14th International HLA and Immunogenetics Workshop: Report on the Prospective Chronic Rejection Project

M. Ozawa; P.I. Terasaki; J.H. Lee; R. Castro; J. Alberu; C. Alonso; I. Alvarez; R. Toledo; H. Alvez; M. Monterio; J. Teixeira; P. Campbell; M. Ciszek; D. Charron; C. Gautreau; Frank Christiansen; R. Conca; B. Gomez; F. Monteon; H. Grosse-Wilde; F. Heinemann; I. Humar; M. Kamoun; P. Kimball; T. Kobayashi; P. Kupatawintu; S. Leech; W. Lefor; N. Mehra; A. Panigrahi; E. Naumova; D. Norman; A. Piazza; F. Poli; B. Colombo; R. Roy; C. Schonemann; G. Sireci; K. Tanabe; H. Ishida; E. Van Den Berg-Loonen; A. Zeevi

doi:10.1111/j.1399-0039.2006.00765.x

14th International HLA and Immunogenetics Workshop: Report on the Prospective Chronic Rejection Project

M. Ozawa, P.I. Terasaki, J.H. Lee, R. Castro, J. Alberu, C. Alonso, I. Alvarez, R. Toledo, H. Alvez, M. Monterio, J. Teixeira, P. Campbell, M. Ciszek, D. Charron, C. Gautreau, Frank Christiansen, R. Conca, B. Gomez, F. Monteon, H. Grosse-WildeF. Heinemann, I. Humar, M. Kamoun, P. Kimball, T. Kobayashi, P. Kupatawintu, S. Leech, W. Lefor, N. Mehra, A. Panigrahi, E. Naumova, D. Norman, A. Piazza, F. Poli, B. Colombo, R. Roy, C. Schonemann, G. Sireci, K. Tanabe, H. Ishida, E. Van Den Berg-Loonen, A. Zeevi

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Abstract

An international collaborative study of 45 transplant centers was undertaken at the 14th International HLA (human leukocyte antigen) and Immunogenetics Workshop to see if HLA antibodies detected posttransplant are predictive of chronic graft failure. With the newly developed assay, MICA (major histocompatibility complex class I-related chain A) antibodies were also measured and their effect analyzed. Total of 5219 sera from patients who were more than 6 months posttransplant with functioning graft were tested for HLA antibodies by enzyme-linked immunosorbent assay, flow cytometry, or Luminex. HLA antibodies were found in 27.2% of kidney patients, 23.6% in the liver, 52.7% in the heart, and 21.7% in the lung. The method of antibody testing did not have a marked influence on the frequency of antibodies detected. MICA antibodies were detected in 15% of kidney patients, 30% of heart patients, and 31% of liver patients. Among 948 kidney patients who had HLA antibodies, 7.3% had rejected their graft within 1 year of testing, compared with 1.7% in 2615 patients without HLA antibodies (P = 0.8 x 10(-17)). Death occurred in 1.4% of total kidney patients and did not correlate to the presence of antibodies. We conclude that patients with posttransplant HLA antibodies indeed have a higher rate of chronic graft failure and that posttransplant antibodies are predictive of chronic rejection.

Original language	English
Pages (from-to)	174-179
Journal	Tissue Antigens
Volume	69
Issue number	Supplement 1
DOIs	https://doi.org/10.1111/j.1399-0039.2006.00765.x
Publication status	Published - 2007

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Ozawa, M., Terasaki, P. I., Lee, J. H., Castro, R., Alberu, J., Alonso, C., Alvarez, I., Toledo, R., Alvez, H., Monterio, M., Teixeira, J., Campbell, P., Ciszek, M., Charron, D., Gautreau, C., Christiansen, F., Conca, R., Gomez, B., Monteon, F., ... Zeevi, A. (2007). 14th International HLA and Immunogenetics Workshop: Report on the Prospective Chronic Rejection Project. Tissue Antigens, 69(Supplement 1), 174-179. https://doi.org/10.1111/j.1399-0039.2006.00765.x

