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• 2016

  Immunodominant T-cell epitopes in the VP1 capsid protein of rhinovirus species A and C

  Gaido, C., Stone, S., Chopra, A., Thomas, W. R., Le Souef, P. N. & Hales, B. J., 2016, In : Journal of Virology. 90, 23, p. 10459-10471 13 p.

  Research output: Contribution to journal › Article

  • rhinovirus viral protein 1
  • Rhinovirus C
  • Immunodominant Epitopes
  • Enterovirus
  • T-Lymphocyte Epitopes
  13 Citations (Scopus)

• Indications for aerosol therapy in children

  Schultz, A. & Le Souef, P. N., 2016, International Society for Aerosol Medicine Textbook of Aerosol Medicine. 1 ed. p. 1157-1183

  Research output: Chapter in Book/Conference paper › Chapter

• No simple answers for the Finnish and Russian Karelia allergy contrast: Methylation of CD14 gene

  Khoo, S-K., Mäkelä, M., Chandler, D., Schultz, E. N., Jamieson, S. E., Goldblatt, J., Haahtela, T., Le Souef, P. & Zhang, G., Nov 2016, In : Pediatric Allergy and Immunology. 27, 7, p. 721-727

  Research output: Contribution to journal › Article

  • Methylation
  • Hypersensitivity
  • Immunoglobulin E
  • Child
  • Genes
  6 Citations (Scopus)

• Pressurised metered dose inhaler-spacer technique in young children improves with video instruction

  Shaw, N., Le Souef, P. N., Turkovic, L., McCahon, L., Kicic, A., Devadason, S. G. & Schultz, A., 2016, In : European Journal of Pediatrics. 2016, 75, p. 1007-1012 6 p.

  Research output: Contribution to journal › Article
  9 Citations (Scopus)

• Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV

  Annamalay, A. A., Abbott, S., Sikazwe, C., Khoo, S-K., Bizzintino, J., Zhang, G., Laing, I., Chidlow, G. R., Smith, D. W., Gern, J., Goldblatt, J., Lehmann, D., Green, R. J. & Le Souef, P. N., Aug 2016, In : Journal of Clinical Virology. 81, p. 58-63

  Research output: Contribution to journal › Article

  • Rhinovirus
  • Respiratory Tract Infections
  • Bronchiolitis
  • HIV
  • Viruses
  11 Citations (Scopus)

• Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil

  Fawkner-Corbett, D. W., Khoo, S-K. K., Duarte, C. M., Bezerra, P. G. M., Bochkov, Y. A., Gern, J. E., Le Souef, P. N. & Mcnamara, P. S., 2016, In : Journal of Medical Virology. 88, 1, p. 58-63 6 p.

  Research output: Contribution to journal › Article

  • Rhinovirus C
  • Respiratory Tract Infections
  • Brazil
  • Rhinovirus
  • Child
  12 Citations (Scopus)

• Rhinovirus species and clinical features in children hospitalised with pneumonia from Mozambique

  Annamalay, A. A., Lanaspa, M., Khoo, S-K., Madrid, L., Acacio, S., Zhang, G., Laing, I. A., Gern, J., Goldblatt, J., Bizzintino, J., Lehmann, D., Le Souef, P. N. & Bassat, Q., Sep 2016, In : TROPICAL MEDICINE & INTERNATIONAL HEALTH. 21, 9, p. 1171-1180

  Research output: Contribution to journal › Article

  • Mozambique
  • Rhinovirus
  • Hospitalized Child
  • Rhinovirus A
  • Rhinovirus C
  4 Citations (Scopus)

• The use of inhaled corticosteroids in pediatric asthma: Update

  Hossny, E., Rosario, N., Lee, B. W., Singh, M., El-Ghoneimy, D., Soh, J. Y. & Le Souef, P., 2016, In : World Allergy Organization Journal. 9, 1

  Research output: Contribution to journal › Review article

  Open Access

  • Adrenal Cortex Hormones
  • Asthma
  • Pediatrics
  • Nebulizers and Vaporizers
  • Equipment and Supplies
  33 Citations (Scopus)

• Western environment/lifestyle is associated with increased genome methylation and decreased gene expression in Chinese immigrants living in Australia

  Zhang, B., Wang, K., Schultz, E. N., Khoo, S-K., Zhang, X., Annamalay, A., Laing, I., Hales, B., Goldblatt, J. & Le Souef, P., 2016, In : Environmental and Molecular Mutagenesis. 57, 1, p. 65-73

  Research output: Contribution to journal › Article
  6 Citations (Scopus)
• 2017

  Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adults

  Bjerregaard, A., Laing, I. A., Poulsen, N., Backer, V., Sverrild, A., Fally, M., Khoo, S. K., Barrett, L., Baltic, S., Thompson, P. J., Chidlow, G., Sikazwe, C., Smith, D. W., Bochkov, Y. A., Le Souëf, P. & Porsbjerg, C., 1 Feb 2017, In : Respiratory Medicine. 123, p. 34-41 8 p.

