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• 2018

  Multidrug-resistant Neisseria gonorrhoeae: Future therapeutic options

  Kahler, C. M., 1 Apr 2018, In : Future Microbiology. 13, 5, p. 499-501 3 p.

  Research output: Contribution to journal › Review article
  2 Citations (Scopus)
• 2013

  Attachment and Invasion of Neisseria meningitidis to Host Cells Is Related to Surface Hydrophobicity, Bacterial Cell Size and Capsule

  Bartley, S., Tzeng, Y-L., Heel, K., Lee, C. W., Mowlaboccus, S., Seemann, T., Lu, W., Lin, Y-H., Ryan, C. S., Peacock, C., Stephens, D. S., Davies, J. K. & Kahler, C., 2013, In : PLoS One. 8, 2, p. 15pp

  Research output: Contribution to journal › Article

  Open Access

  File
  33 Citations (Scopus)

  472 Downloads (Pure)
• 2019

  B part of it school leaver protocol: An observational repeat cross-sectional study to assess the impact of a meningococcal serogroup b (4cmenb) vaccine programme on carriage of neisseria meningitidis

  Marshall, H. S., McMillan, M., Koehler, A., Lawrence, A., MacLennan, J., Maiden, M., Ramsay, M., Ladhani, S. N., Trotter, C., Borrow, R., Finn, A., Sullivan, T., Richmond, P., Kahler, C., Whelan, J. & Vadivelu, K., 1 May 2019, In : BMJ Open. 9, 5, 7 p., e027233.

  Research output: Contribution to journal › Article

  Open Access

  • 4CMenB vaccine
  • Neisseria meningitidis
  • South Australia
  • Serogroup
  • Students
  3 Citations (Scopus)
• 2013

  The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin

  Wanty, C., Anandan, A., Piek, S., Walshe, J., Ganguly, J., Carlson, R. W., Stubbs, K., Kahler, C. & Vrielink, A., 2013, In : Journal of Molecular Biology. 425, 18, p. 3389-3402

  Research output: Contribution to journal › Article
  63 Citations (Scopus)
• 2018

  Structure-function relationships of the neisserial EptA enzyme responsible for phosphoethanolamine decoration of lipid A: Rationale for drug targeting

  Kahler, C. M., Nawrocki, K. L., Anandan, A., Vrielink, A. & Shafer, W. M., 21 Aug 2018, In : Frontiers in Microbiology. 9, JUL, 1922.

  Research output: Contribution to journal › Review article

  Open Access

  • phosphorylethanolamine
  • Lipid A
  • Drug Delivery Systems
  • Enzymes
  • Endotoxins
  8 Citations (Scopus)
• 2016

  Temporal changes in BEXSERO® antigen sequence type associated with genetic lineages of Neisseria meningitidis over a 15-year period in Western Australia

  Mowlaboccus, S., Perkins, T., Smith, H., Sloots, T., Tozer, S., Prempeh, L., Tay, A. C. Y., Peters, F., Speers, D., Keil, A. D. & Kahler, C., 29 Jun 2016, In : PLoS One. 11, 6

  Research output: Contribution to journal › Article

  Open Access

  • Western Australia
  • Neisseria meningitidis
  • Antigens
  • Meningococcal Infections
  • Vaccines
  17 Citations (Scopus)
• 2017

  Clonal expansion of new penicillin-resistant clade of neisseria meningitidis serogroup w clonal complex 11, Australia

  Mowlaboccus, S., Jolley, K. A., Bray, J. E., Pang, S., Lee, Y. T., Bew, J. D., Speers, D. J., Keil, A. D., Coombs, G. W. & Kahler, C. M., 1 Aug 2017, In : Emerging Infectious Diseases. 23, 8, p. 1364-1367 4 p.

  Research output: Contribution to journal › Article

  Open Access

  • Neisseria meningitidis
  • Penicillins
  • Serogroup
  • Meningococcal Infections
  • Western Australia
  18 Citations (Scopus)
• 2019

  Genomic characterisation of perinatal Western Australian Streptococcus agalactiae isolates

  Furfaro, L. L., Chang, B. J., Kahler, C. M. & Payne, M. S., 1 Jan 2019, In : PLoS One. 14, 10, e0223256.

  Research output: Contribution to journal › Article

  Open Access

  • Western Australia
  • Streptococcus agalactiae
  • Vaccines
  • genomics
  • Genes
  2 Citations (Scopus)
• 2018

  Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease

  Blakeway, L. V., Tan, A., Lappan, R., Ariff, A., Pickering, J. L., Peacock, C. S., Blyth, C. C., Kahler, C. M., Chang, B. J., Lehmann, D., Kirkham, L-A. S., Murphy, T. F., Jennings, M. P., Bakaletz, L. O., Atack, J. M., Peak, I. R. & Seib, K. L., 1 Nov 2018, In : Genome Biology and Evolution. 10, 11, p. 2932-2946 15 p.

  Research output: Contribution to journal › Article

  Open Access

  • DNA Restriction-Modification Enzymes
  • Moraxella catarrhalis
  • Moraxella (Branhamella) catarrhalis
  • restriction endonucleases
  • phylogenetics
  9 Citations (Scopus)
• 2017

  Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis

  Bartley, S. N., Mowlaboccus, S., Mullally, C. A., Stubbs, K. A., Vrielink, A., Maiden, M. C. J., Harrison, O. B., Perkins, T. T. & Kahler, C. M., 14 Mar 2017, In : Scientific Reports. 7, 14 p., 44442.

  Research output: Contribution to journal › Article

  Open Access

  • Horizontal Gene Transfer
  • Uridine Diphosphate
  • Neisseria meningitidis
  • Islands
  • Capsules
  9 Citations (Scopus)
• 2018

  Enzyme targets for drug design of new anti-virulence therapeutics

  Kahler, C. M., Sarkar-Tyson, M., Kibble, E. A., Stubbs, K. A. & Vrielink, A., 1 Dec 2018, In : Current Opinion in Structural Biology. 53, p. 140-150 11 p.

  Research output: Contribution to journal › Review article

  Open Access

  File

  • Drug Design
  • Virulence
  • Enzymes
  • cis-trans-Isomerases
  • Protein Disulfide Reductase (Glutathione)
  6 Citations (Scopus)

  750 Downloads (Pure)

• Genomic epidemiology and population structure of Neisseria gonorrhoeae from remote highly endemic Western Australian populations

  Al Suwayyid, B. A., Coombs, G. W., Speers, D. J., Pearson, J., Wise, M. J. & Kahler, C. M., 27 Feb 2018, In : BMC Genomics. 19, 1, 165.

  Research output: Contribution to journal › Article

  Open Access

  • Metagenomics
  • Neisseria gonorrhoeae
  • Western Australia
  • Epidemiology
  • Gonorrhea
  11 Citations (Scopus)
• 2017

  Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding

  Anandan, A., Evans, G. L., Condic-Jurkic, K., O'Mara, M. L., John, C. M., Phillips, N. J., Jarvis, G. A., Wills, S. S., Stubbs, K. A., Moraes, I., Kahler, C. M. & Vrielink, A., 28 Feb 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. 2218-2223 6 p.

  Research output: Contribution to journal › Article

  Open Access

  • phosphorylethanolamine
  • Lipid A
  • Transferases
  • Membranes
  • Endotoxins
  71 Citations (Scopus)

• Differences in the population structure of Neisseria meningitidis in two Australian states: Victoria and Western Australia

  Mowlaboccus, S., Mullally, C. A., Richmond, P. C., Howden, B. P., Stevens, K., Speers, D. J., Keil, A. D., Bjørnstad, O. N., Perkins, T. T. & Kahler, C. M., 1 Oct 2017, In : PLoS One. 12, 10, e0186839.

  Research output: Contribution to journal › Article

  Open Access

  • 4CMenB vaccine
  • Neisseria meningitidis
  • Western Australia
  • Victoria
  • Victoria (Australia)
  4 Citations (Scopus)
• 2018

  B Part of It protocol: A cluster randomised controlled trial to assess the impact of 4CMenB vaccine on pharyngeal carriage of Neisseria meningitidis in adolescents

  Marshall, H. S., McMillan, M., Koehler, A., Lawrence, A., Maclennan, J. M., Maiden, M. C. J., Ramsay, M., Ladhani, S. N., Trotter, C., Borrow, R., Finn, A., Sullivan, T., Richmond, P., Kahler, C. M., Whelan, J. & Vadivelu, K., 1 Jul 2018, In : BMJ Open. 8, 7, e020988.

  Research output: Contribution to journal › Article

  Open Access

  • 4CMenB vaccine
  • Neisseria meningitidis
  • South Australia
  • Students
  • Randomized Controlled Trials
  16 Citations (Scopus)
• 2017

  Emergence of a Urogenital Pathotype of Neisseria meningitidis

  Kahler, C. M., 1 Jul 2017, In : Trends in Microbiology. 25, 7, p. 510-512 3 p.

  Research output: Contribution to journal › Short survey

  • Neisseria meningitidis
  • Urethritis
  • Meningitis
  • Capsules
  • Sepsis
  6 Citations (Scopus)
• 2019

  Communication ambassadors—an Australian social media initiative to develop communication skills in early career scientists

  Wang, J. T. H., Power, C. J., Kahler, C. M., Lyras, D., Young, P. R., Iredell, J. & Robins-Browne, R., 1 Jan 2019, In : Journal of Microbiology and Biology Education. 19, 1, 1428.

  Research output: Contribution to journal › Article

  Open Access

  • communication skills
  • social networks
  • Social Media
  • communication sciences
  • communication (human)

• The Detroit 562 pharyngeal immortalized cell line model for the assessment of infectivity of pathogenic neisseria sp.

  Kibble, E. A., Sarkar-Tyson, M., Coombs, G. W. & Kahler, C. M., 16 Mar 2019, Neisseria meningitidis: Methods and Protocols. Seib, K. L. & Peak, I. R. (eds.). USA: Humana Press, Vol. 1969. p. 123-133 11 p. (Methods in Molecular Biology; vol. 1969).

  Research output: Chapter in Book/Conference paper › Chapter

  • Neisseria
  • Cell Line
  • Neisseria meningitidis
  • Neisseria gonorrhoeae
  • Infection
• 2016

  Inhibitors of macrophage infectivity potentiator-like PPIases affect neisserial and chlamydial pathogenicity

  Reimer, A., Seufert, F., Weiwad, M., Ebert, J., Bzdyl, N. M., Kahler, C. M., Sarkar-Tyson, M., Holzgrabe, U., Rudel, T. & Kozjak-Pavlovic, V., 1 Oct 2016, In : International Journal of Antimicrobial Agents. 48, 4, p. 401-408 8 p.

  Research output: Contribution to journal › Article

  • Peptidylprolyl Isomerase
  • Virulence
  • Macrophages
  • Neisseria meningitidis
  • Neisseria gonorrhoeae
  14 Citations (Scopus)
• 2018

  Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis

  Smith, R. P., Whitten, A. E., Paxman, J. J., Kahler, C. M., Scanlon, M. J. & Heras, B., 2018, In : Acta Crystallographica. Section F: Structural Biology Communications. 74, 1, p. 31-38 8 p.

  Research output: Contribution to journal › Article

  • Pathogens
  • Neisseria meningitidis
  • Crystallization
  • Purification
  • enzymes
  1 Citation (Scopus)

• Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens

  Smith, R. P., Mohanty, B., Mowlaboccus, S., Paxman, J. J., Williams, M. L., Headey, S. J., Wang, G., Subedi, P., Doak, B. C., Kahler, C. M., Scanlon, M. J. & Heras, B., 26 Oct 2018, In : Journal of Biological Chemistry. 293, 43, p. 16559-16571 13 p.

  Research output: Contribution to journal › Article
  3 Citations (Scopus)
• 2019

  Peptidyl-Prolyl Isomerase ppiB Is Essential for Proteome Homeostasis and Virulence in Burkholderia pseudomallei

  Bzdyl, N. M., Scott, N. E., Norville, I. H., Scott, A. E., Atkins, T., Pang, S., Sarovich, D. S., Coombs, G., Inglis, T. J. J., Kahler, C. M. & Sarkar-Tyson, M., Oct 2019, In : Infection and Immunity. 87, 10

  Research output: Contribution to journal › Article

  Open Access

  File

  • Burkholderia pseudomallei
  • Peptidylprolyl Isomerase
  • Proteome
  • Cyclophilins
  • Melioidosis
  3 Citations (Scopus)

  537 Downloads (Pure)