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  • Jiake Xu
2014

TAK1 inhibition for the prevention of inflammation-induced preterm birth

Ireland, D., Pugazhenthi, K., Xu, J. & Keelan, J., 2014, Annual Meeting of the Society for Gynecologic Investigation, Reprod Sci. United States: SAGE Publications Ltd, Vol. 21. p. 238A

Research output: Chapter in Book/Conference paperConference paper

2014

Differential expression of extracellular-Signal-Regulated kinase 5 (ERK5) in normal and degenerated human nucleus pulposus tissues and cells

Liang, W., Fang, D., Ye, D., Zou, L., Shen, Y., Dai, L. & Xu, J., 2014, In : Biochemical and Biophysical Research Communications. 449, 4, p. 466-470

Research output: Contribution to journalArticle

3 Citations (Scopus)
2013

New Bone Formation and Microstructure Assessed by Combination of Confocal Laser Scanning Microscopy and Differential Interference Contrast Microscopy

Yang, X., Qin, L., Liang, W., Wang, W., Tan, J., Liang, P., Xu, J., Li, S. & Cui, S., 2013, In : Calcified Tissue International. 94, p. 338-347

Research output: Contribution to journalArticle

5 Citations (Scopus)

SC-514, a selective inhibitor of IKKβ attenuates RANKL-induced osteoclastogenesis and NF-κB activation

Liu, Q., Wu, H., Chim, S., Zhou, L., Zhao, J., Feng, H., Wei, Q., Wang, Q., Zheng, M., Tan, R. X., Gu, Q., Xu, J., Pavlos, N., Tickner, J. & Xu, J., 2013, In : Biochemical Pharmacology. 86, 12, p. 1775-1783

Research output: Contribution to journalArticle

28 Citations (Scopus)
2015

Macrophage migration inhibitory factor is essential for osteoclastogenic mechanisms in vitro and in vivo mouse model of arthritis

Gu, R., Santos, L. L., Ngo, D., Fan, H., Singh, P. P., Fingerle-Rowson, G. R., Bucala, R. J., Xu, J., Quinn, J. M. W. & Morand, E. F., Apr 2015, In : Cytokine. 72, 2, p. 135-145

Research output: Contribution to journalArticle

17 Citations (Scopus)

microRNA-103a functions as a mechanosensitive microRNA to inhibit bone formation through targeting Runx2

Zuo, B., Zhu, J., Li, J., Wang, C., Zhao, X., Cai, G., Li, Z., Peng, J., Wang, P., Shen, C., Huang, Y., Xu, J., Zhang, X. & Chen, X., 2015, In : Journal of Bone and Mineral Research. 30, 2, p. 330-345

Research output: Contribution to journalArticle

84 Citations (Scopus)

Predicting selective liver X receptor β agonists using multiple machine learning methods

Li, Y., Wang, L., Liu, Z., Li, C., Xu, J., Gu, Q. & Xu, J., 1 May 2015, In : Molecular Biosystems. 11, 5, p. 1241-1250

Research output: Contribution to journalArticle

15 Citations (Scopus)

Parthenolide reduces empty lacunae and osteoclastic bone surface resorption induced by polyethylene particles in a murine calvarial model of peri-implant osteolysis

Zawawi, M. S. F., Marino, V., Perilli, E., Cantley, M. D., Xu, J., Purdue, P. E., Dharmapatni, A. A. S. S. K., Haynes, D. R. & Crotti, T. N., 2015, In : Journal of Biomedical Materials Research Part A. 103, 11, p. 3572-3579

Research output: Contribution to journalArticle

8 Citations (Scopus)
2018

Carnosic acid inhibits inflammation response and joint destruction on osteoclasts, fibroblast-like synoviocytes, and collagen-induced arthritis rats

