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• 2016

  Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: A genetic association study

  Cleynen, I., Boucher, G., Jostins, L., Schumm, L. P., Zeissig, S., Ahmad, T., Andersen, V., Andrews, J. M., Annese, V., Brand, S., Brant, S. R., Cho, J. H., Daly, M. J., Dubinsky, M., Duerr, R. H., Ferguson, L. R., Franke, A., Gearry, R. B., Goyette, P., Hakonarson, H. & 22 others, Halfvarson, J., Hov, J. R., Huang, H., Kennedy, N. A., Kupcinskas, L., Lawrance, I., Lee, J. C., Satsangi, J., Schreiber, S., Théâtre, E., Van Der Meulen-De Jong, A. E., Weersma, R. K., Wilson, D. C., Parkes, M., Vermeire, S., Rioux, J. D., Mansfield, J., Silverberg, M. S., Radford-Smith, G., Mcgovern, D. P. B., Barrett, J. C. & Lees, C. W., 9 Jan 2016, In : The Lancet. 387, 10014, p. 156-167 12 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Genetic Association Studies
  • Ulcerative Colitis
  • Crohn Disease
  • Inflammatory Bowel Diseases
  • Phenotype
  327 Citations (Scopus)

  431 Downloads (Pure)

• The multidisciplinary team

  Lawrance, I., 2016, In : Journal of Gastroenterology and Hepatology (Australia). 31, p. 17

  Research output: Contribution to journal › Article
  2 Citations (Scopus)
• 2017

  A multi-centre double blind randomised placebo-controlled study of the use of rectal tacrolimus in the treatment of resistant ulcerative proctitis

  Lawrance, I., Baird, A., Lightowler, D., Radford-Smith, G., Andrews, J. M. & Connor, S., Feb 2017.

  Research output: Contribution to conference › Conference presentation/ephemera

• Cellular and Molecular Mediators of Intestinal Fibrosis

  Lawrance, I., Rogler, G., Bamias, G., Breynaert, C., Florholmen, J., Pellino, G., Reif, S., Speca, S. & Latella, G., Dec 2017, In : Journal of Crohn's and Colitis. 11, 12, p. 1491–1503 13 p.

  Research output: Contribution to journal › Article

  Open Access

  • Fibrosis
  • Inflammatory Bowel Diseases
  • Inflammation
  • Anti-Inflammatory Agents
  50 Citations (Scopus)

• Dysplasia and colorectal cancer surveillance in inflammatory bowel disease

  Pulusu, S. S. R. & Lawrance, I. C., 3 Aug 2017, In : Expert Review of Gastroenterology and Hepatology. 11, 8, p. 711-722 12 p.

  Research output: Contribution to journal › Review article

  • Inflammatory Bowel Diseases
  • Colorectal Neoplasms
  • Mesalamine
  • Needs Assessment
  • Chemoprevention
  9 Citations (Scopus)

• Efficacy of rectal tacrolimus for induction therapy in patients with resistant ulcerative proctitis

  Lawrance, I. C., Baird, A., Lightowler, D., Radford-Smith, G., Andrews, J. M. & Connor, S., 1 Aug 2017, In : Clinical Gastroenterology and Hepatology. 15, 8, p. 1248-1255 8 p.

  Research output: Contribution to journal › Article

  • Proctitis
  • Tacrolimus
  • Placebos
  • Therapeutics
  • Ulcerative Colitis
  25 Citations (Scopus)

• Emu oil improves clinical indicators of disease in a mouse model of colitis-associated colorectal cancer

  Chartier, L. C., Howarth, G. S., Lawrance, I. C., Trinder, D., Barker, S. J. & Mashtoub, S., Aug 2017, In : Journal of Gastroenterology and Hepatology (Australia). 32, p. 56-56 1 p.

  Research output: Contribution to journal › Abstract/Meeting Abstract

• Emu Oil Reduces Colonic Damage Severity in a Mouse Model of Chronic Ulcerative Colitis

  Safaeian, R., Howarth, G. S., Lawrance, I. C., Trinder, D. & Mashtoub, S., Apr 2017, In : FASEB Journal. 31, 1 p.

