Combinatorial therapeutics in high-risk infant acute lymphoblastic leukaemia

2023

Characterization of mesenchymal stem cells in pre-B acute lymphoblastic leukemia

Hughes, A. M., Kuek, V., Oommen, J., Chua, G. A., van Loenhout, M., Malinge, S., Kotecha, R. S. & Cheung, L. C., 20 Jan 2023, In: Frontiers in Cell and Developmental Biology. 11, 12 p., 1005494.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia

Mateos, M. K., Marshall, G. M., Barbaro, P. M., Quinn, M. C. J., George, C., Mayoh, C., Sutton, R., Revesz, T., Giles, J. E., Barbaric, D., Alvaro, F., Mechinaud, F., Catchpoole, D., Lawson, J. A., Chenevix-Trench, G., MacGregor, S., Kotecha, R. S., Dalla-Pozza, L. & Trahair, T. N., Mar 2022, In: Haematologica. 107, 3, p. 635-643 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Prospective longitudinal evaluation of treatment-related toxicity and health-related quality of life during the first year of treatment for pediatric acute lymphoblastic leukemia

Schilstra, C. E., McCleary, K., Fardell, J. E., Donoghoe, M. W., McCormack, E., Kotecha, R. S., Lourenco, R. D. A., Ramachandran, S., Cockcroft, R., Conyers, R., Cross, S., Dalla-Pozza, L., Downie, P., Revesz, T., Osborn, M., Alvaro, F., Wakefield, C. E., Marshall, G. M., Mateos, M. K. & Trahair, T. N., Dec 2022, In: BMC Cancer. 22, 1, 12 p., 985.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

The Bone Marrow Microenvironment in B-Cell Development and Malignancy

Hughes, A. M., Kuek, V., Kotecha, R. S. & Cheung, L. C., 1 May 2022, In: Cancers. 14, 9, 2089.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Citations (Scopus)

2021

Case Report: Long-Term Survival of a Pediatric Patient With an Intra-Abdominal Undifferentiated Carcinoma of Unknown Primary

Stirnweiss, A., Dholaria, H., Oommen, J., Hardy, K., Jevon, G., Beesley, A. H. & Kotecha, R. S., 10 May 2021, In: Frontiers in Oncology. 11, 590913.

Research output: Contribution to journal › Article › peer-review

Open Access

Malignant Melanoma in Children and Adolescents Treated in Pediatric Oncology Centers: An Australian and New Zealand Children’s Oncology Group (ANZCHOG) Study

Ryan, A. L., Burns, C., Gupta, A. K., Samarasekera, R., Ziegler, D. S., Kirby, M. L., Alvaro, F., Downie, P., Laughton, S. J., Cross, S., Hassall, T., McCowage, G. B., Hansford, J. R., Kotecha, R. S. & Gottardo, N. G., 29 Apr 2021, In: Frontiers in Oncology. 11, 660172.

Research output: Contribution to journal › Article › peer-review

Open Access

Outcomes for Australian children with relapsed/refractory acute lymphoblastic leukaemia treated with blinatumomab

Sutton, R., Pozza, L. D., Khaw, S. L., Fraser, C., Revesz, T., Chamberlain, J., Mitchell, R., Trahair, T. N., Bateman, C. M., Venn, N. C., Law, T., Ong, E., Heatley, S. L., McClure, B. J., Meyer, C., Marschalek, R., Henderson, M. J., Cross, S., White, D. L. & Kotecha, R. S., May 2021, In: Pediatric Blood and Cancer. 68, 5, e28922.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic Leukemia

Cheung, L. C., de Kraa, R., Oommen, J., Chua, G. A., Singh, S., Hughes, A. M., Ferrari, E., Ford, J., Chiu, S. K., Stam, R. W., Kees, U. R., Malinge, S. & Kotecha, R. S., 15 Apr 2021, In: Frontiers in Oncology. 11, 631594.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

Matthijssens, F., Sharma, N. D., Nysus, M., Nickl, C. K., Kang, H., Perez, D. R., Lintermans, B., Van Loocke, W., Roels, J., Peirs, S., Demoen, L., Pieters, T., Reunes, L., Lammens, T., De Moerloose, B., Van Nieuwerburgh, F., Deforce, D. L., Cheung, L. C., Kotecha, R. S., Risseeuw, M. D. P., & 17 othersVan Calenbergh, S., Takarada, T., Yoneda, Y., Van Delft, F. W., Lock, R. B., Merkley, S. D., Chigaev, A., Sklar, L. A., Mullighan, C. G., Loh, M. L., Winter, S. S., Hunger, S. P., Goossens, S., Castillo, E. F., Ornatowski, W., Van Vlierberghe, P. & Matlawska-Wasowska, K., 15 Mar 2021, In: Journal of Clinical Investigation. 131, 6, e141566.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

2020

Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia

Laurent, A. P., Siret, A., Ignacimouttou, C., Panchal, K., Diop, MB., Jenni, S., Tsai, Y. C., Roos-Weil, D., Aid, Z., Prade, N., Lagarde, S., Plassard, D., Pierron, G., Daudigeos, E., Lecluse, Y., Droin, N., Bornhauser, B. C., Cheung, L. C., Crispino, J. D., Gaudry, M., & 10 othersBernard, O. A., Macintyre, E., Barin Bonnigal, C., Kotecha, R. S., Geoerger, B., Ballerini, P., Bourquin, J. P., Delabesse, E., Mercher, T. & Malinge, S., Jul 2020, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 26, 13, p. 3307-3318 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome

Laurent, A. P., Kotecha, R. S. & Malinge, S., 1 Aug 2020, In: Leukemia. 34, 8, p. 1984-1999 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

21 Citations (Scopus)

Immunogenicity of the inactivated influenza vaccine in children who have undergone allogeneic haematopoietic stem cell transplant

Ryan, A. L., Wadia, U. D., Jacoby, P., Cheung, L. C., Kerr, F., Fraser, C., Tapp, H., Mechinaud, F., Carolan, L. A., Laurie, K. L., Barr, I. G., Blyth, C. C., Gottardo, N. G., Richmond, P. C. & Kotecha, R. S., 1 Apr 2020, In: Bone Marrow Transplantation. 55, 4, p. 773-779 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia

Wander, P., Cheung, L. C., Pinhanҫos, S. S., Jones, L., Kerstjens, M., Arentsen-Peters, S. T. C. J. M., Singh, S., Chua, G. A., Castro, P. G., Schneider, P., Dolman, M. E. M., Koopmans, B., Molenaar, J. J., Pieters, R., Zwaan, C. M., Kotecha, R. S. & Stam, R. W., 1 Nov 2020, In: Leukemia. 34, 11, p. 2898-2902 5 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Targeting cytokine- And therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

De Smedt, R., Morscio, J., Reunes, L., Roels, J., Bardelli, V., Lintermans, B., Van Loocke, W., Almeida, A., Cheung, L. C., Kotecha, R. S., Mansour, M. R., Uyttebroeck, A., Vandenberghe, P., La Starza, R., Mecucci, C., Lammens, T., Van Roy, N., De Moerloose, B., Barata, J. T., Taghon, T., & 2 othersGoossens, S. & Van Vlierberghe, P., 7 May 2020, In: Blood. 135, 19, p. 1685-1695 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Citations (Scopus)

2019

Epidemiology of invasive fungal infections in immunocompromised children; an Australian national 10-year review

Bartlett, A. W., Cann, M. P., Yeoh, D. K., Bernard, A., Ryan, A. L., Blyth, C. C., Kotecha, R. S., McMullan, B. J., Moore, A. S., Haeusler, G. M. & Clark, J. E., 1 Apr 2019, In: Pediatric Blood and Cancer. 66, 4, 8 p., e27564.

Research output: Contribution to journal › Article › peer-review

Open Access

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28 Citations (Scopus)

56 Downloads (Pure)

Romidepsin enhances the efficacy of cytarabine in vivo, revealing histone deacetylase inhibition as a promising therapeutic strategy for KMT2A-rearranged infant acute lymphoblastic leukemia

Cheung, L. C., Cruickshank, M. N., Hughes, A. M., Singh, S., Chua, G-A., Ford, J., Ferrari, E., Oommen, J., Malinge, S., Lock, R. B., Kees, U. R. & Kotecha, R. S., 30 Jun 2019, In: Haematologica. 104, 7, p. e300-e303 4 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

8 Citations (Scopus)

Vaccine-preventable disease following allogeneic haematopoietic stem cell transplant in Western Australia

Ryan, A. L., Kerr, F., Gough, H., Carter, T. L. & Kotecha, R. S., 1 Mar 2019, In: Journal of Paediatrics and Child Health. 55, 3, p. 343-348 6 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

2018

New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment

Cheung, L. C., Tickner, J., Hughes, A. M., Skut, P., Howlett, M., Foley, B., Oommen, J., Wells, J. E., He, B., Singh, S., Chua, G. A., Ford, J., Mullighan, C. G., Kotecha, R. S. & Kees, U. R., 1 Nov 2018, In: Leukemia. 32, 11, p. 2326-2338 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Citations (Web of Science)

Combinatorial therapeutics in high-risk infant acute lymphoblastic leukaemia

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