  Research output: Contribution to journal › Article

  • thymic stromal lymphopoietin
  • Asthma
  • Sputum
  • Viruses
  • Phenotype
  10 Citations (Scopus)

• Clinical characteristics of eosinophilic asthma exacerbations

  Bjerregaard, A., Laing, I. A., Backer, V., Fally, M., Khoo, S. K., Chidlow, G., Sikazwe, C., Smith, D. W., Le Souëf, P. & Porsbjerg, C., 1 Feb 2017, In : Respirology. 22, 2, p. 295-300 6 p.

  Research output: Contribution to journal › Article

  • Asthma
  • Sputum
  • Eosinophils
  • Eosinophilia
  • Nitric Oxide
  6 Citations (Scopus)

• Dual responses of CD14 methylation to distinct environments: a role in asthma and allergy

  Song, Y., Khoo, S-K., Lee, K. H., Mäkelä, M., Haahtela, T., LeSouëf, P. & Zhang, G. B., Dec 2017, In : The European Respiratory Journal. 50, 6, 1701228.

  Research output: Contribution to journal › Letter
  2 Citations (Scopus)

• EFFECTS OF IN UTERO SMOKE EXPOSURE ON LUNG FUNCTION FROM INFANCY TO ADULTHOOD AND THE CONTRIBUTION OF GLUTATHIONE S-TRANSFERASE POLYMORPHISMS

  Owens, L., Laing, I., Zhang, G., Murdzoska, J., Turner, S., Mullane, D., Cox, D. & Le Souef, P., Mar 2017, In : Respirology. 22, p. 46-46 1 p.

  Research output: Contribution to journal › Abstract/Meeting Abstract

• Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling

  Ferreira, M. A. R., Jansen, R., Willemsen, G., Penninx, B. W., Bain, L. M., Vicente, C. T., Revez, J. A., Matheson, M. C., Hui, J., Tung, J. Y., Baltic, S., Le Souëf, P., Montgomery, G. W., Martin, N. G., Robertson, C. F., James, A., Thompson, P. J., Boomsma, D. I., Hopper, J. L., Hinds, D. A. & 3 others, Werder, R. B., Phipps, S. & Australian Asthma Genetics Consortium Collaborators, 1 Apr 2017, In : Journal of Allergy and Clinical Immunology. 139, 4, p. 1148-1157 10 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Quantitative Trait Loci
  • Nucleotides
  • Asthma
  • Genome-Wide Association Study
  • Genes
  32 Citations (Scopus)

  423 Downloads (Pure)

• Genetic Variants in the IL-4/IL-13 Pathway Influence Measles Vaccine Responses and Vaccine Failure in Children from Mozambique

  Clifford, H. D., Hayden, C. M., Khoo, S-K., Naniche, D., Mandomando, I. M., Zhang, G., Richmond, P. & Le Souef, P. N., Sep 2017, In : Viral Immunology. 30, 7, p. 472-478 7 p.

  Research output: Contribution to journal › Article
  2 Citations (Scopus)

• High fractional exhaled nitric oxide and sputum eosinophils are associated with an increased risk of future virus-induced exacerbations: A prospective cohort study

  Bjerregaard, A., Laing, I. A., Backer, V., Sverrild, A., Khoo, S. K., Chidlow, G., Sikazwe, C., Smith, D. W., Le Souëf, P. & Porsbjerg, C., 1 Aug 2017, In : Clinical and Experimental Allergy. 47, 8, p. 1007-1013 7 p.

  Research output: Contribution to journal › Article

  • Sputum
  • Eosinophils
  • Nitric Oxide
  • Cohort Studies
  • Viruses
  19 Citations (Scopus)

• Infant lung function predicts asthma persistence and remission in young adults

  Owens, L., Laing, I. A., Zhang, G. & Le Souëf, P. N., 1 Feb 2017, In : Respirology. 22, 2, p. 289-294 6 p.

