5.17 Three-dimensional bioengineered cancer models

B. A. Pereira, N. L. Lister, E. M. De-Juan-Pardo, G. P. Risbridger, S. J. Ellem

Research output: Chapter in Book/Conference paperChapter

Abstract

Cancer is an evolving, dynamic, evasive and heterogeneous disease, characterized by high morbidity and mortality. It is widely acknowledged that the tumor microenvironment plays a fundamental role in cancer development and progression. Despite this, most in vitro cancer models are simple, two-dimensional monocultures of immortalized tumor cell lines. There is an immediate need to develop three-dimensional, multicellular biomimetic in vitro constructs that can model specific stages of tumorigenesis to aid cancer research and drug discovery. This chapter aims to review the latest advances in three-dimensional bioengineered cancer modeling, with particular focus on models that retain the biological and physical characteristics of the in vivo tumor microenvironment.

Original languageEnglish
Title of host publicationComprehensive Biomaterials II
PublisherElsevier BV
Pages303-328
Number of pages26
Volume5
Edition2
ISBN (Electronic)9780081006924
ISBN (Print)9780081006917
DOIs
Publication statusPublished - 2017
Externally publishedYes

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  • Cite this

    Pereira, B. A., Lister, N. L., De-Juan-Pardo, E. M., Risbridger, G. P., & Ellem, S. J. (2017). 5.17 Three-dimensional bioengineered cancer models. In Comprehensive Biomaterials II (2 ed., Vol. 5, pp. 303-328). Elsevier BV. https://doi.org/10.1016/B978-0-12-803581-8.09297-3