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  • 2020
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  • Mark Nicol
2020

Chronic lung disease in children and adolescents with HIV: a case–control study

the BREATHE Clinical Trial Team, 1 Jan 2020, In : Tropical Medicine and International Health.

Research output: Contribution to journalArticle

2019

Guidance for Studies Evaluating the Accuracy of Sputum-Based Tests to Diagnose Tuberculosis

Schumacher, S. G., Wells, W. A., Nicol, M. P., Steingart, K. R., Theron, G., Dorman, S. E., Pai, M., Churchyard, G., Scott, L., Stevens, W., Nabeta, P., Alland, D., Weyer, K., Denkinger, C. M. & Gilpin, C., 8 Oct 2019, In : The Journal of infectious diseases. 220, S3, p. S99-S107

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Treatment of bronchiectasis exacerbations in children: which antibiotic?

Zar, H. J. & Nicol, M. P., 6 Oct 2018, In : The Lancet. 392, 10154, p. 1169-1170 2 p.

Research output: Contribution to journalComment/debate

Human breast milk bacteriome in health and disease

Ojo-Okunola, A., Nicol, M. & du Toit, E., 3 Nov 2018, In : Nutrients. 10, 11, 1643.

Research output: Contribution to journalReview article

Open Access
14 Citations (Scopus)
2017

Improved method for collection of sputum for tuberculosis testing to ensure adequate sample volumes for molecular diagnostic testing

Fisher, M., Dolby, T., Surtie, S., Omar, G., Hapeela, N., Basu, D., DeWalt, A., Kelso, D., Nicol, M. & McFall, S., 1 Apr 2017, In : Journal of Microbiological Methods. 135, p. 35-40 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Optimizing Tuberculosis Diagnosis in Human Immunodeficiency Virus-Infected Inpatients Meeting the Criteria of Seriously Ill in the World Health Organization Algorithm

Griesel, R., Stewart, A., van der Plas, H., Sikhondze, W., Rangaka, M. X., Nicol, M. P., Kengne, A. P., Mendelson, M. & Maartens, G., 6 Nov 2017, In : Clinical Infectious Diseases. 66, 9, p. 1419-1426 8 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2018

Lymphadenopathy in a TB-Endemic Region: Employing Focused Techniques in a Rapid Access Lymph Node Biopsy Clinic

Antel, K. R., Verburgh, E., Louw, V. J., Oosthuizen, J., Malherbe, F., Gary, M. & Nicol, M., 29 Nov 2018, In : Blood. 132, 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2019

Recent developments in the diagnosis of drug-resistant tuberculosis

Nicol, M. P. & Cox, H., 1 Jan 2019, In : Microbiology Australia. 40, 2, p. 82-86 5 p.

Research output: Contribution to journalArticle

Strengthening Diagnosis of Pulmonary Tuberculosis in Children: The Role of Xpert MTB/RIF Ultra

Zar, H. J. & Nicol, M. P., 1 Nov 2019, In : Pediatrics. 144, 5

Research output: Contribution to journalArticle

1 Citation (Scopus)

Association of maternal prenatal psychological stressors and distress with maternal and early infant faecal bacterial profile

Naudé, P. J. W., Claassen-Weitz, S., Gardner-Lubbe, S., Botha, G., Kaba, M., Zar, H. J., Nicol, M. P. & Stein, D. J., 22 Nov 2019, In : Acta Neuropsychiatrica. p. 1-31 31 p.