  Research output: Contribution to journal › Abstract/Meeting Abstract

• Fine-mapping inflammatory bowel disease loci to single-variant resolution

  Huang, H., Fang, M., Jostins, L., Umićević Mirkov, M., Boucher, G., Anderson, C. A., Andersen, V., Cleynen, I., Cortes, A., Crins, F., D'Amato, M., Deffontaine, V., Dmitrieva, J., Docampo, E., Elansary, M., Farh, K. K-H., Franke, A., Gori, A-S., Goyette, P., Halfvarson, J. & 27 others, Haritunians, T., Knight, J., Lawrance, I. C., Lees, C. W., Louis, E., Mariman, R., Meuwissen, T., Mni, M., Momozawa, Y., Parkes, M., Spain, S. L., Théâtre, E., Trynka, G., Satsangi, J., van Sommeren, S., Vermeire, S., Xavier, R. J., Weersma, R. K., Duerr, R. H., Mathew, C. G., Rioux, J. D., McGovern, D. P. B., Cho, J. H., Georges, M., Daly, M. J., Barrett, J. C. & International Inflammatory Bowel Disease Genetics Consortium, 13 Jul 2017, In : Nature. 547, 7662, p. 173-178 6 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Inflammatory Bowel Diseases
  • Genome-Wide Association Study
  • Ulcerative Colitis
  • Crohn Disease
  • Epigenomics
  178 Citations (Scopus)

  405 Downloads (Pure)

• Infliximab vs. adalimumab in Crohn's disease: results from 327 patients in an Australian and New Zealand observational cohort study

  the Australian and New Zealand Inflammatory Bowel Disease Consortium, 1 Feb 2017, In : Alimentary Pharmacology and Therapeutics. 45, 4, p. 542-552 11 p.

  Research output: Contribution to journal › Article

  • Adalimumab
  • Infliximab
  • New Zealand
  • Crohn Disease
  • Observational Studies
  23 Citations (Scopus)

• OP007 A multi-centre double blind randomised placebo-controlled study of the use of rectal tacrolimus in the treatment of resistant ulcerative proctitis

  Lawrance, I., Baird, A., Lightowler, D., Radford-Smith, G., Andrews, J. M. & Connor, S., 26 Jan 2017, In : JOURNAL OF CROHNS & COLITIS. 11, 1

  Research output: Contribution to journal › Abstract/Meeting Abstract

  Open Access

• Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method

  Chen, G. B., Lee, S. H., Montgomery, G. W., Wray, N. R., Visscher, P. M., Gearry, R. B., Lawrance, I. C., Andrews, J. M., Bampton, P., Mahy, G., Bell, S., Walsh, A., Connor, S., Sparrow, M., Bowdler, L. M., Simms, L. A., Krishnaprasad, K., Radford-Smith, G. L. & Moser, G., 29 Aug 2017, In : BMC Medical Genetics. 18, 1, 94.

  Research output: Contribution to journal › Article

  Open Access

  • Inflammatory Bowel Diseases
  • Genome-Wide Association Study
  • Single Nucleotide Polymorphism
  • Crohn Disease
  • Ulcerative Colitis
  9 Citations (Scopus)

• Serologic antibodies in relation to outcome in postoperative Crohn's disease

  Hamilton, A. L., Kamm, M. A., De Cruz, P., Wright, E. K., Selvaraj, F., Princen, F., Gorelik, A., Liew, D., Lawrance, I. C., Andrews, J. M., Bampton, P. A., Sparrow, M. P., Florin, T. H., Gibson, P. R., Debinski, H., Gearry, R. B., Macrae, F. A., Leong, R. W., Kronborg, I., Radford-Smith, G. & 4 others, Selby, W., Bell, S. J., Brown, S. J. & Connell, W. R., 1 Jun 2017, In : Journal of Gastroenterology and Hepatology (Australia). 32, 6, p. 1195-1203 9 p.

  Research output: Contribution to journal › Article

  • Crohn Disease
  • Recurrence
  • Antibodies
  • Anti-Idiotypic Antibodies
  • Bacterial Antibodies
  9 Citations (Scopus)
• 2018

  Anti-TNF therapeutic drug monitoring in postoperative Crohn's disease

  Wright, E. K., Kamm, M. A., De Cruz, P., Hamilton, A. L., Selvaraj, F., Princen, F., Gorelik, A., Liew, D., Prideaux, L., Lawrance, I. C., Andrews, J. M., Bampton, P. A., Jakobovits, S. L., Florin, T. H., Gibson, P. R., Debinski, H., Macrae, F. A., Samuel, D., Kronborg, I., Radford-Smith, G. & 5 others, Gearry, R. B., Selby, W., Bell, S. J., Brown, S. J. & Connell, W. R., 25 May 2018, In : Journal of Crohn's and Colitis. 12, 6, p. 653-661 9 p.

  Research output: Contribution to journal › Article

  • Adalimumab
  • Drug Monitoring
  • Crohn Disease
  • Recurrence
  • Anti-Idiotypic Antibodies
  5 Citations (Scopus)

• Emu Oil Improves Clinical Indicators of Disease in a Mouse Model of Colitis-Associated Colorectal Cancer

  Chartier, L. C., Howarth, G. S., Lawrance, I. C., Trinder, D., Barker, S. J. & Mashtoub, S., 2018, In : Digestive Diseases and Sciences. 63, 1, p. 135–145 11 p.

