Furin: Carving-up vital substrates for bone remodelling and homeostasis

2025

Transcriptional regulation of Rankl by Txnip-Ecd in aging and diabetic related osteoporosis

Cao, X., Liu, K., Yuan, J., Hua, Q., Rong, K., Zhou, T., He, W., Pang, Y., Yang, X., Yu, Y., Zhang, P., Ma, P., Cao, Y., Zhao, J., Morahan, G., Xu, J. & Qin, A., 16 Jan 2025, (E-pub ahead of print) In: Journal of Advanced Research. p. 1-14 14 p.

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2023

ADR3, a next generation i-body to human RANKL, inhibits osteoclast formation and bone resorption

Qiu, H., Hosking, C., Rothzerg, E., Samantha, A., Chen, K., Kuek, V., Jin, H., Zhu, S., Vrielink, A., Lim, K., Foley, M. & Xu, J., Feb 2023, In: The Journal of Biological Chemistry. 299, 2, p. 102889 102889.

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7 Citations (Scopus)

Antidementia medication acetylcholinesterase inhibitors have therapeutic benefits on osteoporotic bone by attenuating osteoclastogenesis and bone resorption

Li, S., Teguh, D., Wu, D., Liu, L., Hu, C., Yuan, J., Inderjeeth, C. A. & Xu, J., Aug 2023, In: Journal of Cellular Physiology. 238, 8, p. 1823-1835 13 p.

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2 Citations (Scopus)

Dragon blood resin ameliorates steroid-induced osteonecrosis of femoral head through osteoclastic pathways

Liu, Y., Mo, L., Lu, H., Wei, Y., Zhang, J., Bennett, S., Xu, J., Zhou, C., Fang, B. & Chen, Z., 22 Aug 2023, In: Frontiers in Cell and Developmental Biology. 11, 14 p., 1202888.

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3 Citations (Scopus)

Leveraging osteoclast genetic regulatory data to identify genes with a role in osteoarthritis

Mullin, B. H., Zhu, K., Brown, S. J., Mullin, S., Dudbridge, F., Pavlos, N. J., Richards, J. B., Grundberg, E., Bell, J. T., Zeggini, E., Walsh, J. P., Xu, J. & Wilson, S. G., 4 Oct 2023, In: Genetics. 225, 2, iyad150.

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5 Citations (Web of Science)

Structure and function of the membrane microdomains in osteoclasts

Hou, J., Liu, J., Huang, Z., Wang, Y., Yao, H., Hu, Z., Shi, C., Xu, J. & Wang, Q., Dec 2023, In: Bone Research. 11, 1, 61.

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2 Citations (Scopus)

2022

Loureirin B downregulates osteoclast differentiation of bone marrow macrophages by targeting the MAPK signaling pathway

Zhang, J., Mo, L., Huang, H., Xu, J., Fan, Y., Li, W., Wang, H., Zhou, C., Fang, H., He, W., Chen, Z. & Liu, Y., 23 Aug 2022, In: Scientific Reports. 12, 1, p. 14382 1 p., 14382.

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11 Citations (Scopus)

Molecular structure, expression, and the emerging role of Siglec-15 in skeletal biology and cancer

Rashid, S., Song, D., Yuan, J., Mullin, B. & Xu, J., Mar 2022, In: Journal of Cellular Physiology. 237, 3, p. 1711-1719 9 p.

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16 Citations (Scopus)

Roburic acid attenuates osteoclastogenesis and bone resorption by targeting RANKL-induced intracellular signaling pathways

Wang, G., Chen, K., Ma, C., Wang, C., Chen, D., He, J., Liu, Y., Jiang, T., Yuan, J., Chen, L., He, W. & Xu, J., Mar 2022, In: Journal of Cellular Physiology. 237, 3, p. 1790-1803 14 p.

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10 Citations (Scopus)

Role of Sostdc1 in skeletal biology and cancer

Tong, X., Zhu, C., Liu, L., Huang, M., Xu, J., Chen, X. & Zou, J., 21 Oct 2022, In: Frontiers in Physiology. 13, 1029646.