Research output: Contribution to journalArticle

Open Access
File
45 Downloads (Pure)

Brief Report: Real-World Performance and Interobserver Agreement of Urine Lipoarabinomannan in Diagnosing HIV-Associated Tuberculosis in an Emergency Center

Van Hoving, D. J., Lahri, S., Lategan, H. J., Nicol, M. P., Maartens, G. & Meintjes, G., 1 May 2019, In : Journal of acquired immune deficiency syndromes (1999). 81, 1, p. e10-e14

Research output: Contribution to journalArticle

2 Citations (Scopus)
2020

Drug-resistant tuberculosis patient care journeys in South Africa: a pilot study using routine laboratory data

Hill, J., Dickson-Hall, L., Grant, A. D., Grundy, C., Black, J., Kielmann, K., Mlisana, K., Mitrani, L., Loveday, M., Moshabela, M., Le Roux, S., Jassat, W., Nicol, M. & Cox, H., 1 Jan 2020, In : International Journal of Tuberculosis & Lung Disease. 24, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

Open Access

Diagnostic accuracy of a novel tuberculosis point-of-care urine lipoarabinomannan assay for people living with HIV: A meta-analysis of individual in- and outpatient data

Broger, T., Nicol, M. P., Székely, R., Bjerrum, S., Sossen, B., Schutz, C., Opintan, J. A., Johansen, I. S., Mitarai, S., Chikamatsu, K., Kerkhoff, A. D., Macé, A., Ongarello, S., Meintjes, G., Denkinger, C. M. & Schumacher, S. G., May 2020, In : PLoS Medicine. 17, 5, p. e1003113

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Serologic Responses in Childhood Pulmonary Tuberculosis

Nonyane, B. A. S., Nicol, M. P., Andreas, N. J., Rimmele, S., Schneiderhan-Marra, N., Workman, L. J., Perkins, M. D., Joos, T., Broger, T., Ellner, J. J., Alland, D., Kampmann, B., Dorman, S. E. & Zar, H. J., 1 Jan 2018, In : Pediatric Infectious Disease Journal. 37, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Precision medicine for drug-resistant tuberculosis in high-burden countries: is individualised treatment desirable and feasible?

Cox, H., Hughes, J., Black, J. & Nicol, M. P., 1 Sep 2018, In : The Lancet Infectious Diseases. 18, 9, p. e282-e287

Research output: Contribution to journalReview article

17 Citations (Scopus)
2020

Accuracy of a novel urine test, Fujifilm SILVAMP TB LAM, for the diagnosis of pulmonary tuberculosis in children

Nicol, M. P., Schumacher, S. G., Workman, L., Broger, T., Baard, C., Prins, M., Bateman, L., du Toit, E., van Heerden, J., Szekely, R., Zar, H. J. & Denkinger, C. M., 6 Aug 2020, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Research output: Contribution to journalArticle

2019

Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis

RSV Global Epidemiology Network & RESCEU Investigators, Aug 2019, In : The Lancet Global Health. 7, 8, p. E1031-E1045 15 p.

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)
2020

Diagnostic accuracy of the Xpert MTB/Rif Ultra for tuberculosis adenitis

Antel, K., Oosthuizen, J., Malherbe, F., Louw, V. J., Nicol, M. P., Maartens, G. & Verburgh, E., 13 Jan 2020, In : BMC Infectious Diseases. 20, 1, p. 33

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

The Influence of DNA Extraction and Lipid Removal on Human Milk Bacterial Profiles

Ojo-Okunola, A., Claassen-Weitz, S., Mwaikono, K. S., Gardner-Lubbe, S., Zar, H. J., Nicol, M. P. & du Toit, E., 15 May 2020, In : Methods and protocols. 3, 2

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Prevention of community-acquired pneumonia in children: South African Thoracic Society guidelines (part 4)

Zar, H. J., Moore, D. P., Andronikou, S., Argent, A. C., Avenant, T., Cohen, C., Green, R. J., Itzikowitz, G., Jeena, P., Nicol, M. P., Pillay, A., Reubenson, G., Masekela, R. & Madhi, S. A., Aug 2020, In : South African Medical Journal. 110, 8, p. 741-746 6 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

First clinical assessment of a prototype assay to detect the enzymatic activity of β-lactamase as a marker for pulmonary tuberculosis

Nabeta, P., Seshadri, P., Havumaki, J., Mbhele, S., Hendricks, L., Perkins, M. D., Nicol, M. P. & Denkinger, C. M., 19 Feb 2020, In : Diagnostic Microbiology and Infectious Disease. 115026.

