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  • Mark Nicol
2017

The Influence of HIV on the Evolution of Mycobacterium tuberculosis

Koch, A. S., Brites, D., Stucki, D., Evans, J. C., Seldon, R., Heekes, A., Mulder, N., Nicol, M., Oni, T., Mizrahi, V., Warner, D. F., Parkhill, J., Gagneux, S., Martin, D. P. & Wilkinson, R. J., 1 Jul 2017, In : Molecular Biology and Evolution. 34, 7, p. 1654-1668 15 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)
2016

Current knowledge and future research directions on fecal bacterial patterns and their association with asthma

Claassen-Weitz, S., Wiysonge, C. S., Machingaidze, S., Thabane, L., Horsnell, W. G. C., Zar, H. J., Nicol, M. P. & Kaba, M., 1 Jan 2016, In : Frontiers in Microbiology. 7, JUN, 838.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)
2017

Disseminated tuberculosis among hospitalised HIV patients in South Africa: A common condition that can be rapidly diagnosed using urine-based assays

Kerkhoff, A. D., Barr, D. A., Schutz, C., Burton, R., Nicol, M. P., Lawn, S. D. & Meintjes, G., 1 Dec 2017, In : Scientific Reports. 7, 1, 10931.

Research output: Contribution to journalArticle

Open Access
26 Citations (Scopus)
2016

How should tuberculosis molecular diagnostics be adapted for use in seriously ill HIV patients?

Nicol, M. P., 1 Dec 2016, In : EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. 16, 12, p. 1237-1239 3 p.

Research output: Contribution to journalEditorial

2017

Diagnostic accuracy, incremental yield and prognostic value of Determine TB-LAM for routine diagnostic testing for tuberculosis in HIV-infected patients requiring acute hospital admission in South Africa: A prospective cohort

Lawn, S. D., Kerkhoff, A. D., Burton, R., Schutz, C., Boulle, A., Vogt, M., Gupta-Wright, A., Nicol, M. P. & Meintjes, G., 21 Mar 2017, In : BMC Medicine. 15, 1, 67.

Research output: Contribution to journalArticle

Open Access
44 Citations (Scopus)
2018

Precision medicine for drug-resistant tuberculosis in high-burden countries: is individualised treatment desirable and feasible?

Cox, H., Hughes, J., Black, J. & Nicol, M. P., 1 Sep 2018, In : The Lancet Infectious Diseases. 18, 9, p. e282-e287

Research output: Contribution to journalReview article

17 Citations (Scopus)
2017

Laboratory-acquired infections of Salmonella enterica serotype Typhi in South Africa: Phenotypic and genotypic analysis of isolates

GERMS-SA Surveillance Network & Nicol, M., 29 Sep 2017, In : BMC Infectious Diseases. 17, 1, 9 p., 656.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2018

Blood and virus detection on barber clippers

Spengane, Z., Korsman, S., Mkentane, K., Davids, L. M., Zemanay, W., Africa, M., Mbhele, S., Nicol, M., Gumedze, F., Ngwanya, D. & Khumalo, N. P., 1 Apr 2018, In : South African Medical Journal. 108, 4, p. 278-282 5 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2017

Development of a real-time PCR assay and comparison to CHROMagar (TM) STEC to screen for Shiga toxin-producing Escherichia coli in stool, Cape Town, South Africa

Kalule, J. B., Keddy, K. H., Smith, A., Nicol, M. P. & Robberts, L., 14 Dec 2017, In : African journal of laboratory medicine. 6, 1, 8 p., 609.