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7 Citations (Scopus)

Thiaplakortone B attenuates RANKL‐induced NF‐κB and MAPK signaling and dampens OVX‐induced bone loss in mice

Wang, Q., Chen, D., Wang, Y., Dong, C., Liu, J., Chen, K., Song, F., Wang, C., Yuan, J., Davis, R. A., Kuek, V., Jin, H. & Xu, J., Oct 2022, In: Biomedicine and Pharmacotherapy. 154, 13 p., 113622.

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9 Citations (Scopus)

Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair

Zhu, S., Chen, M., Ying, Y., Wu, Q., Huang, Z., Ni, W., Wang, X., Xu, H., Bennett, S., Xiao, J. & Xu, J., Dec 2022, In: Bone Research. 10, 1, 30.

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39 Citations (Scopus)

2021

A missense mutation sheds light on a novel structure–function relationship of RANKL

Qiu, H., Qin, A., Cheng, T., Chim, S. M., Smithers, L., Chen, K., Song, D., Liu, Q., Zhao, J., Wang, C., Teguh, D., Zhang, G., Tickner, J., Vrielink, A., Pavlos, N. J. & Xu, J., Apr 2021, In: Journal of Cellular Physiology. 236, 4, p. 2800-2816 17 p.

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18 Citations (Scopus)

Biological insights into the rapid tissue regeneration of freshwater crayfish and crustaceans

Feleke, M., Bennett, S., Chen, J., Chandler, D., Hu, X. & Xu, J., Aug 2021, In: Cell Biochemistry and Function. 39, 6, p. 740-753 14 p.

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7 Citations (Scopus)

475 Downloads (Pure)

Carnosol suppresses RANKL-induced osteoclastogenesis and attenuates titanium particles-induced osteolysis

Li, Y., Lin, S., Liu, P., Huang, J., Qiu, J., Wen, Z., Yuan, J., Qiu, H., Liu, Y., Liu, Q., Zhou, T., Luo, P., Guo, H., Ma, Y., Guo, D., Mo, G., Tang, Y., Xu, L., Liang, D. & Xu, J. & 2 others, Ding, Y. & Zhang, S., Mar 2021, In: Journal of Cellular Physiology. 236, 3, p. 1950-1966 17 p.

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19 Citations (Scopus)

248 Downloads (Pure)

Current research progress in targeted anti-angiogenesis therapy for osteosarcoma

Liu, Y., Huang, N., Liao, S., Rothzerg, E., Yao, F., Li, Y., Wood, D. & Xu, J., Sept 2021, In: Cell Proliferation. 54, 9, e13102.

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56 Citations (Scopus)

Editorial: Novel Therapies for Combating Bone Diseases Through Advances in Bone Remodeling

Jiao, Y., Xu, J., Liang, C. & Li, C., 14 Oct 2021, In: Frontiers in Cell and Developmental Biology. 9, 766963.

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Inhibitory Effects of Rhaponticin on Osteoclast Formation and Resorption by Targeting RANKL-Induced NFATc1 and ROS Activity

He, J., Chen, K., Deng, T., Xie, J., Zhong, K., Yuan, J., Wang, Z., Xiao, Z., Gu, R., Chen, D., Li, X., Lin, D. & Xu, J., 23 Sept 2021, In: Frontiers in Pharmacology. 12, 645140.

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19 Citations (Scopus)

Molecular structure, gene expression and functional role of WFDC1 in angiogenesis and cancer

Zhu, S., Ye, L., Bennett, S., Xu, H., He, D. & Xu, J., Jul 2021, In: Cell Biochemistry and Function. 39, 5, p. 588-595 8 p.

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8 Citations (Web of Science)

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Molecular structure and function of microfibrillar-associated proteins in skeletal and metabolic disorders and cancers

Zhu, S., Ye, L., Bennett, S., Xu, H., He, D. & Xu, J., Jan 2021, In: Journal of Cellular Physiology. 236, 1, p. 41-48 8 p.

