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• 2015

  Embryonic transcription is controlled by maternally defined chromatin state

  Hontelez, S., Van Kruijsbergen, I., Georgiou, G., Van Heeringen, S. J., Bogdanovic, O., Lister, R. & Veenstra, G. J. C., 2015, In : Nature Communications. 6, p. 1-11

  Research output: Contribution to journal › Article

  Open Access

  • chromatin
  • Transcription
  • Chromatin
  • Mothers
  • Nucleic Acid Regulatory Sequences
  48 Citations (Scopus)
• 2008

  Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men

  Loke, W., Hodgson, J., Proudfoot, J., Mckinley, A., Puddey, I. & Croft, K., 2008, In : American Journal of Clinical Nutrition. 88, 4, p. 1018-25

  Research output: Contribution to journal › Article

  • Catechin
  • Quercetin
  • Endothelin-1
  • Flavonoids
  • Nitric Oxide
  261 Citations (Scopus)
• 2001

  Soluble markers as predictors of response to combination therapy with IFN-a and ribavirin in chronic HCV infection

  Lee, S., Macquillan, G., Keane, N. & Price, P., 2001, Australasian Soc for Immunology Inc. Canberra, Australia. 31st Annual Scientific Mtg. Program & Abstracts. 2-6 Dec 2001. Altin, J. (ed.). Canberra, Australia

  Research output: Chapter in Book/Conference paper › Other chapter contribution
• 2011

  The relationship between MECP2 mutation type and health status and service use trajectories over time in a Rett syndrome population

  Young, D., Bebbington, A., De Klerk, N., Bower, C., Nagarajan, L. & Leonard, H., 2011, In : Research in Autism Spectrum Disorders. 5, 1, p. 442–449

  Research output: Contribution to journal › Article

  • Rett Syndrome
  • Health Services
  • Health Status
  • Mutation
  • Population
  13 Citations (Scopus)
• 1995

  Superoxide dismutase (SOD1) mutations in amyotrophic lateral sclerosis (ALS)

  Dench, J., Wilton, S., Yeung, L., Nicholson, G., Kakulas, B. & Laing, N., 1995, Sixteenth Annual Neuroscience Colloquium of Western Australia. Perth: Organising Committee, Sixteenth Annual Neuroscience Colloquium of Western Australia, p. 17

  Research output: Chapter in Book/Conference paper › Other chapter contribution
• 1996

  In vitro cytotoxicity assay of synthetic hydrogels as potential vitreous substitutes

  Hong, Y., Chirila, T. V., Vijayasekaran, S., Davies, M. J., Maley, M. A. L. & Maley, M., 1996, In : In Vitro Toxicology. 9, 1, p. 73-82

  Research output: Contribution to journal › Article

  9 Citations (Scopus)
• 1992

  Drug Induced, Toxic and Nutritional Myopathies

  Kakulas, B. & Mastaglia, F., 1992, Skeletal Muscle Pathology (2nd edn). Kakulas, B. A. & Mastaglia, F. L. (eds.). Edinburgh: Churchill Livingstone, Vol. 1. p. 511-540

  Research output: Chapter in Book/Conference paper › Chapter
• 1994

  Neocollagen synthesis within hydrogel sponges implanted into the rabbit cornea

  Chirila, T. V., Vijayasekaran, S., Crawford, G. J., Thompson-Wallis, D. E. & Constable, I., 1994, National Ophthalmic and Visual Science Meeting. Deakin University, Geelong, Victoria: Desk Top, Vol. 1994. p. 60

  Research output: Chapter in Book/Conference paper › Conference paper
• 2012

  Intellectual disability and other neuropsychiatric outcomes in high-risk children of mothers with schizophrenia, bipolar disorder and unipolar major depression

  Morgan, V., Croft, M., Valuri, G., Zubrick, S., Bower, C., Mcneil, T. & Jablensky, A., 2012, In : British Journal of Psychiatry. 200, 4, p. 282-289

  Research output: Contribution to journal › Article

  Open Access
  54 Citations (Scopus)
• 2013

  Enhanced rates of herbicide metabolism in low herbicide-dose selected resistant Lolium rigidum

  Yu, Q., Han, H., Cawthray, G., Wang, S. & Powles, S., 2013, In : Plant, Cell and Environment. 36, p. 818 - 827

  Research output: Contribution to journal › Article
  50 Citations (Scopus)
• 2020

  Low-dose 2-deoxy glucose stabilises tolerogenic dendritic cells and generates potent in vivo immunosuppressive effects

  Christofi, M., Le Sommer, S., Mölzer, C., Klaska, I. P., Kuffova, L. & Forrester, J. V., 19 Oct 2020, In : Cellular and Molecular Life Sciences.

  Research output: Contribution to journal › Article

  Open Access

  • Dendritic Cells
  • Immunosuppressive Agents
  • Glucose
  • Glycolysis
  • Oxidative Phosphorylation
• 2017

  The ORGAN experiment: An axion haloscope above 15 GHz

  McAllister, B. T., Flower, G., Ivanov, E. N., Goryachev, M., Bourhill, J. & Tobar, M. E., Dec 2017, In : Physics Of The Dark Universe. 18, p. 67-72 6 p.

  Research output: Contribution to journal › Article
  81 Citations (Scopus)
• 2014

  Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics

  Hato, S. V., Khong, A., De Vries, I. J. M. & Lesterhuis, W., 1 Jun 2014, In : Clinical Cancer Research. 20, 11, p. 2831-2837

  Research output: Contribution to journal › Article

  Open Access

  • Platinum
  • Pharmaceutical Preparations
  • Neoplasms
  • IGF Type 2 Receptor
  • Calreticulin
  196 Citations (Scopus)
• 2015

  Precision measurement of a low-loss cylindrical dumbbell-shaped sapphire mechanical oscillator using radiation pressure

  Bourhill, J., Ivanov, E. & Tobar, M., 11 Aug 2015, In : Physical Review A - Atomic, Molecular, and Optical Physics. 92, 2, p. 023817-1 - 023817-12

  Research output: Contribution to journal › Article

  • mechanical oscillators
  • radiation pressure
  • sapphire
  • crystals
  • frequency modulation
  8 Citations (Scopus)
• 2020

  In “high-risk” infants with sufficient vitamin d status at birth, infant vitamin D supplementation had no effect on allergy outcomes: A randomized controlled trial

  Rueter, K., Jones, A. P., Siafarikas, A., Lim, E. M., Prescott, S. L. & Palmer, D. J., Jun 2020, In : Nutrients. 12, 6, p. 1-12 12 p., 1747.

  Research output: Contribution to journal › Article

  Open Access

  • vitamin D
  • hypersensitivity
  • Vitamins
  • Vitamin D
  • vitamins
• 2018

  Taking a prebiotic approach to early immunomodulation for allergy prevention

  Pretorius, R., Prescott, S. L. & Palmer, D. J., 2 Jan 2018, In : Expert Review of Clinical Immunology. 14, 1, p. 43-51 9 p.

  Research output: Contribution to journal › Review article

  • Prebiotics
  • Immunomodulation
  • Hypersensitivity
  • Volatile Fatty Acids
  • Oligosaccharides
  13 Citations (Scopus)
• 2016

  Early life nutrition and the opportunity to influence long-term health: an Australasian perspective

  Davies, P. S. W. S. W., Funder, J., Palmer, D. J., Sinn, J., Vickers, M. H. H. & Wall, C. R. R., 2016, In : Journal of Developmental Origins of Health and Disease. 7, 5, p. 440-448 9 p.

  Research output: Contribution to journal › Article

  • New Zealand
  • Health Policy
  • Health
  • Fetus
  • Child
  11 Citations (Scopus)
• 2019

  Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model

  Liu, Y-H., Molzer, C., Milne, G. C., Kuffova, L. & Forrester, J. V., Feb 2019, In : Data in Brief. 22, p. 140-144 5 p.