Research output: Contribution to journalArticle

Open Access
2018

Longitudinal characterization of nasopharyngeal colonization with Streptococcus pneumoniae in a South African birth cohort post 13-valent pneumococcal conjugate vaccine implementation

Dube, F. S., Ramjith, J., Gardner-Lubbe, S., Nduru, P., Robberts, F. J. L., Wolter, N., Zar, H. J. & Nicol, M. P., 1 Dec 2018, In : Scientific Reports. 8, 1, 12497.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Preventing tuberculosis-related death in children with HIV

Tootla, H. D. & Nicol, M. P., 1 Feb 2018, In : The lancet. HIV. 5, 2, p. e62-e64

Research output: Contribution to journalComment/debate

2020

Differential RD-1-specific IFN-γ host responses to diverse Mycobacterium tuberculosis strains in HIV-uninfected persons may be explained by genotypic variation in the ESX-1 region

Tomasicchio, M., Limberis, J., van der Merwe, R., Jacobson, R., Meldau, R., Theron, G., Nicol, M., Warren, R. & Dheda, K., 1 Jul 2020, In : International Journal of Infectious Diseases. 96, p. 240-243

Research output: Contribution to journalArticle

Open Access
2018

Development of a clinical prediction rule to diagnose Pneumocystis jirovecii pneumonia in the World Health Organization's algorithm for seriously ill HIV-infected patients

Maartens, G., Stewart, A., Griesel, R., Kengne, A. P., Dube, F., Nicol, M., Rangaka, M. X. & Mendelson, M., 2018, In : Southern African Journal of HIV Medicine. 19, 1, p. 851

Research output: Contribution to journalArticle

Open Access
2020

Chronic lung disease in children and adolescents with HIV: a case–control study

the BREATHE Clinical Trial Team, 1 Jan 2020, In : Tropical Medicine and International Health.

Research output: Contribution to journalArticle

Diagnostic accuracy of a novel tuberculosis point-of-care urine lipoarabinomannan assay for people living with HIV: A meta-analysis of individual in- and outpatient data

Broger, T., Nicol, M. P., Székely, R., Bjerrum, S., Sossen, B., Schutz, C., Opintan, J. A., Johansen, I. S., Mitarai, S., Chikamatsu, K., Kerkhoff, A. D., Macé, A., Ongarello, S., Meintjes, G., Denkinger, C. M. & Schumacher, S. G., May 2020, In : PLoS Medicine. 17, 5, p. e1003113

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Drug-resistant tuberculosis patient care journeys in South Africa: a pilot study using routine laboratory data

Hill, J., Dickson-Hall, L., Grant, A. D., Grundy, C., Black, J., Kielmann, K., Mlisana, K., Mitrani, L., Loveday, M., Moshabela, M., Le Roux, S., Jassat, W., Nicol, M. & Cox, H., 1 Jan 2020, In : International Journal of Tuberculosis & Lung Disease. 24, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

Open Access

Diagnosis of community-acquired pneumonia in children: South African Thoracic Society guidelines (part 2)

Zar, H. J., Moore, D. P., Itzikowitz, G., Green, R. J., Argent, A. C., Avenant, T., Cohen, C., Jeena, P., Masekela, R., Pillay, A., Reubenson, G., Madhi, S. A., Andronikou, S. & Nicol, M. P., Jul 2020, In : SAMJ South African Medical Journal. 110, 7, p. 588-593 6 p.

Research output: Contribution to journalArticle

Prevention of community-acquired pneumonia in children: South African Thoracic Society guidelines (part 4)

Zar, H. J., Moore, D. P., Andronikou, S., Argent, A. C., Avenant, T., Cohen, C., Green, R. J., Itzikowitz, G., Jeena, P., Nicol, M. P., Pillay, A., Reubenson, G., Masekela, R. & Madhi, S. A., Aug 2020, In : South African Medical Journal. 110, 8, p. 741-746 6 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018
2016

Analytical and clinical evaluation of the epistem genedrive assay for detection of mycobacterium tuberculosis

Shenai, S., Armstrong, D. T., Valli, E., Dolinger, D. L., Nakiyingi, L., Dietze, R., Dalcolmo, M. P., Nicol, M. P., Zemanay, W., Manabe, Y., Hadad, D. J., Marques-Rodrigues, P., Palaci, M., Peres, R. L., Gaeddert, M., Armakovitch, S., Nonyane, B. A. S., Denkinger, C. M., Banada, P., Joloba, M. L. & 4 others, Ellner, J., Boehme, C., Alland, D. & Dorman, S. E., 1 Apr 2016, In : Journal of Clinical Microbiology. 54, 4, p. 1051-1057 7 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)
2018

