β2-adrenoceptor polymorphisms predict response to β2-agonists in children with acute asthma

A.C. Martin, GC Zhang, K. Rueter, Siew-Kim Khoo, J. Bizzintino, Catherine Hayden, Gary Geelhoed, Jack Goldblatt, Ingrid Laing, Peter Le Souef

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37 Citations (Scopus)

Abstract

The aim of this study was to determine the influence of single nucleotide polymorphisms in the beta(2)-adrenoceptor gene, on the response to inhaled beta(2)-agonists in children with acute asthma. We hypothesised that children with polymorphisms that generate enhanced receptor downregulation in vitro, Gly16 and Gln27, would have a slower response to beta(2)-agonist therapy during acute asthma. One hundred and forty-eight children with acute asthma were recruited and genotyped for beta(2)Arg16Gly and beta(2)Gln27Glu. For Gln27Glu, individuals Gln27Gln took longest to stretch out to 1, 2 and 4 hourly beta(2)-agonists, followed by heterozygotes who were intermediate and Glu27Glu who responded most rapidly (1hourly: 2.6hr vs. 2.0 vs. 1.4, p = 0.02; 2 hourly: 10.6hr vs. 10.7 vs. 6.8, p = 0.07; 4 hourly: 29.8hr vs. 28.5 vs. 24.3, p = 0.30). The ability to prospectively identify children who respond less effectively to beta(2)-agonists during an acute asthma attack has the potential to allow the generation of genotype-specific treatment pathways.
Original languageEnglish
Pages (from-to)383-383
Number of pages6
JournalJournal of Asthma
Volume45
Issue number5
DOIs
Publication statusPublished - Jun 2008

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