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34 Citations (Scopus)

Morin attenuates osteoclast formation and function by suppressing the NF-κB, MAPK and calcium signalling pathways

Shi, Y., Ye, L., Shen, S., Qian, T., Pan, Y., Jiang, Y., Lin, J., Liu, C., Wu, Y., Wang, X., Xu, J. & Jin, H., Oct 2021, In: Phytotherapy Research. 35, 10, p. 5694-5707 14 p.

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8 Citations (Scopus)

New physiological insights into the phenomena of deer antler: A unique model for skeletal tissue regeneration

Feleke, M., Bennett, S., Chen, J., Hu, X., Williams, D. & Xu, J., Mar 2021, In: Journal of Orthopaedic Translation. 27, p. 57-66 10 p.

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29 Citations (Scopus)

Osteoblast-derived EGFL6 couples angiogenesis to osteogenesis during bone repair

Chen, K., Liao, S., Li, Y., Jiang, H., Liu, Y., Wang, C., Kuek, V., Kenny, J., Li, B., Huang, Q., Hong, J., Huang, Y., Chim, S. M., Tickner, J., Pavlos, N. J., Zhao, J., Liu, Q., Qin, A. & Xu, J., 2021, In: Theranostics. 11, 20, p. 9738-9751 14 p.

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28 Citations (Scopus)

STAT3 and its targeting inhibitors in osteosarcoma

Liu, Y., Liao, S., Bennett, S., Tang, H., Song, D., Wood, D., Zhan, X. & Xu, J., Feb 2021, In: Cell Proliferation. 54, 2, e12974.

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109 Citations (Scopus)

The Hippo in the room: Targeting the Hippo signalling pathway for osteosarcoma therapies

Rothzerg, E., Ingley, E., Mullin, B., Xue, W., Wood, D. & Xu, J., Mar 2021, In: Journal of Cellular Physiology. 236, 3, p. 1606-1615 10 p.

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22 Citations (Scopus)

The molecular structure and function of sorting nexin 10 in skeletal disorders, cancers, and other pathological conditions

Xu, J., Qiu, H., Zhao, J. & Pavlos, N. J., Jun 2021, In: Journal of Cellular Physiology. 236, 6, p. 4207-4215 9 p.

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7 Citations (Scopus)

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The molecular structure and role of CCL2 (MCP-1) and C-C chemokine receptor CCR2 in skeletal biology and diseases

Zhu, S., Liu, M., Bennett, S., Wang, Z., Pfleger, K. D. G. & Xu, J., Oct 2021, In: Journal of Cellular Physiology. 236, 10, p. 7211-7222 12 p.

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65 Citations (Scopus)

239 Downloads (Pure)

The Role of Irisin in Exercise-Mediated Bone Health

Liu, L., Guo, J., Chen, X., Tong, X., Xu, J. & Zou, J., 4 May 2021, In: Frontiers in Cell and Developmental Biology. 9, 668759.

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25 Citations (Scopus)

2020

Arctiin abrogates osteoclastogenesis and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation

Chen, D., Ye, Z., Wang, C., Wang, Q., Wang, H., Kuek, V., Wang, Z., Qiu, H., Yuan, J., Kenny, J., Yang, F., He, J., Liu, Y., Wang, G., Zhang, M., Zhang, G., Wang, J., Chen, P. & Xu, J., Sept 2020, In: Pharmacological Research. 159, 104944.

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts

Mullin, B., Tickner, J., Zhu, K., Kenny, J., Mullin, S., Brown, S. J., Dudbridge, F., Pavlos, N., Mocarski, E. S., Walsh, J. P., Xu, J. & Wilson, S., 26 Mar 2020, In: Genome Biology. 21, 1, 80.