  Research output: Contribution to journal › Article

  • emu Oil
  • Colitis
  • Colorectal Neoplasms
  • Dextran Sulfate
  • Azoxymethane
  10 Citations (Scopus)

• High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis

  Ghaly, S., Kaakoush, N. O., Lloyd, F., McGonigle, T., Mok, D., Baird, A., Klopcic, B., Gordon, L., Gorman, S., Forest, C., Bouillon, R., Lawrance, I. C. & Hart, P. H., 1 Dec 2018, In : Scientific Reports. 8, 1, 11511.

  Research output: Contribution to journal › Article

  Open Access

  • Colitis
  • Microbiota
  • Vitamin D
  • Dextran Sulfate
  • Serum Albumin
  19 Citations (Scopus)

• IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

  The International IBD Genetics Consortium, 1 Dec 2018, In : Nature Communications. 9, 1, 2427.

  Research output: Contribution to journal › Article

  Open Access

  • genes
  • loci
  • Inflammatory Bowel Diseases
  • Genes
  • modules
  32 Citations (Scopus)

• Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease

  Roberts, R. L., Wallace, M. C., Seinen, M. L., van Bodegraven, A. A., Krishnaprasad, K., Jones, G. T., van Rij, A. M., Baird, A., Lawrance, I. C., Prosser, R., Bampton, P., Grafton, R., Simms, L. A., Studd, C., Bell, S. J., Kennedy, M. A., Halliwell, J., Gearry, R. B., Radford-Smith, G., Andrews, J. M. & 2 others, McHugh, P. C. & Barclay, M. L., 29 Nov 2018, In : Inflammatory Bowel Diseases. 24, 12, p. 2606-2612 7 p.

  Research output: Contribution to journal › Article

  • 6-methylthiopurine
  • Guanine
  • Ligases
  • 6-thioguanylic acid
  • Inflammatory Bowel Diseases

• Ultraviolet irradiation of skin alters the faecal microbiome independently of vitamin D in mice

  Ghaly, S., Kaakoush, N. O., Lloyd, F., Gordon, L., Forest, C., Lawrance, I. C. & Hart, P. H., 11 Aug 2018, In : Nutrients. 10, 8, 1069.

  Research output: Contribution to journal › Article

  Open Access

  • vitamin D
  • Microbiota
  • microbiome
  • Vitamin D
  • colitis
  14 Citations (Scopus)

• Vedolizumab (VDZ) real-world outcomes in ulcerative colitis (UC)

  Pulusu, S. S. R., Srinivasan, A., Krishnaprasad, K., Cheng, D., Mogilevski, T., Flanagan, E., Keung, C., Wu, C., Prosser, R., Sawyer, E., Rizvi, Q. U. A., Su, H., Leung, W., Edmundson, A., Cooke, S., Mahy, G., Thin, L., Radford-Smith, G., Sparrow, M. P., Andrews, J. M. & 10 others, Connor, S., Bampton, P. A., Ghaly, S., van Langenberg, D., Bell, S., De Cruz, P., Begun, J., Ng, S., Travis, S. & Lawrance, I., 1 Feb 2018, In : Journal of Crohn's and Colitis. 12, 1, P571.

  Research output: Contribution to journal › Abstract/Meeting Abstract
• 2019

  Anti TNFα-induced Interstitial Pneumonitis in Inflammatory Bowel Disease Patients: A Multi-Centre Western Australia Case Series

  Lightowler, D., Thin, L. & Lawrance, I., 4 Sep 2019, In : Journal of Gastroenterology and Hepatology (Australia). 34, S2, p. 119-120

  Research output: Contribution to journal › Abstract/Meeting Abstract

• Antitumor necrosis factor-alpha induced interstitial pneumonitis in patients with inflammatory bowel disease: A multicenter Western Australia case series

  Lightowler, D., Thin, L. & Lawrance, I., Sep 2019, In : Journal of Gastroenterology and Hepatology. 34, p. 119-120 2 p.

  Research output: Contribution to journal › Abstract/Meeting Abstract

• Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

  International Inflammatory Bowel Disease Genetics Consortium (IIBDGC), 17 Jul 2019, In : Scientific Reports. 9, 1, 10351.

  Research output: Contribution to journal › Article

  Open Access

  • Machine Learning
  • Crohn Disease
  • Genome
  • Logistic Models
  • ROC Curve
  13 Citations (Scopus)

• Emu Oil reduces disease severity in a mouse model of chronic ulcerative colitis

  Safaeian, R., Howarth, G. S., Lawrance, I. C., Trinder, D. & Mashtoub, S., 4 Mar 2019, In : Scandinavian Journal of Gastroenterology. 54, 3, p. 273-280 8 p.