Liu, M., Zhou, X., Zhou, L., Liu, Z., Yuan, J., Cheng, J., Zhao, J., Wu, L., Li, H., Qiu, H. & Xu, J., 1 Aug 2018, In : Journal of Cellular Physiology. 233, 8, p. 6291-6303 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2012

miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression

Guo, J., Ren, F., Wang, Y., Li, S., Gao, Z., Wang, X., Ning, H., Wu, J., Li, Y., Wang, Z., Chim, S., Xu, J. & Chang, Z., 2012, In : Journal of Bone and Mineral Research. 27, p. 1607-1618

Research output: Contribution to journalArticle

28 Citations (Scopus)
2018

Macrophages release plasma membrane-derived particles rich in accessible cholesterol

He, C., Hu, X., Weston, T. A., Jung, R. S., Sandhu, J., Huang, S., Heizer, P., Kim, J., Ellison, R., Xu, J., Kilburn, M., Bensinger, S. J., Riezman, H., Tontonoz, P., Fong, L. G., Jiang, H. & Young, S. G., 4 Sep 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 36, p. E8499-E8508

Research output: Contribution to journalArticle

4 Citations (Scopus)

Zoledronic Acid: Pleiotropic Anti-tumor Mechanism and Therapeutic Outlook for Osteosarcoma

Ouyang, Z., Li, H., Zhai, Z., Xu, J., Dass, C. R., Qin, A. & Dai, K., 2018, In : Current Drug Targets. 19, 5, p. 409-421 13 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)
2016

Treadmill running exercise prevents senile osteoporosis and upregulates the Wnt signaling pathway in SAMP6 mice

Chen, X., Li, L., Guo, J., Zhang, L., Yuan, Y., Chen, B., Sun, Z., Xu, J. & Zou, J., 2016, In : Oncotarget. 7, 44, p. 71072-71086 15 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2011

Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-kB and ERK activation

Ang, E., Yang, X., Chen, H., Liu, Q., Zheng, M. & Xu, J., 2011, In : FEBS Letters. 585, 17, p. 2755-2762

Research output: Contribution to journalArticle

67 Citations (Scopus)
2015

Choline kinase β mutant mice exhibit reduced phosphocholine, elevated osteoclast activity, and low bone mass

Kular, J., Tickner, J., Pavlos, N., Viola, H., Abel, T., Lim, B., Yang, X., Chen, H., Cook, R., Hool, L., Zheng, M. & Xu, J., 16 Jan 2015, In : Journal of Biological Chemistry. 290, 3, p. 1729-1742

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)
2019

Therapeutic anabolic and anticatabolic benefits of natural Chinese medicines for the treatment of osteoporosis

He, J., Li, X., Wang, Z., Bennett, S., Chen, K., Xiao, Z., Zhan, J., Chen, S., Hou, Y., Chen, J., Wang, S., Xu, J. & Lin, D., 25 Nov 2019, In : Frontiers in Pharmacology. 10, 1344.

Research output: Contribution to journalArticle

Open Access
2017

Evaluation of N-phosphonium chitosan as a novel vaccine carrier for intramuscular immunization

Cai, J., Zhang, W., Xu, J., Xue, W. & Liu, Z., 1 Nov 2017, In : Journal of Biomaterials Applications. 32, 5, p. 677-685 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2018

Cyanidin Chloride inhibits ovariectomy-induced osteoporosis by suppressing RANKL-mediated osteoclastogenesis and associated signaling pathways

Cheng, J., Zhou, L., Liu, Q., Tickner, J., Tan, Z., Li, X., Liu, M., Lin, X., Wang, T., Pavlos, N. J., Zhao, J. & Xu, J., 1 Mar 2018, In : Journal of Cellular Physiology. 233, 3, p. 2502-2512 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2016

The y6 receptor suppresses bone resorption and stimulates bone formation in mice via a suprachiasmatic nucleus relay

Khor, E. C., Yulyaningsih, E., Driessler, F., Kovaĉić, N., Wee, N. K. Y., Kulkarni, R. N., Lee, N. J., Enriquez, R. F., Xu, J., Zhang, L., Herzog, H. & Baldock, P. A., Mar 2016, In : Bone. 84, p. 139-147 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2017