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46 Citations (Scopus)

Dracorhodin perchlorate inhibits osteoclastogenesis through repressing RANKL-stimulated NFATc1 activity

Liu, Y., Wang, Z., Ma, C., Wei, Z., Chen, K., Wang, C., Zhou, C., Chen, L., Zhang, Q., Chen, Z., He, W. & Xu, J., 1 Mar 2020, In: Journal of Cellular and Molecular Medicine. 24, 6, p. 3303-3313 11 p.

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17 Citations (Scopus)

Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling

Zhou, L., Hong, G., Li, S., Liu, Q., Song, F., Zhao, J., Yuan, J., Tickner, J. & Xu, J., 2020, In: International Journal of Biological Sciences. 16, 2, p. 309-319 11 p.

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14 Citations (Scopus)

Hederagenin protects mice against ovariectomy-induced bone loss by inhibiting RANKL-induced osteoclastogenesis and bone resorption

Tian, K., Su, Y., Ding, J., Wang, D., Zhan, Y., Li, Y., Liang, J., Lin, X., Song, F., Wang, Z., Xu, J., Liu, Q. & Zhao, J., 1 Mar 2020, In: Life Sciences. 244, 117336.

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18 Citations (Scopus)

Hymenialdisine: A Marine Natural Product That Acts on Both Osteoblasts and Osteoclasts and Prevents Estrogen-Dependent Bone Loss in Mice

Wang, Q., Chen, D., Jin, H., Ye, Z., Wang, C., Chen, K., Kuek, V., Xu, K., Qiu, H., Chen, P., Song, D., Zhao, J., Liu, Q., Davis, R. A., Song, F. & Xu, J., 1 Aug 2020, In: Journal of Bone and Mineral Research. 35, 8, p. 1582-1596 15 p.

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44 Citations (Scopus)

PKC-δ deficiency in B cells displays osteopenia accompanied with upregulation of RANKL expression and osteoclast–osteoblast uncoupling

Li, S., Liu, Q., Wu, D., He, T., Yuan, J., Qiu, H., Tickner, J., Zheng, S. G., Li, X., Xu, J. & Rong, L., 1 Sept 2020, In: Cell Death and Disease. 11, 9, 762.

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13 Citations (Scopus)

Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts

Chen, K., Liu, Y., He, J., Pavlos, N., Wang, C., Kenny, J., Yuan, J., Zhang, Q., Xu, J. & He, W., 2020, In: International Journal of Biological Sciences. 16, 11, p. 1888-1900 13 p.

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85 Citations (Scopus)

The emerging roles of hnRNPK

Wang, Z., Qiu, H., He, J., Liu, L., Xue, W., Fox, A., Tickner, J. & Xu, J., 1 Mar 2020, In: Journal of Cellular Physiology. 235, 3, p. 1995-2008 14 p.

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98 Citations (Scopus)

Vindoline inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in mice

Zhan, Y., Liang, J., Tian, K., Che, Z., Wang, Z., Yang, X., Su, Y., Lin, X., Song, F., Zhao, J., Xu, J., Liu, Q. & Zhou, B., 1 Jan 2020, In: Frontiers in Pharmacology. 10, 01587.

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23 Citations (Scopus)

2019

Advanced Genetic Approaches in Discovery and Characterization of Genes Involved With Osteoporosis in Mouse and Human

Yuan, J., Tickner, J., Mullin, B. H., Zhao, J., Zeng, Z., Morahan, G. & Xu, J., 2 Apr 2019, In: Frontiers in Genetics. 10, APR, 13 p., 288.

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20 Citations (Scopus)

Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-kappa B signaling pathways

He, L., Hong, G., Zhou, L., Zhang, J., Fang, J., He, W., Tickner, J., Han, X., Zhao, L. & Xu, J., Apr 2019, In: Journal of Cellular Physiology. 234, 4, p. 4267-4276 10 p.

