article

Open Access

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