  Research output: Contribution to journal › Article

  • Young Adult
  • Asthma
  • Lung
  • Term Birth
  • Functional Residual Capacity
  19 Citations (Scopus)

• Rhinovirus C is associated with wheezing and rhinovirus A is associated with pneumonia in hospitalized children in Morocco

  Annamalay, A. A., Jroundi, I., Bizzintino, J., Khoo, S. K., Zhang, G., Lehmann, D., Laing, I. A., Gern, J., Goldblatt, J., Mahraoui, C., Benmessaoud, R., Moraleda, C., Bassat, Q. & Le Souëf, P., 1 Apr 2017, In : Journal of Medical Virology. 89, 4, p. 582-588 7 p.

  Research output: Contribution to journal › Article

  • Rhinovirus A
  • Rhinovirus C
  • Morocco
  • Rhinovirus
  • Hospitalized Child
  9 Citations (Scopus)

• Severe winter asthma exacerbations can be prevented by omalizumab, but there is no carryover effect

  Sly, P. D., Varghese, J., Noor, F., Tang, M. L. K., Laing, I., Oo, S., Prastanti, F., Le Souef, P. & Holt, P. G., 1 Feb 2017, In : Journal of Allergy and Clinical Immunology. 139, 2, p. 703-705 2 p., e4.

  Research output: Contribution to journal › Article
  3 Citations (Scopus)

• Vascular ring: Unmasked

  Ishak, A., Souëf, P. L. & Schultz, A., 1 May 2017, In : Journal of Paediatrics and Child Health. 53, 5, p. 503-506 4 p.

  Research output: Contribution to journal › Article

• Viral-bacterial interactions in childhood respiratory tract infections

  Annamalay, A. & Le Souëf, P., 2 May 2017, Viral Infections in Children. Springer International Publishing Switzerland, Vol. 1. p. 193-214 22 p.

  Research output: Chapter in Book/Conference paper › Chapter

  • Respiratory Tract Infections
  • Bacteria
  • Viruses
  • Respiratory System
  • Coinfection
  1 Citation (Scopus)
• 2019

  Glutathione S-Transferase Genotype Protects against In Utero Tobacco-linked Lung Function Deficits

  Owens, L., Laing, I. A., Murdzoska, J., Zhang, G., Turner, S. W. & Le Souef, P. N., 15 Aug 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 4, p. 462-470 9 p.

  Research output: Contribution to journal › Article

  Open Access
  4 Citations (Scopus)

• Pediatric asthma: An unmet need for more effective, focused treatments

  Papadopoulos, N. G., Custovic, A., Cabana, M. D., Dell, S. D., Deschildre, A., Hedlin, G., Hossny, E., Le Souef, P., Matricardi, P. M., Nieto, A., Phipatanakul, W., Pitrez, P. M., Pohunek, P., Gavornikova, M., Jaumont, X. & Price, D. B., Feb 2019, In : Pediatric Allergy and Immunology. 30, 1, p. 7-16 10 p.

  Research output: Contribution to journal › Review article

  Open Access
  19 Citations (Scopus)

• Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children

  Leffler, J., Read, J. F., Jones, A. C., Mok, D., Hollams, E. M., Laing, I. A., Le Souef, P. N., Sly, P. D., Kusel, M. M. H., de Klerk, N. H., Bosco, A., Holt, P. G. & Strickland, D. H., Sep 2019, In : Pediatric Allergy and Immunology. 30, 6

  Research output: Contribution to journal › Article

  • Fc Receptors
  • Blood Cells
  • Asthma
  • Dendritic Cells
  • Child
  7 Citations (Scopus)

• Testing the socioeconomic and environmental determinants of better child-health outcomes in Africa: a cross-sectional study among nations

  Bradshaw, C. J. A., Otto, S. P., Mehrabi, Z., Annamalay, A. A., Heft-Neal, S., Wagner, Z. & Le Souëf, P. N., 30 Sep 2019, In : BMJ Open. 9, 9, p. e029968

  Research output: Contribution to journal › Article

  Open Access

  • Child Health
  • Sanitation
  • Air Pollution
  • Cross-Sectional Studies
  • Water Quality

• Upper airway cell transcriptomics identify a major new immunological phenotype with strong clinical correlates in young children with acute wheezing

  Khoo, S. K., Read, J., Franks, K., Zhang, G., Bizzintino, J., Coleman, L., McCrae, C., Öberg, L., Troy, N. M., Prastanti, F., Everard, J., Oo, S., Borland, M. L., Maciewicz, R. A., Le Souëf, P. N., Laing, I. A. & Bosco, A., 1 Jan 2019, In : Journal of Immunology. 202, 6, p. 1845-1858 14 p.

