Outer space is steadily evolving as a site of human-computer interactions. With the ongoing investments of state and private companies in space exploration, these interactions and their design are becoming increasingly crucial for the unfolding of our futures on and beyond the globe. Yet outside the Earth, our relations with technologies necessitate situational adjustments, requiring a range of adaptive strategies designed to negotiate the extreme extra-Terrestrial. While the domain of human-computer-interaction adopted methods from spaceflight the NASA Task Load Index (TLX), for example, in this workshop we especially consider ways in which the setting of outer space provides a testing ground for new forms of designing and performing human-computer interactions. Through a range of examples, we will explore the nuances emerging amidst exchanges between humans, technologies and space environments, and address them from a range of different research perspectives.