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title = "14th International HLA and Immunogenetics Workshop: Report on the Prospective Chronic Rejection Project",

abstract = "An international collaborative study of 45 transplant centers was undertaken at the 14th International HLA (human leukocyte antigen) and Immunogenetics Workshop to see if HLA antibodies detected posttransplant are predictive of chronic graft failure. With the newly developed assay, MICA (major histocompatibility complex class I-related chain A) antibodies were also measured and their effect analyzed. Total of 5219 sera from patients who were more than 6 months posttransplant with functioning graft were tested for HLA antibodies by enzyme-linked immunosorbent assay, flow cytometry, or Luminex. HLA antibodies were found in 27.2% of kidney patients, 23.6% in the liver, 52.7% in the heart, and 21.7% in the lung. The method of antibody testing did not have a marked influence on the frequency of antibodies detected. MICA antibodies were detected in 15% of kidney patients, 30% of heart patients, and 31% of liver patients. Among 948 kidney patients who had HLA antibodies, 7.3% had rejected their graft within 1 year of testing, compared with 1.7% in 2615 patients without HLA antibodies (P = 0.8 x 10(-17)). Death occurred in 1.4% of total kidney patients and did not correlate to the presence of antibodies. We conclude that patients with posttransplant HLA antibodies indeed have a higher rate of chronic graft failure and that posttransplant antibodies are predictive of chronic rejection.",

author = "M. Ozawa and P.I. Terasaki and J.H. Lee and R. Castro and J. Alberu and C. Alonso and I. Alvarez and R. Toledo and H. Alvez and M. Monterio and J. Teixeira and P. Campbell and M. Ciszek and D. Charron and C. Gautreau and Frank Christiansen and R. Conca and B. Gomez and F. Monteon and H. Grosse-Wilde and F. Heinemann and I. Humar and M. Kamoun and P. Kimball and T. Kobayashi and P. Kupatawintu and S. Leech and W. Lefor and N. Mehra and A. Panigrahi and E. Naumova and D. Norman and A. Piazza and F. Poli and B. Colombo and R. Roy and C. Schonemann and G. Sireci and K. Tanabe and H. Ishida and {Van Den Berg-Loonen}, E. and A. Zeevi",

year = "2007",

doi = "10.1111/j.1399-0039.2006.00765.x",

language = "English",

volume = "69",

pages = "174--179",

journal = "Tissue Antigens",

issn = "0001-2815",

publisher = "Wiley-Blackwell",

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Ozawa, M, Terasaki, PI, Lee, JH, Castro, R, Alberu, J, Alonso, C, Alvarez, I, Toledo, R, Alvez, H, Monterio, M, Teixeira, J, Campbell, P, Ciszek, M, Charron, D, Gautreau, C, Christiansen, F, Conca, R, Gomez, B, Monteon, F, Grosse-Wilde, H, Heinemann, F, Humar, I, Kamoun, M, Kimball, P, Kobayashi, T, Kupatawintu, P, Leech, S, Lefor, W, Mehra, N, Panigrahi, A, Naumova, E, Norman, D, Piazza, A, Poli, F, Colombo, B, Roy, R, Schonemann, C, Sireci, G, Tanabe, K, Ishida, H, Van Den Berg-Loonen, E & Zeevi, A 2007, '14th International HLA and Immunogenetics Workshop: Report on the Prospective Chronic Rejection Project', Tissue Antigens, vol. 69, no. Supplement 1, pp. 174-179. https://doi.org/10.1111/j.1399-0039.2006.00765.x

TY - JOUR

T1 - 14th International HLA and Immunogenetics Workshop: Report on the Prospective Chronic Rejection Project

AU - Ozawa, M.

AU - Terasaki, P.I.

AU - Lee, J.H.

AU - Castro, R.

AU - Alberu, J.

AU - Alonso, C.

AU - Alvarez, I.

AU - Toledo, R.

AU - Alvez, H.

AU - Monterio, M.