  Research output: Contribution to journal › Article

  • Respiratory Sounds
  • Phenotype
  • Child
  • Asthma
  • Up-Regulation
  11 Citations (Scopus)

• Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing children

  Cuthbertson, L., Oo, S. W. C., Cox, M. J., Khoo, S. K., Cox, D. W., Chidlow, G., Franks, K., Prastanti, F., Borland, M. L., Gern, J. E., Smith, D. W., Bizzintino, J. A., Laing, I. A., Le Souëf, P. N., Moffatt, M. F. & Cookson, W. O. C., 1 Jan 2019, In : PLoS One. 14, 10, e0223990.

  Research output: Contribution to journal › Article

  Open Access

  • Respiratory Sounds
  • bacterial communities
  • Microbiota
  • microbiome
  • Respiratory Tract Infections
  1 Citation (Scopus)

• Western oropharyngeal and gut microbial profiles are associated with allergic conditions in Chinese immigrant children

  Guo, J., Lv, Q., Ariff, A., Zhang, X., Peacock, C. S., Song, Y., Wen, X., Saiganesh, A., Melton, P. E., Dykes, G. A., Moses, E. K., LE Souëf, P. N., Lu, F. & Zhang, G., 1 Aug 2019, In : The World Allergy Organization Journal. 12, 8, 100051.

  Research output: Contribution to journal › Article

  Open Access

  • Microbiota
  • Child
  • Hypersensitivity
  • Gastrointestinal Microbiome
  • Life Style
  3 Citations (Scopus)
• 2020

  Aberrant cell migration contributes to defective airway epithelial repair in childhood wheeze

  Western Australian Epithelial Research Program (WAERP), Australian Respiratory Epithelium Consortium (AusREC), Buckley, A. G., Coleman, L., Ling, K. M., Garratt, L. W., Martinovich, K. M., Shaw, N. C., Karpievitch, Y. V., Le Souëf, P., Laing, I. A., Vijayasekaran, S., Stick, S. M. & Kicic, A., 24 Mar 2020, In : JCI Insight. 5, 7, e133125.

  Research output: Contribution to journal › Article

  Open Access

  • Integrins
  • Cell Movement
  • Phosphatidylinositol 3-Kinases
  • Celecoxib
  • Asthma

• Gene Expression: the Key to Understanding HIV-1 Infection?

  Judge, M., Parker, E., Naniche, D. & Le Souëf, P., 20 May 2020, In : Microbiology and molecular biology reviews : MMBR. 84, 2

  Research output: Contribution to journal › Review article

  • HIV Infections
  • HIV-1
  • HIV
  • Gene Expression
  • T-Lymphocytes
  1 Citation (Scopus)

• Impact of COVID-19 on Pediatric Asthma: Practice Adjustments and Disease Burden

  Papadopoulos, N. G., Custovic, A., Deschildre, A., Mathioudakis, A. G., Phipatanakul, W., Wong, G., Xepapadaki, P., Agache, I., Bacharier, L., Bonini, M., Castro-Rodriguez, J. A., Chen, Z., Craig, T., Ducharme, F. M., El-Sayed, Z. A., Feleszko, W., Fiocchi, A., Garcia-Marcos, L., Gern, J. E., Goh, A. & 49 others, Gómez, R. M., Hamelmann, E. H., Hedlin, G., Hossny, E. M., Jartti, T., Kalayci, O., Kaplan, A., Konradsen, J., Kuna, P., Lau, S., Le Souef, P., Lemanske, R. F., Mäkelä, M. J., Morais-Almeida, M., Murray, C., Nagaraju, K., Namazova-Baranova, L., Garcia, A. N., Yusuf, O. M., Pitrez, P. M. C., Pohunek, P., Pozo Beltrán, C. F., Roberts, G. C., Valiulis, A., Zar, H. J., Taam, R. A., Azuara, H., Brouard, J., Cros, P., De Lira, C., Dubus, J. C., Dunder, T., Efendieva, K., Egron, C., Emeryk, A., Huerta Villalobos, Y. R., Karen, N., Le Roux, P., Levina, J., Medley, M., Najaraju, M., Yeverino, D. R., Ruotsalainen, M., Szefler, S., Schweitzer, C., Benhumea, B. V., Villarreal, R., Weiss, L. & Zawadzka-Krajewska, A., Sep 2020, In : Journal of Allergy and Clinical Immunology: In Practice. 8, 8, p. 2592-2599.e3

