The Diels-Alder reaction between 5-hydroxy-1,4-naphthoquinone and 5,5-dimethyl-3-vinyl-1,2-cyclohexadienyl acetate by endo addition gives the title compound, C22H22O5, in 68% yield. This racemic diastereoisomer has the opposite regiochemistry to ochromycinone analogues produced previously and may allow access to a new type of anticancer-active saquayamycin analogue.
|Journal||Acta Crystallographica Section C - Crystal Structure Communications|
|Publication status||Published - 2003|
Rozek, T., Bowie, J. H., Skelton, B., & White, A. (2003). 11-Hydroxy-3,3-dimethyl-7,12-dioxo-3,4,6,6a,7,12,12a,12b-octahydrobenz[a]anthracen-1-yl acetate. Acta Crystallographica Section C - Crystal Structure Communications, 59(8), o431-o432. https://doi.org/10.1107/S0108270103013374