A polyamidoamne dendrimer functionalized graphene oxide for DOX and MMP-9 shRNA plasmid co-delivery

Gu, Y., Guo, Y., Wang, C., Xu, J., Wu, J., Kirk, T. B., Ma, D. & Xue, W., 1 Jan 2017, In : Materials Science and Engineering C. 70, p. 572-585 14 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2019

Protein Cytl1: its role in chondrogenesis, cartilage homeostasis, and disease

Zhu, S., Kuek, V., Bennett, S., Xu, H., Rosen, V. & Xu, J., 14 May 2019, In : Cellular and Molecular Life Sciences. 76, 18, p. 3515-3523

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)
2017

Natural Compounds for the Treatment of Psoriatic Arthritis: A Proposal Based on Multi-Targeted Osteoclastic Regulation and on a Preclinical Study

Deng, S., Cheng, J., Zhao, J., Yao, F. & Xu, J., 11 Jul 2017, In : JMIR Research Protocols. 6, 7, e132.

Research output: Contribution to journalArticle

Open Access
2014

HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1/5/8, ERK and p38 phosphorylation

Wu, X., Chim, S., Kuek, V., Lim, B. S., Chow, S. T., Zhao, J., Yang, S., Rosen, V., Tickner, J. & Xu, J., Jan 2014, In : FEBS Letters. 588, 1, p. 143-150

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)
2017

Molecular structure and differential function of choline kinases CHKα and CHKβ in musculoskeletal system and cancer

Chen, X., Qiu, H., Wang, C., Yuan, Y., Tickner, J., Xu, J. & Zou, J., Feb 2017, In : Cytokine and Growth Factor Reviews. 33, p. 65-72 8 p.

Research output: Contribution to journalReview article

Open Access
File
1 Citation (Scopus)
251 Downloads (Pure)
2019

A005, a novel inhibitor of phosphatidylinositol 3-kinase/mammalian target of rapamycin, prevents osteosarcoma-induced osteolysis

Lian, Z., Han, J., Huang, L., Wei, C., Fan, Y., Xu, J., Zhou, M., Feng, H., Liu, Q., Chen, L., Li, Z., Cheng, H., Yuan, G., Lin, X., Song, F., Su, Y., Wang, C., Huang, G., Qin, A., Song, Y. & 1 othersYao, G., 1 Jan 2019, In : Carcinogenesis. 40, 2, p. E1-E13

Research output: Contribution to journalArticle

2 Citations (Scopus)
2013
Open Access
57 Citations (Scopus)
2018

TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42

Xu, S., Zhang, Y., Wang, J., Li, K., Tan, K., Liang, K., Shen, J., Cai, D., Jin, D., Li, M., Xiao, G., Xu, J., Jiang, Y. & Bai, X., Sep 2018, In : Cell Death and Differentiation. 25, 9, p. 1549–1566

Research output: Contribution to journalArticle

1 Citation (Scopus)

Roles of neurotrophins in skeletal tissue formation and healing

Su, Y. W., Zhou, X. F., Foster, B. K., Grills, B. L., Xu, J. & Xian, C. J., 1 Mar 2018, In : Journal of Cellular Physiology. 233, 3, p. 2133-2145 13 p.

Research output: Contribution to journalReview article

13 Citations (Scopus)
2019

Scutellarein inhibits RANKL-induced osteoclast formation in vitro and prevents LPS-induced bone loss in vivo

Fu, F., Shao, S., Wang, Z., Song, F., Lin, X., Ding, J., Li, C., Wu, Z., Li, K., Xiao, Y., Su, Y., Zhao, J., Liu, Q. & Xu, J., 1 Jul 2019, In : Journal of Cellular Physiology. 234, 7, p. 11951-11959 9 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
96 Downloads (Pure)

