Designing new therapeutics using medical synthetic biology

Status	Curtailed
Effective start/end date	1/01/19 → 9/10/20

Access Project

ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription
Dai, C. Y., Ng, C. C., Hung, G. C. C., Kirmes, I., Hughes, L. A., Du, Y., Brosnan, C. A., Ahier, A., Hahn, A., Haynes, C. M., Rackham, O., Filipovska, A. & Zuryn, S., 17 Jul 2023, In: Nature Cell Biology. 25, 8, p. 1111-1120 10 p.
Research output: Contribution to journal › Article › peer-review
Computationally designed hyperactive Cas9 enzymes
Vos, P. D., Rossetti, G., Mantegna, J. L., Siira, S. J., Gandadireja, A. P., Bruce, M., Raven, S. A., Khersonsky, O., Fleishman, S. J., Filipovska, A. & Rackham, O., 31 May 2022, In: Nature Communications. 13, 1, 11 p., 3023.
Research output: Contribution to journal › Article › peer-review

Open Access
4 Citations (Scopus)
In silico evolution of nucleic acid-binding proteins from a nonfunctional scaffold
Raven, S. A., Payne, B., Bruce, M., Filipovska, A. & Rackham, O., Apr 2022, In: Nature Chemical Biology. 18, 4, p. 403-411 9 p.
Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)