Gene mining for novel molecular determinants of the skeleton

2023

ADR3, a next generation i-body to human RANKL, inhibits osteoclast formation and bone resorption

Qiu, H., Hosking, C., Rothzerg, E., Samantha, A., Chen, K., Kuek, V., Jin, H., Zhu, S., Vrielink, A., Lim, K., Foley, M. & Xu, J., Feb 2023, In: The Journal of Biological Chemistry. 299, 2, p. 102889 102889.

Research output: Contribution to journal › Article › peer-review

Open Access

Antidementia medication acetylcholinesterase inhibitors have therapeutic benefits on osteoporotic bone by attenuating osteoclastogenesis and bone resorption

Li, S., Teguh, D., Wu, D., Liu, L., Hu, C., Yuan, J., Inderjeeth, C. A. & Xu, J., Aug 2023, In: Journal of Cellular Physiology. 238, 8, p. 1823-1835 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Loureirin B downregulates osteoclast differentiation of bone marrow macrophages by targeting the MAPK signaling pathway

Zhang, J., Mo, L., Huang, H., Xu, J., Fan, Y., Li, W., Wang, H., Zhou, C., Fang, H., He, W., Chen, Z. & Liu, Y., 23 Aug 2022, In: Scientific Reports. 12, 1, p. 14382 1 p., 14382.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Roburic acid attenuates osteoclastogenesis and bone resorption by targeting RANKL-induced intracellular signaling pathways

Wang, G., Chen, K., Ma, C., Wang, C., Chen, D., He, J., Liu, Y., Jiang, T., Yuan, J., Chen, L., He, W. & Xu, J., Mar 2022, In: Journal of Cellular Physiology. 237, 3, p. 1790-1803 14 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Thiaplakortone B attenuates RANKL‐induced NF‐κB and MAPK signaling and dampens OVX‐induced bone loss in mice

Wang, Q., Chen, D., Wang, Y., Dong, C., Liu, J., Chen, K., Song, F., Wang, C., Yuan, J., Davis, R. A., Kuek, V., Jin, H. & Xu, J., Oct 2022, In: Biomedicine and Pharmacotherapy. 154, 13 p., 113622.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

2021

A missense mutation sheds light on a novel structure–function relationship of RANKL

Qiu, H., Qin, A., Cheng, T., Chim, S. M., Smithers, L., Chen, K., Song, D., Liu, Q., Zhao, J., Wang, C., Teguh, D., Zhang, G., Tickner, J., Vrielink, A., Pavlos, N. J. & Xu, J., Apr 2021, In: Journal of Cellular Physiology. 236, 4, p. 2800-2816 17 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Carnosol suppresses RANKL-induced osteoclastogenesis and attenuates titanium particles-induced osteolysis

Li, Y., Lin, S., Liu, P., Huang, J., Qiu, J., Wen, Z., Yuan, J., Qiu, H., Liu, Y., Liu, Q., Zhou, T., Luo, P., Guo, H., Ma, Y., Guo, D., Mo, G., Tang, Y., Xu, L., Liang, D., Xu, J., & 2 othersDing, Y. & Zhang, S., Mar 2021, In: Journal of Cellular Physiology. 236, 3, p. 1950-1966 17 p.

Research output: Contribution to journal › Article › peer-review

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13 Citations (Scopus)

74 Downloads (Pure)

Inhibitory Effects of Rhaponticin on Osteoclast Formation and Resorption by Targeting RANKL-Induced NFATc1 and ROS Activity

He, J., Chen, K., Deng, T., Xie, J., Zhong, K., Yuan, J., Wang, Z., Xiao, Z., Gu, R., Chen, D., Li, X., Lin, D. & Xu, J., 23 Sept 2021, In: Frontiers in Pharmacology. 12, 645140.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

Morin attenuates osteoclast formation and function by suppressing the NF-κB, MAPK and calcium signalling pathways