Research output: Contribution to journalArticle

Open Access
2018

Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study

Dorman, S. E., Schumacher, S. G., Alland, D., Nabeta, P., Armstrong, D. T., King, B., Hall, S. L., Chakravorty, S., Cirillo, D. M., Tukvadze, N., Bablishvili, N., Stevens, W., Scott, L., Rodrigues, C., Kazi, M. I., Joloba, M., Nakiyingi, L., Nicol, M. P., Ghebrekristos, Y., Anyango, I. & 12 others, Murithi, W., Dietze, R., Lyrio Peres, R., Skrahina, A., Auchynka, V., Chopra, K. K., Hanif, M., Liu, X., Yuan, X., Boehme, C. C., Ellner, J. J. & Denkinger, C. M., 1 Jan 2018, In : The Lancet Infectious Diseases. 18, 1, p. 76-84 9 p.

Research output: Contribution to journalArticle

Open Access
165 Citations (Scopus)

Age-related waning of immune responses to BCG in healthy children supports the need for a booster dose of BCG in TB endemic countries

Whittaker, E., Nicol, M. P., Zar, H. J., Tena-Coki, N. G. & Kampmann, B., 1 Dec 2018, In : Scientific Reports. 8, 1, 15309.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Tuberculin skin test conversion and primary progressive tuberculosis disease in the first 5 years of life: a birth cohort study from Cape Town, South Africa

Martinez, L., le Roux, D. M., Barnett, W., Stadler, A., Nicol, M. P. & Zar, H. J., 1 Jan 2018, In : The Lancet Child & Adolescent Health. 2, 1, p. 46-55 10 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)
2017

Diagnostic accuracy, incremental yield and prognostic value of Determine TB-LAM for routine diagnostic testing for tuberculosis in HIV-infected patients requiring acute hospital admission in South Africa: A prospective cohort

Lawn, S. D., Kerkhoff, A. D., Burton, R., Schutz, C., Boulle, A., Vogt, M., Gupta-Wright, A., Nicol, M. P. & Meintjes, G., 21 Mar 2017, In : BMC Medicine. 15, 1, 67.

Research output: Contribution to journalArticle

Open Access
44 Citations (Scopus)

Impact of point-of-care xpert MTB/RIF on tuberculosis treatment initiation: A cluster-randomized trial

Lessells, R. J., Cooke, G. S., McGrath, N., Nicol, M. P., Newell, M. L. & Godfrey-Faussett, P., 1 Oct 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 7, p. 901-910 10 p.

Research output: Contribution to journalArticle

Open Access
19 Citations (Scopus)

Delays and loss to follow-up before treatment of drug-resistant tuberculosis following implementation of Xpert MTB/RIF in South Africa: A retrospective cohort study

Cox, H., Dickson-Hall, L., Ndjeka, N., van’t Hoog, A., Grant, A., Cobelens, F., Stevens, W. & Nicol, M., 1 Feb 2017, In : PLoS Medicine. 14, 2, e1002238.

Research output: Contribution to journalArticle

Open Access
46 Citations (Scopus)
2018

Longitudinal characterization of nasopharyngeal colonization with Streptococcus pneumoniae in a South African birth cohort post 13-valent pneumococcal conjugate vaccine implementation

Dube, F. S., Ramjith, J., Gardner-Lubbe, S., Nduru, P., Robberts, F. J. L., Wolter, N., Zar, H. J. & Nicol, M. P., 1 Dec 2018, In : Scientific Reports. 8, 1, 12497.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)
2020

Differential RD-1-specific IFN-γ host responses to diverse Mycobacterium tuberculosis strains in HIV-uninfected persons may be explained by genotypic variation in the ESX-1 region

Tomasicchio, M., Limberis, J., van der Merwe, R., Jacobson, R., Meldau, R., Theron, G., Nicol, M., Warren, R. & Dheda, K., 1 Jul 2020, In : International Journal of Infectious Diseases. 96, p. 240-243

