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• 2019

  The Detroit 562 pharyngeal immortalized cell line model for the assessment of infectivity of pathogenic neisseria sp.

  Kibble, E. A., Sarkar-Tyson, M., Coombs, G. W. & Kahler, C. M., 16 Mar 2019, Neisseria meningitidis: Methods and Protocols. Seib, K. L. & Peak, I. R. (eds.). USA: Humana Press, Vol. 1969. p. 123-133 11 p. (Methods in Molecular Biology; vol. 1969).

  Research output: Chapter in Book/Conference paper › Chapter

  • Neisseria
  • Cell Line
  • Neisseria meningitidis
  • Neisseria gonorrhoeae
  • Infection
• 2018

  Structure-function relationships of the neisserial EptA enzyme responsible for phosphoethanolamine decoration of lipid A: Rationale for drug targeting

  Kahler, C. M., Nawrocki, K. L., Anandan, A., Vrielink, A. & Shafer, W. M., 21 Aug 2018, In : Frontiers in Microbiology. 9, JUL, 1922.

  Research output: Contribution to journal › Review article

  Open Access

  • phosphorylethanolamine
  • Lipid A
  • Drug Delivery Systems
  • Enzymes
  • Endotoxins
  7 Citations (Scopus)
• 2013

  Attachment and Invasion of Neisseria meningitidis to Host Cells Is Related to Surface Hydrophobicity, Bacterial Cell Size and Capsule

  Bartley, S., Tzeng, Y-L., Heel, K., Lee, C. W., Mowlaboccus, S., Seemann, T., Lu, W., Lin, Y-H., Ryan, C. S., Peacock, C., Stephens, D. S., Davies, J. K. & Kahler, C., 2013, In : PLoS One. 8, 2, p. 15pp

  Research output: Contribution to journal › Article

  Open Access

  File
  30 Citations (Scopus)

  451 Downloads (Pure)
• 2017

  Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding

  Anandan, A., Evans, G. L., Condic-Jurkic, K., O'Mara, M. L., John, C. M., Phillips, N. J., Jarvis, G. A., Wills, S. S., Stubbs, K. A., Moraes, I., Kahler, C. M. & Vrielink, A., 28 Feb 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. 2218-2223 6 p.

  Research output: Contribution to journal › Article

  Open Access

  • phosphorylethanolamine
  • Lipid A
  • Transferases
  • Membranes
  • Endotoxins
  67 Citations (Scopus)
• 2015

  Novel Moraxella catarrhalis prophages display hyperconserved non-structural genes despite their genomic diversity

  Ariff, A., Wise, M., Kahler, C., Tay, A. C. Y., Peters, F., Perkins, T. & Chang, B., 24 Oct 2015, In : BMC Genomics. 16, 1, p. 1-19 19 p., 860.

  Research output: Contribution to journal › Article

  Open Access

  • Prophages
  • Moraxella (Branhamella) catarrhalis
  • Genes
  • Bacteriophages
  • Virulence
  9 Citations (Scopus)
• 2016

  Inhibitors of macrophage infectivity potentiator-like PPIases affect neisserial and chlamydial pathogenicity

  Reimer, A., Seufert, F., Weiwad, M., Ebert, J., Bzdyl, N. M., Kahler, C. M., Sarkar-Tyson, M., Holzgrabe, U., Rudel, T. & Kozjak-Pavlovic, V., 1 Oct 2016, In : International Journal of Antimicrobial Agents. 48, 4, p. 401-408 8 p.

  Research output: Contribution to journal › Article

  • Peptidylprolyl Isomerase
  • Virulence
  • Macrophages
  • Neisseria meningitidis
  • Neisseria gonorrhoeae
  13 Citations (Scopus)
• 2020

  Meningococcal B vaccine and meningococcal carriage in adolescents in Australia

  Marshall, H. S., McMillan, M., Koehler, A. P., Lawrence, A., Sullivan, T. R., MacLennan, J. M., Maiden, M. C. J., Ladhani, S. N., Ramsay, M. E., Trotter, C., Borrow, R., Finn, A., Kahler, C. M., Whelan, J., Vadivelu, K. & Richmond, P., 23 Jan 2020, In : New England Journal of Medicine. 382, 4, p. 318-327 10 p.

