4-Ethoxyamphetamine: Effects on intracranial self-stimulation and in vitro uptake and release of 3H-dopamine and 3H-serotonin in the brains of rats

K. M. Hegadoren, A. J. Greenshaw, G. B. Baker, M. T. Martin-Iverson, B. A. Lodge, S. Soin

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Experiments were conducted to compare the effects of 4-ethoxyamphetamine, a novel 'designer' amphetamine, with (+)-amphetamine and an earlier 'designer' amphetamine, 4-methoxyamphetamine, on rats. (+)-Amphetamine significantly decreased frequency threshold measures in an intracranial self-stimulation (ICSS) procedure using medial forebrain bundle electrodes, while 4-methoxyamphetamine and 4-ethoxyamphetamine increased these ICSS frequency thresholds. 4-Methoxyamphetamine and 4-ethoxyamphetamine had more potent effects on inhibition of uptake and stimulation of spontaneous release of 5-hydroxytryptamine (serotonin) than of dopamine. It is concluded that the neuropsychopharmacological profile of 4-ethoxyamthetamine is unlike that of (+)-amphetamine, but similar to that of 4-methoxyamphetamine, a potent hallucinogen in humans.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalJournal of Psychiatry and Neuroscience
Issue number1
Publication statusPublished - 1 Jan 1994
Externally publishedYes


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