α-Glucosidase inhibitory activity of selected Philippine plants

Ivan Lawag, Alicia Aguinaldo, Suad Naheed, Mohammad Mosihuzzaman

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Ethnopharmacological relevance: Antidesma bunius Spreng. (Phyllantaceae), Averrhoa bilimbi L. (Oxalidaceae), Biophytum sensitivum (L.) DC. (Oxalidaceae), Ceriops tagal (Perr.) C.B. Rob. (Rhizophoraceae), Kyllinga monocephala Rottb. (Cyperaceae), and Rhizophora mucronata Lam. (Rhizophoraceae) are used as remedies to control diabetes. In the present study, these plants were screened for their potential α-glucosidase inhibitory activity. Materials and methods: The 80 aqueous ethanolic extracts were screened for their α-glucosidase enzyme inhibitory activity using yeast alpha glucosidase enzyme. Results: Except for A. bilimbi with IC50 at 519.86±3.07, all manifested a significant enzyme inhibitory activity. R. mucronata manifested the highest activity with IC50 at 0.08±1.82 μg mL-1, followed by C. tagal with IC 50 at 0.85±1.46 μg mL-1 and B. sensitivum with IC50 at 2.24±1.58 μg mL-1. Conclusion: This is the first report on the α-glucosidase inhibitory effect of the six Philippine plants; thus, partly defining the mechanism on why these medicinal plants possess antidiabetic properties.
Original languageEnglish
Pages (from-to)217-219
Number of pages3
JournalJournal of Ethnopharmacology
Volume144
Issue number1
DOIs
Publication statusPublished - 31 Oct 2012
Externally publishedYes

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