TY - JOUR
T1 - α-Glucosidase inhibitory activity of selected Philippine plants
AU - Lawag, Ivan
AU - Aguinaldo, Alicia
AU - Naheed, Suad
AU - Mosihuzzaman, Mohammad
PY - 2012/10/31
Y1 - 2012/10/31
N2 - Ethnopharmacological relevance: Antidesma bunius Spreng. (Phyllantaceae), Averrhoa bilimbi L. (Oxalidaceae), Biophytum sensitivum (L.) DC. (Oxalidaceae), Ceriops tagal (Perr.) C.B. Rob. (Rhizophoraceae), Kyllinga monocephala Rottb. (Cyperaceae), and Rhizophora mucronata Lam. (Rhizophoraceae) are used as remedies to control diabetes. In the present study, these plants were screened for their potential α-glucosidase inhibitory activity. Materials and methods: The 80 aqueous ethanolic extracts were screened for their α-glucosidase enzyme inhibitory activity using yeast alpha glucosidase enzyme. Results: Except for A. bilimbi with IC50 at 519.86±3.07, all manifested a significant enzyme inhibitory activity. R. mucronata manifested the highest activity with IC50 at 0.08±1.82 μg mL-1, followed by C. tagal with IC 50 at 0.85±1.46 μg mL-1 and B. sensitivum with IC50 at 2.24±1.58 μg mL-1. Conclusion: This is the first report on the α-glucosidase inhibitory effect of the six Philippine plants; thus, partly defining the mechanism on why these medicinal plants possess antidiabetic properties.
AB - Ethnopharmacological relevance: Antidesma bunius Spreng. (Phyllantaceae), Averrhoa bilimbi L. (Oxalidaceae), Biophytum sensitivum (L.) DC. (Oxalidaceae), Ceriops tagal (Perr.) C.B. Rob. (Rhizophoraceae), Kyllinga monocephala Rottb. (Cyperaceae), and Rhizophora mucronata Lam. (Rhizophoraceae) are used as remedies to control diabetes. In the present study, these plants were screened for their potential α-glucosidase inhibitory activity. Materials and methods: The 80 aqueous ethanolic extracts were screened for their α-glucosidase enzyme inhibitory activity using yeast alpha glucosidase enzyme. Results: Except for A. bilimbi with IC50 at 519.86±3.07, all manifested a significant enzyme inhibitory activity. R. mucronata manifested the highest activity with IC50 at 0.08±1.82 μg mL-1, followed by C. tagal with IC 50 at 0.85±1.46 μg mL-1 and B. sensitivum with IC50 at 2.24±1.58 μg mL-1. Conclusion: This is the first report on the α-glucosidase inhibitory effect of the six Philippine plants; thus, partly defining the mechanism on why these medicinal plants possess antidiabetic properties.
UR - http://www.scopus.com/inward/record.url?scp= 84867522572&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2012.08.019
DO - 10.1016/j.jep.2012.08.019
M3 - Article
SN - 0378-8741
VL - 144
SP - 217
EP - 219
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 1
ER -