  Research output: Contribution to journal › Data article

  Open Access
  1 Citation (Scopus)
• 2014

  The efficacy of tumor debulking surgery is improved by adjuvant immunotherapy using imiquimod and anti-CD40

  Khong, A., Cleaver, A., Alatas, M. F., Wylie, B., O'Connor, T., Fisher, S., Broomfield, S., Lesterhuis, W., Currie, A., Lake, R. & Robinson, B., 2014, In : BMC Cancer. 14, p. 1-9

  Research output: Contribution to journal › Article

  Open Access
  16 Citations (Scopus)
• 1997

  Recombinant house dust mite allergens

  Thomas, W. R., Smith, W-A., Hales, B., Carter, M. D., Bennett, B. J., Shen, H-D., Tovey, E. R. & Chua, K. Y., 1997, Regulatory Control and Standardization of Allergen Extracts. Kurth, R., Haustein, D. & Lin, Y. (eds.). Bethesda, Maryland ed. Stuttgart: Gustav Fischer Verlag, Vol. n/a. p. 87-96

  Research output: Chapter in Book/Conference paper › Conference paper

  4 Citations (Scopus)
• 2017

  Direct inhibition of STAT signaling by platinum drugs contributes to their anti-cancer activity

  Hato, S. V., Figdor, C. G., Takahashi, S., Pen, A. E., Halilovic, A., Bol, K. F., Vasaturo, A., Inoue, Y., Haas, N. D., Verweij, D., Van Herpen, C. M. L., Kaanders, J. H., van Krieken, J. H. J. M., Van Laarhoven, H. W. M., Hooijer, G. K. J., Punt, C. J. A., Asai, A., de Vries, I. J. M. & Lesterhuis, W. J., 1 Jan 2017, In : Oncotarget. 8, 33, p. 54434-54443 10 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • STAT Transcription Factors
  • Platinum
  • Transducers
  • Cisplatin
  • Squamous Cell Carcinoma of Head and Neck
  11 Citations (Scopus)

  483 Downloads (Pure)
• 2018

  Clinical significance of circulating microRNAs as markers in detecting and predicting congenital heart defects in children

  Song, Y., Higgins, H., Guo, J., Harrison, K., Schultz, E. N., Hales, B. J., Moses, E. K., Goldblatt, J., Pachter, N. & Zhang, G., 27 Feb 2018, In : Journal of Translational Medicine. 16, 1, 42.

  Research output: Contribution to journal › Article

  Open Access

  • Circulating MicroRNA
  • Congenital Heart Defects
  • Atrial Heart Septal Defects
  • Defects
  • MicroRNAs
  13 Citations (Scopus)
• 2017

  Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition

  Ebbing, E. A., Steins, A., Fessler, E., Stathi, P., Lesterhuis, W. J., Krishnadath, K. K., Vermeulen, L., Medema, J. P., Bijlsma, M. F. & van Laarhoven, H. W. M., 1 Jul 2017, In : Gastroenterology. 153, 1, p. 63-76.e14

  Research output: Contribution to journal › Article

  • TYK2 Kinase
  • ErbB-2 Receptor
  • Trastuzumab
  • Epithelial-Mesenchymal Transition
  • pertuzumab
  10 Citations (Scopus)

• THE EFFECT OF PARTICLE SIZE DELIVERED BY PRESSURIZED METER DOSE INHALERS (pMDIs) IN ASTHMATIC ADOLESCENTS

  Johnson, N., Ditcham, W., Allen, C., Trend, S. & Devadason, S., Mar 2017, In : Respirology. 22, p. 46-46 1 p.

  Research output: Contribution to journal › Abstract/Meeting Abstract
• 2018

  A marked shift in innate and adaptive immune response in Chinese immigrants living in a Western environment

  Saiganesh, A., Hales, B. J., Li, Y., Holt, P. G., Le Souëf, P. N. & Zhang, G., Oct 2018, In : Allergy: European Journal of Allergy and Clinical Immunology. 73, 10, p. 2092-2094

  Research output: Contribution to journal › Letter
  5 Citations (Scopus)
• 2015

  New directions in mesothelioma treatment

  Nowak, A. K., Lesterhuis-Vasbinder, D. & Lesterhuis, W. J., 2015, In : Lung Cancer Management. 4, 6, p. 299-307

  Research output: Contribution to journal › Review article

  • Pemetrexed
  • Mesothelioma
  • Pleural Effusion
  • tremelimumab
  • Cisplatin
• 2010

  Hydrocephalus in babies: a specific neonatal EEG pattern

  Nagarajan, L., Ghosh, S., Palumbo, L., Kohan, R. & Thonell, S., 2010, In : Child's Nervous System. 349, 2, p. 213-224

  Research output: Contribution to journal › Review article
• 2003

  Que/qui sont les etres semi-vivants crees par Tissue Culture & Art

  Zurr, I., Catts, O. & Ben-Ary, G., 2003, Nantes, France: Filigranes Editions.