Serologic Responses in Childhood Pulmonary Tuberculosis

Nonyane, B. A. S., Nicol, M. P., Andreas, N. J., Rimmele, S., Schneiderhan-Marra, N., Workman, L. J., Perkins, M. D., Joos, T., Broger, T., Ellner, J. J., Alland, D., Kampmann, B., Dorman, S. E. & Zar, H. J., 1 Jan 2018, In : Pediatric Infectious Disease Journal. 37, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2020

Diagnostic accuracy of the Xpert MTB/Rif Ultra for tuberculosis adenitis

Antel, K., Oosthuizen, J., Malherbe, F., Louw, V. J., Nicol, M. P., Maartens, G. & Verburgh, E., 13 Jan 2020, In : BMC Infectious Diseases. 20, 1, p. 33

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2016

Aetiology of childhood pneumonia in a well vaccinated South African birth cohort: A nested case-control study of the Drakenstein Child Health Study

Zar, H. J., Barnett, W., Stadler, A., Gardner-Lubbe, S., Myer, L. & Nicol, M. P., 1 Jun 2016, In : The Lancet Respiratory Medicine. 4, 6, p. 463-472 10 p.

Research output: Contribution to journalArticle

Open Access
67 Citations (Scopus)
2017
Open Access
6 Citations (Scopus)
2016

Diagnostic Test Accuracy in Childhood Pulmonary Tuberculosis: A Bayesian Latent Class Analysis

Schumacher, S. G., Van Smeden, M., Dendukuri, N., Joseph, L., Nicol, M. P., Pai, M. & Zar, H. J., 1 Nov 2016, In : American Journal of Epidemiology. 184, 9, p. 690-700 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2018

Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study

Dorman, S. E., Schumacher, S. G., Alland, D., Nabeta, P., Armstrong, D. T., King, B., Hall, S. L., Chakravorty, S., Cirillo, D. M., Tukvadze, N., Bablishvili, N., Stevens, W., Scott, L., Rodrigues, C., Kazi, M. I., Joloba, M., Nakiyingi, L., Nicol, M. P., Ghebrekristos, Y., Anyango, I. & 12 others, Murithi, W., Dietze, R., Lyrio Peres, R., Skrahina, A., Auchynka, V., Chopra, K. K., Hanif, M., Liu, X., Yuan, X., Boehme, C. C., Ellner, J. J. & Denkinger, C. M., 1 Jan 2018, In : The Lancet Infectious Diseases. 18, 1, p. 76-84 9 p.

Research output: Contribution to journalArticle

Open Access
165 Citations (Scopus)
2017

Optimizing Tuberculosis Diagnosis in Human Immunodeficiency Virus-Infected Inpatients Meeting the Criteria of Seriously Ill in the World Health Organization Algorithm

Griesel, R., Stewart, A., van der Plas, H., Sikhondze, W., Rangaka, M. X., Nicol, M. P., Kengne, A. P., Mendelson, M. & Maartens, G., 6 Nov 2017, In : Clinical Infectious Diseases. 66, 9, p. 1419-1426 8 p.

Research output: Contribution to journalArticle

2020

Composition of gut microbiota of children and adolescents with perinatal HIV infection taking antiretroviral therapy in Zimbabwe

Breathe Study Team, 14 Jan 2020, In : The Journal of infectious diseases. 221, 3, p. 483-492

Research output: Contribution to journalArticle

Open Access
File
5 Downloads (Pure)
2016

Tuberculosis diagnostics: State of the art and future directions

Pai, M., Nicol, M. P. & Boehme, C. C., 1 Jan 2016, In : Microbiology Spectrum. 4, 5, TBTB2-0019-2016.