Shi, Y., Ye, L., Shen, S., Qian, T., Pan, Y., Jiang, Y., Lin, J., Liu, C., Wu, Y., Wang, X., Xu, J. & Jin, H., Oct 2021, In: Phytotherapy Research. 35, 10, p. 5694-5707 14 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

2020

Arctiin abrogates osteoclastogenesis and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation

Chen, D., Ye, Z., Wang, C., Wang, Q., Wang, H., Kuek, V., Wang, Z., Qiu, H., Yuan, J., Kenny, J., Yang, F., He, J., Liu, Y., Wang, G., Zhang, M., Zhang, G., Wang, J., Chen, P. & Xu, J., Sept 2020, In: Pharmacological Research. 159, 104944.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts

Mullin, B., Tickner, J., Zhu, K., Kenny, J., Mullin, S., Brown, S. J., Dudbridge, F., Pavlos, N., Mocarski, E. S., Walsh, J. P., Xu, J. & Wilson, S., 26 Mar 2020, In: Genome Biology. 21, 1, 80.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Citations (Scopus)

Dracorhodin perchlorate inhibits osteoclastogenesis through repressing RANKL-stimulated NFATc1 activity

Liu, Y., Wang, Z., Ma, C., Wei, Z., Chen, K., Wang, C., Zhou, C., Chen, L., Zhang, Q., Chen, Z., He, W. & Xu, J., 1 Mar 2020, In: Journal of Cellular and Molecular Medicine. 24, 6, p. 3303-3313 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling

Zhou, L., Hong, G., Li, S., Liu, Q., Song, F., Zhao, J., Yuan, J., Tickner, J. & Xu, J., 2020, In: International Journal of Biological Sciences. 16, 2, p. 309-319 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

Hymenialdisine: A Marine Natural Product That Acts on Both Osteoblasts and Osteoclasts and Prevents Estrogen-Dependent Bone Loss in Mice

Wang, Q., Chen, D., Jin, H., Ye, Z., Wang, C., Chen, K., Kuek, V., Xu, K., Qiu, H., Chen, P., Song, D., Zhao, J., Liu, Q., Davis, R. A., Song, F. & Xu, J., 1 Aug 2020, In: Journal of Bone and Mineral Research. 35, 8, p. 1582-1596 15 p.

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts

Chen, K., Liu, Y., He, J., Pavlos, N., Wang, C., Kenny, J., Yuan, J., Zhang, Q., Xu, J. & He, W., 2020, In: International Journal of Biological Sciences. 16, 11, p. 1888-1900 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Citations (Scopus)

2019

Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-kappa B signaling pathways

He, L., Hong, G., Zhou, L., Zhang, J., Fang, J., He, W., Tickner, J., Han, X., Zhao, L. & Xu, J., Apr 2019, In: Journal of Cellular Physiology. 234, 4, p. 4267-4276 10 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Asperpyrone A attenuates RANKL-induced osteoclast formation through inhibiting NFATc1, Ca²⁺ signalling and oxidative stress

Chen, X., Wang, C., Qiu, H., Yuan, Y., Chen, K., Cao, Z., Xiang Tan, R., Tickner, J., Xu, J. & Zou, J., 1 Dec 2019, In: Journal of Cellular and Molecular Medicine. 23, 12, p. 8269-8279 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

Cumambrin A prevents OVX-induced osteoporosis via the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways

Zhou, L., Liu, Q., Hong, G., Song, F., Zhao, J., Yuan, J., Xu, J., Tan, R. X., Tickner, J., Gu, Q. & Xu, J., 1 Jun 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 6, p. 6726-6735 10 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Cytochalasin Z11 inhibits RANKL-induced osteoclastogenesis: Via suppressing NFATc1 activation

Lu, W., Chen, K., He, J., Kenny, J., Yuan, Y., Chen, J., Liu, Q., Tan, R., Zhao, J. & Xu, J., 25 Nov 2019, In: RSC Advances. 9, 66, p. 38438-38446 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Discovery of new inhibitors against both NF-κB and osteoclastogenesis from in-house library with α, β-unsaturated-enone fragment

Zhao, C., Huang, D., Li, R., Xu, J., Gu, Q. & Xu, J., 1 Jun 2019, In: Bioorganic Chemistry. 87, p. 638-646 9 p.