  Research output: Book/Report › Book
• 1988

  The development of rat α₂‐macroglobulin: Studies in vivo and in cultured fetal rat hepatocytes

  FLETCHER, S., THOMAS, T., SCHREIBER, G., HEINRICH, P. C. & YEOH, G. C. T., 1 Jan 1988, In : European Journal of Biochemistry. 171, 3, p. 703-709 7 p.

  Research output: Contribution to journal › Article

  • Hepatocytes
  • Rats
  • Liver
  • Decidua
  • Tissue
  22 Citations (Scopus)
• 2018

  The Evolution of Public Health Genomics: Exploring Its Past, Present, and Future

  Molster, C. M., Bowman, F. L., Bilkey, G. A., Cho, A. S., Burns, B. L., Nowak, K. & Dawkins, H. J. S., 4 Sep 2018, In : Frontiers in Public Health. 6, 11 p., 247.

  Research output: Contribution to journal › Review article

  Open Access
  12 Citations (Scopus)
• 2011

  MicroRNA Regulation of Growth Factor Receptor Signaling in Human Cancer Cells

  Giles, K., Barker, A. P., Zhang, P., Epis, M. & Leedman, P., 2011, MicroRNA and Cancer: Methods and Protocols. Wu, W. (ed.). 1st Edition ed. United States: Humana Press, p. 147-163

  Research output: Chapter in Book/Conference paper › Other chapter contribution

  30 Citations (Scopus)
• 2001

  Combined effect of cyclosporine and sirolimus on improving the longevity of recombinant adenovirus-mediated transgene expression in the retina

  Shen, W-Y., Lai, C-M., Beilby, J., Barnett, N. L., Liu, J., Constable, I. & Rakoczy, E., 2001, In : Archives of Ophthalmology. 119, 7, p. 1033-1043

  Research output: Contribution to journal › Article

  • Sirolimus
  • Transgenes
  • Adenoviridae
  • Cyclosporine
  • Longevity
  20 Citations (Scopus)
• 2018

  The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy

  Chaurasia, S. S., Lim, R. R., Parikh, B. H., Wey, Y. S., Tun, B. B., Wong, T. Y., Luu, C. D., Agrawal, R., Ghosh, A., Mortellaro, A., Rackoczy, E., Mohan, R. R. & Barathi, V. A., 1 Dec 2018, In : Scientific Reports. 8, 1, 2847.

  Research output: Contribution to journal › Article

  Open Access

  • Pathologic Neovascularization
  • Inflammasomes
  • Diabetic Retinopathy
  • Retina
  • Interleukin-1
  38 Citations (Scopus)
• 2000

  Massive idiosyncratic exon skipping corrects the nonsense mutation in dystrophic mouse muscle and produces functional revertant fibers by clonal expansion

  Lu, Q. L., Morris, G. E., Wilton, S., Ly, T., Artemyeva, O. V., Strong, P. & Partridge, T. A., 2000, In : The Journal of Cell Biology. 148, 5, p. 985-995

  Research output: Contribution to journal › Article
  161 Citations (Scopus)
• 2014

  A cost-effectiveness analysis of sensor-augmented insulin pump therapy and automated insulin suspension versus standard pump therapy for hypoglycemic unaware patients with type 1 diabetes

  Ly, T., Brnabic, A. J. M., Eggleston, A., Kolivos, A., Mcbride, M. E., Schrover, R. & Jones, T., 2014, In : Value in Health. 17, 5, p. 561-569

  Research output: Contribution to journal › Article

  Open Access

  • Hypoglycemic Agents
  • Type 1 Diabetes Mellitus
  • Suspensions
  • Cost-Benefit Analysis
  • Insulin
  28 Citations (Scopus)
• 2019

  Breakpoint junction features of seven DMD deletion mutations

  Keegan, N. P., Wilton, S. D. & Fletcher, S., 1 Dec 2019, In : Human Genome Variation. 6, 1, 39.

