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  • Jiake Xu
2017

Artesunate suppresses RANKL-induced osteoclastogenesis through inhibition of PLCγ1-Ca2+–NFATc1 signaling pathway and prevents ovariectomy-induced bone loss

Zeng, X., Zhang, Y., Wang, S., Wang, K., Tao, L., Zou, M., Chen, N., Xu, J., Liu, S. & Li, X., 15 Jan 2017, In : Biochemical Pharmacology. 124, p. 57-68 12 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2014

Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of mice

Yan, W., Wang, T-Y., Fan, Q-M., Du, L., Xu, J., Zhai, Z-J., Li, H-W. & Tang, T-T., 2014, In : Acta Pharmacologica Sinica. 35, p. 124-134

Research output: Contribution to journalArticle

27 Citations (Scopus)
2015

Parthenolide reduces empty lacunae and osteoclastic bone surface resorption induced by polyethylene particles in a murine calvarial model of peri-implant osteolysis

Zawawi, M. S. F., Marino, V., Perilli, E., Cantley, M. D., Xu, J., Purdue, P. E., Dharmapatni, A. A. S. S. K., Haynes, D. R. & Crotti, T. N., 2015, In : Journal of Biomedical Materials Research Part A. 103, 11, p. 3572-3579

Research output: Contribution to journalArticle

8 Citations (Scopus)
2016

Sinomenine down-regulates TLR4/TRAF6 expression and attenuates lipopolysaccharide-induced osteoclastogenesis and osteolysis

He, L., Duan, H., Li, X., Wang, S., Zhang, Y., Lei, L., Xu, J. & Liu, S., 2016, In : European Journal of Pharmacology. 779, p. 66-79

Research output: Contribution to journalArticle

13 Citations (Scopus)
2019

Emerging Trend in the Pharmacotherapy of Osteoarthritis

Zhang, W., Robertson, W. B., Zhao, J., Chen, W. & Xu, J., 2 Jul 2019, In : Frontiers in Endocrinology. 10, 9 p., 431.

Research output: Contribution to journalReview article

Open Access
12 Citations (Scopus)
2014

International Combined Orthopaedic Research Societies: A model for international collaboration to promote orthopaedic and musculoskeletal research

Miclau, T., Adachi, N., Antoniou, J., Baldini, N., Blunn, G., Boyd, S., Chang, JK., Grimm, B., Guo, X. E., Im, GI., Kim, SY., Korkusuz, F., Lee, OKS., Mccaskie, A., Richards, R. G., Shetty, G., Sivananthan, S., Tang, T., Xu, J. & Qin, L., 2014, In : Journal of Orthopaedic Translation. Online, p. 1-6

Research output: Contribution to journalLetter

Open Access
10 Citations (Scopus)
2011

Mangiferin Attenuates Osteoclastogenesis, Bone Resorption, and RANKL-Induced Activation of NF-kB and ERK

Ang, E., Liu, Q., Qi, M., Liu, H. G., Yang, X., Chen, H., Zheng, M. & Xu, J., 2011, In : Journal of Cellular Biochemistry. 112, 1, p. 89-97

Research output: Contribution to journalArticle

63 Citations (Scopus)
2018

Luteoloside prevents lipopolysaccharide-induced osteolysis and suppresses RANKL-induced osteoclastogenesis through attenuating RANKL signaling cascades

Song, F., Wei, C., Zhou, L., Qin, A., Yang, M., Tickner, J., Huang, Y., Zhao, J. & Xu, J., 1 Feb 2018, In : Journal of Cellular Physiology. 233, 2, p. 1723-1735 13 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
250 Downloads (Pure)
2016

Hemocompatibility evaluation in vitro of methoxy polyethyleneglycol-polycaprolactone copolymer solutions

Hu, Q., Zhang, Y., Wang, C., Xu, J., Wu, J., Liu, Z. & Xue, W., 2016, In : Journal of Biomedical Materials Research - Part A. 104, 3, p. 802-812

Research output: Contribution to journalArticle

7 Citations (Scopus)
2019

Dehydrocostus lactone (DHC) suppresses estrogen deficiency-induced osteoporosis

Li, Z., Yuan, G., Lin, X., Liu, Q., Xu, J., Lian, Z., Song, F., Zheng, J., Xie, D., Chen, L., Wang, X., Feng, H., Zhou, M. & Yao, G., 1 May 2019, In : Biochemical Pharmacology. 163, p. 279-289 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Daphnetin attenuates LPS-induced osteolysis and RANKL mediated osteoclastogenesis through suppression of ERK and NFATc1 pathways