AU - Teixeira, J.

AU - Campbell, P.

AU - Ciszek, M.

AU - Charron, D.

AU - Gautreau, C.

AU - Christiansen, Frank

AU - Conca, R.

AU - Gomez, B.

AU - Monteon, F.

AU - Grosse-Wilde, H.

AU - Heinemann, F.

AU - Humar, I.

AU - Kamoun, M.

AU - Kimball, P.

AU - Kobayashi, T.

AU - Kupatawintu, P.

AU - Leech, S.

AU - Lefor, W.

AU - Mehra, N.

AU - Panigrahi, A.

AU - Naumova, E.

AU - Norman, D.

AU - Piazza, A.

AU - Poli, F.

AU - Colombo, B.

AU - Roy, R.

AU - Schonemann, C.

AU - Sireci, G.

AU - Tanabe, K.

AU - Ishida, H.

AU - Van Den Berg-Loonen, E.

AU - Zeevi, A.

PY - 2007

Y1 - 2007

N2 - An international collaborative study of 45 transplant centers was undertaken at the 14th International HLA (human leukocyte antigen) and Immunogenetics Workshop to see if HLA antibodies detected posttransplant are predictive of chronic graft failure. With the newly developed assay, MICA (major histocompatibility complex class I-related chain A) antibodies were also measured and their effect analyzed. Total of 5219 sera from patients who were more than 6 months posttransplant with functioning graft were tested for HLA antibodies by enzyme-linked immunosorbent assay, flow cytometry, or Luminex. HLA antibodies were found in 27.2% of kidney patients, 23.6% in the liver, 52.7% in the heart, and 21.7% in the lung. The method of antibody testing did not have a marked influence on the frequency of antibodies detected. MICA antibodies were detected in 15% of kidney patients, 30% of heart patients, and 31% of liver patients. Among 948 kidney patients who had HLA antibodies, 7.3% had rejected their graft within 1 year of testing, compared with 1.7% in 2615 patients without HLA antibodies (P = 0.8 x 10(-17)). Death occurred in 1.4% of total kidney patients and did not correlate to the presence of antibodies. We conclude that patients with posttransplant HLA antibodies indeed have a higher rate of chronic graft failure and that posttransplant antibodies are predictive of chronic rejection.

AB - An international collaborative study of 45 transplant centers was undertaken at the 14th International HLA (human leukocyte antigen) and Immunogenetics Workshop to see if HLA antibodies detected posttransplant are predictive of chronic graft failure. With the newly developed assay, MICA (major histocompatibility complex class I-related chain A) antibodies were also measured and their effect analyzed. Total of 5219 sera from patients who were more than 6 months posttransplant with functioning graft were tested for HLA antibodies by enzyme-linked immunosorbent assay, flow cytometry, or Luminex. HLA antibodies were found in 27.2% of kidney patients, 23.6% in the liver, 52.7% in the heart, and 21.7% in the lung. The method of antibody testing did not have a marked influence on the frequency of antibodies detected. MICA antibodies were detected in 15% of kidney patients, 30% of heart patients, and 31% of liver patients. Among 948 kidney patients who had HLA antibodies, 7.3% had rejected their graft within 1 year of testing, compared with 1.7% in 2615 patients without HLA antibodies (P = 0.8 x 10(-17)). Death occurred in 1.4% of total kidney patients and did not correlate to the presence of antibodies. We conclude that patients with posttransplant HLA antibodies indeed have a higher rate of chronic graft failure and that posttransplant antibodies are predictive of chronic rejection.

U2 - 10.1111/j.1399-0039.2006.00765.x

DO - 10.1111/j.1399-0039.2006.00765.x

M3 - Article

C2 - 17445195

SN - 0001-2815

VL - 69

SP - 174

EP - 179

JO - Tissue Antigens

JF - Tissue Antigens

IS - Supplement 1

ER -

14th International HLA and Immunogenetics Workshop: Report on the Prospective Chronic Rejection Project

Abstract

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