Preclinical evaluation of a novel allosteric IL-1R inhibitor (rytvela) for the prevention of perinatal inflammation-induced fetal injury

Status	Finished
Effective start/end date	1/01/18 → 31/12/22

Access Project

Inhibition of interleukin-1 signaling protects against Group B streptococcus-induced preterm birth and fetal loss in mice
Chin, P. Y., Moldenhauer, L. M., Lubell, W. D., Olson, D. M., Chemtob, S., Keelan, J. A. & Robertson, S. A., Jun 2025, In: Journal of Reproductive Immunology. 169, p. 1-11 11 p., 104520.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Citation (Scopus)
Interleukin-1 Receptor Antagonists Partially Inhibited Histological Injury but Not Tissue Inflammation in a Sheep Model of Pregnancy
Takahashi, Y., Fee, E. L., Takahashi, T., Usuda, H., Ikeda, H., Carter, S. W., Saito, Y., Sato, S., Mochii, N., Chemtob, S., Olson, D. M., Keelan, J. A., Kumagai, Y., Choolani, M. A., Illanes, S. E., Saito, M. & Kemp, M. W., Apr 2025, In: Reproductive Sciences. 32, 4, p. 1213-1227 15 p.
Research output: Contribution to journal › Article › peer-review
Pharmacological blockade of the interleukin-1 receptor suppressed Escherichia coli lipopolysaccharide-induced neuroinflammation in preterm fetal sheep
Takahashi, Y., Takahashi, T., Usuda, H., Carter, S., Fee, E. L., Furfaro, L., Chemtob, S., Olson, D. M., Keelan, J. A., Kallapur, S. & Kemp, M. W., Nov 2023, In: American Journal of Obstetrics and Gynecology MFM. 5, 11, 14 p., 101124.
Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus)