TY - JOUR
T1 - β2 adrenoceptor Arg16Gly polymorphism, airway responsiveness, lung function and asthma in infants and children
AU - Turner, S.W.
AU - Khoo, Siew-Kim
AU - Laing, Ingrid
AU - Palmer, Lyle
AU - Gibson, Neil
AU - Rye, P.
AU - Landau, Louis
AU - Goldblatt, Jack
AU - Le Souef, Peter
PY - 2004
Y1 - 2004
N2 - Background We have previously reported a relationship between increased airway responsiveness (AR) in infancy and reduced childhood lung function.Objective The current study aimed to determine whether the Arg16Gly polymorphism of the β2 adrenoceptor (β2AR) gene was important to this relationship.Methods A cohort that initially numbered 253 individuals underwent assessments of AR and lung function aged 1 month, 6 and 11 years; genotyping for polymorphisms of the β2AR was performed.Results At 1 month of age, the genotype homozygous Arg16 (n=24) was associated with a mean increase in log dose–response slope (AR) of 0.27 [95% confidence interval (CI) 0.07, 0.49] compared with the genotype homozygous Gly16 (n=58), P=0.01. At 11 years of age, the genotype homozygous Arg16 (n=35) was associated with a mean reduction in the percentage of forced expiratory volume in 1 s of 5.3% [95% CI 0.3, 10.2] compared with the genotype homozygous Gly16 (n=65), P=0.03. There was no association between the Arg16Gly polymorphism and atopy or diagnosed asthma. However, nine of 69 individuals with the genotype homozygous Gly16 were admitted to hospital with asthma compared with five out of 111 individuals with the remaining genotypes (P
AB - Background We have previously reported a relationship between increased airway responsiveness (AR) in infancy and reduced childhood lung function.Objective The current study aimed to determine whether the Arg16Gly polymorphism of the β2 adrenoceptor (β2AR) gene was important to this relationship.Methods A cohort that initially numbered 253 individuals underwent assessments of AR and lung function aged 1 month, 6 and 11 years; genotyping for polymorphisms of the β2AR was performed.Results At 1 month of age, the genotype homozygous Arg16 (n=24) was associated with a mean increase in log dose–response slope (AR) of 0.27 [95% confidence interval (CI) 0.07, 0.49] compared with the genotype homozygous Gly16 (n=58), P=0.01. At 11 years of age, the genotype homozygous Arg16 (n=35) was associated with a mean reduction in the percentage of forced expiratory volume in 1 s of 5.3% [95% CI 0.3, 10.2] compared with the genotype homozygous Gly16 (n=65), P=0.03. There was no association between the Arg16Gly polymorphism and atopy or diagnosed asthma. However, nine of 69 individuals with the genotype homozygous Gly16 were admitted to hospital with asthma compared with five out of 111 individuals with the remaining genotypes (P
U2 - 10.1111/j.1365-2222.2004.02001.x
DO - 10.1111/j.1365-2222.2004.02001.x
M3 - Article
SN - 0954-7894
VL - 34
SP - 1043
EP - 1048
JO - Clinical and Experimental Allergy
JF - Clinical and Experimental Allergy
IS - 7
ER -