  Research output: Contribution to journal › Article

  • Meningococcal Vaccines
  • Neisseria meningitidis
  • Odds Ratio
  • Confidence Intervals
  • 4CMenB vaccine
  32 Citations (Scopus)
• 2018

  B Part of It protocol: A cluster randomised controlled trial to assess the impact of 4CMenB vaccine on pharyngeal carriage of Neisseria meningitidis in adolescents

  Marshall, H. S., McMillan, M., Koehler, A., Lawrence, A., Maclennan, J. M., Maiden, M. C. J., Ramsay, M., Ladhani, S. N., Trotter, C., Borrow, R., Finn, A., Sullivan, T., Richmond, P., Kahler, C. M., Whelan, J. & Vadivelu, K., 1 Jul 2018, In : BMJ Open. 8, 7, e020988.

  Research output: Contribution to journal › Article

  Open Access

  • 4CMenB vaccine
  • Neisseria meningitidis
  • South Australia
  • Students
  • Randomized Controlled Trials
  16 Citations (Scopus)
• 2017

  Emergence of a Urogenital Pathotype of Neisseria meningitidis

  Kahler, C. M., 1 Jul 2017, In : Trends in Microbiology. 25, 7, p. 510-512 3 p.

  Research output: Contribution to journal › Short survey

  • Neisseria meningitidis
  • Urethritis
  • Meningitis
  • Capsules
  • Sepsis
  3 Citations (Scopus)
• 2019

  Peptidyl-Prolyl Isomerase ppiB Is Essential for Proteome Homeostasis and Virulence in Burkholderia pseudomallei

  Bzdyl, N. M., Scott, N. E., Norville, I. H., Scott, A. E., Atkins, T., Pang, S., Sarovich, D. S., Coombs, G., Inglis, T. J. J., Kahler, C. M. & Sarkar-Tyson, M., Oct 2019, In : Infection and Immunity. 87, 10

  Research output: Contribution to journal › Article

  Open Access

  File

  • Burkholderia pseudomallei
  • Peptidylprolyl Isomerase
  • Proteome
  • Cyclophilins
  • Melioidosis
  2 Citations (Scopus)

  444 Downloads (Pure)
• 2018

  Enzyme targets for drug design of new anti-virulence therapeutics

  Kahler, C. M., Sarkar-Tyson, M., Kibble, E. A., Stubbs, K. A. & Vrielink, A., 1 Dec 2018, In : Current Opinion in Structural Biology. 53, p. 140-150 11 p.

  Research output: Contribution to journal › Review article

  Open Access

  File

  • Drug Design
  • Virulence
  • Enzymes
  • cis-trans-Isomerases
  • Protein Disulfide Reductase (Glutathione)
  5 Citations (Scopus)

  631 Downloads (Pure)

• Genomic epidemiology and population structure of Neisseria gonorrhoeae from remote highly endemic Western Australian populations

  Al Suwayyid, B. A., Coombs, G. W., Speers, D. J., Pearson, J., Wise, M. J. & Kahler, C. M., 27 Feb 2018, In : BMC Genomics. 19, 1, 165.

  Research output: Contribution to journal › Article

  Open Access

  • Metagenomics
  • Neisseria gonorrhoeae
  • Western Australia
  • Epidemiology
  • Gonorrhea
  8 Citations (Scopus)
• 2020

  The Goldilocks Zone: Searching for a Phylogenetic Approach for the Recombinogenic Neisseria gonorrhoeae

  Kahler, C. M., 9 Nov 2020, In : The Journal of infectious diseases. 222, 11, p. 1762-1763 2 p.

