β2-adrenoceptor polymorphisms and asthma phenotypes: Interactions with passive smoking

Brad Zhang; Catherine Hayden; Siew-Kim Khoo; Pierre Candelaria; Ingrid Laing; S Turner; Peter Franklin; Stephen Stick; Louis Landau; Jack Goldblatt; Peter Le Souef

doi:10.1183/09031936.00123206

β2-adrenoceptor polymorphisms and asthma phenotypes: Interactions with passive smoking

Brad Zhang, Catherine Hayden, Siew-Kim Khoo, Pierre Candelaria, Ingrid Laing, S Turner, Peter Franklin, Stephen Stick, Louis Landau, Jack Goldblatt, Peter Le Souef

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Abstract

The aim of the present study was to assess the effects of possible interactions between beta(2)-adrenoceptor gene polymorphisms and passive smoking on forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and exhaled nitric oxide (eNO) in children aged 11 yrs. A cross-sectional analysis of the longitudinal cohort was conducted for associations between beta(2)-adrenoceptor gene polymorphisms and lung function and eNO with regard to passive smoking. Among children exposed to tobacco smoke, those with Arg16 (at least one Arg allele) exhibited lower adjusted mean FEV1 (2.19 versus 2.38 L) and FVC (2.43 versus 2.64 L) than Gly16 homozygotes. Those with Gln27 (at least one Gin allelle) also exhibited a lower adjusted mean FEV1 relative to Glu27 homozygotes (2.24 versus 2.39 L). Among children with no exposure to smoking, those with Arg16 or Gln27 showed lower adjusted geometric mean eNO levels compared with Gly16 homozygotes (15.4 versus 30.9 ppb) and Glu27 homozygotes (18.0 versus 49.7 ppb). In conclusion, passive smoking had a significant effect on associations between beta(2)-adrenoceptor gene polymorphisms and asthma-related phenotypes, enhancing the relationship between Arg-16 and lung function and removing the relationship between Arg16 or Girl and exhaled nitric oxide levels.

Original language	English
Pages (from-to)	48-55
Journal	The European Respiratory Journal
Volume	30
Issue number	1
DOIs	https://doi.org/10.1183/09031936.00123206
Publication status	Published - 2007

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title = "β2-adrenoceptor polymorphisms and asthma phenotypes: Interactions with passive smoking",

abstract = "The aim of the present study was to assess the effects of possible interactions between beta(2)-adrenoceptor gene polymorphisms and passive smoking on forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and exhaled nitric oxide (eNO) in children aged 11 yrs. A cross-sectional analysis of the longitudinal cohort was conducted for associations between beta(2)-adrenoceptor gene polymorphisms and lung function and eNO with regard to passive smoking. Among children exposed to tobacco smoke, those with Arg16 (at least one Arg allele) exhibited lower adjusted mean FEV1 (2.19 versus 2.38 L) and FVC (2.43 versus 2.64 L) than Gly16 homozygotes. Those with Gln27 (at least one Gin allelle) also exhibited a lower adjusted mean FEV1 relative to Glu27 homozygotes (2.24 versus 2.39 L). Among children with no exposure to smoking, those with Arg16 or Gln27 showed lower adjusted geometric mean eNO levels compared with Gly16 homozygotes (15.4 versus 30.9 ppb) and Glu27 homozygotes (18.0 versus 49.7 ppb). In conclusion, passive smoking had a significant effect on associations between beta(2)-adrenoceptor gene polymorphisms and asthma-related phenotypes, enhancing the relationship between Arg-16 and lung function and removing the relationship between Arg16 or Girl and exhaled nitric oxide levels.",

author = "Brad Zhang and Catherine Hayden and Siew-Kim Khoo and Pierre Candelaria and Ingrid Laing and S Turner and Peter Franklin and Stephen Stick and Louis Landau and Jack Goldblatt and {Le Souef}, Peter",

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doi = "10.1183/09031936.00123206",

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T1 - β2-adrenoceptor polymorphisms and asthma phenotypes: Interactions with passive smoking

AU - Zhang, Brad

AU - Hayden, Catherine

AU - Khoo, Siew-Kim

AU - Candelaria, Pierre

AU - Laing, Ingrid

AU - Turner, S

AU - Franklin, Peter

AU - Stick, Stephen

AU - Landau, Louis

AU - Goldblatt, Jack

AU - Le Souef, Peter

PY - 2007

Y1 - 2007

N2 - The aim of the present study was to assess the effects of possible interactions between beta(2)-adrenoceptor gene polymorphisms and passive smoking on forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and exhaled nitric oxide (eNO) in children aged 11 yrs. A cross-sectional analysis of the longitudinal cohort was conducted for associations between beta(2)-adrenoceptor gene polymorphisms and lung function and eNO with regard to passive smoking. Among children exposed to tobacco smoke, those with Arg16 (at least one Arg allele) exhibited lower adjusted mean FEV1 (2.19 versus 2.38 L) and FVC (2.43 versus 2.64 L) than Gly16 homozygotes. Those with Gln27 (at least one Gin allelle) also exhibited a lower adjusted mean FEV1 relative to Glu27 homozygotes (2.24 versus 2.39 L). Among children with no exposure to smoking, those with Arg16 or Gln27 showed lower adjusted geometric mean eNO levels compared with Gly16 homozygotes (15.4 versus 30.9 ppb) and Glu27 homozygotes (18.0 versus 49.7 ppb). In conclusion, passive smoking had a significant effect on associations between beta(2)-adrenoceptor gene polymorphisms and asthma-related phenotypes, enhancing the relationship between Arg-16 and lung function and removing the relationship between Arg16 or Girl and exhaled nitric oxide levels.

AB - The aim of the present study was to assess the effects of possible interactions between beta(2)-adrenoceptor gene polymorphisms and passive smoking on forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and exhaled nitric oxide (eNO) in children aged 11 yrs. A cross-sectional analysis of the longitudinal cohort was conducted for associations between beta(2)-adrenoceptor gene polymorphisms and lung function and eNO with regard to passive smoking. Among children exposed to tobacco smoke, those with Arg16 (at least one Arg allele) exhibited lower adjusted mean FEV1 (2.19 versus 2.38 L) and FVC (2.43 versus 2.64 L) than Gly16 homozygotes. Those with Gln27 (at least one Gin allelle) also exhibited a lower adjusted mean FEV1 relative to Glu27 homozygotes (2.24 versus 2.39 L). Among children with no exposure to smoking, those with Arg16 or Gln27 showed lower adjusted geometric mean eNO levels compared with Gly16 homozygotes (15.4 versus 30.9 ppb) and Glu27 homozygotes (18.0 versus 49.7 ppb). In conclusion, passive smoking had a significant effect on associations between beta(2)-adrenoceptor gene polymorphisms and asthma-related phenotypes, enhancing the relationship between Arg-16 and lung function and removing the relationship between Arg16 or Girl and exhaled nitric oxide levels.

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DO - 10.1183/09031936.00123206

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EP - 55

JO - The European Respiratory Journal

JF - The European Respiratory Journal

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β2-adrenoceptor polymorphisms and asthma phenotypes: Interactions with passive smoking

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