Innovative and multi-disciplinary treatment strategies for secondary degeneration following neurotrauma

2023

Secondary Degeneration Impairs Myelin Ultrastructural Development in Adulthood following Adolescent Neurotrauma in the Rat Optic Nerve

Lins, B. R., Anyaegbu, C. C., McGonigle, T., Hellewell, S. C., Patel, P., Reagan, H., Rooke-Wiesner, C., Warnock, A., Archer, M., Hemmi, J. M., Bartlett, C. & Fitzgerald, M., Feb 2023, In: International Journal of Molecular Sciences. 24, 4, 3343.

Research output: Contribution to journal › Article › peer-review

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2020

Intravitreal application of AAV-BDNF or mutant AAV-CRMP2 protects retinal ganglion cells and stabilizes axons and myelin after partial optic nerve injury

Chiha, W., Bartlett, C. A., Petratos, S., Fitzgerald, M. & Harvey, A. R., 1 Apr 2020, In: Experimental Neurology. 326, 113167.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Citations (Web of Science)

Towards the Development of an Integrative, Evidence-Based Suite of Indicators for the Prediction of Outcome Following Mild Traumatic Brain Injury: Results from a Pilot Study

Gozt, A., Licari, M., Halstrom, A., Milbourn, H., Lydiard, S., Black, A., Arendts, G., Macdonald, S., Song, S., MacDonald, E., Vlaskovsky, P., Burrows, S., Bynevelt, M., Pestell, C., Fatovich, D. & Fitzgerald, M., 2 Jan 2020, In: Brain Sciences. 10, 1, 23.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

2019

Comparing modes of delivery of a combination of ion channel inhibitors for limiting secondary degeneration following partial optic nerve transection

Toomey, L. M., Bartlett, C. A., Gavriel, N., McGonigle, T., Majimbi, M., Gopalasingam, G., Rodger, J. & Fitzgerald, M., 1 Dec 2019, In: Scientific Reports. 9, 1, 15297.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Comparison of ion channel inhibitor combinations for limiting secondary degeneration following partial optic nerve transection

Toomey, L. M., Bartlett, C. A., Majimbi, M., Gopalasingam, G., Rodger, J. & Fitzgerald, M., 31 Jan 2019, In: Experimental Brain Research. 237, 1, p. 161-171 11 p.

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4 Citations (Scopus)

183 Downloads (Pure)

Differential responses to increasing numbers of mild traumatic brain injury in a rodent closed-head injury model

Fehily, B., Bartlett, C. A., Lydiard, S., Archer, M., Milbourn, H., Majimbi, M., Hemmi, J. M., Dunlop, S. A., Yates, N. J. & Fitzgerald, M., Jun 2019, In: Journal of Neurochemistry. 149, 5, p. 660-678 19 p.

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15 Citations (Scopus)

97 Downloads (Pure)

Elucidating the inability of functionalized nanoparticles to cross the blood-brain barrier and target specific cells in vivo

Naidu, P. S. R., Gavriel, N., Gray, C. G. G., Bartlett, C. A., Toomey, L. M., Kretzmann, J. A., Patalwala, D., McGonigle, T., Denham, E., Hee, C., Ho, D., Taylor, N. L., Norret, M., Smith, N. M., Dunlop, S. A., Iyer, K. S. & Fitzgerald, M., 26 Jun 2019, In: ACS APPLIED MATERIALS & INTERFACES. 11, 25, p. 22085-22095 11 p.

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11 Citations (Scopus)

97 Downloads (Pure)

Novel Hydrophilic Copolymer-Based Nanoparticle Enhances the Therapeutic Efficiency of Doxorubicin in Cultured MCF-7 Cells

Naidu, P. S. R., Norret, M., Dunlop, S. A., Fitzgerald, M., Clemons, T. D. & Iyer, K. S., 22 Oct 2019, In: ACS Omega. 4, 17, p. 17083-17089 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Web of Science)

The effects of a combination of ion channel inhibitors on pathology in a model of demyelinating disease

Gopalasingam, G., Bartlett, C. A., McGonigle, T., Majimbi, M., Warnock, A., Ford, A., Gough, A., Toomey, L. M. & Fitzgerald, M., 1 Sep 2019, In: Multiple Sclerosis and Related Disorders. 34, p. 1-8 8 p.