Wu, Z., Wu, H., Li, C., Fu, F., Ding, J., Shao, S., Li, K., Yu, X., Su, Y., Liang, J., Lin, X., Yuan, G., Zhou, J., Song, F., Zhao, J., Xu, J., Liu, Q. & Xu, F., 1 Oct 2019, In : Journal of Cellular Physiology. 234, 10, p. 17812-17823 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2013

Divergent effects of endogenous and exogenous glucocorticoid-induced leucine zipper in animal models of inflammation and arthritis

Ngo, D., Beaulieu, E., Gu, R., Leaney, A., Santos, L., Fan, H., Yang, Y., Kao, W., Xu, J., Escriou, V., Loiler, S. A., Vervoordeldonk, M. J. B. M. & Morand, E. F., 2013, In : ARTHRITIS AND RHEUMATISM. 65, 5, p. 1203-1212

Research output: Contribution to journalArticle

Open Access
File
32 Citations (Scopus)
385 Downloads (Pure)
2015

Parthenolide inhibits pro-inflammatory cytokine production and exhibits protective effects on progression of collagen-induced arthritis in a rat model

Liu, Q., Zhao, J., Tan, R., Zhou, H., Lin, Z., Zheng, M., Romas, E., Xu, J. & Sims, NA., May 2015, In : Scandinavian Journal of Rheumatology. 44, 3, p. 182-191

Research output: Contribution to journalArticle

20 Citations (Scopus)
2013
Open Access
20 Citations (Scopus)
2011

Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-kB and ERK activation

Ang, E., Yang, X., Chen, H., Liu, Q., Zheng, M. & Xu, J., 2011, In : FEBS Letters. 585, 17, p. 2755-2762

Research output: Contribution to journalArticle

69 Citations (Scopus)
2014

Epidermal stem cells cultured on collagen-modified chitin membrane induce in Situ tissue regeneration of full-thickness skin defects in mice

Shen, Y., Dai, L., Li, X., Liang, R., Guan, G., Zhang, Z., Cao, W., Liu, Z., Mei, S., Liang, W., Qin, S., Xu, J. & Chen, H., 2014, In : PLoS One. 9, 2, p. 1-14

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)
2013

Sinomenine Suppresses Osteoclast Formation and Mycobacterium tuberculosis H37Ra-Induced Bone Loss by Modulating RANKL Signaling Pathways

Li, X., He, L., Hu, Y., Duan, H., Li, X., Tan, S., Zou, M., Gu, C., Zeng, X., Yu, L., Xu, J. & Liu, S., 2013, In : PLoS One. 8, 9, p. 15pp

Research output: Contribution to journalArticle

Open Access
26 Citations (Scopus)
2014

High-resolution measurements of the multilayer ultra-structure of articular cartilage and their translational potential

He, B., Wu, J., Kirk, T. B., Carrino, J. A., Xiang, C. & Xu, J., 12 Mar 2014, In : Arthritis Research and Therapy. 16, 2, p. 16pp

Research output: Contribution to journalArticle

Open Access
30 Citations (Scopus)
2020

Betulinic Acid Protects From Bone Loss in Ovariectomized Mice and Suppresses RANKL-Associated Osteoclastogenesis by Inhibiting the MAPK and NFATc1 Pathways

Wei, J., Li, Y., Liu, Q., Lan, Y., Wei, C., Tian, K., Wu, L., Lin, C., Xu, J., Zhao, J. & Yang, Y., 7 Jul 2020, In : Frontiers in Pharmacology. 11, 1025.

Research output: Contribution to journalArticle

Open Access
2012

Membrane-bound receptor activator of NFκB ligand (RANKL) activity displayed by osteoblasts is differentially regulated by osteolytic factors

Singh, P. P., Van Der Kraan, A. G. J., Xu, J., Gillespie, M. T. & Quinn, J. M. W., 2012, In : Biochemical and Biophysical Research Communications. 422, p. 48-53

Research output: Contribution to journalArticle

26 Citations (Scopus)
2019

Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-kappa B signaling pathways

He, L., Hong, G., Zhou, L., Zhang, J., Fang, J., He, W., Tickner, J., Han, X., Zhao, L. & Xu, J., Apr 2019, In : Journal of Cellular Physiology. 234, 4, p. 4267-4276 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Chondromodulin-1 in health, osteoarthritis, cancer, and heart disease

Zhu, S., Qiu, H., Bennett, S., Kuek, V., Rosen, V., Xu, H. & Xu, J., Nov 2019, In : Cellular and Molecular Life Sciences. 76, 22, p. 4493-4502