Research output: Contribution to journalArticle

Open Access
2019

Clinical, microbiologic, and immunologic determinants of mortality in hospitalized patients with HIV-associated tuberculosis: A prospective cohort study

Schutz, C., Barr, D., Andrade, B. B., Shey, M., Ward, A., Janssen, S., Burton, R., Wilkinson, K. A., Sossen, B., Fukutani, K. F., Nicol, M., Maartens, G., Wilkinson, R. J. & Meintjes, G., Jul 2019, In : PLoS Medicine. 16, 7, p. e1002840

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Prevalence and antibiotic susceptibility patterns of enteric bacterial pathogens in human and non-human sources in an urban informal settlement in Cape Town, South Africa

Kalule, J. B., Smith, A. M., Vulindhlu, M., Tau, N. P., Nicol, M. P., Keddy, K. H. & Robberts, L., 6 Nov 2019, In : BMC Microbiology. 19, 1, 244.

Research output: Contribution to journalArticle

Open Access
2017

Laboratory-acquired infections of Salmonella enterica serotype Typhi in South Africa: Phenotypic and genotypic analysis of isolates

GERMS-SA Surveillance Network & Nicol, M., 29 Sep 2017, In : BMC Infectious Diseases. 17, 1, 9 p., 656.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2019

What causes symptoms suggestive of tuberculosis in HIV-positive people with negative initial investigations?

Hanifa, Y., Toro Silva, S., Karstaedt, A., Sahid, F., Charalambous, S., Chihota, V. N., Churchyard, G. J., von Gottberg, A., McCarthy, K., Nicol, M. P., Ndlovu, N. T., Stevens, W., Fielding, K. L. & Grant, A. D., 1 Feb 2019, In : International Journal of Tuberculosis & Lung Disease. 23, 2, p. 157-165 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Variation in the observed effect of Xpert MTB/RIF testing for tuberculosis on mortality: A systematic review and analysis of trial design considerations

Ochodo, E. A., Kalema, N., Schumacher, S., Steingart, K., Young, T., Mallett, S., Deeks, J., Cobelens, F., Bossuyt, P. M., Nicol, M. P. & Cattamanchi, A., 2019, In : Wellcome Open Research. 4, p. 173

Research output: Contribution to journalReview article

Open Access
2020

"A very humiliating illness": a qualitative study of patient-centered Care for Rifampicin-Resistant Tuberculosis in South Africa

Furin, J., Loveday, M., Hlangu, S., Dickson-Hall, L., le Roux, S., Nicol, M. & Cox, H., 17 Jan 2020, In : BMC Public Health. 20, 1, 76.

Research output: Contribution to journalArticle

Open Access

'SILVAMP TB LAM' rapid urine tuberculosis test predicts mortality in hospitalized HIV patients in South Africa

Sossen, B., Broger, T., Kerkhoff, A. D., Schutz, C., Trollip, A., Moreau, E., Schumacher, S. G., Burton, R., Ward, A., Wilkinson, R. J., Barr, D. A., Nicol, M. P., Denkinger, C. M. & Meintjes, G., 9 Jan 2020, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Research output: Contribution to journalReview article

Open Access

Correction to: Diagnostic accuracy of the Xpert MTB/Rif Ultra for tuberculosis adenitis

Antel, K., Oosthuizen, J., Malherbe, F., Louw, V. J., Nicol, M. P., Maartens, G. & Verburgh, E., 2 Mar 2020, In : BMC Infectious Diseases. 20, 1, p. 187

Research output: Contribution to journalLetter

Open Access
2018

Gene expression in cord blood links genetic risk for neurodevelopmental disorders with maternal psychological distress and adverse childhood outcomes

Breen, M. S., Wingo, A. P., Koen, N., Donald, K. A., Nicol, M., Zar, H. J., Ressler, K. J., Buxbaum, J. D. & Stein, D. J., 1 Oct 2018, In : Brain, Behavior, and Immunity. 73, p. 320-330 11 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
2017

