4-Ethoxyamphetamine: Effects on intracranial self-stimulation and in vitro uptake and release of 3H-dopamine and 3H-serotonin in the brains of rats

K. M. Hegadoren; A. J. Greenshaw; G. B. Baker; M. T. Martin-Iverson; B. A. Lodge; S. Soin

4-Ethoxyamphetamine: Effects on intracranial self-stimulation and in vitro uptake and release of 3H-dopamine and 3H-serotonin in the brains of rats

K. M. Hegadoren, A. J. Greenshaw, G. B. Baker, M. T. Martin-Iverson, B. A. Lodge, S. Soin

Research output: Contribution to journal › Article › peer-review

Abstract

Experiments were conducted to compare the effects of 4-ethoxyamphetamine, a novel 'designer' amphetamine, with (+)-amphetamine and an earlier 'designer' amphetamine, 4-methoxyamphetamine, on rats. (+)-Amphetamine significantly decreased frequency threshold measures in an intracranial self-stimulation (ICSS) procedure using medial forebrain bundle electrodes, while 4-methoxyamphetamine and 4-ethoxyamphetamine increased these ICSS frequency thresholds. 4-Methoxyamphetamine and 4-ethoxyamphetamine had more potent effects on inhibition of uptake and stimulation of spontaneous release of 5-hydroxytryptamine (serotonin) than of dopamine. It is concluded that the neuropsychopharmacological profile of 4-ethoxyamthetamine is unlike that of (+)-amphetamine, but similar to that of 4-methoxyamphetamine, a potent hallucinogen in humans.

Original language	English
Pages (from-to)	57-62
Number of pages	6
Journal	Journal of Psychiatry and Neuroscience
Volume	19
Issue number	1
Publication status	Published - 1 Jan 1994
Externally published	Yes

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title = "4-Ethoxyamphetamine: Effects on intracranial self-stimulation and in vitro uptake and release of 3H-dopamine and 3H-serotonin in the brains of rats",

abstract = "Experiments were conducted to compare the effects of 4-ethoxyamphetamine, a novel 'designer' amphetamine, with (+)-amphetamine and an earlier 'designer' amphetamine, 4-methoxyamphetamine, on rats. (+)-Amphetamine significantly decreased frequency threshold measures in an intracranial self-stimulation (ICSS) procedure using medial forebrain bundle electrodes, while 4-methoxyamphetamine and 4-ethoxyamphetamine increased these ICSS frequency thresholds. 4-Methoxyamphetamine and 4-ethoxyamphetamine had more potent effects on inhibition of uptake and stimulation of spontaneous release of 5-hydroxytryptamine (serotonin) than of dopamine. It is concluded that the neuropsychopharmacological profile of 4-ethoxyamthetamine is unlike that of (+)-amphetamine, but similar to that of 4-methoxyamphetamine, a potent hallucinogen in humans.",

keywords = "4-ethoxyamphetamine, 4-methoxyamphetamine, amphetamine, intracranial self-stimulation, neurotransmitter amines, uptake and release",

author = "Hegadoren, {K. M.} and Greenshaw, {A. J.} and Baker, {G. B.} and Martin-Iverson, {M. T.} and Lodge, {B. A.} and S. Soin",

year = "1994",

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T2 - Effects on intracranial self-stimulation and in vitro uptake and release of 3H-dopamine and 3H-serotonin in the brains of rats

AU - Hegadoren, K. M.

AU - Greenshaw, A. J.

AU - Baker, G. B.

AU - Martin-Iverson, M. T.

AU - Lodge, B. A.

AU - Soin, S.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Experiments were conducted to compare the effects of 4-ethoxyamphetamine, a novel 'designer' amphetamine, with (+)-amphetamine and an earlier 'designer' amphetamine, 4-methoxyamphetamine, on rats. (+)-Amphetamine significantly decreased frequency threshold measures in an intracranial self-stimulation (ICSS) procedure using medial forebrain bundle electrodes, while 4-methoxyamphetamine and 4-ethoxyamphetamine increased these ICSS frequency thresholds. 4-Methoxyamphetamine and 4-ethoxyamphetamine had more potent effects on inhibition of uptake and stimulation of spontaneous release of 5-hydroxytryptamine (serotonin) than of dopamine. It is concluded that the neuropsychopharmacological profile of 4-ethoxyamthetamine is unlike that of (+)-amphetamine, but similar to that of 4-methoxyamphetamine, a potent hallucinogen in humans.

AB - Experiments were conducted to compare the effects of 4-ethoxyamphetamine, a novel 'designer' amphetamine, with (+)-amphetamine and an earlier 'designer' amphetamine, 4-methoxyamphetamine, on rats. (+)-Amphetamine significantly decreased frequency threshold measures in an intracranial self-stimulation (ICSS) procedure using medial forebrain bundle electrodes, while 4-methoxyamphetamine and 4-ethoxyamphetamine increased these ICSS frequency thresholds. 4-Methoxyamphetamine and 4-ethoxyamphetamine had more potent effects on inhibition of uptake and stimulation of spontaneous release of 5-hydroxytryptamine (serotonin) than of dopamine. It is concluded that the neuropsychopharmacological profile of 4-ethoxyamthetamine is unlike that of (+)-amphetamine, but similar to that of 4-methoxyamphetamine, a potent hallucinogen in humans.

KW - 4-ethoxyamphetamine

KW - 4-methoxyamphetamine

KW - amphetamine

KW - intracranial self-stimulation

KW - neurotransmitter amines

KW - uptake and release

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M3 - Article

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EP - 62

JO - Journal of Psychiatry and Neuroscience

JF - Journal of Psychiatry and Neuroscience

IS - 1

ER -

4-Ethoxyamphetamine: Effects on intracranial self-stimulation and in vitro uptake and release of 3H-dopamine and 3H-serotonin in the brains of rats

Abstract

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