20-Hydroxyeicosatetraenoic acid is not associated with circulating insulin in lean to overweight humans

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Abstract

Hypertension is often associated with insulin resistance or hyperinsulinemia. Metabolism of arachidonic acid by cytochrome P450 to the vasoconstrictor 20-HETE is thought to be involved in the pathogenesis of hypertension, but the relationship of 20-HETE with insulin resistance is not clearly understood. Obesity is a major determinant of insulin resistance, and we have previously demonstrated a positive relationship between BMI and 20-HETE in untreated hypertensive and normotensive individuals. The present analysis sought to determine if this relationship was related to insulin levels or insulin resistance (HOMA). We analysed 24 It urinary excretion of 20-HETE, serum insulin levels and insulin resistance in 66 lean to overweight untreated hypertensive and normotensive individuals. There was a significant positive association between 20-HETE and BMI (p < 0.001), and serum insulin and BMI (p = 0.003). There were no associations between 20-HETE excretion and either serum insulin or insulin resistance, before or after adjustment for age, gender, BMI and BP, or when hypertensive and normotensive individuals were considered separately.The results of the present study suggest that the observed positive association between urinary 20-HETE excretion and BMI may not be related to circulating insulin levels or insulin resistance. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)197-200
JournalDiabetes Research and Clinical Practice
Volume74
Issue number2
DOIs
Publication statusPublished - 2006

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Insulin Resistance
Insulin
Serum
Hypertension
Hyperinsulinism
Vasoconstrictor Agents
20-hydroxy-5,8,11,14-eicosatetraenoic acid
Ireland
Arachidonic Acid
Cytochrome P-450 Enzyme System
Obesity

Cite this

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title = "20-Hydroxyeicosatetraenoic acid is not associated with circulating insulin in lean to overweight humans",
abstract = "Hypertension is often associated with insulin resistance or hyperinsulinemia. Metabolism of arachidonic acid by cytochrome P450 to the vasoconstrictor 20-HETE is thought to be involved in the pathogenesis of hypertension, but the relationship of 20-HETE with insulin resistance is not clearly understood. Obesity is a major determinant of insulin resistance, and we have previously demonstrated a positive relationship between BMI and 20-HETE in untreated hypertensive and normotensive individuals. The present analysis sought to determine if this relationship was related to insulin levels or insulin resistance (HOMA). We analysed 24 It urinary excretion of 20-HETE, serum insulin levels and insulin resistance in 66 lean to overweight untreated hypertensive and normotensive individuals. There was a significant positive association between 20-HETE and BMI (p < 0.001), and serum insulin and BMI (p = 0.003). There were no associations between 20-HETE excretion and either serum insulin or insulin resistance, before or after adjustment for age, gender, BMI and BP, or when hypertensive and normotensive individuals were considered separately.The results of the present study suggest that the observed positive association between urinary 20-HETE excretion and BMI may not be related to circulating insulin levels or insulin resistance. (c) 2006 Elsevier Ireland Ltd. All rights reserved.",
author = "Natalie Ward and Jonathan Hodgson and Ian Puddey and Lawrence Beilin and Kevin Croft",
year = "2006",
doi = "10.1016/j.diabres.2006.04.001",
language = "English",
volume = "74",
pages = "197--200",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier",
number = "2",

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TY - JOUR

T1 - 20-Hydroxyeicosatetraenoic acid is not associated with circulating insulin in lean to overweight humans

AU - Ward, Natalie

AU - Hodgson, Jonathan

AU - Puddey, Ian

AU - Beilin, Lawrence

AU - Croft, Kevin

PY - 2006

Y1 - 2006

N2 - Hypertension is often associated with insulin resistance or hyperinsulinemia. Metabolism of arachidonic acid by cytochrome P450 to the vasoconstrictor 20-HETE is thought to be involved in the pathogenesis of hypertension, but the relationship of 20-HETE with insulin resistance is not clearly understood. Obesity is a major determinant of insulin resistance, and we have previously demonstrated a positive relationship between BMI and 20-HETE in untreated hypertensive and normotensive individuals. The present analysis sought to determine if this relationship was related to insulin levels or insulin resistance (HOMA). We analysed 24 It urinary excretion of 20-HETE, serum insulin levels and insulin resistance in 66 lean to overweight untreated hypertensive and normotensive individuals. There was a significant positive association between 20-HETE and BMI (p < 0.001), and serum insulin and BMI (p = 0.003). There were no associations between 20-HETE excretion and either serum insulin or insulin resistance, before or after adjustment for age, gender, BMI and BP, or when hypertensive and normotensive individuals were considered separately.The results of the present study suggest that the observed positive association between urinary 20-HETE excretion and BMI may not be related to circulating insulin levels or insulin resistance. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

AB - Hypertension is often associated with insulin resistance or hyperinsulinemia. Metabolism of arachidonic acid by cytochrome P450 to the vasoconstrictor 20-HETE is thought to be involved in the pathogenesis of hypertension, but the relationship of 20-HETE with insulin resistance is not clearly understood. Obesity is a major determinant of insulin resistance, and we have previously demonstrated a positive relationship between BMI and 20-HETE in untreated hypertensive and normotensive individuals. The present analysis sought to determine if this relationship was related to insulin levels or insulin resistance (HOMA). We analysed 24 It urinary excretion of 20-HETE, serum insulin levels and insulin resistance in 66 lean to overweight untreated hypertensive and normotensive individuals. There was a significant positive association between 20-HETE and BMI (p < 0.001), and serum insulin and BMI (p = 0.003). There were no associations between 20-HETE excretion and either serum insulin or insulin resistance, before or after adjustment for age, gender, BMI and BP, or when hypertensive and normotensive individuals were considered separately.The results of the present study suggest that the observed positive association between urinary 20-HETE excretion and BMI may not be related to circulating insulin levels or insulin resistance. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

U2 - 10.1016/j.diabres.2006.04.001

DO - 10.1016/j.diabres.2006.04.001

M3 - Article

VL - 74

SP - 197

EP - 200

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

IS - 2

ER -