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7 Citations (Scopus)

18 Downloads (Pure)

2018

Oligodendroglia are particularly vulnerable to oxidative damage after neurotrauma in vivo

Giacci, M. K., Bartlett, C. A., Smith, N. M., Iyer, K. S., Toomey, L. M., Jiang, H., Guagliardo, P., Kilburn, M. R. & Fitzgerald, M., 18 Jul 2018, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 38, 29, p. 6491-6504 14 p.

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45 Citations (Scopus)

59 Downloads (Pure)

Partial Transection of Adult Rat Optic Nerve as a Model of Secondary Degeneration in the Central Nervous System

Bartlett, C. A. & Fitzgerald, M., 20 Dec 2018, In: Bio-Protocol. 8, 24, 14 p., 3118.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Web of Science)

The Effects of a Combination of Ion Channel Inhibitors in Female Rats Following Repeated Mild Traumatic Brain Injury

Mao, Y., Black, A. M. B., Milbourn, H. R., Krakonja, S., Nesbit, M., Bartlett, C. A., Fehily, B., Takechi, R., Yates, N. J. & Fitzgerald, M., Nov 2018, In: International Journal of Molecular Sciences. 19, 11, 18 p., 3408.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

2017

Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors

Yates, N. J., Giacci, M. K., O'Hare Doig, R. L., Chiha, W., Ashworth, B. E., Kenna, J., Bartlett, C. A. & Fitzgerald, M., 1 Feb 2017, In: Neural Regeneration Research. 12, 2, p. 307-316 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury

Halstrom, A., MacDonald, E., Neil, C., Arendts, G., Fatovich, D. & Fitzgerald, M., 1 Jan 2017, In: Journal of Clinical Neuroscience. 35, 1, p. 104-108 5 p.

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17 Citations (Scopus)

386 Downloads (Pure)

Repeated Mild Traumatic Brain Injury: Potential Mechanisms of Damage

Fehily, B. & Fitzgerald, M., Jul 2017, In: Cell Transplantation. 26, 7, p. 1131-1155 25 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

109 Citations (Scopus)

Repeated mild traumatic brain injury in female rats increases lipid peroxidation in neurons

Yates, N. J., Lydiard, S., Fehily, B., Weir, G., Chin, A., Bartlett, C. A., Alderson, J. & Fitzgerald, M., 1 Jul 2017, In: Experimental Brain Research. 235, 7, p. 2133-2149 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Citations (Scopus)

Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

Doig, R. L. OH., Chiha, W., Giacci, M. K., Yates, N. J., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Harvey, A. R. & Fitzgerald, M., 14 Aug 2017, In: BMC Neuroscience. 18, 1, 16 p., 62.

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Open Access

23 Citations (Scopus)

The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function

Naidu, P. S. R., Norret, M., Smith, N. M., Dunlop, S. A., Taylor, N. L., Fitzgerald, M. & Iyer, K. S., 14 Nov 2017, In: Langmuir. 33, 45, p. 12926-12933 8 p.

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15 Citations (Scopus)

274 Downloads (Pure)

2016

A new perspective on delivery of red-near-infrared light therapy for disorders of the brain

Hart, N. S. & Fitzgerald, M., 19 Sep 2016, In: Discovery Medicine. 22, 120, 1 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles

Smith, N., Gachulincova, I., Ho, D., Bailey, C., Bartlett, C., Norret, M., Murphy, J., Buckley, A., Rigby, P., House, M., St Pierre, T., Fitzgerald, M., Swaminatha Iyer, K. & Dunlop, S., 4 Mar 2016, In: Scientific Reports. 6, p. 1-9 9 p., 22595.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Citations (Scopus)

Poly(glycidyl methacrylate) coated dual mode upconverting nanoparticles for neuronal cell imaging

Smith, N., Ho, D., Munshi, A. M., House, M., Dunlop, S., Fitzgerald, M. & Swaminathan Iyer, K., Aug 2016, In: New Journal of Chemistry. 40, 8, p. 6692-6696 5 p.

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4 Citations (Scopus)

247 Downloads (Pure)

Specific combinations of Ca2+ channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro

Doig, R., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Dunlop, S. A., Hool, L. & Fitzgerald, M., 17 Dec 2016, In: Neuroscience. 339, p. 450-462 13 p.

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13 Citations (Scopus)

257 Downloads (Pure)

Innovative and multi-disciplinary treatment strategies for secondary degeneration following neurotrauma

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