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

Protein Cytl1: its role in chondrogenesis, cartilage homeostasis, and disease

Zhu, S., Kuek, V., Bennett, S., Xu, H., Rosen, V. & Xu, J., 14 May 2019, In : Cellular and Molecular Life Sciences. 76, 18, p. 3515-3523

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)
2018

Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats

Su, Y. W., Chim, S. M., Zhou, L., Hassanshahi, M., Chung, R., Fan, C., Song, Y., Foster, B. K., Prestidge, C. A., Peymanfar, Y., Tang, Q., Butler, L. M., Gronthos, S., Chen, D., Xie, Y., Chen, L., Zhou, X. F., Xu, J. & Xian, C. J., 1 Nov 2018, In : Bone. 116, p. 232-247 16 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2019

Asperpyrone A attenuates RANKL-induced osteoclast formation through inhibiting NFATc1, Ca2+ signalling and oxidative stress

Chen, X., Wang, C., Qiu, H., Yuan, Y., Chen, K., Cao, Z., Xiang Tan, R., Tickner, J., Xu, J. & Zou, J., 1 Dec 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8269-8279 11 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

The Effect of Exercise on the Prevention of Osteoporosis and Bone Angiogenesis

Tong, X., Chen, X., Zhang, S., Huang, M., Shen, X., Xu, J. & Zou, J., 2019, In : BioMed Research International. 2019, 8 p., 8171897.

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)
2017

Massage alleviates delayed onset muscle soreness after strenuous exercise: A systematic review and meta-analysis

Guo, J., Li, L., Gong, Y., Zhu, R., Xu, J., Zou, J. & Chen, X., 27 Sep 2017, In : Frontiers in Physiology. 8, 747.

Research output: Contribution to journalReview article

Open Access
11 Citations (Scopus)

Molecular structure and differential function of choline kinases CHKα and CHKβ in musculoskeletal system and cancer

Chen, X., Qiu, H., Wang, C., Yuan, Y., Tickner, J., Xu, J. & Zou, J., Feb 2017, In : Cytokine and Growth Factor Reviews. 33, p. 65-72 8 p.

Research output: Contribution to journalReview article

Open Access
File
1 Citation (Scopus)
295 Downloads (Pure)
2014

Construction and biomechanical properties of polyaxial self-locking anatomical plate based on the geometry of distal tibia

Liang, W., Ye, W., Ye, D., Zhou, Z., Chen, Z., Li, A., Xie, Z., Zhang, L. & Xu, J., 2014, In : BioMed Research International. 2014, p. 1-7

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2016

Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats

Su, Y., Chung, R., Ruan, C., Chim, S., Kuek, V., Dwivedi, P., Hassanshahi, M., Chen, K., Xie, Y., Chen, L., Foster, B., Rosen, V., Zhou, X., Xu, J. & Xian, C., Jun 2016, In : Journal of Bone & Mineral Research. 31, 6, p. 1258-1274

Research output: Contribution to journalArticle

26 Citations (Scopus)
2015

A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation of microRNAs in osteoclasts

Liu, J., Dang, L., Li, D., Liang, C., He, X., Wu, H., Qian, A., Yang, Z., Au, D. W. T., Chiang, M. W. L., Zhang, B. T., Han, Q., Yue, K. K. M., Zhang, H., Lv, C., Pan, X., Xu, J., Bian, Z., Shang, P., Tan, W. & 4 others, Liang, Z., Guo, B., Lu, A. & Zhang, G., 2015, In : Biomaterials. 52, 1, p. 148-160

Research output: Contribution to journalArticle

39 Citations (Scopus)
2014

Electrochemical behavior of (Ti1-xNbx) 5Si3 nanocrystalline films in simulated physiological media

Liu, L., Xu, J., Munroe, P. R., Xu, J. & Xie, Z., 2014, In : Acta Biomaterialia. 10, 2, p. 1005-1013

Research output: Contribution to journalArticle

20 Citations (Scopus)
2016

Dihydroartemisinin, an Anti-Malaria Drug, Suppresses Estrogen Deficiency-Induced Osteoporosis, Osteoclast Formation, and RANKL-Induced Signaling Pathways

Zhou, L., Liu, Q., Yang, M., Wang, T., Yao, J., Cheng, J. W., Yuan, J., Lin, X., Zhao, J., Tickner, J. & Xu, J., May 2016, In : Journal of Bone and Mineral Research. 31, 5, p. 964-974

Research output: Contribution to journalArticle

Open Access
File
51 Citations (Scopus)
308 Downloads (Pure)
2017

Evaluation of N-phosphonium chitosan as a novel vaccine carrier for intramuscular immunization