Research output: Contribution to journal › Article › peer-review

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3 Citations (Scopus)

53 Downloads (Pure)

Genetic regulatory mechanisms in human osteoclasts suggest a role for the STMP1 and DCSTAMP genes in Paget’s disease of bone

Mullin, B. H., Zhu, K., Brown, S. J., Mullin, S., Tickner, J., Pavlos, N. J., Dudbridge, F., Xu, J., Walsh, J. P. & Wilson, S. G., 1 Dec 2019, In: Scientific Reports. 9, 1, 1052.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Citations (Web of Science)

Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies

Baird, D. A., Evans, D. S., Kamanu, F. K., Gregory, J. S., Saunders, F. R., Giuraniuc, C. V., Barr, R. J., Aspden, R. M., Jenkins, D., Kiel, D. P., Orwoll, E. S., Cummings, S. R., Lane, N. E., Mullin, B. H., Williams, F. M., Richards, J. B., Wilson, S. G., Spector, T. D., Faber, B. G., Lawlor, D. A., & 10 othersGrundberg, E., Ohlsson, C., Pettersson-Kymmer, U., Capellini, T. D., Richard, D., Beck, T. J., Evans, D. M., Paternoster, L., Karasik, D. & Tobias, J. H., Feb 2019, In: Journal of Bone & Mineral Research. 34, 2, p. 241-251 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Citations (Scopus)

Loureirin B suppresses RANKL-induced osteoclastogenesis and ovariectomized osteoporosis via attenuating NFATc1 and ROS activities

Liu, Y., Wang, C., Wang, G., Sun, Y., Deng, Z., Chen, L., Chen, K., Tickner, J., Kenny, J., Song, D., Zhang, Q., Wang, H., Chen, Z., Zhou, C., He, W. & Xu, J., 2019, In: Theranostics. 9, 16, p. 4648-4662 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

112 Citations (Scopus)

Meta-analysis of genomewide association studies reveals genetic variants for hip bone geometry

Hsu, Y. H., Estrada, K., Evangelou, E., Ackert-Bicknell, C., Akesson, K., Beck, T., Brown, S. J., Capellini, T., Carbone, L., Cauley, J., Cheung, C. L., Cummings, S. R., Czerwinski, S., Demissie, S., Econs, M., Evans, D., Farber, C., Gautvik, K., Harris, T., Kammerer, C., & 32 othersKemp, J., Koller, D. L., Kung, A., Lawlor, D., Lee, M., Lorentzon, M., McGuigan, F., Medina-Gomez, C., Mitchell, B., Newman, A., Nielson, C., Ohlsson, C., Peacock, M., Reppe, S., Richards, J. B., Robbins, J., Sigurdsson, G., Spector, T. D., Stefansson, K., Streeten, E., Styrkarsdottir, U., Tobias, J., Trajanoska, K., Uitterlinden, A., Vandenput, L., Wilson, S. G., Yerges-Armstrong, L., Young, M., Zillikens, C., Rivadeneira, F., Kiel, D. P. & Karasik, D., Jul 2019, In: Journal of Bone & Mineral Research. 34, 7, p. 1284-1296 13 p., e3698.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Web of Science)

2018

Expression quantitative trait locus study of bone mineral density GWAS variants in human osteoclasts

Mullin, B. H., Zhu, K., Xu, J., Brown, S. J., Mullin, S., Tickner, J., Pavlos, N. J., Dudbridge, F., Walsh, J. P. & Wilson, S. G., Jun 2018, In: Journal of Bone & Mineral Research. 33, 6, p. 1044-1051 8 p.

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27 Citations (Scopus)

286 Downloads (Pure)

Gene mining for novel molecular determinants of the skeleton

Research output

Search results