Research output: Contribution to journalArticle

Open Access
29 Citations (Scopus)
2017

Diagnostic accuracy of two multiplex real-Time polymerase chain reaction assays for the diagnosis of meningitis in children in a resource-limited setting

Khumalo, J., Nicol, M., Hardie, D., Muloiwa, R., Mteshana, P. & Bamford, C., 1 Mar 2017, In : PLoS One. 12, 3, e0173948.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2018

Proteomic comparison of three clinical diarrhoeagenic drug-resistant Escherichia coli isolates grown on CHROMagar™STEC media

Kalule, J. B., Fortuin, S., Calder, B., Robberts, L., Keddy, K. H., Nel, A. J. M., Garnett, S., Nicol, M., Warner, D. F., Soares, N. C. & Blackburn, J. M., 30 May 2018, In : Journal of Proteomics. 180, p. 25-35 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Treatment of bronchiectasis exacerbations in children: which antibiotic?

Zar, H. J. & Nicol, M. P., 6 Oct 2018, In : The Lancet. 392, 10154, p. 1169-1170 2 p.

Research output: Contribution to journalComment/debate

HIV-exposure, early life feeding practices and delivery mode impacts on faecal bacterial profiles in a South African birth cohort

Claassen-Weitz, S., Gardner-Lubbe, S., Nicol, P., Botha, G., Mounaud, S., Shankar, J., Nierman, W. C., Mulder, N., Budree, S., Zar, H. J., Nicol, M. P. & Kaba, M., 1 Dec 2018, In : Scientific Reports. 8, 1, 5078.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2017

Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function

Hemingway, C., Berk, M., Anderson, S. T., Wright, V. J., Hamilton, S., Eleftherohorinou, H., Kaforou, M., Goldgof, G. M., Hickman, K., Kampmann, B., Schoeman, J., Eley, B., Beatty, D., Pienaar, S., Nicol, M. P., Griffiths, M. J., Waddell, S. J., Newton, S. M., Coin, L. J., Relman, D. A. & 2 others, Montana, G. & Levin, M., 1 Nov 2017, In : PLoS One. 12, 11, e0185973.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2020

Correction to: Diagnostic accuracy of the Xpert MTB/Rif Ultra for tuberculosis adenitis

Antel, K., Oosthuizen, J., Malherbe, F., Louw, V. J., Nicol, M. P., Maartens, G. & Verburgh, E., 2 Mar 2020, In : BMC Infectious Diseases. 20, 1, p. 187

Research output: Contribution to journalLetter

Open Access
2017

Regulatory T cells and pro-inflammatory responses predominate in children with tuberculosis

Whittaker, E., Nicol, M., Zar, H. J. & Kampmann, B., 25 Apr 2017, In : Frontiers in Immunology. 8, APR, 448.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)
2016

Human brucellosis in South Africa: Public health and diagnostic pitfalls

Wojno, J. M., Moodley, C., Pienaar, J., Beylis, N., Jacobsz, L., Nicol, M. P., Rossouw, J. & Bamford, C., 1 Jan 2016, In : South African Medical Journal. 106, 9, p. 883-885 3 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2020

The Determinants of the Human Milk Metabolome and Its Role in Infant Health

Ojo-Okunola, A., Cacciatore, S., Nicol, M. P. & du Toit, E., 20 Feb 2020, In : Metabolites. 10, 2

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)
2016

Diagnostic accuracy of lateral flow urine LAM assay for TB screening of adults with advanced immunosuppression attending routine HIV care in South Africa

Hanifa, Y., Fielding, K. L., Chihota, V. N., Adonis, L., Charalambous, S., Karstaedt, A., McCarthy, K., Nicol, M. P., Ndlovu, N. T., Sahid, F., Churchyard, G. J. & Grant, A. D., 1 Jun 2016, In : PLoS One. 11, 6, e0156866.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)
2020

Longitudinal changes in the nasopharyngeal resistome of South African infants using shotgun metagenomic sequencing

Manenzhe, R. I., Dube, F. S., Wright, M., Lennard, K., Zar, H. J., Mounaud, S., Nierman, W. C., Nicol, M. P. & Moodley, C., 2020, In : PLoS One. 15, 4, p. e0231887

Research output: Contribution to journalArticle

Open Access

'SILVAMP TB LAM' rapid urine tuberculosis test predicts mortality in hospitalized HIV patients in South Africa

