Yuben Moodley


  • The University of Western Australia (M582), 35 Stirling Highway,

    6009 Perth


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Personal profile


I have done seminal studies in three areas of research that have now moved to clinical trials in the last 3 years. I carried out first ever studies in signal transduction through the interleukin-6 receptor in Idiopathic Pulmonary Fibrosis (IPF). In addition, for the first time ever, used stem cells from the human umbilical cord and human placental amnion cells to treat animal models of lung diseases. The latter has led to clinical trials in treating premature babies with bronchopulmonary dysplasia in Melbourne.

I am a Chief Investigator on a Centre of Research Excellence in Pulmonary Fibrosis awarded by the NHMRC, recognition of my achievement and reputation. During this 5-year program, the team of scientists under my supervision were the first ever to demonstrate specific circulating lung cancer RNA in patients with progressive IPF, linking cancer to this disorder. In addition, I led an international study that resulted in the discovery of circulatory biomarkers that predict progression in IPF (European Respiratory Journal). I have led my team in delineating the immune response in human patients with Chronic Obstructive Pulmonary Disease (COPD) following infusion with mesenchymal stromal cells.

Present Research

  • Investigating the role of circulating monocytes in the progression of IPF.
  • The association of circulating biomarker levels with clinical progression in IPF patients treated with antifibrotics.
  • Profiling of miRNA in circulating small extracellular vesicles in progressive IPF.
  • Epigenetic and transcriptomic profile in primary lung cells contributing to IPF.
  • Spatial transcriptomics of early lung injury and fibrosis.
  • Identification of early activated pathways in alveolar epithelial cell line derived from stem cells.


I am the lead coordinator for Internal Medicine in Medicine Year 3 (MD3) and a member of the MD3 teaching committee.


I am consultant Respiratory Physician at Fiona Stanley Hospital.


Foundational role in building formal networks that facilitate the significant exchange of ideas on a regular basis

I am a member of the writing teams for two Thoracic Society of Australia New Zealand Australasian guideline documents on the management of Interstitial lung diseases that have

I am Senior Editor of the journal Respirology, one of the major journals in our field with an impact factor of 6.4.

I am a member on the inaugural national steering committee of the Australian Lung Foundation.  

I am Deputy Director of the Institute of Respiratory Health.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research expertise keywords

  • Cellular therapy for lung disease
  • Lung fibrosis
  • Regenerative medicine


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  • Assessment of health-related quality of life in Australian patients with idiopathic pulmonary fibrosis: a comparison of the EQ-5D-5L and the AQoL-8D

    Cox, I. A., Campbell, J., de Graaff, B., Otahal, P., Corte, T. J., Moodley, Y., Hopkins, P., Macansh, S., Walters, E. H. & Palmer, A. J., Feb 2023, In: Quality of Life Research. 32, 2, p. 473-493 21 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Idiopathic Pulmonary Fibrosis Is Associated with Common Genetic Variants and Limited Rare Variants

    NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Peljto, A. L., Blumhagen, R. Z., Walts, A. D., Cardwell, J., Powers, J., Corte, T. J., Dickinson, J. L., Glaspole, I., Moodley, Y. P., Vasakova, M. K., Bendstrup, E., Davidsen, J. R., Borie, R., Crestani, B., Dieude, P., Bonella, F., Costabel, U., Gudmundsson, G., Donnelly, S. C., & 96 othersEgan, J., Henry, M. T., Keane, M. P., Kennedy, M. P., McCarthy, C., McElroy, A. N., Olaniyi, J. A., O'Reilly, K. M. A., Richeldi, L., Leone, P. M., Poletti, V., Puppo, F., Tomassetti, S., Luzzi, V., Kokturk, N., Mogulkoc, N., Fiddler, C. A., Hirani, N., Jenkins, G., Maher, T. M., Molyneaux, P. L., Parfrey, H., Braybrooke, R., Blackwell, T. S., Jackson, P. D., Nathan, S. D., Porteous, M. K., Brown, K. K., Christie, J. D., Collard, H. R., Eickelberg, O., Foster, E. E., Gibson, K. F., Glassberg, M., Kass, D., Kropski, J. A., Lederer, D., Linderholm, A. L., Loyd, J., Mathai, S. K., Montesi, S. B., Noth, I., Oldham, J. M., Palmisciano, A. J., Reichner, C. A., Rojas, M., Roman, J., Schluger, N., Shea, B. S., Swigris, J. J., Wolters, P. J., Zhang, Y., Prele, C. M. A., Enghelmayer, J. I., Otaola, M., Ryerson, C. J., Salinas, M., Sterclova, M., Gebremariam, T. H., Myllärniemi, M., Carbone, R., Furusawa, H., Hirose, M., Inoue, Y., Miyazaki, Y., Ohta, K., Ohta, S., Okamoto, T., Kim, D. S., Pardo, A., Selman, M., Aranda, A. U., Park, M. S., Park, J. S., Song, J. W., Molina-Molina, M., Planas-Cerezales, L., Westergren-Thorsson, G., Smith, A. V., Manichaikul, A. W., Kim, J. S., Rich, S. S., Oelsner, E. C., Barr, R. G., Rotter, J. I., Dupuis, J., O'Connor, G., Vasan, R. S., Cho, M. H., Silverman, E. K., Schwarz, M. I., Steele, M. P., Lee, J. S., Yang, I. V., Fingerlin, T. E. & Schwartz, D. A., 1 May 2023, In: American Journal of Respiratory and Critical Care Medicine. 207, 9, p. 1194-1202 9 p.

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)
  • Preclinical interstitial lung disease in relatives of familial pulmonary fibrosis patients

    Lucas, S. E. M., Raspin, K., Mackintosh, J., Glaspole, I., Reynolds, P. N., Chia, C., Grainge, C., Kendall, P., Troy, L., Schwartz, D. A., Wood-Baker, R., Walsh, S. L. F., Moodley, Y., Robertson, J., Macansh, S., Walters, E. H., Chambers, D., Corte, T. J. & Dickinson, J. L., 1 May 2023, In: Pulmonology. 29, 3, p. 257-260 4 p.

    Research output: Contribution to journalLetterpeer-review

    Open Access
  • A Phase 1/2 Study of a Respiratory Syncytial Virus Prefusion F Vaccine With and Without Adjuvant in Healthy Older Adults

    Baber, J., Arya, M., Moodley, Y., Jaques, A., Jiang, Q., Swanson, K. A., Cooper, D., Maddur, M. S., Loschko, J., Gurtman, A., Jansen, K. U., Gruber, W. C., Dormitzer, P. R. & Schmoele-Thoma, B., 15 Dec 2022, In: Journal of Infectious Diseases. 226, 12, p. 2054-2063 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    5 Citations (Scopus)
  • Biomarker signatures for progressive idiopathic pulmonary fibrosis

    Clynick, B., Corte, T. J., Jo, H. E., Stewart, I., Glaspole, I. N., Grainge, C., Maher, T. M., Navaratnam, V., Hubbard, R., Hopkins, P. M. A., Reynolds, P. N., Chapman, S., Zappala, C., Keir, G. J., Cooper, W. A., Mahar, A. M., Ellis, S., Goh, N. S., De Jong, E., Cha, L., & 6 othersTan, D. B. A., Leigh, L., Oldmeadow, C., Walters, E. H., Jenkins, R. G. & Moodley, Y., 1 Mar 2022, In: The European Respiratory Journal. 59, 3

    Research output: Contribution to journalArticlepeer-review

    Open Access
    10 Citations (Scopus)