Genome sequence for shiga toxin- producing Escherichia coli O26: H11, associated with a cluster of hemolytic- uremic syndrome cases in South Africa, 2017

Smith, A. M., Bosco, K. J., Nicol, M. P., Kleynhans, J., McCulloch, M., Duze, S. T., Ismail, A., Allam, M., Tau, N. P. & Keddy, K. H., 1 Sep 2017, In : Genome Announcements. 5, 38, e00989-17.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)
2019

Longitudinal Population Dynamics of Staphylococcus aureus in the Nasopharynx During the First Year of Life

Abdulgader, S. M., Robberts, L., Ramjith, J., Nduru, P. M., Dube, F., Gardner-Lubbe, S., Zar, H. J. & Nicol, M. P., 15 Mar 2019, In : Frontiers in Genetics. 10, 10 p., 198.

Research output: Contribution to journalArticle

Open Access
2018

Proteomic comparison of three clinical diarrhoeagenic drug-resistant Escherichia coli isolates grown on CHROMagar™STEC media

Kalule, J. B., Fortuin, S., Calder, B., Robberts, L., Keddy, K. H., Nel, A. J. M., Garnett, S., Nicol, M., Warner, D. F., Soares, N. C. & Blackburn, J. M., 30 May 2018, In : Journal of Proteomics. 180, p. 25-35 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

Remembering the basics: interventions to improve sputum collection for tuberculosis diagnosis

Centner, C. M. & Nicol, M. P., 1 Aug 2017, In : The Lancet Global Health. 5, 8, p. e728-e729

Research output: Contribution to journalComment/debate

2018

Preventing tuberculosis-related death in children with HIV

Tootla, H. D. & Nicol, M. P., 1 Feb 2018, In : The lancet. HIV. 5, 2, p. e62-e64

Research output: Contribution to journalComment/debate

2017

Disseminated tuberculosis among hospitalised HIV patients in South Africa: A common condition that can be rapidly diagnosed using urine-based assays

Kerkhoff, A. D., Barr, D. A., Schutz, C., Burton, R., Nicol, M. P., Lawn, S. D. & Meintjes, G., 1 Dec 2017, In : Scientific Reports. 7, 1, 10931.

Research output: Contribution to journalArticle

Open Access
26 Citations (Scopus)
2019

False rifampicin resistant results using Xpert MTB/RIF on urine samples in hospitalised HIV-infected patients

Schutz, C., Ward, A., Burton, R., Nicol, M. P., Blumenthal, U., Meintjes, G. & Kerkhoff, A. D., 28 Aug 2019, In : Southern African Journal of HIV Medicine. 20, 1, 10 p., 978.

Research output: Contribution to journalArticle

Open Access
2020

Diagnostic accuracy of three urine lipoarabinomannan tuberculosis assays in HIV-negative outpatients

Broger, T., Nicol, M., Sigal, G., Gotuzzo, E., Zimmer, A. J., Surtie, S., Caceres-Nakiche, T., Mantsoki, A., Reipold, E. I., Székely, R., Tsionsky, M., van Heerden, J., Plisova, T., Chikamatsu, K., Lowary, T. L., Pinter, A., Mitarai, S., Moreau, E., Schumacher, S. G. & Denkinger, C. M., 21 Jul 2020, In : The Journal of clinical investigation.

Research output: Contribution to journalArticle

Diagnostic limitations of clinical case definitions of pertussis in infants and children with severe lower respiratory tract infection

Muloiwa, R., Nicol, M. P., Hussey, G. D. & Zar, H. J., 17 Jul 2020, In : PLoS One. 15, 7, p. e0235703

Research output: Contribution to journalArticle

Open Access

Optimizing 16S rRNA gene profile analysis from low biomass nasopharyngeal and induced sputum specimens

Claassen-Weitz, S., Gardner-Lubbe, S., Mwaikono, K. S., du Toit, E., Zar, H. J. & Nicol, M. P., 12 May 2020, In : BMC Microbiology. 20, 1, 26 p., 113.

Research output: Contribution to journalArticle

Open Access