Cai, J., Zhang, W., Xu, J., Xue, W. & Liu, Z., 1 Nov 2017, In : Journal of Biomaterials Applications. 32, 5, p. 677-685 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Biocompatibility and cellular uptake mechanisms of poly(N -isopropylacrylamide) in different cells

Guo, Z., Li, S., Wang, C., Xu, J., Kirk, B., Wu, J., Liu, Z. & Xue, W., 1 Jan 2017, In : Journal of Bioactive and Compatible Polymers. 32, 1, p. 17-31 15 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2018

Synthesis of Janus Au nanorods/polydivinylbenzene hybrid nanoparticles for chemo-photothermal therapy

Wang, Y., Ji, X., Pang, P., Shi, Y., Dai, J., Xu, J., Wu, J., Kirk, T. B. & Xue, W., 28 Apr 2018, In : Journal of Materials Chemistry B. 6, 16, p. 2481-2488 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2017

Differential protein expression between normal and degenerated human nucleus pulposus cells by proteomic and bioinformatics analyses

Ye, D. P., Liang, W. G., Dai, L., Yao, Y., Chen, H., Zhou, Y. & Xu, J., 2017, In : International Journal of Clinical and Experimental Medicine. 10, 12, p. 16172-16180 9 p.

Research output: Contribution to journalArticle

Open Access
File
62 Downloads (Pure)

A polyamidoamne dendrimer functionalized graphene oxide for DOX and MMP-9 shRNA plasmid co-delivery

Gu, Y., Guo, Y., Wang, C., Xu, J., Wu, J., Kirk, T. B., Ma, D. & Xue, W., 1 Jan 2017, In : Materials Science and Engineering C. 70, p. 572-585 14 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2012
18 Citations (Scopus)
2018

Light-Triggered Biomimetic Nanoerythrocyte for Tumor-Targeted Lung Metastatic Combination Therapy of Malignant Melanoma

Liu, W., Ruan, M., Wang, Y., Song, R., Ji, X., Xu, J., Dai, J. & Xue, W., 20 Sep 2018, In : Small. 14, 38, 1801754.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2013

Angiogenic factors in bone local environment

Chim, S., Tickner, J., Chow, S. T., Kuek, V., Guo, B., Zhang, G., Rosen, V., Erber, W. & Xu, J., 2013, In : Cytokine and Growth Factor Reviews. 24, 3, p. 297-310

Research output: Contribution to journalReview article

133 Citations (Scopus)
2015

Comparative and quantitative proteomic analysis of normal and degenerated human annulus fibrosus cells

Ye, D., Liang, W., Dai, L., Zhou, L., Yao, Y., Zhong, X., Chen, H. & Xu, J., 2015, In : Clinical and Experimental Pharmacology and Physiology. 42, 5, p. 530-536

Research output: Contribution to journalArticle

10 Citations (Scopus)
2016
Open Access
11 Citations (Scopus)
2017

Neohesperidin suppresses osteoclast differentiation, bone resorption and ovariectomised-induced osteoporosis in mice

Tan, Z., Cheng, J., Liu, Q., Zhou, L., Kenny, J., Wang, T., Lin, X., Yuan, J., Quinn, J. M. W., Tickner, J., Hong, G., Qin, A., Zhao, J. & Xu, J., 5 Jan 2017, In : Molecular and Cellular Endocrinology. 439, p. 369-378 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2020

Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts

Chen, K., Liu, Y., He, J., Pavlos, N., Wang, C., Kenny, J., Yuan, J., Zhang, Q., Xu, J. & He, W., 2020, In : International Journal of Biological Sciences. 16, 11, p. 1888-1900 13 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Rheumatoid arthritis: Pathological mechanisms and modern pharmacologic therapies

Guo, Q., Wang, Y., Xu, D., Nossent, J., Pavlos, N. J. & Xu, J., 1 Dec 2018, In : Bone Research. 6, 1, 16.

Research output: Contribution to journalReview article

Open Access
144 Citations (Scopus)
2012

An overview of the regulation of bone remodelling at the cellular level

Kular, J., Tickner, J., Chim, S. & Xu, J., 2012, In : Clinical Biochemistry. 45, p. 863-873

Research output: Contribution to journalArticle

211 Citations (Scopus)
2011

EGFL6 promotes endothelial cell migration and angiogenesis through the activation of Extracellular Signal-regulated Kinase

Chim, S., Qin, A., Tickner, J., Pavlos, N., Davey, T. N., Wang, H., Guo, Y., Zheng, M. & Xu, J., 2011, In : Journal of Biological Chemistry. 286, 25, p. 22035-22046

Research output: Contribution to journalArticle

59 Citations (Scopus)