Improving cancer diagnostic imaging and drug delivery by breaking down extracellular matrix barriers

Hamzah, Juliana (Investigator 01)
Ganss, Ruth (Investigator 02)
Ruoslahti, Erkki (Investigator 03)

UWA Centre for Medical Research (affiliated with the Harry Perkins Institute of Medical Research)

Status	Finished
Effective start/end date	1/01/17 → 31/12/20

Funding

NHMRC National Health and Medical Research Council : A$748,152.00

Access Project

http://purl.org/au-research/grants/nhmrc/1121131

3 Article

ECM Depletion Is Required to Improve the Intratumoral Uptake of Iron Oxide Nanoparticles in Poorly Perfused Hepatocellular Carcinoma
Yeow, Y. L., Wu, J., Wang, X., Winteringham, L., Feindel, K. W., Tirnitz-Parker, J. E. E., Leedman, P. J., Ganss, R. & Hamzah, J., 22 Feb 2022, In: Frontiers in Oncology. 12, 837234.
Research output: Contribution to journal › Article › peer-review

Open Access
3 Citations (Scopus)
Enhanced Detection of Desmoplasia by Targeted Delivery of Iron Oxide Nanoparticles to the Tumour-Specific Extracellular Matrix
Chopra, M., Wu, J., Yeow, Y. L., Winteringham, L., Clemons, T. D., Saunders, M., Kotamraju, V. R., Ganss, R., Feindel, K. W. & Hamzah, J., 12 Oct 2021, In: Pharmaceutics. 13, 10, 16 p., 1663.
Research output: Contribution to journal › Article › peer-review

Open Access
5 Citations (Scopus)
Immune-mediated ECM depletion improves tumour perfusion and payload delivery
Yeow, Y. L., Kotamraju, V. R., Wang, X., Chopra, M., Azme, N., Wu, J., Schoep, T. D., Delaney, D. S., Feindel, K., Li, J., Kennedy, K. M., Allen, W. M., Kennedy, B. F., Larma, I., Sampson, D. D., Mahakian, L. M., Fite, B. Z., Zhang, H., Friman, T., Mann, A. P., & 11 othersAziz, F. A., Kumarasinghe, M. P., Johansson, M., Ee, H. C., Yeoh, G., Mou, L., Ferrara, K. W., Billiran, H., Ganss, R., Ruoslahti, E. & Hamzah, J., 1 Dec 2019, In: EMBO Molecular Medicine. 11, 12, e10923.
Research output: Contribution to journal › Article › peer-review

Open Access
23 Citations (Scopus)