  Research output: Contribution to journal › Article

  Open Access

  • Duchenne Muscular Dystrophy
  • Sequence Deletion
  • Bioinformatics
  • Muscle
  • Genes
• 2020

  Surrogate Musicianship in the Age of In-vitro intelligence - Redefining the Live Performer

  Ben-Ary, G., Thompson, N. & Moore, D., 1 Jun 2020, The Future of Live Music. Mazierska, E., Gillon, L. & Rigg, T. (eds.). Bloomsbury Academic, p. 99–113 14 p.

  Research output: Chapter in Book/Conference paper › Chapter
• 1996

  Ocular gene therapy - aspects of targeting the retinal pigment epithelium

  Da Cruz, L., Rakoczy, E. & Constable, I., 1996, The Royal Australian College of Ophthalmologists 28th Annual Scientific Congress. Morlet, G. (ed.). Perth ed. West Perth: Congress West, Vol. 28. p. 75

  Research output: Chapter in Book/Conference paper › Conference paper
• 1994

  Identification of mutations in patients with retinitis pigmentosa in beta subunit cGMPPDE

  Di Grandi, S., Rakoczy, E., Humphrey, M. F. & Constable, I., 1994, National Ophthalmic and Visual Science Meeting. Deakin University, Geelong, Victoria: Desk Top, Vol. 1994. p. 11

  Research output: Chapter in Book/Conference paper › Conference paper
• 2006

  Limited iron export by hepatocytes contributes to hepatic iron-loading in the Hfe knockout mouse

  Chua, A., Drake, S. F., Herbison, C. E., Olynyk, J., Leedman, P. & Trinder, D., 2006, In : Journal of Hepatology. 44, 1, p. 176-182

  Research output: Contribution to journal › Article

  • Knockout Mice
  • Hepatocytes
  • Iron
  • Liver
  • metal transporting protein 1
  13 Citations (Scopus)
• 2008

  Exon skipping in Duchenne muscular dystrophy

  Wilton, S., 2008, In : Neuromuscular Disorders. 18, p. 431-432

  Research output: Contribution to journal › Letter
• 2010

  Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials

  Popplewell, L. J., Adkin, C., Arechavala-Gomeza, V., Aartsma-Rus, A., De Winter, C. L., Wilton, S., Morgan, J. E., Muntoni, F., Graham, I. R. & Dickson, G., 2010, In : Neuromuscular Disorders. 20, 2, p. 102-110

  Research output: Contribution to journal › Article
  28 Citations (Scopus)
• 2017

  Csk-binding protein controls red blood cell development via regulation of Lyn tyrosine kinase activity

  Plani-Lam, J. H. C., Slavova-Azmanova, N. S., Kucera, N., Louw, A., Satiaputra, J., Singer, P., Lam, K. P., Hibbs, M. L. & Ingley, E., 1 Feb 2017, In : Experimental Hematology. 46, p. 70-82 13 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Mouse Pag1 protein
  • src-Family Kinases
  • Protein-Tyrosine Kinases
  • Carrier Proteins
  • Erythrocytes
  616 Downloads (Pure)
• 2020

  Durvalumab with first-line chemotherapy in previously untreated malignant pleural mesothelioma (DREAM): a multicentre, single-arm, phase 2 trial with a safety run-in

  Nowak, A. K., Lesterhuis, W. J., Kok, P. S., Brown, C., Hughes, B. GM., Karikios, D. J., John, T., Kao, S. C. H., Leslie, C., Cook, A. M., Pavlakis, N., Briscoe, K., O'Byrne, K. J., Karapetis, C. S., Lam, W. S., Langford, A., Yip, S. & Stockler, M. R., Sep 2020, In : The Lancet Oncology. 21, 9, p. 1213-1223 11 p.

