[66Ga]oxine complex, preparation and stability as a possible PET radiopharmaceutical

Amir Reza Jalilian, Pejman Rowshan Farzad, A. Rahiminejad, Amir A. Rajamand, A. Novinrooz

Research output: Contribution to journalArticle

Abstract

Background: Gallium-66 (T1/2= 9.49 h) is an interesting radionuclide that has potential for positron emission tomography (PET) imaging of biological processes in intermediate to slow target tissue uptake. Oxine has been labeled with this radioisotope in the form of [66Ga]gallium chloride for its possible diagnostic properties. Materials and methods: 66Ga was produced in the 30 MeV cyclotron (Cyclon-30, IBA) via the 66Zn(p,n)66Ga reaction.TLC was performed on polymer backed silica gel. A Gamma spectrometer HPGe detector was used for countings. Results: After the bombardment, the production yield was 11.2 mCi/ m Ah. The [66Ga]Oxine complex was obtained at the pH=5 in phosphate buffer medium at 37 ° C in 10 minutes. Radio-TLC showed an overall radiochemical yield of 97% (radiochemical purity > 98%). The chemical stability of the complex was checked in vitro with a specific activity of 896 mCi/ml. Conclusion: [66Ga]oxine can be used in diagnostic studies due to its suitable physico-chemical properties both in vitro and in vivo.
Original languageEnglish
Pages (from-to)157-161
Number of pages4
JournalInternational Journal of Radiation Research
Volume1
Issue number3
Publication statusPublished - 2003
Externally publishedYes

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Oxyquinoline
Radiopharmaceuticals
Positron-Emission Tomography
Radioisotopes
Cyclotrons
Biological Phenomena
Gallium
Silica Gel
Radio
Buffers
Polymers
Phosphates
In Vitro Techniques

Cite this

Jalilian, Amir Reza ; Rowshan Farzad, Pejman ; Rahiminejad, A. ; Rajamand, Amir A. ; Novinrooz, A. / [66Ga]oxine complex, preparation and stability as a possible PET radiopharmaceutical. In: International Journal of Radiation Research. 2003 ; Vol. 1, No. 3. pp. 157-161.
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title = "[66Ga]oxine complex, preparation and stability as a possible PET radiopharmaceutical",
abstract = "Background: Gallium-66 (T1/2= 9.49 h) is an interesting radionuclide that has potential for positron emission tomography (PET) imaging of biological processes in intermediate to slow target tissue uptake. Oxine has been labeled with this radioisotope in the form of [66Ga]gallium chloride for its possible diagnostic properties. Materials and methods: 66Ga was produced in the 30 MeV cyclotron (Cyclon-30, IBA) via the 66Zn(p,n)66Ga reaction.TLC was performed on polymer backed silica gel. A Gamma spectrometer HPGe detector was used for countings. Results: After the bombardment, the production yield was 11.2 mCi/ m Ah. The [66Ga]Oxine complex was obtained at the pH=5 in phosphate buffer medium at 37 ° C in 10 minutes. Radio-TLC showed an overall radiochemical yield of 97{\%} (radiochemical purity > 98{\%}). The chemical stability of the complex was checked in vitro with a specific activity of 896 mCi/ml. Conclusion: [66Ga]oxine can be used in diagnostic studies due to its suitable physico-chemical properties both in vitro and in vivo.",
author = "Jalilian, {Amir Reza} and {Rowshan Farzad}, Pejman and A. Rahiminejad and Rajamand, {Amir A.} and A. Novinrooz",
year = "2003",
language = "English",
volume = "1",
pages = "157--161",
journal = "Iranian Journal of Radiation Research",
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[66Ga]oxine complex, preparation and stability as a possible PET radiopharmaceutical. / Jalilian, Amir Reza; Rowshan Farzad, Pejman; Rahiminejad, A.; Rajamand, Amir A.; Novinrooz, A.

In: International Journal of Radiation Research, Vol. 1, No. 3, 2003, p. 157-161.

Research output: Contribution to journalArticle

TY - JOUR

T1 - [66Ga]oxine complex, preparation and stability as a possible PET radiopharmaceutical

AU - Jalilian, Amir Reza

AU - Rowshan Farzad, Pejman

AU - Rahiminejad, A.

AU - Rajamand, Amir A.

AU - Novinrooz, A.

PY - 2003

Y1 - 2003

N2 - Background: Gallium-66 (T1/2= 9.49 h) is an interesting radionuclide that has potential for positron emission tomography (PET) imaging of biological processes in intermediate to slow target tissue uptake. Oxine has been labeled with this radioisotope in the form of [66Ga]gallium chloride for its possible diagnostic properties. Materials and methods: 66Ga was produced in the 30 MeV cyclotron (Cyclon-30, IBA) via the 66Zn(p,n)66Ga reaction.TLC was performed on polymer backed silica gel. A Gamma spectrometer HPGe detector was used for countings. Results: After the bombardment, the production yield was 11.2 mCi/ m Ah. The [66Ga]Oxine complex was obtained at the pH=5 in phosphate buffer medium at 37 ° C in 10 minutes. Radio-TLC showed an overall radiochemical yield of 97% (radiochemical purity > 98%). The chemical stability of the complex was checked in vitro with a specific activity of 896 mCi/ml. Conclusion: [66Ga]oxine can be used in diagnostic studies due to its suitable physico-chemical properties both in vitro and in vivo.

AB - Background: Gallium-66 (T1/2= 9.49 h) is an interesting radionuclide that has potential for positron emission tomography (PET) imaging of biological processes in intermediate to slow target tissue uptake. Oxine has been labeled with this radioisotope in the form of [66Ga]gallium chloride for its possible diagnostic properties. Materials and methods: 66Ga was produced in the 30 MeV cyclotron (Cyclon-30, IBA) via the 66Zn(p,n)66Ga reaction.TLC was performed on polymer backed silica gel. A Gamma spectrometer HPGe detector was used for countings. Results: After the bombardment, the production yield was 11.2 mCi/ m Ah. The [66Ga]Oxine complex was obtained at the pH=5 in phosphate buffer medium at 37 ° C in 10 minutes. Radio-TLC showed an overall radiochemical yield of 97% (radiochemical purity > 98%). The chemical stability of the complex was checked in vitro with a specific activity of 896 mCi/ml. Conclusion: [66Ga]oxine can be used in diagnostic studies due to its suitable physico-chemical properties both in vitro and in vivo.

M3 - Article

VL - 1

SP - 157

EP - 161

JO - Iranian Journal of Radiation Research

JF - Iranian Journal of Radiation Research

SN - 2322-3243

IS - 3

ER -