  Research output: Contribution to journal › Editorial
• 2015

  Influence of in situ progressive N-terminal is still controversial truncation of glycogen branching enzyme in Escherichia coli DH5α on glycogen structure, accumulation, and bacterial viability

  Wang, L., Regina, A., Butardo, V. M., Kosar-Hashemi, B., Larroque, O., Kahler, C. & Wise, M., 2015, In : BMC Microbiology. 15, 96, p. 1-14

  Research output: Contribution to journal › Article

  Open Access

  • 1,4-alpha-Glucan Branching Enzyme
  • Microbial Viability
  • Glycogen
  • Escherichia coli
  • Desiccation
  8 Citations (Scopus)
• 2018

  Multidrug-resistant Neisseria gonorrhoeae: Future therapeutic options

  Kahler, C. M., 1 Apr 2018, In : Future Microbiology. 13, 5, p. 499-501 3 p.

  Research output: Contribution to journal › Review article
  2 Citations (Scopus)
• 2019

  B part of it school leaver protocol: An observational repeat cross-sectional study to assess the impact of a meningococcal serogroup b (4cmenb) vaccine programme on carriage of neisseria meningitidis

  Marshall, H. S., McMillan, M., Koehler, A., Lawrence, A., MacLennan, J., Maiden, M., Ramsay, M., Ladhani, S. N., Trotter, C., Borrow, R., Finn, A., Sullivan, T., Richmond, P., Kahler, C., Whelan, J. & Vadivelu, K., 1 May 2019, In : BMJ Open. 9, 5, 7 p., e027233.

  Research output: Contribution to journal › Article

  Open Access

  • 4CMenB vaccine
  • Neisseria meningitidis
  • South Australia
  • Serogroup
  • Students
  3 Citations (Scopus)
• 2017

  Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis

  Bartley, S. N., Mowlaboccus, S., Mullally, C. A., Stubbs, K. A., Vrielink, A., Maiden, M. C. J., Harrison, O. B., Perkins, T. T. & Kahler, C. M., 14 Mar 2017, In : Scientific Reports. 7, 14 p., 44442.

  Research output: Contribution to journal › Article

  Open Access

  • Horizontal Gene Transfer
  • Uridine Diphosphate
  • Neisseria meningitidis
  • Islands
  • Capsules
  9 Citations (Scopus)
• 2020

  Meningococcal Disease-Associated Prophage-Like Elements Are Present in Neisseria gonorrhoeae and Some Commensal Neisseria Species

  Al Suwayyid, B. A., Rankine-Wilson, L., Speers, D. J., Wise, M. J., Coombs, G. W. & Kahler, C. M., 8 Feb 2020, In : Genome Biology and Evolution. 12, 2, p. 3938-3950 13 p.

  Research output: Contribution to journal › Article

  Open Access

  • Neisseria
  • Prophages
  • commensal
  • Meningococcal Infections
  • Neisseria gonorrhoeae
• 2019

  Communication ambassadors—an Australian social media initiative to develop communication skills in early career scientists

  Wang, J. T. H., Power, C. J., Kahler, C. M., Lyras, D., Young, P. R., Iredell, J. & Robins-Browne, R., 1 Jan 2019, In : Journal of Microbiology and Biology Education. 19, 1, 1428.

  Research output: Contribution to journal › Article

  Open Access

  • communication skills
  • social networks
  • Social Media
  • communication sciences
  • communication (human)
• 2013

  The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin

  Wanty, C., Anandan, A., Piek, S., Walshe, J., Ganguly, J., Carlson, R. W., Stubbs, K., Kahler, C. & Vrielink, A., 2013, In : Journal of Molecular Biology. 425, 18, p. 3389-3402

  Research output: Contribution to journal › Article
  62 Citations (Scopus)
• 2017

  Differences in the population structure of Neisseria meningitidis in two Australian states: Victoria and Western Australia

  Mowlaboccus, S., Mullally, C. A., Richmond, P. C., Howden, B. P., Stevens, K., Speers, D. J., Keil, A. D., Bjørnstad, O. N., Perkins, T. T. & Kahler, C. M., 1 Oct 2017, In : PLoS One. 12, 10, e0186839.