Helvolic acid attenuates osteoclast formation and function via suppressing RANKL-induced NFATc1 activation

Chen, K., Yuan, Y., Wang, Z., Song, D., Zhao, J., Cao, Z., Chen, J., Guo, Q., Chen, L., Tickner, J. & Xu, J., May 2019, In : Journal of Cellular Physiology. 234, 5, p. 6477-6488 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Loureirin B suppresses RANKL-induced osteoclastogenesis and ovariectomized osteoporosis via attenuating NFATc1 and ROS activities

Liu, Y., Wang, C., Wang, G., Sun, Y., Deng, Z., Chen, L., Chen, K., Tickner, J., Kenny, J., Song, D., Zhang, Q., Wang, H., Chen, Z., Zhou, C., He, W. & Xu, J., 2019, In : Theranostics. 9, 16, p. 4648-4662 15 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Asperpyrone A attenuates RANKL-induced osteoclast formation through inhibiting NFATc1, Ca2+ signalling and oxidative stress

Chen, X., Wang, C., Qiu, H., Yuan, Y., Chen, K., Cao, Z., Xiang Tan, R., Tickner, J., Xu, J. & Zou, J., 1 Dec 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8269-8279 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2014

CHIP/Stub1 functions as a tumor suppressor and represses NF-κB-mediated signaling in colorectal cancer

Wang, Y., Ren, F., Feng, Y., Wang, D., Jia, B., Qiu, Y., Wang, S., Yu, J., Sung, J., Xu, J., Zeps, N. & Chang, Z., 2014, In : Carcinogenesis. 35, 5, p. 983-991

Research output: Contribution to journalArticle

48 Citations (Scopus)
2016

Dihydroartemisinin, an Anti-Malaria Drug, Suppresses Estrogen Deficiency-Induced Osteoporosis, Osteoclast Formation, and RANKL-Induced Signaling Pathways

Zhou, L., Liu, Q., Yang, M., Wang, T., Yao, J., Cheng, J. W., Yuan, J., Lin, X., Zhao, J., Tickner, J. & Xu, J., May 2016, In : Journal of Bone and Mineral Research. 31, 5, p. 964-974

Research output: Contribution to journalArticle

Open Access
File
43 Citations (Scopus)
269 Downloads (Pure)
2019

Pectolinarigenin prevents bone loss in ovariectomized mice and inhibits RANKL-induced osteoclastogenesis via blocking activation of MAPK and NFATc1 signaling

Xiao, Y., Li, K., Wang, Z., Fu, F., Shao, S., Song, F., Zhao, J., Chen, W., Liu, Q. & Xu, J., 1 Aug 2019, In : Journal of Cellular Physiology. 234, 8, p. 13959-13968 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2020

Hederagenin protects mice against ovariectomy-induced bone loss by inhibiting RANKL-induced osteoclastogenesis and bone resorption

Tian, K., Su, Y., Ding, J., Wang, D., Zhan, Y., Li, Y., Liang, J., Lin, X., Song, F., Wang, Z., Xu, J., Liu, Q. & Zhao, J., 1 Mar 2020, In : Life Sciences. 244, 117336.

Research output: Contribution to journalArticle

2012

Membrane-bound receptor activator of NFκB ligand (RANKL) activity displayed by osteoblasts is differentially regulated by osteolytic factors

Singh, P. P., Van Der Kraan, A. G. J., Xu, J., Gillespie, M. T. & Quinn, J. M. W., 2012, In : Biochemical and Biophysical Research Communications. 422, p. 48-53

Research output: Contribution to journalArticle

23 Citations (Scopus)
2017

Differential protein expression between normal and degenerated human nucleus pulposus cells by proteomic and bioinformatics analyses

Ye, D. P., Liang, W. G., Dai, L., Yao, Y., Chen, H., Zhou, Y. & Xu, J., 2017, In : International Journal of Clinical and Experimental Medicine. 10, 12, p. 16172-16180 9 p.