  Research output: Contribution to journal › Article

  • durvalumab
  • Malignant Mesothelioma
  • Pemetrexed
  • Cisplatin
  • Safety
  7 Citations (Scopus)

• The Rapid ASKAP Continuum Survey I: Design and first results

  McConnell, D., Hale, C. L., Lenc, E., Banfield, J. K., Heald, G., Hotan, A. W., Leung, J. K., Moss, V. A., Murphy, T., O'Brien, A., Pritchard, J., Raja, W., Sadler, E. M., Stewart, A., Thomson, A. J. M., Whiting, M., Allison, J. R., Amy, S. W., Anderson, C., Ball, L. & 29 others, Bannister, K. W., Bell, M., Bock, D. C. J., Bolton, R., Bunton, J. D., Chippendale, A. P., Collier, J. D., Cooray, F. R., Cornwell, T. J., Diamond, P. J., Edwards, P. G., Gupta, N., Hayman, D. B., Heywood, I., Jackson, C. A., Koribalski, B. S., Lee-Waddell, K., McClure-Griffiths, N. M., Ng, A., Norris, R. P., Phillips, C., Reynolds, J. E., Roxby, D. N., Schinckel, A. E. T., Shields, M., Tremblay, C., Tzioumis, A., Voronkov, M. A. & Westmeier, T., 2020, (Accepted/In press) In : Publications of the Astronomical Society of Australia. 37, 18 p., e048.

  Research output: Contribution to journal › Article

  Open Access

  • continuums
  • sky
  • radio
  • declination
  • catalogs
• 2015

  Tumor-infiltrating dendritic cells exhibit defective cross-presentation of tumor antigens, but is reversed by chemotherapy

  Mcdonnell, A., Lesterhuis, W., Khong, A., Nowak, A., Lake, R., Currie, A. J. & Robinson, B., Jan 2015, In : European Journal of Immunology. 45, 1, p. 49-59

  Research output: Contribution to journal › Article

  Open Access

  • Cross-Priming
  • Neoplasm Antigens
  • Dendritic Cells
  • Drug Therapy
  • Neoplasms
  39 Citations (Scopus)
• 2020

  Severity of Experimental Autoimmune Uveitis Is Reduced by Pretreatment with Live Probiotic Escherichia coli Nissle 1917

  Dusek, O., Fajstova, A., Klimova, A., Svozilkova, P., Hrncir, T., Kverka, M., Coufal, S., Slemin, J., Tlaskalova-Hogenova, H., Forrester, J. V. & Heissigerova, J., 25 Dec 2020, In : Cells. 10, 1, 19 p.

  Research output: Contribution to journal › Article

  Open Access

  • Probiotics
  • Escherichia coli
  • Uveitis
  • Immunization
  • Lymph Nodes

• High-Fiber Diet during Pregnancy Characterized by More Fruit and Vegetable Consumption

  Pretorius, R. A. & Palmer, D. J., 24 Dec 2020, In : Nutrients. 13, 1, 11 p.

  Research output: Contribution to journal › Article

  Open Access

  • high fiber diet
  • vegetable consumption
  • fruit consumption
  • Dietary Fiber
  • Vegetables
• 2017

  Indirect methods to control population distribution in a large spin system

  Zhao, L., Goryachev, M., Bourhill, J. & Tobar, M. E., 1 Mar 2017, In : New Journal of Physics. 19, 3, 033016.

  Research output: Contribution to journal › Article

  Open Access

  • photons
  • nonequilibrium thermodynamics
  • whispering gallery modes
  • excitation
  • pumping
• 2011

  Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

  Lesterhuis, W., Punt, C. J. A., Hato, S. V., Eleveld-Trancikova, D., Jansen, B. J. H., Nierkens, S., Schreibelt, G., De Boer, A., Van Herpen, C. M. L., Kaanders, J. H., Van Krieken, J. H. J. M., Adema, G. J., Figdor, C. G. & De Vries, I. J. M., 2011, In : Journal of Clinical Investigation. 121, 8, p. 3100-3108

  Research output: Contribution to journal › Article

  Open Access
  161 Citations (Scopus)