  Research output: Contribution to journal › Article

  Open Access

  • 4CMenB vaccine
  • Neisseria meningitidis
  • Western Australia
  • Victoria
  • Victoria (Australia)
  4 Citations (Scopus)
• 2018

  Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease

  Blakeway, L. V., Tan, A., Lappan, R., Ariff, A., Pickering, J. L., Peacock, C. S., Blyth, C. C., Kahler, C. M., Chang, B. J., Lehmann, D., Kirkham, L-A. S., Murphy, T. F., Jennings, M. P., Bakaletz, L. O., Atack, J. M., Peak, I. R. & Seib, K. L., 1 Nov 2018, In : Genome Biology and Evolution. 10, 11, p. 2932-2946 15 p.

  Research output: Contribution to journal › Article

  Open Access

  • DNA Restriction-Modification Enzymes
  • Moraxella catarrhalis
  • Moraxella (Branhamella) catarrhalis
  • restriction endonucleases
  • phylogenetics
  9 Citations (Scopus)
• 2019

  Genomic characterisation of perinatal Western Australian Streptococcus agalactiae isolates

  Furfaro, L. L., Chang, B. J., Kahler, C. M. & Payne, M. S., 1 Jan 2019, In : PLoS One. 14, 10, e0223256.

  Research output: Contribution to journal › Article

  Open Access

  • Western Australia
  • Streptococcus agalactiae
  • Vaccines
  • genomics
  • Genes
  2 Citations (Scopus)
• 2018

  Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens

  Smith, R. P., Mohanty, B., Mowlaboccus, S., Paxman, J. J., Williams, M. L., Headey, S. J., Wang, G., Subedi, P., Doak, B. C., Kahler, C. M., Scanlon, M. J. & Heras, B., 26 Oct 2018, In : Journal of Biological Chemistry. 293, 43, p. 16559-16571 13 p.

  Research output: Contribution to journal › Article
  3 Citations (Scopus)

• Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis

  Smith, R. P., Whitten, A. E., Paxman, J. J., Kahler, C. M., Scanlon, M. J. & Heras, B., 2018, In : Acta Crystallographica. Section F: Structural Biology Communications. 74, 1, p. 31-38 8 p.

  Research output: Contribution to journal › Article

  • Pathogens
  • Neisseria meningitidis
  • Crystallization
  • Purification
  • enzymes
  1 Citation (Scopus)
• 2016

  Temporal changes in BEXSERO® antigen sequence type associated with genetic lineages of Neisseria meningitidis over a 15-year period in Western Australia

  Mowlaboccus, S., Perkins, T., Smith, H., Sloots, T., Tozer, S., Prempeh, L., Tay, A. C. Y., Peters, F., Speers, D., Keil, A. D. & Kahler, C., 29 Jun 2016, In : PLoS One. 11, 6

  Research output: Contribution to journal › Article

  Open Access

  • Western Australia
  • Neisseria meningitidis
  • Antigens
  • Meningococcal Infections
  • Vaccines
  17 Citations (Scopus)
• 2017

  Clonal expansion of new penicillin-resistant clade of neisseria meningitidis serogroup w clonal complex 11, Australia

  Mowlaboccus, S., Jolley, K. A., Bray, J. E., Pang, S., Lee, Y. T., Bew, J. D., Speers, D. J., Keil, A. D., Coombs, G. W. & Kahler, C. M., 1 Aug 2017, In : Emerging Infectious Diseases. 23, 8, p. 1364-1367 4 p.

  Research output: Contribution to journal › Article

  Open Access

  • Neisseria meningitidis
  • Penicillins
  • Serogroup
  • Meningococcal Infections
  • Western Australia
  15 Citations (Scopus)