TY - JOUR
T1 - 3,5-Dibromophenyl-functionalised imidazolium salts and their corresponding [Au(NHC)2]+ complexes
T2 - synthesis, supramolecular chemistry and anti-cancer activity
AU - Al-Buthabhak, Hawraa S.
AU - Yu, Yu
AU - Sobolev, Alexandre
AU - Al-Salami, Hani
AU - Baker, Murray V.
PY - 2021/12
Y1 - 2021/12
N2 - The synthesis and spectroscopic and structural characterisation of new 3,5-dibromophenyl-functionalised imidazolium salts and their corresponding [Au(NHC)2]+ complexes is reported. X-ray diffraction studies revealed intra- and intermolecular interactions involving the 3,5-dibromophenyl group, including Br…π interactions with imidazolyl and C6 arene rings. Au-NHC complexes functionalised with 3,5-dibromophenyl substituents showed potent activity against OVCAR-8 (ovarian cancer) cells at low micromolar concentrations.
AB - The synthesis and spectroscopic and structural characterisation of new 3,5-dibromophenyl-functionalised imidazolium salts and their corresponding [Au(NHC)2]+ complexes is reported. X-ray diffraction studies revealed intra- and intermolecular interactions involving the 3,5-dibromophenyl group, including Br…π interactions with imidazolyl and C6 arene rings. Au-NHC complexes functionalised with 3,5-dibromophenyl substituents showed potent activity against OVCAR-8 (ovarian cancer) cells at low micromolar concentrations.
KW - 3,5-Dibromophenyl-functionalised compounds
KW - Anti-cancer activity
KW - Au-NHC complexes
KW - Imidazolium salts
KW - Lipophilic cations
KW - Supramolecular Br…π interactions
KW - X-ray structures
UR - http://www.scopus.com/inward/record.url?scp=85108502534&partnerID=8YFLogxK
U2 - 10.1007/s10847-021-01082-6
DO - 10.1007/s10847-021-01082-6
M3 - Article
AN - SCOPUS:85108502534
VL - 101
SP - 227
EP - 242
JO - Journal of Inclusion Phenomena and Macrocyclic Chemistry
JF - Journal of Inclusion Phenomena and Macrocyclic Chemistry
SN - 1388-3127
IS - 3-4
ER -