Research output: Contribution to journalArticle

Open Access
File
49 Downloads (Pure)

CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma

Shang, Y., He, J., Wang, Y., Feng, Q., Zhang, Y., Guo, J., Li, J., Li, S., Wang, Y., Yan, G., Ren, F., Shi, Y., Xu, J., Zeps, N., Zhai, Y., He, D. & Chang, Z., 20 Jul 2017, In : Oncogene. 36, 29, p. 4191-4200 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2015

Redox poly(ethylene glycol)-b-poly(l-lactide) micelles containing diselenide bonds for effective drug delivery

Zeng, X., Zhou, X., Li, M., Wang, C., Xu, J., Ma, D. & Xue, W., 2015, In : Journal of Materials Science: Materials in Medicine. 26, 9, p. 1-12

Research output: Contribution to journalArticle

14 Citations (Scopus)
2020

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts

Mullin, B., Tickner, J., Zhu, K., Kenny, J., Mullin, S., Brown, S. J., Dudbridge, F., Pavlos, N., Mocarski, E. S., Walsh, J. P., Xu, J. & Wilson, S., 26 Mar 2020, In : Genome Biology. 21, 80.

Research output: Contribution to journalArticle

Open Access
2019
Open Access
2 Citations (Scopus)
2017

Therapeutic potential and outlook of alternative medicine for osteoporosis

Wang, T., Liu, Q., Tjhioe, W., Zhao, J., Lu, A., Zhang, G., Tan, R. X., Zhou, M., Xu, J. & Feng, H. T., 1 Jul 2017, In : Current Drug Targets. 18, 9, p. 1051-1068 18 p.

Research output: Contribution to journalReview article

19 Citations (Scopus)
2019

Daphnetin attenuates LPS-induced osteolysis and RANKL mediated osteoclastogenesis through suppression of ERK and NFATc1 pathways

Wu, Z., Wu, H., Li, C., Fu, F., Ding, J., Shao, S., Li, K., Yu, X., Su, Y., Liang, J., Lin, X., Yuan, G., Zhou, J., Song, F., Zhao, J., Xu, J., Liu, Q. & Xu, F., 1 Oct 2019, In : Journal of Cellular Physiology. 234, 10, p. 17812-17823 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2016

Sinomenine down-regulates TLR4/TRAF6 expression and attenuates lipopolysaccharide-induced osteoclastogenesis and osteolysis

He, L., Duan, H., Li, X., Wang, S., Zhang, Y., Lei, L., Xu, J. & Liu, S., 2016, In : European Journal of Pharmacology. 779, p. 66-79

Research output: Contribution to journalArticle

12 Citations (Scopus)
2019

Pseurotin A inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppressing reactive oxygen species

Chen, K., Qiu, P., Yuan, Y., Zheng, L., He, J., Wang, C., Guo, Q., Kenny, J., Liu, Q., Zhao, J., Chen, J., Tickner, J., Fan, S., Lin, X. & Xu, J., 28 Feb 2019, In : Theranostics. 9, 6, p. 1634-1650

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
325 Downloads (Pure)

Modulating calcium-mediated NFATc1 and mitogen-activated protein kinase deactivation underlies the inhibitory effects of kavain on osteoclastogenesis and bone resorption

Guo, Q., Cao, Z., Wu, B., Chen, F., Tickner, J., Wang, Z., Qiu, H., Wang, C., Chen, K., Tan, R., Gao, Q. & Xu, J., Jan 2019, In : Journal of Cellular Physiology. 234, 1, p. 789-801 13 p.

Research output: Contribution to journalArticle

File
5 Citations (Scopus)
124 Downloads (Pure)
2018

Coupling factors and exosomal packaging microRNAs involved in the regulation of bone remodelling

Zhu, S., Yao, F., Qiu, H., Zhang, G., Xu, H. & Xu, J., Feb 2018, In : Biological Reviews. 93, 1, p. 469-480 12 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
400 Downloads (Pure)