  Research output: Contribution to journal › Article

  • emu Oil
  • Ulcerative Colitis
  • Peroxidase
  • Water
  • Dextran Sulfate
  3 Citations (Scopus)

• Inflammatory bowel diseases: interrelationships between dietary vitamin D, exposure to UV radiation and the fecal microbiome

  Ghaly, S., Hart, P. H. & Lawrance, I. C., 2 Nov 2019, In : Expert Review of Gastroenterology and Hepatology. 13, 11, p. 1039-1048 10 p.

  Research output: Contribution to journal › Review article

  • Ultraviolet Rays
  • Microbiota
  • Inflammatory Bowel Diseases
  • Vitamin D
  • Gastrointestinal Microbiome
  1 Citation (Scopus)

• Level of UV Exposure, Skin Type, and Age Are More Important than Thiopurine Use for Keratinocyte Carcinoma Development in IBD Patients

  Wu, Y., Ghaly, S., Kerr, S., Jackson, B., Hanigan, K., Martins, D., Krishnaprasad, K., Mountifield, R. E., Whiteman, D. C., Bampton, P. A., Gearry, R. B., Radford-Smith, G. L. & Lawrance, I. C., 6 Sep 2019, In : Digestive Diseases and Sciences.

  Research output: Contribution to journal › Article

  • Keratinocytes
  • Inflammatory Bowel Diseases
  • Carcinoma
  • Solar System
  • Skin

• Vitamin D metabolites are lower with active Crohn’s disease and spontaneously recover with development of remission

  Haifer, C., Lawrance, I. C., Center, J. R., Clarke, M. W., Hart, P. H., Eisman, J. A., Lucas, R. & Ghaly, S., 26 Jul 2019, In : Therapeutic Advances in Gastroenterology. 12, 12 p.

  Research output: Contribution to journal › Article

  Open Access

  • Crohn Disease
  • Vitamin D
  • Vitamin D-Binding Protein
  • Inflammation
  • 25-hydroxyvitamin D
• 2020

  Anti-TNF Therapy in Pregnant Women with Inflammatory Bowel Disease: Effects of Therapeutic Strategies on Disease Behavior and Birth Outcomes

  Julsgaard, M., Hvas, C. L., Gearry, R. B., Gibson, P. R., Fallingborg, J., Sparrow, M. P., Bibby, B. M., Connell, W. R., Brown, S. J., Kamm, M. A., Lawrance, I. C., Vestergaard, T., Svenningsen, L., Baekdal, M., Kammerlander, H., Walsh, A., Boysen, T., Bampton, P., Radford-Smith, G., Kjeldsen, J. & 10 others, Andrews, J. M., Subramaniam, K., Moore, G. T., Jensen, N. M., Connor, S. J., Wildt, S., Wilson, B., Ellard, K., Christensen, L. A. & Bell, S. J., Jan 2020, In : Inflammatory Bowel Diseases. 26, 1, p. 93-102 10 p.

  Research output: Contribution to journal › Article

  • Inflammatory Bowel Diseases
  • Therapeutic Uses
  • Pregnant Women
  • Tumor Necrosis Factor-alpha
  • Parturition
  5 Citations (Scopus)

• Orally administered emu oil attenuates disease in a mouse model of Crohn’s-like colitis

  Mitchell, C. J., Howarth, G. S., Chartier, L. C., Trinder, D., Lawrance, I. C., Huang, L. S. & Mashtoub, S., Dec 2020, In : Experimental Biology and Medicine. 245, 18, p. 1697-1707

  Research output: Contribution to journal › Article

  • emu Oil
  • Colitis
  • Crohn Disease
  • Inflammatory Bowel Diseases
  • Colonoscopy

• The role of a plant-based diet in the pathogenesis, etiology and management of the inflammatory bowel diseases

  Grosse, C. S. J., Christophersen, C. T., Devine, A. & Lawrance, I. C., 3 Mar 2020, In : Expert Review of Gastroenterology and Hepatology. 14, 3, p. 137-145 9 p.

  Research output: Contribution to journal › Review article

  • Inflammatory Bowel Diseases
  • Diet
  • Symbiosis
  • Diet Therapy
  • Expert Testimony
  2 Citations (Scopus)

• Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford

  Pulusu, S. S. R., Srinivasan, A., Krishnaprasad, K., Cheng, D., Begun, J., Keung, C., van Langenberg, D., Thin, L., Mogilevski, T., De Cruz, P., Radford-Smith, G., Flanagan, E., Bell, S., Kashkooli, S., Sparrow, M. P., Ghaly, S., Bampton, P. A., Sawyer, E., Connor, S., Rizvi, Q-U-A. & 4 others, Andrews, J. M., Mahy, G., Chivers, P. & Lawrance, I., 14 Aug 2020, In : World Journal of Gastroenterology. 26, 30, p. 4428-4441

  Research output: Contribution to journal › Article

  Open Access

  • vedolizumab
  • Ulcerative Colitis
  • integrin beta7
  • Integrin alpha4
  • Antibodies, Monoclonal, Humanized