3,5-Dibromophenyl-functionalised imidazolium salts and their corresponding [Au(NHC)2]+ complexes: synthesis, supramolecular chemistry and anti-cancer activity

Hawraa S. Al-Buthabhak, Yu Yu, Alexandre Sobolev, Hani Al-Salami, Murray V. Baker

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis and spectroscopic and structural characterisation of new 3,5-dibromophenyl-functionalised imidazolium salts and their corresponding [Au(NHC)2]+ complexes is reported. X-ray diffraction studies revealed intra- and intermolecular interactions involving the 3,5-dibromophenyl group, including Br…π interactions with imidazolyl and C6 arene rings. Au-NHC complexes functionalised with 3,5-dibromophenyl substituents showed potent activity against OVCAR-8 (ovarian cancer) cells at low micromolar concentrations.

Original languageEnglish
Pages (from-to)227-242
Number of pages16
JournalJournal of Inclusion Phenomena and Macrocyclic Chemistry
Volume101
Issue number3-4
DOIs
Publication statusPublished - Dec 2021

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