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31 Citations (Scopus)

Asperpyrone A attenuates RANKL-induced osteoclast formation through inhibiting NFATc1, Ca²⁺ signalling and oxidative stress

Chen, X., Wang, C., Qiu, H., Yuan, Y., Chen, K., Cao, Z., Xiang Tan, R., Tickner, J., Xu, J. & Zou, J., 1 Dec 2019, In: Journal of Cellular and Molecular Medicine. 23, 12, p. 8269-8279 11 p.

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15 Citations (Web of Science)

Astilbin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis

Jin, H., Wang, Q., Chen, K., Xu, K., Pan, H., Chu, F., Ye, Z., Wang, Z., Tickner, J., Qiu, H., Wang, C., Kenny, J., Xu, H., Wang, T. & Xu, J., 1 Dec 2019, In: Journal of Cellular and Molecular Medicine. 23, 12, p. 8355-8368 14 p.

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18 Citations (Scopus)

Cepharanthine suppresses osteoclast formation by modulating the nuclear factor-κB and nuclear factor of activated T-cell signaling pathways

Lin, X., Song, F., Zhou, L., Wang, Z., Wei, C., Xu, J., Zhao, J. & Liu, Q., 1 Feb 2019, In: Journal of Cellular Biochemistry. 120, 2, p. 1990-1996 7 p.

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15 Citations (Scopus)

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Chondromodulin-1 in health, osteoarthritis, cancer, and heart disease

Zhu, S., Qiu, H., Bennett, S., Kuek, V., Rosen, V., Xu, H. & Xu, J., 1 Nov 2019, In: Cellular and Molecular Life Sciences. 76, 22, p. 4493-4502 10 p.

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23 Citations (Scopus)

Cumambrin A prevents OVX-induced osteoporosis via the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways

Zhou, L., Liu, Q., Hong, G., Song, F., Zhao, J., Yuan, J., Xu, J., Tan, R. X., Tickner, J., Gu, Q. & Xu, J., 1 Jun 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 6, p. 6726-6735 10 p.

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14 Citations (Scopus)

Cytochalasin Z11 inhibits RANKL-induced osteoclastogenesis: Via suppressing NFATc1 activation

Lu, W., Chen, K., He, J., Kenny, J., Yuan, Y., Chen, J., Liu, Q., Tan, R., Zhao, J. & Xu, J., 25 Nov 2019, In: RSC Advances. 9, 66, p. 38438-38446 9 p.

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10 Citations (Web of Science)

Diosmetin inhibits osteoclast formation and differentiation and prevents LPS-induced osteolysis in mice

Shao, S., Fu, F., Wang, Z., Song, F., Li, C., Wu, Z. X., Ding, J., Li, K., Xiao, Y., Su, Y., Lin, X., Yuan, G., Zhao, J., Liu, Q. & Xu, J., 1 Aug 2019, In: Journal of Cellular Physiology. 234, 8, p. 12701-12713 13 p.

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20 Citations (Scopus)

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Discovery of new inhibitors against both NF-κB and osteoclastogenesis from in-house library with α, β-unsaturated-enone fragment

Zhao, C., Huang, D., Li, R., Xu, J., Gu, Q. & Xu, J., 1 Jun 2019, In: Bioorganic Chemistry. 87, p. 638-646 9 p.

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4 Citations (Scopus)

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Evodiamine inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in mice

Jin, H., Yao, L., Chen, K., Liu, Y., Wang, Q., Wang, Z., Liu, Q., Cao, Z., Kenny, J., Tickner, J., Wang, X. & Xu, J., Jan 2019, In: Journal of Cellular and Molecular Medicine. 23, 1, p. 522-534 13 p.

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25 Citations (Scopus)

Helvolic acid attenuates osteoclast formation and function via suppressing RANKL-induced NFATc1 activation

Chen, K., Yuan, Y., Wang, Z., Song, D., Zhao, J., Cao, Z., Chen, J., Guo, Q., Chen, L., Tickner, J. & Xu, J., May 2019, In: Journal of Cellular Physiology. 234, 5, p. 6477-6488 12 p.

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Furin: Carving-up vital substrates for bone remodelling and homeostasis

Research output

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