Sossen, B., Broger, T., Kerkhoff, A. D., Schutz, C., Trollip, A., Moreau, E., Schumacher, S. G., Burton, R., Ward, A., Wilkinson, R. J., Barr, D. A., Nicol, M. P., Denkinger, C. M. & Meintjes, G., 9 Jan 2020, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Research output: Contribution to journalReview article

Open Access

Diagnostic accuracy of three urine lipoarabinomannan tuberculosis assays in HIV-negative outpatients

Broger, T., Nicol, M., Sigal, G., Gotuzzo, E., Zimmer, A. J., Surtie, S., Caceres-Nakiche, T., Mantsoki, A., Reipold, E. I., Székely, R., Tsionsky, M., van Heerden, J., Plisova, T., Chikamatsu, K., Lowary, T. L., Pinter, A., Mitarai, S., Moreau, E., Schumacher, S. G. & Denkinger, C. M., 21 Jul 2020, In : The Journal of clinical investigation.

Research output: Contribution to journalArticle

2017

A clinical scoring system to prioritise investigation for tuberculosis among adults attending HIV clinics in South Africa

Hanifa, Y., Fielding, K. L., Chihota, V. N., Adonis, L., Charalambous, S., Foster, N., Karstaedt, A., McCarthy, K., Nicol, M. P., Ndlovu, N. T., Sinanovic, E., Sahid, F., Stevens, W., Vassall, A., Churchyard, G. J. & Grant, A. D., 1 Aug 2017, In : PLoS One. 12, 8, e0181519.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2020

Management of community-acquired pneumonia in children: South African Thoracic Society guidelines (part 3)

Reubenson, G., Avenant, T., Moore, D. P., Itzikowitz, G., Andronikou, S., Cohen, C., Green, R. J., Jeena, P., Masekela, R., Nicol, M. P., Pillay, A., Madhi, S. A., Zar, H. J. & Argent, A. C., Aug 2020, In : South African Medical Journal. 110, 8, p. 734-740 7 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

The Influence of DNA Extraction and Lipid Removal on Human Milk Bacterial Profiles

Ojo-Okunola, A., Claassen-Weitz, S., Mwaikono, K. S., Gardner-Lubbe, S., Zar, H. J., Nicol, M. P. & du Toit, E., 15 May 2020, In : Methods and protocols. 3, 2

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Advances in the diagnosis of pulmonary tuberculosis in children

Nicol, M. P. & Zar, H. J., 25 May 2020, In : Paediatric Respiratory Reviews.

Research output: Contribution to journalReview article

First clinical assessment of a prototype assay to detect the enzymatic activity of β-lactamase as a marker for pulmonary tuberculosis

Nabeta, P., Seshadri, P., Havumaki, J., Mbhele, S., Hendricks, L., Perkins, M. D., Nicol, M. P. & Denkinger, C. M., 19 Feb 2020, In : Diagnostic Microbiology and Infectious Disease. 115026.

Research output: Contribution to journalArticle

Open Access
2017

Advances in the diagnosis of pneumonia in children

Zar, H. J., Andronikou, S. & Nicol, M. P., 26 Jul 2017, In : BMJ (Online). 358, j2739.

Research output: Contribution to journalReview article

19 Citations (Scopus)
2020

Diagnostic limitations of clinical case definitions of pertussis in infants and children with severe lower respiratory tract infection

Muloiwa, R., Nicol, M. P., Hussey, G. D. & Zar, H. J., 17 Jul 2020, In : PLoS One. 15, 7, p. e0235703

Research output: Contribution to journalArticle

Open Access
2017

Carriage of extended-spectrum beta-lactamase-producing enterobacteriaceae in HIV-infected children in Zimbabwe

Wilmore, S. M. S., Kranzer, K., Williams, A., Makamure, B., Nhidza, A. F., Mayini, J., Bandason, T., Metcalfe, J., Nicol, M. P., Balakrishnan, I., Ellington, M. J., Woodford, N., Hopkins, S., McHugh, T. D. & Ferrand, R. A., 1 May 2017, In : Journal of Medical Microbiology. 66, 5, p. 609-615 7 p., 000474.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)