  Research output: Contribution to journal › Article

  Open Access

  • Coronavirus
  • Social Adjustment
  • Asthma
  • Pediatrics
  • Pandemics
  8 Citations (Scopus)

• Linking the westernised oropharyngeal microbiome to the immune response in Chinese immigrants

  Guo, J., Zhang, X., Saiganesh, A., Peacock, C., Chen, S., Dykes, G. A., Hales, B. J., Le Souëf, P. N. & Zhang, G., 25 Jul 2020, In : Allergy, Asthma and Clinical Immunology. 16, 1, 67.

  Research output: Contribution to journal › Article

  Open Access

  • Microbiota
  • Immunoglobulin G
  • Adaptive Immunity
  • Leptotrichia
  • Actinomycetales

• Research Priorities in Pediatric Asthma: Results of a Global Survey of Multiple Stakeholder Groups by the Pediatric Asthma in Real Life (PeARL) Think Tank

  Mathioudakis, A. G., Custovic, A., Deschildre, A., Ducharme, F. M., Kalayci, O., Murray, C., Garcia, A. N., Phipatanakul, W., Price, D., Sheikh, A., Agache, I., Bacharier, L., Bonini, M., Castro-Rodriguez, J. A., De Carlo, G., Craig, T., Diamant, Z., Feleszko, W., Ierodiakonou, D., Gern, J. E. & 23 others, Grigg, J., Hedlin, G., Hossny, E. M., Jartti, T., Kaplan, A., Lemanske, R. F., Le Souef, P., Makela, M. J., Matricardi, P. M., Miligkos, M., Morais-Almeida, M., Pite, H., Pitrez, P. M. C., Pohunek, P., Roberts, G., Sanchez-Garcia, S., Tsiligianni, I., Turner, S., Winders, T. A., Wong, G., Xepapadaki, P., Zar, H. J. & Papadopoulos, N. G., Jun 2020, In : Journal of Allergy and Clinical Immunology: In Practice. 8, 6, p. 1953-1960.e9

  Research output: Contribution to journal › Article

  • Asthma
  • Pediatrics
  • Age Groups
  • Drug Industry
  • Administrative Personnel
  3 Citations (Scopus)

• Suboptimal asthma care: Lessons from Australia and a way forward

  Schultz, A., le Souef, P. & Barwick, M., Jan 2020, In : Respirology. 25, 1, p. 45-46 2 p.

  Research output: Contribution to journal › Editorial

  Open Access

  • Asthma

• The impact of cytokine levels in young South African children with and without HIV-associated acute lower respiratory infections

  Annamalay, A. A., Abbott, S., Khoo, S. K., Hibbert, J., Bizzintino, J., Zhang, G., Laing, I., Currie, A., Le Souëf, P. N. & Green, R. J., 2020, (Accepted/In press) In : Journal of Medical Virology.

  Research output: Contribution to journal › Article

  • Respiratory Tract Infections
  • HIV
  • Cytokines
  • Child
  • Interferons

• Toll-like receptor signalling has inverted U-shaped response over time with the Western environment

  Guo, J., Song, Y., Saiganesh, A., Hales, B. J., Bosco, A., Le Souëf, P. N. & Zhang, G., 1 Oct 2020, In : Allergy: European Journal of Allergy and Clinical Immunology. 75, 10, p. 2665-2667

  Research output: Contribution to journal › Letter

• Vitamin D receptor polymorphisms are associated with severity of wheezing illnesses and asthma exacerbations in children

  Leiter, K., Franks, K., Borland, M. L., Coleman, L., Harris, L., Le Souëf, P. N. & Laing, I. A., Jul 2020, In : Journal of Steroid Biochemistry and Molecular Biology. 201, 105692.

  Research output: Contribution to journal › Article

  • Polymorphism
  • Calcitriol Receptors
  • Respiratory Sounds
  • Asthma
  • Genotype