1.4T study of proton magnetic relaxation rates, iron concentrations, and plaque burden in Alzheimer's disease and control postmortem brain tissue

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Abstract

We measured proton magnetic longitudinal (R-1) and transverse (R-2) relaxation rates at 1.4T, iron concentrations, water contents, and amyloid plaque densities in postmortem brain tissue samples from three Alzheimer's disease (AD), two possible AD, and five control subjects. Iron concentrations and R, were significantly higher in the temporal cortex region of our AD group compared to the controls. Frequency analyses showed that the observed trends of higher iron, R-1, and R-2 in AD gray matter regions were statistically significant. Simple regression models indicated that for AD and control gray matter the iron concentrations and water contents have significant linear correlations with R, and R2. Multiple regression models based on iron concentrations and water contents were highly significant for all groups and tissue types and suggested that the effects of iron become more important in determining R, and R2 in the AD samples. At 1.4T R-1 and R-2 are strongly affected by water content and to a lesser extent by variations in iron concentrations. The AD plaque density did not correlate with iron concentrations, water contents, R-1, or R-2, suggesting that increases in AD brain iron are not strongly related to the accumulation of amyloid plaques.
Original languageEnglish
Pages (from-to)41-52
JournalMagnetic Resonance in Medicine
Volume60
Issue number1
DOIs
Publication statusPublished - 2008

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Protons
Alzheimer Disease
Iron
Brain
Water
Amyloid Plaques
Temporal Lobe

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title = "1.4T study of proton magnetic relaxation rates, iron concentrations, and plaque burden in Alzheimer's disease and control postmortem brain tissue",
abstract = "We measured proton magnetic longitudinal (R-1) and transverse (R-2) relaxation rates at 1.4T, iron concentrations, water contents, and amyloid plaque densities in postmortem brain tissue samples from three Alzheimer's disease (AD), two possible AD, and five control subjects. Iron concentrations and R, were significantly higher in the temporal cortex region of our AD group compared to the controls. Frequency analyses showed that the observed trends of higher iron, R-1, and R-2 in AD gray matter regions were statistically significant. Simple regression models indicated that for AD and control gray matter the iron concentrations and water contents have significant linear correlations with R, and R2. Multiple regression models based on iron concentrations and water contents were highly significant for all groups and tissue types and suggested that the effects of iron become more important in determining R, and R2 in the AD samples. At 1.4T R-1 and R-2 are strongly affected by water content and to a lesser extent by variations in iron concentrations. The AD plaque density did not correlate with iron concentrations, water contents, R-1, or R-2, suggesting that increases in AD brain iron are not strongly related to the accumulation of amyloid plaques.",
author = "Mike House and {St Pierre}, Tim and C. Mclean",
year = "2008",
doi = "10.1002/mrm.21586",
language = "English",
volume = "60",
pages = "41--52",
journal = "Magnetic Resonance in Medicine",
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TY - JOUR

T1 - 1.4T study of proton magnetic relaxation rates, iron concentrations, and plaque burden in Alzheimer's disease and control postmortem brain tissue

AU - House, Mike

AU - St Pierre, Tim

AU - Mclean, C.

PY - 2008

Y1 - 2008

N2 - We measured proton magnetic longitudinal (R-1) and transverse (R-2) relaxation rates at 1.4T, iron concentrations, water contents, and amyloid plaque densities in postmortem brain tissue samples from three Alzheimer's disease (AD), two possible AD, and five control subjects. Iron concentrations and R, were significantly higher in the temporal cortex region of our AD group compared to the controls. Frequency analyses showed that the observed trends of higher iron, R-1, and R-2 in AD gray matter regions were statistically significant. Simple regression models indicated that for AD and control gray matter the iron concentrations and water contents have significant linear correlations with R, and R2. Multiple regression models based on iron concentrations and water contents were highly significant for all groups and tissue types and suggested that the effects of iron become more important in determining R, and R2 in the AD samples. At 1.4T R-1 and R-2 are strongly affected by water content and to a lesser extent by variations in iron concentrations. The AD plaque density did not correlate with iron concentrations, water contents, R-1, or R-2, suggesting that increases in AD brain iron are not strongly related to the accumulation of amyloid plaques.

AB - We measured proton magnetic longitudinal (R-1) and transverse (R-2) relaxation rates at 1.4T, iron concentrations, water contents, and amyloid plaque densities in postmortem brain tissue samples from three Alzheimer's disease (AD), two possible AD, and five control subjects. Iron concentrations and R, were significantly higher in the temporal cortex region of our AD group compared to the controls. Frequency analyses showed that the observed trends of higher iron, R-1, and R-2 in AD gray matter regions were statistically significant. Simple regression models indicated that for AD and control gray matter the iron concentrations and water contents have significant linear correlations with R, and R2. Multiple regression models based on iron concentrations and water contents were highly significant for all groups and tissue types and suggested that the effects of iron become more important in determining R, and R2 in the AD samples. At 1.4T R-1 and R-2 are strongly affected by water content and to a lesser extent by variations in iron concentrations. The AD plaque density did not correlate with iron concentrations, water contents, R-1, or R-2, suggesting that increases in AD brain iron are not strongly related to the accumulation of amyloid plaques.

U2 - 10.1002/mrm.21586

DO - 10.1002/mrm.21586

M3 - Article

VL - 60

SP - 41

EP - 52

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 1

ER -